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S. Žuklys · SciRah

Researcher profile · Semantic Scholar

S. Žuklys

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S. Žuklys — researcher profile on SciRah

h-index: 20
Works: 47
Citations: 2,812

Most-cited papers

Delta-like 4 is indispensable in thymic environment specific for T cell development
K. Hozumi, C. Mailhos, Naoko Negishi, K. Hirano +6 more
2008Journal of Experimental Medicine411 citations Open access
Semantic Scholar
Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)1
S. Žuklys, Gina Balc̆iūnaite, A. Agarwal, E. Fasler-Kan +2 more
2000Journal of Immunology292 citations Open access
Semantic Scholar
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
Gina Balc̆iūnaite, M. Keller, Egle Balciunaite, L. Piali +6 more
2002Nature Immunology285 citations
Semantic Scholar
Monoallelic expression of the interleukin-2 locus.
G. Holländer, S. Žuklys, C. Morel, E. Mizoguchi +7 more
1998Science247 citations
Semantic Scholar
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
Simona W. Rossi, L. Jeker, T. Ueno, Sachiyo Kuse +7 more
2007Blood221 citations Open access
Semantic Scholar
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a-mediated suppression of interferon alpha receptor
A. Papadopoulou, J. Dooley, M. Linterman, Wim Pierson +8 more
2011Nature Immunology183 citations Open access
Semantic Scholar
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
S. Žuklys, A. Handel, S. Zhanybekova, F. Govani +9 more
2016Nature Immunology167 citations Open access
Semantic Scholar
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells
I. Ohigashi, S. Žuklys, Mie Sakata, C. E. Mayer +5 more
2013Proceedings of the National Academy of Sciences of the United States of America139 citations Open access
Semantic Scholar
Cellular and molecular events during early thymus development
G. Holländer, J. Gill, S. Žuklys, N. Iwanami +2 more
2006Immunological Reviews126 citations
Semantic Scholar
IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCRγδ+ Intraepithelial Lymphocytes
Soichiro Shitara, T. Hara, Bingfei Liang, Keisuke Wagatsuma +6 more
2013Journal of Immunology86 citations
Semantic Scholar
Stabilized β-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function1
S. Žuklys, J. Gill, M. Keller, Mathias M. Hauri-Hohl +10 more
2009Journal of Immunology85 citations Open access
Semantic Scholar
Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors.
I. Ohigashi, S. Žuklys, Mie Sakata, C. E. Mayer +4 more
2015Cell Reports83 citations Open access
Semantic Scholar
TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
Mathias M. Hauri-Hohl, S. Žuklys, M. Keller, L. Jeker +4 more
2008Blood74 citations Open access
Semantic Scholar
Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
C. E. Mayer, S. Žuklys, S. Zhanybekova, I. Ohigashi +9 more
2016European Journal of Immunology69 citations Open access
Semantic Scholar
A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
Mathias M. Hauri-Hohl, S. Žuklys, G. Holländer, S. Ziegler
2014Nature Immunology67 citations Open access
Semantic Scholar
miRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection
S. Žuklys, C. E. Mayer, S. Zhanybekova, H. Stefanski +13 more
2012Journal of Immunology60 citations Open access
Semantic Scholar
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development
S. Jenkinson, Joy A. Williams, Hyein Jeon, Jingjing Zhang +13 more
2013Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation
Alexandria C. Wells, Kaito A. Hioki, Constance C. Angelou, Adam C. Lynch +11 more
2023Nature Communications28 citations Open access
Semantic Scholar
IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes
Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, C. Détraves +11 more
2022Frontiers in Immunology21 citations Open access
Semantic Scholar
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells
F. Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio +11 more
2022bioRxiv20 citations Open access
Semantic Scholar
Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
E. Vroegindeweij, S. Crobach, M. Itoi, R. Satoh +8 more
2010Molecular Immunology20 citations
Semantic Scholar
Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
A. Handel, Noriko Shikama-Dorn, S. Zhanybekova, Stefano Maio +4 more
2018Frontiers in Immunology19 citations Open access
Semantic Scholar
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
L. Jeker, T. Barthlott, M. Keller, S. Žuklys +3 more
2008Blood17 citations Open access
Semantic Scholar
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
T. Barthlott, A. Handel, H. Teh, Rushika C. Wirasinha +7 more
2021Nature Communications15 citations Open access
Semantic Scholar
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency
Ioanna A. Rota, A. Handel, Stefano Maio, Fabian Klein +27 more
2021Science Advances15 citations Open access
Semantic Scholar
On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
G. Holländer, S. Žuklys, E. Förster, W. Krenger
