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L. Caja · SciRah

Researcher profile · Semantic Scholar

L. Caja

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L. Caja — researcher profile on SciRah

h-index: 27
Works: 50
Citations: 2,514

Most-cited papers

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
L. Caja, F. Dituri, Serena Mancarella, D. Caballero-Diaz +3 more
2018International Journal of Molecular Sciences320 citations Open access
Semantic Scholar
Transforming growth factor β as regulator of cancer stemness and metastasis
C. Bellomo, L. Caja, A. Moustakas
2016British Journal of Cancer222 citations Open access
Semantic Scholar
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.
I. Carmona-Cuenca, C. Roncero, P. Sancho, L. Caja +3 more
2008Journal of Hepatology219 citations
Semantic Scholar
Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan Syndrome
E. Crosas-Molist, T. Meirelles, Judit López‐Luque, Carla Serra-Peinado +19 more
2015Arteriosclerosis, Thrombosis and Vascular Biology136 citations Open access
Semantic Scholar
Overactivation of the TGF‐β pathway confers a mesenchymal‐like phenotype and CXCR4‐dependent migratory properties to liver tumor cells
E. Bertrán, E. Crosas-Molist, P. Sancho, L. Caja +7 more
2013Hepatology124 citations Open access
Semantic Scholar
Regulation of Transcription Factor Twist Expression by the DNA Architectural Protein High Mobility Group A2 during Epithelial-to-Mesenchymal Transition*
E-Jean Tan, S. Thuault, L. Caja, Tea Carletti +2 more
2012Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.
L. Caja, P. Sancho, E. Bertrán, Daniel Iglesias-Serret +2 more
2009Cancer Research111 citations Open access
Semantic Scholar
The transforming growth factor‐beta (TGF‐β) mediates acquisition of a mesenchymal stem cell‐like phenotype in human liver cells
L. Caja, E. Bertrán, J. Campbell, N. Fausto +1 more
2011Journal of Cellular Physiology99 citations
Semantic Scholar
Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.
L. Caja, C. Ortiz, E. Bertrán, M. Murillo +3 more
2007Cellular Signalling91 citations
Semantic Scholar
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
P. Sancho, E. Bertrán, L. Caja, I. Carmona-Cuenca +2 more
2009Biochimica et Biophysica Acta88 citations Open access
Semantic Scholar
SORAFENIB SENSITIZES HEPATOCELLULAR CARCINOMA CELLS TO PHYSIOLOGICAL APOPTOTIC STIMULI
J. Fernando, P. Sancho, C. Fernández-Rodríguez, J. Lledó +4 more
2012Journal of Cellular Physiology78 citations Open access
Semantic Scholar
Snail depletes the tumorigenic potential of glioblastoma
K. Savary, D. Çağlayan, L. Caja, K. Tzavlaki +9 more
2013Oncogene74 citations Open access
Semantic Scholar
Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.
E. Bertrán, L. Caja, E. Navarro, P. Sancho +5 more
2009Cellular Signalling73 citations
Semantic Scholar
Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.
L. Caja, P. Sancho, E. Bertrán, I. Fabregat
2011Journal of Hepatology60 citations
Semantic Scholar
Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells
L. Caja, K. Tzavlaki, M. Dadras, E-Jean Tan +10 more
2018Oncogene53 citations Open access
Semantic Scholar
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17
J. Moreno-Caceres, L. Caja, J. Mainez, R. Mayoral +6 more
2014Cell Death and Disease49 citations Open access
Semantic Scholar
The TGF-β Family in Glioblastoma
Irene Golán-Cancela, L. Caja
2024International Journal of Molecular Sciences48 citations Open access
Semantic Scholar
Transforming growth factor β and bone morphogenetic protein actions in brain tumors
L. Caja, C. Bellomo, A. Moustakas
2015FEBS Letters48 citations Open access
Semantic Scholar
The Epstein–Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
G. Coppotelli, Nouman Mughal, Simone Callegari, R. Sompallae +5 more
2013Nucleic Acids Research43 citations Open access
Semantic Scholar
Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.
C. Ortiz, L. Caja, P. Sancho, E. Bertrán +1 more
2008Biochemical Pharmacology42 citations
Semantic Scholar
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins.
Alba Pérez-Perarnau, S. Preciado, C. M. Palmeri, Cristina Moncunill-Massaguer +16 more
2014Angewandte Chemie41 citations
Semantic Scholar
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
C. Bellomo, L. Caja, I. Fabregat, W. Mikulits +3 more
2017Cell Death and Differentiation37 citations Open access
Semantic Scholar
TANK‐binding kinase 1 is a mediator of platelet‐induced EMT in mammary carcinoma cells
Yan-Yu Zhang, Ragaseema Valsala Madhavan Unnithan, A. Hamidi, L. Caja +4 more
2019The FASEB Journal32 citations Open access
Semantic Scholar
The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity
Panagiotis Papoutsoglou, Yutaro Tsubakihara, L. Caja, A. Morén +4 more
2019Cell Reports32 citations Open access
Semantic Scholar
Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition
Judit López‐Luque, E. Bertrán, E. Crosas-Molist, O. Maiques +6 more
2019Cancer Letters31 citations Open access
Semantic Scholar
Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
