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G. Simos · SciRah

Researcher profile · Semantic Scholar

G. Simos

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G. Simos — researcher profile on SciRah

h-index: 42
Works: 112
Citations: 5,580

Most-cited papers

Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α*
Ilias Mylonis, G. Chachami, M. Samiotaki, G. Panayotou +5 more
2006Journal of Biological Chemistry286 citations Open access
Semantic Scholar
Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism
Ilias Mylonis, G. Simos, E. Paraskeva
2019Cells282 citations Open access
Semantic Scholar
Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores
H. Santos‐Rosa, Horacio Moreno, G. Simos, A. Segref +3 more
1998Molecular and Cellular Biology282 citations Open access
Semantic Scholar
Yeast Los1p Has Properties of an Exportin-Like Nucleocytoplasmic Transport Factor for tRNA
K. Hellmuth, Denise Lau, F. Bischoff, M. Künzler +2 more
1998Molecular and Cellular Biology243 citations Open access
Semantic Scholar
Mtr10p functions as a nuclear import receptor for the mRNA‐binding protein Npl3p
B. Senger, G. Simos, F. Bischoff, A. Podtelejnikov +2 more
1998EMBO Journal197 citations Open access
Semantic Scholar
A Novel In Vivo Assay Reveals Inhibition of Ribosomal Nuclear Export in Ran-Cycle and Nucleoporin Mutants
E. Hurt, Stefan Hannus, Birgit Schmelzl, Denise Lau +2 more
1999Journal of Cell Biology181 citations Open access
Semantic Scholar
An aminoacylation-dependent nuclear tRNA export pathway in yeast.
H. Grosshans, E. Hurt, G. Simos
2000Genes & Development178 citations Open access
Semantic Scholar
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Ilias Mylonis, H. Sembongi, C. Befani, P. Liakos +2 more
2012Journal of Cell Science153 citations Open access
Semantic Scholar
Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export
H. Grosshans, Karina Deinert, E. Hurt, G. Simos
2001Journal of Cell Biology148 citations Open access
Semantic Scholar
Characterization of Yeast Protein Deg1 as Pseudouridine Synthase (Pus3) Catalyzing the Formation of Ψ38 and Ψ39 in tRNA Anticodon Loop*
F. Lecointe, G. Simos, A. Sauer, E. Hurt +2 more
1998Journal of Biological Chemistry145 citations Open access
Semantic Scholar
Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators
Angelos Yfantis, Ilias Mylonis, G. Chachami, M. Nikolaidis +3 more
2023Cells127 citations Open access
Semantic Scholar
The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity.
Y. Motorin, G. Keith, C. Simon, D. Foiret +3 more
1998RNA: A publication of the RNA Society120 citations Open access
Semantic Scholar
The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions.
Ilias Mylonis, A. Lakka, A. Tsakalof, G. Simos
2010Biochemical and Biophysical Research Communications - BBRC118 citations
Semantic Scholar
Cobalt induces hypoxia-inducible factor-1α (HIF-1α) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
A. Triantafyllou, P. Liakos, A. Tsakalof, E. Georgatsou +2 more
2006114 citations
Semantic Scholar
Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
C. Befani, P. Vlachostergios, E. Hatzidaki, A. Patrikidou +4 more
2011Journal of molecular medicine108 citations
Semantic Scholar
Atypical CRM1-dependent Nuclear Export Signal Mediates Regulation of Hypoxia-inducible Factor-1α by MAPK*
Ilias Mylonis, G. Chachami, E. Paraskeva, G. Simos
2008Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.
G. Chachami, G. Simos, A. Hatziefthimiou, S. Bonanou +2 more
2004American Journal of Respiratory Cell and Molecular Biology96 citations
Semantic Scholar
Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect
Suhas Darekar, Konstantinos Georgiou, Mariya Y Yurchenko, S. P. Yenamandra +4 more
2012PLoS ONE95 citations Open access
Semantic Scholar
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
Alkmini Kalousi, Ilias Mylonis, A. Politou, G. Chachami +2 more
2010Journal of Cell Science82 citations Open access
Semantic Scholar
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
A. Daponte, M. Ioannou, Ilias Mylonis, G. Simos +3 more
2008BMC Cancer80 citations Open access
Semantic Scholar
Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
Ilias Mylonis, Maria Kourti, M. Samiotaki, G. Panayotou +1 more
2017Journal of Cell Science79 citations
Semantic Scholar
Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.
G. Chachami, E. Paraskeva, J. Mingot, G. Braliou +2 more
2009Biochemical and Biophysical Research Communications - BBRC78 citations
Semantic Scholar
Mitotic Phosphorylation of the Lamin B Receptor by a Serine/Arginine Kinase and p34cdc2*
E. Nikolakaki, J. Meier, G. Simos, S. Georgatos +1 more
1997Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Flavonoids induce HIF-1α but impair its nuclear accumulation and activity
A. Triantafyllou, Ilias Mylonis, G. Simos, S. Bonanou +1 more
200877 citations
Semantic Scholar
Lack of Pseudouridine 38/39 in the Anticodon Arm of Yeast Cytoplasmic tRNA Decreases in Vivo Recoding Efficiency*
F. Lecointe, O. Namy, I. Hatin, G. Simos +2 more
2002Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Arc1p Organizes the Yeast Aminoacyl-tRNA Synthetase Complex and Stabilizes Its Interaction with the Cognate tRNAs*
Karina Deinert, F. Fasiolo, E. Hurt, G. Simos