1999Transplantation Proceedings12 citations
Semantic Scholar
Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution
María J. García-León, Marta Mosquera, Carmela Cela, J. Alcain +3 more
2022Frontiers in Immunology9 citations Open access
Semantic Scholar
Topological shape transform for thymus structures
Hao Yang, Vadim Lebovici, Andreas Tarcevski, Liliana Tchernev +4 more
20262 citations
Semantic Scholar
Beyond conventional adoptive T cell therapy.
Marina Cavazzana, Juliette Paillet, A. Fandi, R. D. Moirangthem +16 more
2025Journal of Allergy and Clinical Immunology2 citations Open access
Semantic Scholar
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a-mediated suppression of interferon alpha receptor
A. Papadopoulou, J. Dooley, M. Linterman, Wim Pierson +9 more
20131 citations
Semantic Scholar
Importance of MHCII expression on thymic epithelium versus dendritic cells for the positive and negative selection of CD4 T Cells (138.28)
S. Jenkinson, S. Žuklys, G. Hollander, Pandelakis A. Koni +2 more
2009Journal of Immunology1 citations
Semantic Scholar
Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance
Andreas Tarcevski, Fatima Dhalla, Joshua W. Moore, S. Žuklys +10 more
2026bioRxiv0 citations Open access
Semantic Scholar
Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging
Irene Calvo-Asensio, Andreas Tarcevski, Fatima Dhalla, Anja Kusch +4 more
2026Science Advances0 citations Open access
Semantic Scholar
Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by ageing
Irene Calvo-Asensio, Andreas Tarcevski, Fatima Dhalla, Anja Kusch +4 more
2025bioRxiv0 citations Open access
Semantic Scholar
A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
Ioanna A. Rota, A. Handel, F. Klein, Stefano Maio +27 more
2021bioRxiv0 citations Open access
Semantic Scholar
Contents: Eur. J. Immunol. 4'16.
H. Y. Kim, Dale T. Umetsu, R. DeKruyff, Laura A. Solt +45 more
2016European Journal of Immunology0 citations
Semantic Scholar
epithelial cells development via enhancements in proliferation and function of thymic Keratinocyte growth factor (KGF) enhances postnatal T-cell
A. Gudkov, Y. Takahama, W. Krenger, B. Blazar +7 more
20130 citations
Semantic Scholar
require Smad4-mediated signalling in thymic epithelial cells Maintenance of a normal thymic microenvironment and T cell homeostasis
G. Holländer, L. Jeker, T. Barthlott, M. Keller +3 more
20130 citations
Semantic Scholar
beta-catenin function is required for thymus organogenesis and maintenance
S. Žuklys, S. Zhanybekova, Mathias M. Hauri-Hohl, T. Barthlott +1 more
20130 citations
Semantic Scholar
This information is current as Lymphocytes Intraepithelial + δγ Thymocytes and TCR Plays a Major Role in the Development of IL-7 Produced by Thymic Epithelial Cells
Soichiro Shitara, T. Hara, Bingfei Liang, Keisuke Wagatsuma +6 more
20130 citations
Semantic Scholar
The role of continued Foxn1 expression in thymus organogenesis and maintenance
A. Bosch, T. Barthlott, S. Žuklys, G. Holländer
20120 citations
Semantic Scholar
Abstract 3081: Loss of Shoca-2 expression in colorectal cancer correlates with metastasis as Shoca-2 represses EGF-regulated STAT3 activation via recruitment of PP1beta
S. Loeffler, M. Kováč, S. Žuklys, M. Keller +5 more
20100 citations
Semantic Scholar
MicroRNAs in immune development/responses (WS-062) Chairpersons: Ken Ishii, Taro Fukao
M. Gururajan, C. Haga, S. Das, C. Leu +50 more
20100 citations
Semantic Scholar
Thymic epithelial cell-specific smad4 deficiency leads to lymphopenia and an increased suppressive capacity of CD103 + CD25 + CD4 + T cells
L. Jeker, S. Žuklys, M. Keller, T. Barthlott +1 more
20070 citations
Semantic Scholar
Identification of differentially expressed gene sequences along granulocytic differentiation of promyelocytic HL60 cells
A. Kulyté, S. Žuklys, A. Gineitis, G. Hollander +1 more
20000 citations
Semantic Scholar
Expression of the cytokine interleukin-2 is controlled by allelic exclusion
G. Holländer, S. Žuklys, C. Moret, K. Mobisson +7 more
19980 citations
Semantic Scholar
miRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection
S. Žuklys, C. E. Mayer, S. Zhanybekova, H. Stefanski +15 more
0 citations
Semantic Scholar

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G. Holländer×38
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G. Holländer — researcher profile on SciRah
T. Barthlott×13
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S. Zhanybekova×11
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M. Keller×10
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Y. Takahama — researcher profile on SciRah

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C. E. Mayer — researcher profile on SciRah

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L. Jeker — researcher profile on SciRah

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J. Gill — researcher profile on SciRah

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A. Handel — researcher profile on SciRah

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