A. Chisari, Irene Golán, Sabrina Campisano, Caroline Gélabert +3 more
2021Frontiers in Pharmacology28 citations Open access
Semantic Scholar
Context-dependent action of transforming growth factor β family members on normal and cancer stem cells.
L. Caja, K. Kahata, A. Moustakas
2012Current pharmaceutical design28 citations
Semantic Scholar
NOX4 regulates TGFβ‐induced proliferation and self‐renewal in glioblastoma stem cells
P. García-Gómez, Irene Golán, M. Dadras, A. Mezheyeuski +5 more
2022Molecular Oncology27 citations Open access
Semantic Scholar
Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes*
C. Ortiz, L. Caja, E. Bertrán, Á. González-Rodríguez +3 more
2012Journal of Biological Chemistry27 citations Open access
Semantic Scholar
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling
Panagiotis Papoutsoglou, Dorival Mendes Rodrigues-Junior, A. Morén, Andrew Bergman +5 more
2021Oncogene26 citations Open access
Semantic Scholar
Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
M. Peleli, I. Antoniadou, Dorival Mendes Rodrigues-Junior, Odysseia Savvoulidou +7 more
2023Redox Biology24 citations Open access
Semantic Scholar
The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.
L. Caja, P. Sancho, E. Bertrán, C. Ortiz +3 more
2011Biochemical Pharmacology17 citations
Semantic Scholar
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
Caroline Gélabert, Panagiotis Papoutsoglou, Irene Golán, Eric Ahlström +4 more
2023Cell Communication and Signaling14 citations Open access
Semantic Scholar
Overactivation of the Mek/erk Pathway in Liver Tumor Cells Confers Resistance to Tgf-b–induced Cell Death through Impairing Up-regulation of the Nadph Oxidase Nox4
L. Caja, P. Sancho, E. Bertrán, Daniel Iglesias-Serret +2 more
12 citations
Semantic Scholar
The protein kinase LKB1 promotes self‐renewal and blocks invasiveness in glioblastoma
L. Caja, M. Dadras, A. Mezheyeuski, Dorival Mendes Rodrigues-Junior +6 more
2021Journal of Cellular Physiology11 citations Open access
Semantic Scholar
NOX4 regulates TGFβ-induced proliferation and self-renewal in glioblastoma stem cells
P. García-Gómez, M. Dadras, C. Bellomo, A. Mezheyeuski +3 more
2019bioRxiv10 citations Open access
Semantic Scholar
Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
Dorival Mendes Rodrigues-Junior, Cristiano Raminelli, Haifa Hassanie, G. Trossini +4 more
2022Scientific Reports6 citations Open access
Semantic Scholar
Lack of aminoacids in mouse hepatocytes in culture induces the selection of preneoplastic cells
A. Chisari, P. Sancho, L. Caja, E. Bertrán +1 more
2012BMC Proceedings6 citations Open access
Semantic Scholar
Metabolic determinants of stemness in medulloblastoma
Paula Martín-Rubio, Pilar Espiau-Romera, A. Royo-García, L. Caja +1 more
2022World Journal of Stem Cells5 citations Open access
Semantic Scholar
The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
M. Dadras, L. Caja, A. Mezheyeuski, Sijia Liu +7 more
2021Cell Death and Disease5 citations Open access
Semantic Scholar
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
Yae Ohata, M. M. Ali, Yutaro Tsubakihara, Yuka Itoh +20 more
2025Cell Death and Differentiation4 citations Open access
Semantic Scholar
The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial‐mesenchymal transition
K. Tzavlaki, Y. Ohata, A. Morén, Y. Watanabe +9 more
2023Journal of Cellular Physiology2 citations Open access
Semantic Scholar
Adaptive response to serine and glycine deprivation enhances the stemness potential of pancreatic cancer cells
Beatriz Parejo-Alonso, M. Mascaraque, S. Courtois, Andrés Gordo-Ortiz +15 more
2026Cancer & Metabolism0 citations Open access
Semantic Scholar
Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma
Caroline Gélabert, Sabrina Campisano, Irene Golán, N. Beyene +5 more
2024bioRxiv0 citations Open access
Semantic Scholar
Editorial: Targeting intra- and extracellular signals contributing to cancer stemness and metastasis in aggressive cancers, Volume II
L. Caja, E. Lonardo, P. Sancho
2022Frontiers in Pharmacology0 citations Open access
Semantic Scholar
Peer Review #1 of "Differential p16 expression levels in the liver, hepatocytes and hepatocellular cell lines (v0.1)"
Barbara Kramar, D. Šuput, I. Milisav, G. Angelico +200 more
20210 citations Open access
Semantic Scholar
TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses
Panagiotis Papoutsoglou, L. Caja, A. Ameur, C. Heldin +1 more
20180 citations
Semantic Scholar
Par3 promotes glioblastoma stem cell self-renewal while inhibiting cell invasion
M. Dadras, L. Caja, C. Heldin, A. Moustakas
20170 citations
Semantic Scholar
The protein kinase LKB1 takes oncogenic actions in glioblastoma promoting self-renewal and invasiveness
M. Dadras, L. Caja, A. Webb, C. Heldin +1 more
20170 citations
Semantic Scholar
TBK1, an NF-κB activating kinase, is required for platelet-induced EMT
Yan-Yu Zhang, Ragaseema Valsala Madhavan Unnithan, L. Caja, Falk Saupe +4 more
20160 citations
Semantic Scholar

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