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J. Groffen · SciRah

Researcher profile · Semantic Scholar

J. Groffen

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J. Groffen — researcher profile on SciRah

h-index: 65
Works: 258
Citations: 20K

Most-cited papers

TGFβ signaling plays a critical role in promoting alternative macrophage activation
Dapeng Gong, Wei Shi, S. Yi, Hui Chen +2 more
2012BMC Immunology420 citations Open access
Semantic Scholar
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.
J. Mira, Valérie Benard, J. Groffen, L. C. Sanders +1 more
2000Proceedings of the National Academy of Sciences of the United States of America272 citations Open access
Semantic Scholar
Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia
Pavinder Kaur, N. Feldhahn, Bin Zhang, Daniel Trageser +4 more
2007Molecular Cancer260 citations Open access
Semantic Scholar
The B cell mutator AID promotes B lymphoid blast crisis and drug-resistance in chronic myeloid leukemia
Lars Klemm, C. Duy, I. Iacobucci, S. Kuchen +14 more
2009Cancer Cell169 citations Open access
Semantic Scholar
Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3
K. Ask, P. Bonniaud, Katja Maass, O. Eickelberg +5 more
2008161 citations Open access
Semantic Scholar
The human gamma-glutamyltransferase gene family
N. Heisterkamp, J. Groffen, D. Warburton, T. Sneddon
2008Human Genetics151 citations
Semantic Scholar
Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requires IKAROS function
Daniel Trageser, I. Iacobucci, R. Nahar, C. Duy +16 more
2009Journal of Experimental Medicine148 citations Open access
Semantic Scholar
TGF-β3-induced Palatogenesis Requires Matrix Metalloproteinases
L. Blavier, A. Lazaryev, J. Groffen, N. Heisterkamp +2 more
2001148 citations Open access
Semantic Scholar
Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.
Anja Reichert, N. Heisterkamp, George Q. Daley, J. Groffen
2001Blood128 citations
Semantic Scholar
Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins
Daeyoung Oh, Seungnam Han, Jinsoo Seo, Jae-Ran Lee +18 more
2010Journal of Neuroscience104 citations Open access
Semantic Scholar
TGF-beta3-induced palatogenesis requires matrix metalloproteinases.
L. Blavier, A. Lazaryev, J. Groffen, N. Heisterkamp +2 more
2001Molecular Biology of the Cell97 citations
Semantic Scholar
B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3
F. Fei, E. Joo, Somayeh S. Tarighat, Isabelle Schiffer +5 more
2015OncoTarget95 citations Open access
Semantic Scholar
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3.
K. Ask, P. Bonniaud, Katja Maass, O. Eickelberg +5 more
2008International Journal of Biochemistry and Cell Biology94 citations
Semantic Scholar
Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications.
Tudung T. Nguyen, A. Mohrbacher, Y. Tsai, J. Groffen +5 more
2000Blood91 citations
Semantic Scholar
Abr and Bcr, Two Homologous Rac GTPase-Activating Proteins, Control Multiple Cellular Functions of Murine Macrophages
Y. Cho, J. Cunnick, S. Yi, V. Kaartinen +2 more
2006Molecular and Cellular Biology84 citations Open access
Semantic Scholar
Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist
R. Parameswaran, Min Yu, M. Lim, J. Groffen +1 more
2011Leukemia74 citations Open access
Semantic Scholar
Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia
Y. Cho, Bin Zhang, V. Kaartinen, L. Haataja +3 more
2005Molecular and Cellular Biology72 citations Open access
Semantic Scholar
Enzyme replacement therapy in a mouse model of aspartylglycosaminuria
U. Dunder, V. Kaartinen, Pirjo Valtonen, Eira VÄÄnÄnen +4 more
2000The FASEB Journal71 citations
Semantic Scholar
Abnormal function of astroglia lacking Abr and Bcr RacGAPs.
V. Kaartinen, I. Gonzalez-Gomez, J. W. Voncken, L. Haataja +4 more
2001Development68 citations
Semantic Scholar
Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2
S. Mishra, V. Pertz, B. Zhang, P. Kaur +5 more
2007Leukemia61 citations
Semantic Scholar
The Small GTPase Rac3 Interacts with the Integrin-binding Protein CIB and Promotes Integrin αIIbβ3-mediated Adhesion and Spreading*
L. Haataja, V. Kaartinen, J. Groffen, N. Heisterkamp
2002Journal of Biological Chemistry58 citations Open access
Semantic Scholar
A functional receptor for B-cell activating factor is expressed on human acute lymphoblastic leukemias
R. Parameswaran, M. Müschen, Yong-Mi Kim, J. Groffen +1 more
2010Cancer Research55 citations Open access
Semantic Scholar
Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models
J. Yun, J. Behan, N. Heisterkamp, A. Butturini +5 more
2010Cancer Prevention Research53 citations Open access
Semantic Scholar
Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells.
Suparna Mishra, Bin Zhang, J. Cunnick, N. Heisterkamp +1 more
2006Cancer Research48 citations Open access
Semantic Scholar
Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia
F. Fei, S. Stoddart, M. Müschen, Yong-Mi Kim +2 more
