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John Mach · SciRah

Researcher profile · Semantic Scholar

John Mach

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John Mach — researcher profile on SciRah

h-index: 19
Works: 56
Citations: 838

Most-cited papers

Disulfiram treatment normalizes body weight in obese mice
M. Bernier, S. Mitchell, Devin Wahl, Antonio Díaz +35 more
2020Cell Metabolism77 citations Open access
Semantic Scholar
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance
M. Mohamad, S. Mitchell, Lindsay E. Wu, Melanie Y. White +15 more
2016Aging Cell71 citations Open access
Semantic Scholar
Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.
Aniko Huizer-Pajkos, A. Kane, S. Howlett, John Mach +4 more
2016The journals of gerontology. Series A, Biological sciences and medical sciences67 citations Open access
Semantic Scholar
Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice.
John Mach, G. Gemikonakli, C. Logan, B. Vander Wyk +7 more
2020The journals of gerontology. Series A, Biological sciences and medical sciences54 citations Open access
Semantic Scholar
Clinical Interventions in Aging Dovepress Animal Models of Frailty: Current Applications in Clinical Research Sarah N Hilmer 2–4
A. Kane, John Mach, S. Mitchell, R. de Cabo +1 more
51 citations
Semantic Scholar
Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type
A. Kane, S. Mitchell, John Mach, Aniko Huizer-Pajkos +6 more
2015Experimental Gerontology48 citations Open access
Semantic Scholar
Interactions between the aging gut microbiome and common geriatric giants: polypharmacy, frailty and dementia.
G. Gemikonakli, John Mach, S. Hilmer
2020The journals of gerontology. Series A, Biological sciences and medical sciences35 citations
Semantic Scholar
A Comparison of Two Mouse Frailty Assessment Tools
A. Kane, Aniko Huizer-Pajkos, John Mach, S. Mitchell +4 more
2017The journals of gerontology. Series A, Biological sciences and medical sciences34 citations Open access
Semantic Scholar
The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)
John Mach, A. Midgley, S. Dank, R. Grant +1 more
2010Nutrients29 citations Open access
Semantic Scholar
Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index.
A. Kane, S. Hilmer, Aniko Huizer-Pajkos, John Mach +5 more
2015The journals of gerontology. Series A, Biological sciences and medical sciences28 citations Open access
Semantic Scholar
Improving health care for assisted living residents.
R. Kane, John Mach
2007The gerontologist28 citations
Semantic Scholar
Polypharmacy With High Drug Burden Index (DBI) Alters the Gut Microbiome Overriding Aging Effects and Is Reversible With Deprescribing
G. Gemikonakli, John Mach, Fan Zhang, Martyn Bullock +3 more
2022The journals of gerontology. Series A, Biological sciences and medical sciences24 citations Open access
Semantic Scholar
Quality of Care Provided in a Special Needs Plan Using a Nurse Care Manager Model
N. Wenger, C. Roth, David Martin, Lorraine D. Nickels +4 more
2011Journal of The American Geriatrics Society22 citations
Semantic Scholar
Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research
Harry Wu, John Mach, D. Gnjidic, V. Naganathan +5 more
2022The journals of gerontology. Series A, Biological sciences and medical sciences21 citations Open access
Semantic Scholar
The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats
John Mach, Aniko Huizer-Pajkos, S. Mitchell, C. McKenzie +7 more
2015Fundamental & Clinical Pharmacology21 citations Open access
Semantic Scholar
Male-Female Differences In The Effects Of Age On Performance Measures Recorded For 23 Hours In Mice.
T. Tran, John Mach, G. Gemikonakli, Harry Wu +4 more
2021The journals of gerontology. Series A, Biological sciences and medical sciences20 citations
Semantic Scholar
Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome
M. Bernier, Dylan J. Harney, Y. Koay, Antonio Díaz +17 more
2020npj Aging and Mechanisms of Disease20 citations Open access
Semantic Scholar
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
John Mach, Aniko Huizer-Pajkos, V. Cogger, C. McKenzie +4 more
2014The journals of gerontology. Series A, Biological sciences and medical sciences20 citations Open access
Semantic Scholar
Polypharmacy and precision medicine
K. Fujita, N. Masnoon, John Mach, L. K. O'Donnell +1 more
2023Cambridge Prisms: Precision Medicine19 citations Open access
Semantic Scholar
Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interactions.
Harry Wu, John Mach, G. Gemikonakli, T. Tran +6 more
2021The journals of gerontology. Series A, Biological sciences and medical sciences16 citations Open access
Semantic Scholar
Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications.
John Mach, H. Allore, D. Gnjidic, G. Gemikonakli +5 more
2022Experimental Gerontology15 citations Open access
Semantic Scholar
Pre-clinical Models for Geriatric Pharmacotherapy
S. Hilmer, K. Johnell, John Mach
2024Drugs & Aging13 citations Open access
Semantic Scholar
Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016
Harry Wu, John Mach, D. L. Le Couteur, S. Hilmer
2021Australasian Journal on Ageing13 citations
Semantic Scholar
Fall-related mortality trends in Australia and the United Kingdom: Implications for research and practice.
Harry Wu, John Mach, D. L. Le Couteur, S. Hilmer
2020Maturitas13 citations
Semantic Scholar
N-Acetyl Cysteine does not prevent liver toxicity from chronic low dose plus sub-acute high dose paracetamol exposure in young or old mice
A. Kane, Aniko Huizer-Pajkos, John Mach, C. McKenzie +6 more
