Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

A. Chadderton · SciRah

Researcher profile · Semantic Scholar

A. Chadderton

Share profile

A. Chadderton — researcher profile on SciRah

h-index: 7
Works: 31
Citations: 233

Most-cited papers

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
2011Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag.
C. Erickson-Miller, J. Kirchner, M. Aivado, R. May +2 more
2010Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis41 citations
Semantic Scholar
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells
A. Chadderton, David J. Villeneuve, S. Glück, A. Kirwan-rhude +3 more
2000Breast Cancer Research and Treatment41 citations
Semantic Scholar
Selection of normalizer genes in conducting relative gene expression analysis of embryos.
Qin J Zhang, A. Chadderton, R. Clark, K. Augustine-Rauch
2003Birth defects research. Clinical and molecular teratology22 citations Open access
Semantic Scholar
The Selective Uptake of Benzoporphyrin Derivative Mono‐Acid Ring A Results in Differential Cell Kill of Multiple Myeloma Cells in vitro
S. Glück, A. Chadderton, A. D. Ho
1996Photochemistry and Photobiology17 citations
Semantic Scholar
Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors
C. Erickson-Miller, A. Chadderton, A. Gibbard, J. Kirchner +8 more
2010Journal of Oncology15 citations Open access
Semantic Scholar
Clinical issues in using buprenorphine in the treatment of opiate dependence
A. Chadderton
200012 citations
Semantic Scholar
Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation.
K. Augustine-Rauch, Qin J Zhang, Jennifer L. Leonard, A. Chadderton +5 more
2004Birth defects research. Clinical and molecular teratology7 citations
Semantic Scholar
Abstract 3929: The FAD-directed LSD1 specific inhibitor, INCB059872, inhibits cell migration and metastasis by suppressing premetastatic niche formation in a spontaneous metastasis mouse model
Sang Hyun Lee, M. Diamond, A. Chadderton, Hui-qiong Liu +16 more
2018Experimental and Molecular Therapeutics5 citations
Semantic Scholar
GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia.
C. Erickson-Miller, C. Creasy, A. Chadderton, C. Hopson +7 more
20075 citations
Semantic Scholar
Abstract 1162: The evaluation of INCB059872, an FAD-directed covalent inhibitor of LSD1, in preclinical models of Ewing sarcoma
V. Roman, M. Ye, Hui-qiong Liu, M. Diamond +13 more
20173 citations
Semantic Scholar
P067 Eltrombopag does not enhance proliferation of non-megakaryocytic leukemia and lymphoma cell lines
C. Erickson-Miller, J. Kirchner, Parrish L. Payne, E. May +1 more
20093 citations
Semantic Scholar
Abstract 1888: The FAD-directed LSD1 specific inhibitor, INCB059872, is a promising epigenetic agent for AML therapy by inducing differentiation of leukemic stem/progenitor cells
A. Chadderton, M. Ye, M. Diamond, V. Roman +11 more
2018Experimental and Molecular Therapeutics2 citations
Semantic Scholar
Abstract 4635: The LSD1 Specific Inhibitor INCB059872 enhances the activity of immune checkpoint blockade by reshaping the myeloid compartment in the syngeneic 4T1 mouse mammary tumor model
T. Condamine, Steve Wang, M. Diamond, Leslie Hall +13 more
20172 citations
Semantic Scholar
Abstract LB-116: GSK2334470: A potent and highly selective inhibitor of PDK1
J. Axten, J. Medina, A. Shu, W. Li +7 more
20102 citations
Semantic Scholar
Abstract 1134: The LSD1 inhibitor INCB059872 is a possible therapeutic option for venetoclax-resistant AML
M. Diamond, A. Chadderton, Chunhong He, Liang-Xing Wu +4 more
2021Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract 2032: Combination of epigenetic regulation via LSD1 inhibition with signal transduction inhibitors significantly enhances anti-tumor activity in models of hematologic malignancies
