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Zhong-Yu Zhu · SciRah

Researcher profile · Semantic Scholar

Zhong-Yu Zhu

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Zhong-Yu Zhu — researcher profile on SciRah

h-index: 40
Works: 109
Citations: 6,407

Most-cited papers

CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
R. Majzner, Johanna Theruvath, Anandani Nellan, S. Heitzeneder +23 more
2019Clinical Cancer Research546 citations Open access
Semantic Scholar
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3 Positive Tumor Cells and Tumor Vasculature
S. Seaman, Zhong-Yu Zhu, S. Saha, Xiaoyan M Zhang +23 more
2017Cancer Cell374 citations Open access
Semantic Scholar
A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection
Katharine N. Bossart, Zhong-Yu Zhu, D. Middleton, Jessica Klippel +10 more
2009PLoS Pathogens334 citations Open access
Semantic Scholar
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
Zhong-Yu Zhu, Samitabh Chakraborti, Yuxian He, Anjeanette Roberts +18 more
2007Proceedings of the National Academy of Sciences of the United States of America305 citations Open access
Semantic Scholar
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
Xiao-Dong Xiao, Wei-zao Chen, Yang Feng, Zhong-Yu Zhu +5 more
2009Biochemical and Biophysical Research Communications - BBRC276 citations Open access
Semantic Scholar
Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody
P. Prabakaran, J. Gan, Yang Feng, Zhong-Yu Zhu +4 more
2006Journal of Biological Chemistry248 citations Open access
Semantic Scholar
Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma
K. Bosse, P. Raman, Zhong-Yu Zhu, M. Lane +25 more
2017Cancer Cell202 citations Open access
Semantic Scholar
Therapeutic Treatment of Nipah Virus Infection in Nonhuman Primates with a Neutralizing Human Monoclonal Antibody
T. Geisbert, C. Mire, J. Geisbert, Y. Chan +9 more
2014Science Translational Medicine188 citations Open access
Semantic Scholar
A neutralizing human monoclonal antibody protects African Green monkeys from Hendra virus challenge
Katharine N. Bossart, T. Geisbert, H. Feldmann, Zhong-Yu Zhu +14 more
2011Science Translational Medicine177 citations Open access
Semantic Scholar
Exceptionally Potent Cross-Reactive Neutralization of Nipah and Hendra Viruses by a Human Monoclonal Antibody
Zhong-Yu Zhu, Katharine N. Bossart, Kimberly A. Bishop, G. Crameri +7 more
2008Journal of Infectious Diseases172 citations Open access
Semantic Scholar
Modulation of Target Antigen Density Improves CAR T Cell Functionality and Persistence
S. Ramakrishna, S. Highfill, Zachary H. Walsh, S. Nguyen +12 more
2019Clinical Cancer Research162 citations Open access
Semantic Scholar
GPC2-CAR T Cells Tuned for Low Antigen Density Mediate Potent Activity Against Neuroblastoma Without Toxicity.
S. Heitzeneder, K. Bosse, Zhong-Yu Zhu, D. Zhelev +37 more
2021Cancer Cell158 citations Open access
Semantic Scholar
A treatment for and vaccine against the deadly Hendra and Nipah viruses
C. Broder, Kai Xu, D. Nikolov, Zhong-Yu Zhu +6 more
2013Antiviral Research148 citations Open access
Semantic Scholar
Multi-specific anti-HIV duoCAR-T cells display broad antiviral activity and potent elimination of HIV-infected cells in vivo
K. Anthony-Gonda, A. Bardhi, A. Ray, Nina C Flerin +12 more
2019Science Translational Medicine147 citations Open access
Semantic Scholar
Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models
D. Schneider, Ying Xiong, Darong Wu, Peirong Hu +9 more
2021Science Translational Medicine137 citations
Semantic Scholar
Antibody Aggregation: Insights from Sequence and Structure
Wei Li, P. Prabakaran, Wei-zao Chen, Zhong-Yu Zhu +2 more
2016Antibodies137 citations Open access
Semantic Scholar
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Li-Rong Yu, Zhong-Yu Zhu, King C. Chan, H. Issaq +2 more
2007Journal of Proteome Research131 citations
Semantic Scholar
Functional studies of host-specific ephrin-B ligands as Henipavirus receptors.
Katharine N. Bossart, M. Tachedjian, Jennifer A. McEachern, G. Crameri +4 more
2008Virology113 citations Open access
Semantic Scholar
Tumor stroma‐targeted antibody‐drug conjugate triggers localized anticancer drug release
C. Szot, S. Saha, Xiaoyan M Zhang, Zhong-Yu Zhu +18 more
2018Journal of Clinical Investigation105 citations Open access
Semantic Scholar
Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers
Wei-zao Chen, Zhong-Yu Zhu, Yang Feng, D. Dimitrov
2008Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar
Zhong-Yu Zhu, B. Ramakrishnan, Jinyu Li, Yan-Ping Wang +6 more
2014mAbs98 citations Open access
Semantic Scholar
Identification of a Putative Crimean-Congo Hemorrhagic Fever Virus Entry Factor
Xiao-Dong Xiao, Yang Feng, Zhong-Yu Zhu, D. Dimitrov
2011Biochemical and Biophysical Research Communications - BBRC92 citations Open access
Semantic Scholar
Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody
Kai Xu, B. Rockx, Yi-Hu Xie, B. DeBuysscher +12 more
2013PLoS Pathogens90 citations Open access
Semantic Scholar
Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies
Zhong-Yu Zhu, H. Qin, Wei-zao Chen, Qi Zhao +20 more