2010Leukemia47 citations Open access
Semantic Scholar
Differential expression of TGF-β isoforms during postlactational mammary gland involution
E. Faure, N. Heisterkamp, J. Groffen, V. Kaartinen
2000Cell and Tissue Research47 citations
Semantic Scholar
TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis.
V. Kaartinen, L. Haataja, A. Nagy, N. Heisterkamp +1 more
2002International Journal of Molecular Medicine46 citations
Semantic Scholar
O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia
R. Parameswaran, M. Lim, A. Arutyunyan, H. Abdel-Azim +7 more
2013Journal of Experimental Medicine45 citations Open access
Semantic Scholar
Use of bone marrow-derived macrophages to model murine innate immune responses.
J. Cunnick, Pavinder Kaur, Young-Sook Cho, J. Groffen +1 more
2006JIM - Journal of Immunological Methods42 citations
Semantic Scholar
Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme.
M. Enoiu, Hayet Aberkane, Jean-Frédéric Salazar, P. Leroy +3 more
2000Free Radical Biology & Medicine41 citations
Semantic Scholar
Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells
B. Zhang, J. Groffen, N. Heisterkamp
2007Leukemia40 citations
Semantic Scholar
Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.
N. Heisterkamp, J. W. Voncken, D. Senadheera, I. Gonzalez-Gomez +5 more
2000Blood40 citations
Semantic Scholar
Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc engineered monoclonal antibody targeting the BAFF-R
R. Parameswaran, M. Lim, F. Fei, H. Abdel-Azim +7 more
2014Molecular Cancer Therapeutics39 citations Open access
Semantic Scholar
Activity of the Aurora Kinase inhibitor VX-680 against Bcr/Abl positive acute lymphoblastic leukemias
F. Fei, S. Stoddart, J. Groffen, N. Heisterkamp
2010Molecular Cancer Therapeutics39 citations Open access
Semantic Scholar
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains
P. Minoo, Ling-Yan Hu, N. Zhu, Z. Borok +4 more
2007Nucleic Acids Research38 citations Open access
Semantic Scholar
Protein kinase CKIIα interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells
Suparna Mishra, A. Reichert, J. Cunnick, D. Senadheera +3 more
2003Oncogene38 citations Open access
Semantic Scholar
Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
Helicia Paz, E. Joo, C. Chou, F. Fei +5 more
2018Journal of experimental & clinical cancer research : CR37 citations Open access
Semantic Scholar
Galectin-3 in pre-B acute lymphoblastic leukemia
F. Fei, H. Abdel-Azim, M. Lim, A. Arutyunyan +3 more
2013Leukemia36 citations Open access
Semantic Scholar
Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF‐β1 signaling and EGF as well as FGF receptor tyrosine kinase‐ERK pathways in mesenchymal cells
W. Ding, Wei Shi, S. Bellusci, J. Groffen +3 more
2007Journal of Cellular Physiology36 citations
Semantic Scholar
Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses
J. Cunnick, S. Schmidhuber, Gang Chen, Min Yu +7 more
2009Molecular and Cellular Biology35 citations Open access
Semantic Scholar
The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.
L. Haataja, V. Kaartinen, J. Groffen, N. Heisterkamp
2002Journal of Biological Chemistry35 citations
Semantic Scholar
Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs
V. Kaartinen, A. Nagy, I. Gonzalez-Gomez, J. Groffen +1 more
2002Developmental Dynamics34 citations
Semantic Scholar
Targeted Expression of Activated Rac3 in Mammary Epithelium Leads to Defective Postlactational Involution and Benign Mammary Gland Lesions
Karen Leung, A. Nagy, I. Gonzalez-Gomez, J. Groffen +2 more
2003Cells Tissues Organs32 citations
Semantic Scholar
BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl
Bianca Hemmeryckx, A. Reichert, Meguru Watanabe, V. Kaartinen +4 more
2002Oncogene32 citations Open access
Semantic Scholar
The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours
C. Morris, L. Haataja, M. McDonald, S. Gough +3 more
2000Cytogenetic and Genome Research30 citations
Semantic Scholar
TGFβ signaling plays a critical role in promoting alternative macrophage activation
Dapeng Gong, Wei Shi, S. Yi, Hui Chen +2 more
2012BMC Immunology29 citations Open access
Semantic Scholar
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.
Bin Zhang, J. Groffen, N. Heisterkamp
2005Blood27 citations Open access
Semantic Scholar
Scambio, a novel guanine nucleotide exchange factor for Rho
C. Curtis, Bianca Hemmeryckx, L. Haataja, D. Senadheera +2 more
2004Molecular Cancer27 citations Open access
Semantic Scholar
Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.
S. D. De Langhe, L. Haataja, D. Senadheera, J. Groffen +1 more
2002International Journal of Molecular Medicine26 citations
Semantic Scholar
Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia
N. Feldhahn, A. Arutyunyan, S. Stoddart, Bin Zhang +5 more
2012Oncoimmunology25 citations Open access
Semantic Scholar

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