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T. Kirkegaard · SciRah

Researcher profile · Semantic Scholar

T. Kirkegaard

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T. Kirkegaard — researcher profile on SciRah

h-index: 24
Works: 50
Citations: 2,937

Most-cited papers

AKT activation predicts outcome in breast cancer patients treated with tamoxifen
T. Kirkegaard, C. Witton, L. Mcglynn, S. Tovey +3 more
2005Journal of Pathology289 citations
Semantic Scholar
Observer variation in immunohistochemical analysis of protein expression, time for a change?
T. Kirkegaard, J. Edwards, S. Tovey, L. Mcglynn +6 more
2006Histopathology268 citations
Semantic Scholar
Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation.
L. Kjøller, S. Kanse, T. Kirkegaard, K. Rodenburg +5 more
1997Experimental Cell Research259 citations
Semantic Scholar
Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn’s disease
T. Kirkegaard, A. Hansen, E. Bruun, J. Brynskov
2004Gut230 citations Open access
Semantic Scholar
Proteinases in bone resorption: obvious and less obvious roles.
J. Delaissé, M. Engsig, V. Everts, Maria del Carmen Ovejero +14 more
2000Clinica chimica acta; international journal of clinical chemistry221 citations
Semantic Scholar
Tumour necrosis factor α converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease
Jørn Brynskov, P. Foegh, G. Pedersen, Christina Ellervik +3 more
2002186 citations Open access
Semantic Scholar
A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells.
T. L. Andersen, Maria del Carmen Ovejero, T. Kirkegaard, T. Lenhard +2 more
2004Bone150 citations
Semantic Scholar
Transforming Growth Factor-β Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression*
M. Karsdal, Pernille Hjorth, K. Henriksen, T. Kirkegaard +4 more
2003Journal of Biological Chemistry145 citations Open access
Semantic Scholar
Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor–Positive Tumors of Tamoxifen-Treated Breast Cancer Patients
T. Kirkegaard, L. Mcglynn, F. Campbell, S. Müller +5 more
2007Clinical Cancer Research111 citations Open access
Semantic Scholar
Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease.
J. Brynskov, P. Foegh, G. Pedersen, C. Ellervik +3 more
2002Gut109 citations
Semantic Scholar
Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption.
P. Hou, Tine Troen, M. C. Ovejero, T. Kirkegaard +7 more
2004Bone100 citations
Semantic Scholar
Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients
L. Mcglynn, T. Kirkegaard, J. Edwards, S. Tovey +4 more
2009Clinical Cancer Research94 citations Open access
Semantic Scholar
Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium
G. Pedersen, T. Saermark, T. Kirkegaard, Jørn Brynskov
2009Clinical and Experimental Immunology78 citations Open access
Semantic Scholar
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells
S. Thrane, A. M. Pedersen, M. Thomsen, T. Kirkegaard +6 more
2014Oncogene61 citations
Semantic Scholar
Bad expression predicts outcome in patients treated with tamoxifen
E. Cannings, T. Kirkegaard, S. Tovey, B. Dunne +2 more
2007Breast Cancer Research and Treatment58 citations
Semantic Scholar
High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor–Positive Metastatic Breast Cancer
Carla L. Alves, Daniel Elías, M. Lyng, M. Bak +3 more
2016Clinical Cancer Research57 citations Open access
Semantic Scholar
Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH
T. Kirkegaard, C. Witton, J. Edwards, K. Nielsen +4 more
2010Histopathology54 citations
Semantic Scholar
Genetic alterations of CCND1 and EMSY in breast cancers
T. Kirkegaard, K. Nielsen, L. B. Jensen, Fiona M. Campbell +5 more
2008Histopathology44 citations
Semantic Scholar
Kinetic analysis of integrin-dependent cell adhesion on vitronectin--the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides.
M. Germer, S. M. Kanse, T. Kirkegaard, L. Kjøller +3 more
1998European Journal of Biochemistry44 citations Open access
Semantic Scholar
T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.
T. Kirkegaard, S. K. Hansen, S. Larsen, B. Reiter +2 more
2014Cancer Letters33 citations
Semantic Scholar
Tumour necrosis factor‐α converting enzyme (TACE) activity in human colonic epithelial cells 1
T. Kirkegaard, G. Pedersen, T. Saermark, Jørn Brynskov
200433 citations Open access
Semantic Scholar
Breast cancer cells can switch between estrogen receptor α and ErbB signaling and combined treatment against both signaling pathways postpones development of resistance
K. Sonne-Hansen, Ida C. Norrie, K. B. Emdal, R. V. Benjaminsen +4 more
2010Breast Cancer Research and Treatment32 citations Open access
Semantic Scholar
Src Drives Growth of Antiestrogen Resistant Breast Cancer Cell Lines and Is a Marker for Reduced Benefit of Tamoxifen Treatment
S. Larsen, A. Lænkholm, A. Duun-Henriksen, M. Bak +2 more
2015PLoS ONE31 citations Open access
Semantic Scholar
Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer
S. Larsen, C. Yde, A. Lænkholm, B. Rasmussen +4 more
2015BMC Cancer28 citations Open access
Semantic Scholar
An assessment of ADAMs in bone cells: absence of TACE activity prevents osteoclast recruitment and the formation of the marrow cavity in developing long bones
P. Boissy, T. Lenhard, T. Kirkegaard, J. Peschon +3 more
2003FEBS Letters24 citations
Semantic Scholar
Vitronectin and Substitution of a β-Strand 5A Lysine Residue Potentiate Activity-neutralization of PA Inhibitor-1 by Monoclonal Antibodies against α-Helix F