2011Journal of Virology89 citations Open access
Semantic Scholar
Residues in the Stalk Domain of the Hendra Virus G Glycoprotein Modulate Conformational Changes Associated with Receptor Binding
Kimberly A. Bishop, Andrew C. Hickey, D. Khetawat, J. Patch +5 more
2008Journal of Virology81 citations Open access
Semantic Scholar
A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity
Yang Feng, Jia-Yin Shen, E. Streaker, Michael B. Lockwood +3 more
2011Arthritis Research & Therapy78 citations Open access
Semantic Scholar
Construction of a large phage–displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain
Wei-zao Chen, Zhong-Yu Zhu, Yang Feng, Xiao-Dong Xiao +1 more
2008Journal of Molecular Biology76 citations Open access
Semantic Scholar
Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development
Wei Li, Zhong-Yu Zhu, Wei-zao Chen, Yang Feng +1 more
2017Frontiers in Immunology70 citations Open access
Semantic Scholar
Cancer cell survival depends on collagen uptake into tumor-associated stroma
Kuo-Sheng Hsu, James M. Dunleavey, C. Szot, Li-Ping Yang +18 more
2022Nature Communications61 citations Open access
Semantic Scholar
Potent Human Monoclonal Antibodies against SARS CoV, Nipah and Hendra Viruses
P. Prabakaran, Zhong-Yu Zhu, Xiao-Dong Xiao, A. Biragyn +3 more
2009Expert Opinion on Biological Therapy60 citations Open access
Semantic Scholar
Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains
Wei-zao Chen, Yang Feng, P. Prabakaran, T. Ying +7 more
2013Journal of Virology59 citations Open access
Semantic Scholar
Construction of a Large Naïve Human Phage-Displayed Fab Library Through One-Step Cloning
Zhong-Yu Zhu, D. Dimitrov
2009Methods in molecular biology58 citations Open access
Semantic Scholar
Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β
Leah M. Alabanza, Ying Xiong, B. Vu, Brian Webster +6 more
2022Frontiers in Immunology57 citations Open access
Semantic Scholar
A Novel Human Monoclonal Antibody that Binds with High Affinity to Mesothelin-Expressing Cells and Kills them by ADCC
Yang Feng, Xiao-Dong Xiao, Zhong-Yu Zhu, E. Streaker +3 more
2009Molecular Cancer Therapeutics55 citations Open access
Semantic Scholar
Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6
G. Ofek, Brett Zirkle, Yong-Ping Yang, Zhong-Yu Zhu +9 more
2013Journal of Virology51 citations Open access
Semantic Scholar
Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation
Monica M. Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhi-Wei Jiang +17 more
2024Cell Reports43 citations Open access
Semantic Scholar
A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia
D. Schneider, Ying Xiong, Peirong Hu, Darong Wu +6 more
2018Frontiers in Oncology41 citations Open access
Semantic Scholar
Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model
Xiao-Dong Xiao, Zhong-Yu Zhu, Jennifer L. Dankmeyer, Michael M Wormald +5 more
2010PLoS ONE40 citations Open access
Semantic Scholar
Cartilage-Targeted IGF-1 Treatment to Promote Longitudinal Bone Growth.
J. Lui, Max Colbert, C. S. Cheung, Michal Ad +5 more
2019Molecular Therapy39 citations Open access
Semantic Scholar
Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates
Wei-zao Chen, Xiao-Dong Xiao, Yan-Ping Wang, Zhong-Yu Zhu +1 more
2010Antiviral Research39 citations Open access
Semantic Scholar
Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton +25 more
2023Cell Reports38 citations
Semantic Scholar
A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III
Da-yin Hu, Zhong-Yu Zhu, Shun Li, Yong-Qiang Deng +17 more
2019PLoS Pathogens38 citations Open access
Semantic Scholar
Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors 1 and 2 with Picomolar Affinity
Qi Zhao, Yang Feng, Zhong-Yu Zhu, D. Dimitrov
2011Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing
P. Prabakaran, Zhong-Yu Zhu, Wei-zao Chen, R. Gong +3 more
2012Front. Microbio.37 citations Open access
Semantic Scholar
Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens
Wei-zao Chen, Yang Feng, R. Gong, Zhong-Yu Zhu +3 more
2011Journal of Virology37 citations Open access
Semantic Scholar
Identification and characterization of fully human anti-CD22 monoclonal antibodies
Xiao-Dong Xiao, Mitchell Ho, Zhong-Yu Zhu, I. Pastan +1 more
2009mAbs37 citations Open access
Semantic Scholar
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
S. Raman, Samantha N Buongervino, M. Lane, D. Zhelev +16 more
2021Cell Reports Medicine36 citations Open access
Semantic Scholar
Potent In Vivo NK Cell-Mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-Bispecific and Hexavalent Broadly Neutralizing Fusion Protein
A. Bardhi, Yan-Ling Wu, Wei-zao Chen, Wei Li +10 more
2017Journal of Virology36 citations Open access
Semantic Scholar
Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics
Wei-zao Chen, Yang Feng, Qi Zhao, Zhong-Yu Zhu +1 more
2012Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Construction of a human antibody domain (VH) library
Wei-zao Chen, Zhong-Yu Zhu, Xiao-Dong Xiao, D. Dimitrov
2009Methods in molecular biology27 citations Open access
Semantic Scholar

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