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Outi Kummu · SciRah

Researcher profile · Semantic Scholar

Outi Kummu

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Outi Kummu — researcher profile on SciRah

h-index: 16
Works: 34
Citations: 1,444

Most-cited papers

Protein carbamylation links inflammation, smoking, uremia and atherogenesis
Ze-Neng Wang, S. Nicholls, E. Rodríguez, Outi Kummu +6 more
2007Nature Medicine683 citations
Semantic Scholar
Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties.
S. Lehti, S. Nguyen, I. Belevich, H. Vihinen +13 more
2017American Journal of Pathology73 citations Open access
Semantic Scholar
Obesity Represses CYP2R1, the Vitamin D 25‐Hydroxylase, in the Liver and Extrahepatic Tissues
Mahmoud-Sobhy Elkhwanky, Outi Kummu, T. Piltonen, J. Laru +4 more
2020JBMR Plus72 citations Open access
Semantic Scholar
Natural antibodies of newborns recognize oxidative stress-related malondialdehyde acetaldehyde adducts on apoptotic cells and atherosclerotic plaques.
Chun-Guang Wang, S. Turunen, Outi Kummu, Marja Veneskoski +3 more
2013International Immunology68 citations
Semantic Scholar
Recognition of Porphyromonas gingivalis Gingipain Epitopes by Natural IgM Binding to Malondialdehyde Modified Low-Density Lipoprotein
S. Turunen, Outi Kummu, K. Harila, Marja Veneskoski +4 more
2012PLoS ONE64 citations Open access
Semantic Scholar
Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a.
Marja Veneskoski, S. Turunen, Outi Kummu, A. Nissinen +3 more
2011Free Radical Biology & Medicine58 citations
Semantic Scholar
Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes
Sanna‐Mari Aatsinki, Mahmoud-Sobhy Elkhwanky, Outi Kummu, Mikko Karpale +10 more
2019Diabetes52 citations Open access
Semantic Scholar
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2‐mediated mechanism
Mikko Karpale, A. Käräjämäki, Outi Kummu, H. Gylling +8 more
2021British Journal of Pharmacology49 citations Open access
Semantic Scholar
Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver
Fatemeh Hassani-Nezhad-Gashti, J. Rysä, Outi Kummu, J. Näpänkangas +4 more
2018Biochemical Pharmacology44 citations Open access
Semantic Scholar
Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves
S. Lehti, R. Käkelä, S. Hörkkö, Outi Kummu +5 more
2013PLoS ONE42 citations Open access
Semantic Scholar
Immunization with malondialdehyde-modified low-density lipoprotein (LDL) reduces atherosclerosis in LDL receptor-deficient mice challenged with Porphyromonas gingivalis
S. Turunen, Outi Kummu, Chun-Guang Wang, K. Harila +4 more
2015Innate Immunity29 citations
Semantic Scholar
Carbamyl Adducts on Low-Density Lipoprotein Induce IgG Response in LDLR −/− Mice and Bind Plasma Autoantibodies in Humans Under Enhanced Carbamylation
Outi Kummu, S. Turunen, Chun-Guang Wang, Jaakko I. Lehtimäki +6 more
2013Antioxidants and Redox Signaling23 citations
Semantic Scholar
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Mikko Karpale, Outi Kummu, O. Kärkkäinen, M. Lehtonen +5 more
2023Molecular Metabolism21 citations Open access
Semantic Scholar
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans
Chun-Guang Wang, J. Kankaanpää, Outi Kummu, S. Turunen +5 more
2016Immunologic research20 citations
Semantic Scholar
Cross‐reactive saliva IgA antibodies to oxidized LDL and periodontal pathogens in humans
R. Akhi, Chun-Guang Wang, Mikael Kyrklund, Outi Kummu +6 more
2017Journal of Clinical Periodontology19 citations Open access
Semantic Scholar
Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals
Brecht Attema, Outi Kummu, Sini Pitkänen, J. Weisell +7 more