2001Journal of Biological Chemistry74 citations Open access
Semantic Scholar
The intracellular location of two aminoacyl‐tRNA synthetases depends on complex formation with Arc1p
K. Galani, H. Grosshans, Karina Deinert, E. Hurt +1 more
2001EMBO Journal72 citations Open access
Semantic Scholar
HIF-1α in colorectal carcinoma: review of the literature.
M. Ioannou, E. Paraskeva, K. Baxevanidou, G. Simos +4 more
2015Journal of B.U.ON. : official journal of the Balkan Union of Oncology70 citations
Semantic Scholar
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression.
G. Braliou, M. V. Verga Falzacappa, G. Chachami, Guillem Casanovas +2 more
2008Journal of Hepatology69 citations
Semantic Scholar
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
C. Befani, Ilias Mylonis, Ioanna-Maria Gkotinakou, P. Georgoulias +3 more
2013International Journal of Biochemistry and Cell Biology67 citations Open access
Semantic Scholar
Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.
Eleni-Anastasia Triantafyllou, E. Georgatsou, Ilias Mylonis, G. Simos +1 more
2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids66 citations
Semantic Scholar
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
H. Simader, M. Hothorn, Christine Köhler, J. Basquin +2 more
2006Nucleic Acids Research64 citations Open access
Semantic Scholar
Low Oxygen Tension Enhances Hepatitis C Virus Replication
N. Vassilaki, Katerina I. Kalliampakou, Ioly Kotta-Loizou, C. Befani +14 more
2012Journal of Virology56 citations Open access
Semantic Scholar
Pus1p-dependent tRNA Pseudouridinylation Becomes Essential When tRNA Biogenesis Is Compromised in Yeast*
H. Grosshans, F. Lecointe, H. Grosjean, E. Hurt +1 more
2001Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Erratum to: Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
C. Befani, P. Vlachostergios, E. Hatzidaki, A. Patrikidou +4 more
2013Journal of molecular medicine53 citations Open access
Semantic Scholar
Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.
A. Triantafyllou, P. Liakos, A. Tsakalof, E. Georgatsou +2 more
2006Free radical research53 citations
Semantic Scholar
Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
M. Ioannou, R. Papamichali, E. Kouvaras, Ilias Mylonis +7 more
2009Lung51 citations
Semantic Scholar
The Role of Sumoylation in the Response to Hypoxia: An Overview
C. Filippopoulou, G. Simos, G. Chachami
2020Cells50 citations Open access
Semantic Scholar
HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia
Angeliki Karagiota, Maria Kourti, G. Simos, Ilias Mylonis
2018Cellular and Molecular Life Sciences46 citations Open access
Semantic Scholar
The flavonoid quercetin induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation by depleting intracellular iron
A. Triantafyllou, P. Liakos, A. Tsakalof, G. Chachami +5 more
200744 citations
Semantic Scholar
eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.
A. Papadakis, E. Paraskeva, Philippos Peidis, Hala Muaddi +5 more
2010Cancer Research42 citations Open access
Semantic Scholar
Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.
A. Triantafyllou, Ilias Mylonis, G. Simos, S. Bonanou +1 more
2008Free Radical Biology & Medicine41 citations
Semantic Scholar
Transfer RNA biogenesis: A visa to leave the nucleus.
G. Simos, E. Hurt
1999Current Biology40 citations Open access
Semantic Scholar
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
Ioanna-Maria Gkotinakou, C. Befani, G. Simos, P. Liakos
2019Journal of Cell Science38 citations Open access
Semantic Scholar
High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6.
Y. Vasilopoulos, F. Sourli, E. Zafiriou, E. Klimi +5 more
2013Cytokine36 citations
Semantic Scholar
MgcRacGAP Interacts with HIF-1α and Regulates its Transcriptional Activity
A. Lyberopoulou, Emmanouil Venieris, Ilias Mylonis, G. Chachami +4 more
2007Cellular Physiology and Biochemistry36 citations
Semantic Scholar
ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, M. Samiotaki +3 more
2021Molecular Oncology35 citations Open access
Semantic Scholar
TNFα induces expression of HIF‐1α mRNA and protein but inhibits hypoxic stimulation of HIF‐1 transcriptional activity in airway smooth muscle cells
Stamatina Tsapournioti, Ilias Mylonis, A. Hatziefthimiou, M. Ioannou +5 more
2013Journal of Cellular Physiology35 citations
Semantic Scholar
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
E. Pangou, C. Befani, Ilias Mylonis, M. Samiotaki +3 more
2016Journal of Cell Science33 citations Open access
Semantic Scholar
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases
A. Lyberopoulou, G. Chachami, N. Gatselis, E. Kyratzopoulou +9 more
2015PLoS ONE33 citations Open access
Semantic Scholar

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Ilias Mylonis×19
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Ilias Mylonis — researcher profile on SciRah
G. Chachami×12
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G. Chachami — researcher profile on SciRah
E. Paraskeva×11
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S. Bonanou — researcher profile on SciRah

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G. Panayotou×4

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E. Hurt — researcher profile on SciRah