2016Fundamental & Clinical Pharmacology13 citations Open access
Semantic Scholar
Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex
T. Tran, John Mach, G. Gemikonakli, Harry Wu +4 more
2022Scientific Reports11 citations Open access
Semantic Scholar
The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats
John Mach, Aniko Huizer-Pajkos, A. Kane, Brett E. Jones +6 more
2015Experimental Gerontology10 citations Open access
Semantic Scholar
Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice
Kevin Winardi, John Mach, Matthew J. McKay, Mark P. Molloy +5 more
2024Aging Cell9 citations Open access
Semantic Scholar
Intrathecal Opioid-Induced Hypothermia Following Subarachnoid Block With Morphine Injection for Elective Cesarean Delivery: A Case Report.
John Mach, Teresa Van Havel, John Gadwood, M. Biegner
2016AANA journal9 citations
Semantic Scholar
Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy
John Mach, Xiao-Suo Wang, S. Hilmer
2020Fundamental & Clinical Pharmacology7 citations
Semantic Scholar
Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy
John Mach, A. Kane, S. Howlett, D. Sinclair +1 more
2022The journals of gerontology. Series A, Biological sciences and medical sciences6 citations Open access
Semantic Scholar
Animal models of frailty: current applications in clinical research
Alice E. Kane, S. Hilmer, John Mach, S. Mitchell +2 more
20165 citations
Semantic Scholar
Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review
Subindra Kazi Thapa, Jia Li, John Mach, S. Hilmer +1 more
2026Drugs & Aging3 citations Open access
Semantic Scholar
Probing polypharmacy, ageing and sex effects on physical function using different tests
G. Gemikonakli, John Mach, T. Tran, Harry Wu +1 more
2024Fundamental & Clinical Pharmacology3 citations Open access
Semantic Scholar
Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells
Kajangi Gnanachandran, D. Hovland, Jakub Pospíšil, K. Szafrańska +3 more
2026bioRxiv2 citations Open access
Semantic Scholar
Using Computational Video Analysis in Aging Mice to Evaluate the Effects of Chronic Monotherapy, Polypharmacy, and Deprescribing Over Time
K. Fujita, John Mach, S. Hilmer
2025The journals of gerontology. Series A, Biological sciences and medical sciences2 citations Open access
Semantic Scholar
Ageing and Polypharmacy in Mesenchymal Stromal Cells: Metabolic Impact Assessed by Hyperspectral Imaging of Autofluorescence
C. N. Chandrasekara, G. Gemikonakli, John Mach, Rui Sang +5 more
2024International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Designing rotating zigzag beds: Understanding dry pressure drop under varying geometries
Niclas Rohde, Felix Febrian, John Mach, Nicole Yong +3 more
2025Chemical Engineering and Processing1 citations Open access
Semantic Scholar
Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion
T. Tran, Kevin Winardi, S. Levick, A. Widiapradja +6 more
2025British Journal of Pharmacology1 citations Open access
Semantic Scholar
A TRANSLATIONAL MODEL TO UNDERSTAND THE IMPACT OF POLYPHARMACY ON ADVERSE GERIATRIC OUTCOMES
S. Hilmer, Aniko Huizer-Pajkos, A. Kane, John Mach +3 more
20171 citations Open access
Semantic Scholar
Correction: Mach, J., et al. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients 2010, 2, 319-329
John Mach, A. Midgley, S. Dank, R. Grant +1 more
2010Nutrients1 citations Open access
Semantic Scholar
WCN26-4137 IMPACT OF POLYPHARMACY ON KIDNEY FUNCTION: AGE- AND SEX-DEPENDENT EFFECTS IN A MOUSE MODEL
Yuting Zhang, Kevin Winardi, John Mach, S. Hilmer +3 more
2026Kidney International Reports0 citations Open access
Semantic Scholar
The association of frailty with age and lifespan in mice differs by strain and sex
Dan-Tong Zhu, Cara L. Green, Sarah J. Mitchell, Michael R. MacArthur +14 more
2026The journals of gerontology. Series A, Biological sciences and medical sciences0 citations Open access
Semantic Scholar
Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response
John Mach, C. Blaker, Bryony L. Winters, Yo Otsu +9 more
2025bioRxiv0 citations Open access
Semantic Scholar
Frailty, polypharmacy, deprescribing, and 23-hour activity: insights from a mouse model
John Mach, Kevin Winardi, S. Hilmer
2025bioRxiv0 citations Open access
Semantic Scholar
INTERGENERATIONAL PLAY AND LEARNING: OPPORTUNITIES FOR ENGAGING PRESCHOOLERS, COLLEGE STUDENTS, AND OLDER ADULTS
S. Hilmer, John Mach, Susan E. Howlett
2024Innovation in aging0 citations
Semantic Scholar
POLYPHARMACY: TRANSLATIONAL RESEARCH TO UNDERSTAND EFFECTS OF AGE, SEX, AND FRAILTY ON KEY OUTCOMES FOR FORTITUDE
John Mach
2024Innovation in aging0 citations Open access
Semantic Scholar
Translational Gerontology Research to Understand the Effects of Medications in Older Adults.
S. Hilmer, John Mach
2021The journals of gerontology. Series A, Biological sciences and medical sciences0 citations Open access
Semantic Scholar
EFFECT OF LONG-TERM POLYPHARMACY AND THE DRUG BURDEN INDEX (DBI) ON CARDIAC FUNCTION AND FIBROSIS IN AGED MICE
T. Tran, John Mach, G. Gemikonakli, S. Howlett +3 more
2018Innovation in aging0 citations Open access
Semantic Scholar
THE EFFECT OF CHRONIC POLYPHARMACY, THE DRUG BURDEN INDEX (DBI) AND DEPRESCRIBING ON PHYSICAL FUNCTION IN AGED MICE
John Mach, G. Gemikonakli, A. Kane, S. Howlett +3 more
2018Innovation in aging0 citations Open access
Semantic Scholar

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R. de Cabo×19
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D. L. Le Couteur×18
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G. Gemikonakli×12

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