S. Schousboe, R. Egelund, T. Kirkegaard, K. Preissner +2 more
2000Thrombosis and Haemostasis23 citations
Semantic Scholar
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer
A. Lykkesfeldt, B. Iversen, M. Jensen, B. Ejlertsen +4 more
2018Acta oncologica22 citations Open access
Semantic Scholar
Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: A potential role in G1/S escape
L. B. Jensen, J. Bartlett, C. Witton, T. Kirkegaard +5 more
2009Cancer Biomarkers22 citations
Semantic Scholar
MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit
S. Løkkegaard, Daniel Elías, Carla L. Alves, M. Bennetzen +16 more
2021npj Breast Cancer21 citations Open access
Semantic Scholar
Tumour necrosis factor-alpha converting enzyme (TACE) activity in human colonic epithelial cells.
T. Kirkegaard, G. Pedersen, T. Saermark, J. Brynskov
2004Clinical and Experimental Immunology20 citations
Semantic Scholar
Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response
Norbert Naß, Angela Dittmer, Vicky Hellwig, T. Lange +8 more
2016OncoTarget15 citations Open access
Semantic Scholar
Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1α,25-dihydroxyvitamin D3.
J. Lundqvist, T. Kirkegaard, A. Lænkholm, A. Duun-Henriksen +3 more
2017Journal of Steroid Biochemistry and Molecular Biology13 citations
Semantic Scholar
Expression of tumor necrosis factor alpha converting enzyme in endocrine cancers.
T. Kirkegaard, A. Naresh, V. Sabine, S. Tovey +5 more
2008American Journal of Clinical Pathology12 citations Open access
Semantic Scholar
Vitronectin and substitution of a beta-strand 5A lysine residue potentiate activity-neutralization of PA inhibitor-1 by monoclonal antibodies against alpha-helix F.
S. Schousboe, R. Egelund, T. Kirkegaard, K. Preissner +2 more
2000Thrombosis and Haemostasis10 citations
Semantic Scholar
Development of new predictive markers for endocrine therapy and resistance in breast cancer
K. L. Henriksen, K. Sonne-Hansen, T. Kirkegaard, T. Frogne +1 more
2008Acta oncologica9 citations Open access
Semantic Scholar
The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
T. Kirkegaard, C. Yde, Marie Kveiborg, A. Lykkesfeldt
2014International Journal of Oncology8 citations Open access
Semantic Scholar
The role of beta-strand 5A of plasminogen activator inhibitor-1 in regulation of its latency transition and inhibitory activity by vitronectin.
S. Jensen, T. Kirkegaard, Katrine Pedersen, Marta Busse +3 more
2002Biochimica et Biophysica Acta8 citations
Semantic Scholar
Assessment of perioperative stress in colorectal cancer by use of in vitro cell models: a systematic review
T. Kirkegaard, M. Gögenur, I. Gögenur
2017PeerJ7 citations Open access
Semantic Scholar
A high level of estrogen-stimulated proteins selects breast cancer patients treated with adjuvant endocrine therapy with good prognosis
Katrine L. H. Weischenfeldt, T. Kirkegaard, B. Rasmussen, A. Giobbie-Hurder +3 more
2017Acta oncologica5 citations Open access
Semantic Scholar
CDX2 expression and perioperative patient serum affects the adhesion properties of cultured colon cancer cells
Johanne Davidsen, S. Jessen, S. Watt, Sylvester Larsen +4 more
2020BMC Cancer3 citations Open access
Semantic Scholar
Abstract P5-09-02: Cell culture models to study mechanisms for endocrine resistant breast cancer, new treatment options and new biomarkers
A. Lykkesfeldt, C. Yde, S. Thrane, S. Larsen +3 more
20132 citations
Semantic Scholar
CDX2 expression and perioperative patient serum affects the adhesion properties of cultured colon cancer cells
Johanne Davidsen, S. Jessen, S. Watt, Sylvester Larsen +4 more
2020BMC Cancer1 citations Open access
Semantic Scholar
Expression and functional activity of tumor necrosis factor (TNF)-α converting enzyme (TACE) in human colonic epithelial cells
T. Kirkegaard, G. Pedersen, Torben Særmark, J. Brynskov
20011 citations
Semantic Scholar
Syddansk Universitet Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer
S. Larsen, C. Yde, A. Lænkholm, B. Rasmussen +4 more
20150 citations
Semantic Scholar
Abstract P6-04-18: Evaluation of the molecular mechanisms behind fulvestrant resistant breast cancer
T. Kirkegaard, S. K. Hansen, B. Reiter, B. Sørensen +1 more
20120 citations
Semantic Scholar
Expression of tumor necrosis factor-_ converting enzyme ( TACE ) in endocrine cancers
T. Kirkegaard, A. Naresh, V. Sabine, S. Tovey +5 more
20090 citations
Semantic Scholar
Novel Pharmacodiagnostics in Breast Cancer
T. Kirkegaard, J. Bartlett
20060 citations
Semantic Scholar
166 β-Strand 5A residues glutamine 321, glutamine 324 and lysine 325 are important for inhibitory function in PAI-1
T. Kirkegaard, S. Schousboe, R. Egelund, P. Andreasen +1 more
19970 citations
Semantic Scholar
36 Plasminogen activator inhibitor type-1 inhibits integrin- and vitronectin-dependent cell migration
L. Kjøller, S. Kanse, T. Kirkegaard, K. Rodenburg +5 more
19970 citations
Semantic Scholar
171 Mechanisms of neutralization of the inhibitory activity of PAI-1 by monoclonal antibodies directed against the β-strand 1A/α-helix F region
S. Schousboe, R. Egelund, T. Kirkegaard, K. Preissner +2 more
19970 citations
Semantic Scholar

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S. Tovey×8
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M. Bak — researcher profile on SciRah

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