2024Archives of Toxicology17 citations Open access
Semantic Scholar
Nutritional status modifies pregnane X receptor regulated transcriptome
Fatemeh Hassani-Nezhad-Gashti, Outi Kummu, Mikko Karpale, J. Rysä +1 more
2019Scientific Reports16 citations Open access
Semantic Scholar
Human monoclonal Fab and human plasma antibodies to carbamyl‐epitopes cross‐react with malondialdehyde‐adducts
Outi Kummu, S. Turunen, P. Prus, Jaakko I. Lehtimäki +3 more
2014Immunology16 citations Open access
Semantic Scholar
Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-/-)-mice.
Eija Kellokoski, Outi Kummu, R. Serpi, P. Lehenkari +3 more
2009Peptides16 citations
Semantic Scholar
Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein
Mikael Kyrklund, Outi Kummu, J. Kankaanpää, R. Akhi +5 more
2018PLoS ONE15 citations Open access
Semantic Scholar
Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension
Roosa Rahunen, Outi Kummu, V. Koivukangas, H. Hautajärvi +3 more
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease14 citations Open access
Semantic Scholar
Humoral immune response to carbamyl-epitopes in atherosclerosis
Outi Kummu
201410 citations
Semantic Scholar
Inhibition of activin receptor 2 signalling ameliorates metabolic dysfunction-associated steatotic liver disease in western diet/L-NAME induced cardiometabolic disease.
J. Swan, Z. Szabó, J. Peters, Outi Kummu +8 more
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6 citations Open access
Semantic Scholar
Rifampicin induces the bone form of alkaline phosphatase in humans
Heba Nabil, Outi Kummu, P. Lehenkari, J. Rysä +3 more
2021Basic & Clinical Pharmacology & Toxicology6 citations Open access
Semantic Scholar
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity
Brecht Attema, Outi Kummu, Mária Krutáková, P. Pávek +3 more
2024Archives of Toxicology5 citations Open access
Semantic Scholar
Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice
Mahmoud-Sobhy Elkhwanky, Outi Kummu, J. Hakkola
2022Endocrinology5 citations Open access
Semantic Scholar
LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver
Anja Konzack, Mikko Karpale, T. Smutny, Mohamed Hassanen +6 more
2025Molecular Pharmacology1 citations
Semantic Scholar
Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts and Porphyromonas gingivalis
Mikael Kyrklund, H. Kaski, R. Akhi, A. Nissinen +5 more
2021Innate Immunity1 citations Open access
Semantic Scholar
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans
Chun-Guang Wang, J. Kankaanpää, Outi Kummu, S. Turunen +5 more
2016Immunologic research1 citations
Semantic Scholar
Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis.
Heba Nabil, Mahmoud-Sobhy Elkhwanky, Mohamed Hassanen, E. Niskanen +4 more
2026Archives of Toxicology0 citations
Semantic Scholar
Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse.
Piia Lassila, Mikko Karpale, Outi Kummu, Aaron Stahl +8 more
2026Archives of Toxicology0 citations Open access
Semantic Scholar
PXR agonist rifampicin elevates serum Lp(a) levels substantially
Topias Kotilainen, Heta Merikallio, Outi Kummu, Mikko Karpale +3 more
2024Atherosclerosis0 citations
Semantic Scholar
Existence of natural mouse monoclonal IgG antibodies recognizing epitopes shared by malondialdehyde acetaldehyde adducts and Porphyromonas gingivalis.
Mikael Kyrklund, H. Kaski, R. Akhi, A. Nissinen +5 more
20200 citations
Semantic Scholar
PO9-242 PRESENCE OF IGG ANTIBODIES TO CARBAMYLATED PROTEINS ARE RELATED TO ANTIBODIES BINDING TO APOPTOTIC CELLS
Outi Kummu, H. Ruskoaho, Y. Kesäniemi, S. Hörkkö
20070 citations
Semantic Scholar

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