Researcher profile · Semantic Scholar

Y. Imaeda

h-index: 18
Works: 34
Citations: 1,181

Most-cited papers

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)*
Nobumichi Ohoka, Keiichiro Okuhira, M. Ito, Katsunori Nagai +13 more
2017Journal of Biological Chemistry173 citations Open access
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Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.
N. Shibata, Katsunori Nagai, Yoko Morita, O. Ujikawa +8 more
2017Journal of Medicinal Chemistry122 citations Open access
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TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
K. Nakayama, M. Szewczyk, C. D. Dela Seña, Hong Wu +20 more
2018OncoTarget118 citations Open access
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Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
Yuta Tanaka, Katsuji Aikawa, G. Nishida, Misaki Homma +12 more
2013Journal of Medicinal Chemistry96 citations Open access
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Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands
N. Shibata, N. Miyamoto, Katsunori Nagai, K. Shimokawa +7 more
2017Cancer Science92 citations Open access
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Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation
Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, K. Shimokawa +14 more
2018Journal of Biological Chemistry73 citations Open access
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Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
M. Ito, Toshio Tanaka, Akinori Toita, N. Uchiyama +15 more
2018Journal of Medicinal Chemistry58 citations Open access
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Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.
Takuya Fujimoto, Y. Imaeda, Noriko Konishi, K. Hiroe +4 more
2009Journal of Medicinal Chemistry51 citations Open access
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Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.
Y. Kamada, Nozomu Sakai, S. Sogabe, K. Ida +8 more
2017Journal of Medicinal Chemistry48 citations Open access
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Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay.
Misa Iwatani-Yoshihara, M. Ito, Y. Ishibashi, H. Oki +8 more
2017ACS Chemical Biology37 citations Open access
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Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship.
Kotaro Sakamoto, S. Sogabe, Y. Kamada, Nozomu Sakai +5 more
2017Biochemical and Biophysical Research Communications - BBRC35 citations
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Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors.
M. Ito, Toshio Tanaka, Douglas R. Cary, Misa Iwatani-Yoshihara +5 more
2017Journal of Medicinal Chemistry30 citations Open access
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Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo.
A. Hori, Y. Imaeda, K. Kubo, M. Kusaka
2002Cancer Letters28 citations
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Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
T. Yasui, Takeshi Yamamoto, Nozomu Sakai, Kouhei Asano +15 more
2017Bioorganic & Medicinal Chemistry27 citations Open access
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Discovery of selective ATP-competitive eIF4A3 inhibitors.
M. Ito, Misa Iwatani, Y. Kamada, S. Sogabe +6 more
2017Bioorganic & Medicinal Chemistry26 citations Open access
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Discovery of imidazo[1,5-c]imidazol-3-ones: weakly basic, orally active factor Xa inhibitors.
Y. Imaeda, T. Kuroita, Hiroki Sakamoto, T. Kawamoto +6 more
2008Journal of Medicinal Chemistry25 citations Open access
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Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.
Tomoya Sameshima, Takeshi Yamamoto, Osamu Sano, S. Sogabe +7 more
2018Biochemistry22 citations
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Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor
Y. Imaeda, Hidekazu Tokuhara, Y. Fukase, R. Kanagawa +6 more
2016ACS Medicinal Chemistry Letters21 citations Open access
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Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active factor Xa inhibitors.
Y. Imaeda, T. Kawamoto, M. Tobisu, Noriko Konishi +4 more
2008Bioorganic & Medicinal Chemistry16 citations Open access
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Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.
R. Mizojiri, Daisuke Nakata, Y. Satoh, D. Morishita +13 more
2017ACS Medicinal Chemistry Letters13 citations Open access
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Antithrombotic and Anticoagulant Profiles of TAK-442, a Novel Factor Xa Inhibitor, in a Rabbit Model of Venous Thrombosis
M. Kawamura, Noriko Konishi, K. Hiroe, K. Shofuda +3 more
2010Journal of Cardiovascular Pharmacology13 citations
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Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Shoichi Nakao, M. Nogami, Misa Iwatani, T. Imaeda +11 more
2020Biochemical and Biophysical Research Communications - BBRC12 citations Open access
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Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors.
Y. Imaeda, T. Miyawaki, Hiroki Sakamoto, F. Itoh +5 more
2008Bioorganic & Medicinal Chemistry12 citations Open access
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Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.
Y. Imaeda, M. Tawada, Shinkichi Suzuki, M. Tomimoto +8 more
2016Bioorganic & Medicinal Chemistry8 citations Open access
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Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Hidekazu Tokuhara, Y. Imaeda, Y. Fukase, Koichiro Iwanaga +10 more
2018Bioorganic & Medicinal Chemistry7 citations Open access
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Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor.
Jonas W. Højfeldt, O. Cruz-Rodríguez, Y. Imaeda, A. Van Dyke +3 more
2014Molecular Endocrinology6 citations Open access
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Novel approach of fragment-based lead discovery applied to renin inhibitors.
M. Tawada, Shinkichi Suzuki, Y. Imaeda, H. Oki +7 more
2016Bioorganic & Medicinal Chemistry5 citations Open access
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Effects of TAK-442, a Direct FXa Inhibitor, and Fondaparinux on Platelet-Associated Prothrombinase in the Balloon Injured Artery of Rats
M. Kawamura, Noriko Konishi, Hiroe Katsuhiko, Y. Imaeda +2 more
20085 citations
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Differential Effects of TAK-442, a Factor Xa Inhibitor, and Ximelagatran, a Thrombin Inhibitor, on Bleeding: Possible Role of Differences in Effects on Factor V-Mediated Feedback on Blood Coagulation Cascade
Noriko Konishi, K. Hiroe, Y. Imaeda, Takuya Fujimoto +2 more
20082 citations
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Discovery of CTX-439: A Potent and Selective CDK12 Inhibitor as a Prospective Anti-Cancer Drug.
Kenichiro Shimokawa, Koji Ono, Moriteru Asano, T. Hirayama +21 more
2026ACS Medicinal Chemistry Letters0 citations Open access
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Abstract 2793: Design, synthesis and evaluations of novel class of orally bioavailable eIF4A3-selective inhibitors
R. Mizojiri, Daisuke Nakata, Y. Satoh, D. Morishita +13 more
2018Experimental and Molecular Therapeutics0 citations
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Abstract 2802: Discovery of the first selective and cell-active eIF4A3 inhibitors
M. Ito, Misa Iwatani-Yoshihara, Toshio Tanaka, Douglas R. Cary +12 more
2018Experimental and Molecular Therapeutics0 citations
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Regulation of the ubiquitin-proteasome system by a small molecule SNIPER and its application to drug development.
Nobumichi Ohoka, Keiichiro Okuhira, Katsunori Nagai, M. Ito +9 more
20160 citations
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Studies on Sulfonylalkylamides as a New Class of Orally Active Factor Xa Inhibitors
Y. Imaeda
20090 citations
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S. Sogabe

×7

Toshio Tanaka×7

Noriko Konishi×7

M. Kawamura×7

Nobuo Cho×6

Tomoya Sameshima×6

Mitsuyo Kondo×6

S. Aparicio×6