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M. Binnie · SciRah

Researcher profile · Semantic Scholar

M. Binnie

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M. Binnie — researcher profile on SciRah

h-index: 20
Works: 32
Citations: 1,315

Most-cited papers

Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra‐pancreatic glucose regulation
R. Ortíz-Andrade, J. C. Sánchez-Salgado, G. Navarrete-Vázquez, S. Webster +6 more
2008Diabetes, obesity and metabolism178 citations
Semantic Scholar
Effect of mydriasis and different field strategies on digital image screening of diabetic eye disease
H. Murgatroyd, A. Ellingford, A. Cox, M. Binnie +3 more
2004British Journal of Ophthalmology152 citations Open access
Semantic Scholar
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.
M. Torres-Piedra, R. Ortíz-Andrade, R. Villalobos-Molina, Narender Singh +5 more
2010European journal of medicinal chemistry142 citations
Semantic Scholar
Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides.
Hermenegilda Moreno-Díaz, R. Villalobos-Molina, R. Ortíz-Andrade, Daniel Díaz-Coutiño +7 more
2008Bioorganic & Medicinal Chemistry Letters105 citations
Semantic Scholar
Partial deficiency or short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves cognitive function in ageing mice
K. Sooy, S. Webster, J. Noble, M. Binnie +3 more
2010Journal of Neuroscience102 citations Open access
Semantic Scholar
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury
Xiaozhong Zheng, Ai-Liang Zhang, M. Binnie, K. Mcguire +4 more
2019Experimental and Molecular Medicine61 citations Open access
Semantic Scholar
Cognitive and disease-modifying effects of 11ß-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease
K. Sooy, J. Noble, A. Mcbride, M. Binnie +5 more
201554 citations
Semantic Scholar
Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
S. Webster, P. Ward, M. Binnie, E. Craigie +5 more
2007Bioorganic & Medicinal Chemistry Letters50 citations Open access
Semantic Scholar
Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion
A. Kitamura, Yasmina Manso, Jessica Duncombe, James L. Searcy +9 more
2017Scientific Reports47 citations Open access
Semantic Scholar
Background and Purpose Experimental Approach Conclusions and Implications
Scott P. Webster, A. Mcbride, M. Binnie, K. Sooy +9 more
47 citations
Semantic Scholar
Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Damian J. Mole, Scott P. Webster, Iain Uings, Xiaozhong Zheng +23 more
2016Nature Medicine45 citations Open access
Semantic Scholar
Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry
D. M. Lowe, M. Gee, Carl P. Haslam, B. Leavens +13 more
2014Journal of biomolecular screening40 citations Open access
Semantic Scholar
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
C. Skouras, Xiaozhong Zheng, M. Binnie, N. Homer +18 more
2016Scientific Reports34 citations Open access
Semantic Scholar
Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer
M. Binnie, F. Alexander, C. Heald, F. Habib
2005The Prostate34 citations
Semantic Scholar
Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities.
G. Navarrete-Vázquez, María Guadalupe Morales-Vilchis, S. Estrada-Soto, J. J. Ramírez-Espinosa +10 more
2014European journal of medicinal chemistry29 citations
Semantic Scholar
Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1.
J. J. Ramírez-Espinosa, S. García-Jiménez, M. Ríos, J. Medina-Franco +6 more
2013Phytomedicine27 citations
Semantic Scholar
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Ann L. Walker, N. Ancellin, B. Beaufils, M. Bergeal +18 more
2017Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification
Kris Wilson, Damian J. Mole, M. Binnie, N. Homer +5 more
2014Protein Expression and Purification23 citations Open access
Semantic Scholar
Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease
K. Sooy, J. Noble, Andrew McBride, M. Binnie +4 more
2015Endocrinology22 citations Open access
Semantic Scholar
Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity by 1,5-Substituted 1H-Tetrazoles
Scott P. Webster, M. Binnie, Kirsty M. M. McConnell, K. Sooy +9 more
2010Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback
Kris Wilson, M. Auer, M. Binnie, Xiaozhong Zheng +4 more
2016Cell Death and Disease20 citations Open access
Semantic Scholar
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
A. Hayes, Xiaozhong Zheng, J. O'Kelly, Lucile P. A. Neyton +16 more
2023Cell Reports19 citations Open access
Semantic Scholar
Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.
R. Leiva, C. Griñán-Ferré, C. Seira, Elena Valverde +8 more
2017European journal of medicinal chemistry17 citations Open access
Semantic Scholar
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
J. Liddle, B. Beaufils, M. Binnie, A. Bouillot +16 more
2017Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors.
Elena Valverde, C. Seira, A. Mcbride, M. Binnie +4 more
2015Bioorganic & Medicinal Chemistry4 citations Open access
Semantic Scholar
Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.
R. Leiva, C. Seira, A. Mcbride, M. Binnie +4 more
2015Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Edinburgh Research Explorer Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343
S. Webster, Andrew McBride, M. Binnie, K. Sooy +9 more
3 citations
Semantic Scholar
Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors
R. Leiva, A. Mcbride, M. Binnie, S. Webster +1 more
2018Molecules1 citations Open access
Semantic Scholar
Cilostazol reduced gliovascular damage and working memory impairment via endotelial protection in a mouse model of vascular dementia
A. Kitamura, Y. Sanz, Jessica Duncombe, J. Koudelka +10 more
20170 citations
Semantic Scholar
Explorer Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion
A. Kitamura, Yasmina Manso, Jessica Duncombe, James L. Searcy +9 more
20170 citations
Semantic Scholar
Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion
A. Kitamura, Yasmina Manso, Jessica Duncombe, James L. Searcy +9 more
2017Scientific Reports0 citations Open access
Semantic Scholar
Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180
D. Mole, S. Webster, I. Uings, Xiaozhong Zheng +23 more
20160 citations
Semantic Scholar

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