Sang Hyun Lee, M. Stubbs, Ashish P. Juvekar, M. Diamond +14 more
20171 citations
Semantic Scholar
Low or Undetectable Levels of Thrombopoietin Receptor (Tpo-R; c-mpl) Expression on Tumor Cell Lines and Primary Tumors Compared with Epo-R, ErbB2, and IGF-1R
C. Erickson-Miller, A. Chadderton, A. Gibbard, J. Kirchner +8 more
20081 citations
Semantic Scholar
Abstract P245: Synergistic effect of combination of pemigatinib with enfortumab vedotin (EV) in human bladder cancer models
Rod Hess, L. Truong, A. Chadderton, M. Frascella +2 more
2021Poster Presentations - Proffered Abstracts0 citations
Semantic Scholar
Abstract A168: The LSD1 specific inhibitor INCB059872 enhances the activity of mechanistically distinct immunotherapeutic agents in the syngeneic 4T1 mouse mammary tumor model
Sang Hyun Lee, M. Diamond, A. Chadderton, T. Condamine +17 more
20180 citations
Semantic Scholar
Abstract 1893: The evaluation of INCB059872, an FAD-directed inhibitor of LSD1, in preclinical models of T-ALL
M. Diamond, Y. Lo, A. Chadderton, M. Ye +12 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 3518: Flow cytometry as a single platform tool to evaluate multiple mechanisms of actions of therapeutic antibodies
A. Chadderton, S. Harvey, Brandy Strake, J. Giles-Komar +2 more
20160 citations
Semantic Scholar
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
20110 citations
Semantic Scholar
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-{2-Amino-6-[(3R)-3-methyl-4-morpholinyl]-4-pyrimidinyl}-1H-indazol-3-amine
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
20110 citations
Semantic Scholar
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
20110 citations
Semantic Scholar
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
20110 citations
Semantic Scholar
Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-phenyl-2-morpholinecarboxamide
J. Medina, C. J. Becker, C. Blackledge, C. Duquenne +21 more
20110 citations
Semantic Scholar
Abstract LB-42: PDK1 knockdown selectively inhibits growth of cancer cells harboring activating mutations involved in MAPK signaling
M. DeYoung, Christine M. Gardiner, A. Chadderton, J. Medina +2 more
20100 citations
Semantic Scholar
Effect of eltrombopag on proliferation of solid and hematologic tumor cell lines in vitro
C. Erickson-Miller, V. Sambandam, J. E. Harwell, Parrish L. Payne +3 more
20080 citations
Semantic Scholar
The Characterization of DYRK3 mRNA and the Utility of DYRK3 Inhibitors in a Carboplatin/Radiation Mouse Model of Anemia.
C. Erickson-Miller, Ho-Man Ying, M. Chomo, Elizabeth I. Valoret +4 more
20070 citations
Semantic Scholar
DYRK3 Encodes an Inhibitor of Erythroid Differentiation and Is Expressed at High Levels in Patients with Anemia.
D. Steensma, J. C. Porcher, A. Chadderton, K. Laubscher +5 more
20070 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

J. Medina×8
Invite
J. Medina — researcher profile on SciRah
S. Rabindran×8
Invite
S. Rabindran — researcher profile on SciRah
J. Axten×8
Invite
J. Axten — researcher profile on SciRah
C. Erickson-Miller×8
Invite
C. Erickson-Miller — researcher profile on SciRah

×8

Invite

Sang Hyun Lee — researcher profile on SciRah

Invite

M. Diamond — researcher profile on SciRah

Invite

Chunhong He — researcher profile on SciRah

Liang-Xing Wu×8

Invite

Liang-Xing Wu — researcher profile on SciRah

Invite

W. Yao — researcher profile on SciRah

Yan-Hong Feng×7

Invite

Yan-Hong Feng — researcher profile on SciRah

Invite

A. Shu — researcher profile on SciRah

Invite

M. Dumble — researcher profile on SciRah