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A. Dulhunty · SciRah

Researcher profile · Semantic Scholar

A. Dulhunty

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A. Dulhunty — researcher profile on SciRah

h-index: 46
Works: 228
Citations: 7,343

Most-cited papers

Adverse Effects of Doxorubicin and Its Metabolic Product on Cardiac RyR2 and SERCA2A
Amy D. Hanna, Alex Lam, Steffi Tham, A. Dulhunty +1 more
2014Molecular Pharmacology154 citations Open access
Semantic Scholar
Skeletal muscle excitation-contraction coupling: who are the dancing partners?
Robyn T. Rebbeck, Yamuna Karunasekara, P. Board, N. Beard +2 more
2014International Journal of Biochemistry and Cell Biology109 citations
Semantic Scholar
An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.
Kyoko Takano, Dan Liu, P. Tarpey, E. Gallant +8 more
2012Human Molecular Genetics102 citations Open access
Semantic Scholar
Neutralizing the pathological effects of extracellular histones with small polyanions
C. O'Meara, L. Coupland, Farzaneh Kordbacheh, B. Quah +18 more
2020Nature Communications78 citations Open access
Semantic Scholar
Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle.
Lan Wei, Amy D. Hanna, N. Beard, A. Dulhunty
2009Cell Calcium70 citations
Semantic Scholar
ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation
Jiao Li, M. Imtiaz, N. Beard, A. Dulhunty +3 more
2013PLoS ONE65 citations Open access
Semantic Scholar
Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling
Takashi Kimura, J. Lueck, P. Harvey, Suzy M. Pace +4 more
2009Cell Calcium62 citations Open access
Semantic Scholar
Multiple targets for flecainide action: implications for cardiac arrhythmogenesis
S. Salvage, K. Chandrasekharan, K. Jeevaratnam, A. Dulhunty +3 more
2018British Journal of Pharmacology60 citations Open access
Semantic Scholar
The β(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail.
Robyn T. Rebbeck, Yamuna Karunasekara, E. Gallant, P. Board +3 more
2011Biophysical Journal40 citations Open access
Semantic Scholar
Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.
K. Walweel, P. Molenaar, M. Imtiaz, A. Denniss +5 more
2017Journal of Molecular and Cellular Cardiology39 citations Open access
Semantic Scholar
C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition
N. Beard, A. Dulhunty
2015Skeletal Muscle38 citations Open access
Semantic Scholar
Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins
Jennifer J. Smith, I. Vetter, R. Lewis, S. Peigneur +6 more
2013Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Regulation of the cardiac muscle ryanodine receptor by glutathione transferases
A. Dulhunty, R. Hewawasam, Dan Liu, M. Casarotto +1 more
2011Drug metabolism reviews (Softcover ed.)33 citations
Semantic Scholar
The voltage-gated calcium-channel β subunit: more than just an accessory
Yamuna Karunasekara, A. Dulhunty, M. Casarotto
2009European Biophysics Journal32 citations
Semantic Scholar
Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor
Han-Shen Tae, M. Casarotto, A. Dulhunty
2009European Biophysics Journal32 citations Open access
Semantic Scholar
Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease.
A. Denniss, A. Dulhunty, N. Beard
2018International Journal of Biochemistry and Cell Biology31 citations
Semantic Scholar
The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target.
A. Dulhunty, M. Casarotto, N. Beard
2011Current Drug Targets30 citations
Semantic Scholar
Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum
K. Walweel, Jiao Li, P. Molenaar, M. Imtiaz +6 more
2014The Journal of General Physiology28 citations Open access
Semantic Scholar
3D Mapping of the SPRY2 Domain of Ryanodine Receptor 1 by Single-Particle Cryo-EM
Àlex Perálvarez-Marín, Han-Shen Tae, P. Board, M. Casarotto +2 more
2011PLoS ONE28 citations Open access
Semantic Scholar
A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels
Lin-Wei Li, Shamaruh Mirza, S. J. Richardson, E. Gallant +6 more
2015Journal of Cell Science26 citations Open access
Semantic Scholar
Multiple Actions of the Anthracycline Daunorubicin on Cardiac Ryanodine Receptors
Amy D. Hanna, M. Janczura, E. Cho, A. Dulhunty +1 more
2011Molecular Pharmacology24 citations
Semantic Scholar
Junctin – the quiet achiever
A. Dulhunty, Lan Wei, N. Beard
2009Journal of Physiology23 citations Open access
Semantic Scholar
How does flecainide impact RyR2 channel function?
S. Salvage, C. Huang, J. Fraser, A. Dulhunty
2022The Journal of General Physiology21 citations Open access
Semantic Scholar
Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse
S. Salvage, E. Gallant, N. Beard, Shiraz Ahmad +4 more
2019Journal of Cell Science20 citations Open access
Semantic Scholar
Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling
A. Dulhunty, N. Beard, M. Casarotto
2018F1000Research20 citations Open access
Semantic Scholar
A Skeletal Muscle Ryanodine Receptor Interaction Domain in Triadin
E. Wium, A. Dulhunty, N. Beard
2012PLoS ONE20 citations Open access
Semantic Scholar
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action
S. Salvage, E. Gallant, J. Fraser, C. Huang +1 more
2021Cells17 citations Open access
Semantic Scholar
β1a490-508, a 19-residue peptide from C-terminal tail of Cav1.1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers.
Erick O. Hernández-Ochoa, R. Olojo, Robyn T. Rebbeck, A. Dulhunty +1 more
2014Biophysical Journal16 citations Open access
Semantic Scholar
Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease
A. Dulhunty, N. Beard, Amy D. Hanna
2012The Journal of General Physiology16 citations Open access
Semantic Scholar
Cyclization of the Intrinsically Disordered α1S Dihydropyridine Receptor II-III Loop Enhances Secondary Structure and in Vitro Function*
Han-Shen Tae, Yan-Fang Cui, Yamuna Karunasekara, P. Board +2 more
2011Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding
S. J. Richardson, Gregory A Steele, E. Gallant, Alex Lam +5 more
2017Journal of Cell Science15 citations
Semantic Scholar
Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment
Amy D. Hanna, Alex Lam, C. Thekkedam, E. Gallant +2 more
2014Journal of Cell Science15 citations Open access
Semantic Scholar
The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor.
R. Hewawasam, Dan Liu, M. Casarotto, A. Dulhunty +1 more
2010Biochemical Pharmacology15 citations
Semantic Scholar
In vitro modulation of the cardiac ryanodine receptor activity by Homer1
P. Pouliquin, Suzy M. Pace, A. Dulhunty
2009Pflügers Archiv: European Journal of Physiology15 citations
Semantic Scholar
FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease
S. J. Richardson, C. Thekkedam, M. G. Casarotto, N. Beard +1 more
2023Philosophical Transactions of the Royal Society of London. Biological Sciences14 citations Open access
Semantic Scholar
The elusive role of the SPRY2 domain in RyR1
Han-Shen Tae, Wei Lan, H. Willemse, Shamaruh Mirza +5 more
2011Channels14 citations Open access
Semantic Scholar
Molecular Changes in the Cardiac RyR2 With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
A. Dulhunty
2022Frontiers in Physiology13 citations Open access
Semantic Scholar
Activation of RyR2 by class I kinase inhibitors
A. Chakraborty, L. A. Gonano, M. L. Munro, L. Smith +6 more
2019British Journal of Pharmacology12 citations Open access
Semantic Scholar
The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.
Dan Liu, R. Hewawasam, Yamuna Karunasekara, M. Casarotto +2 more
2012Biochemical Pharmacology11 citations
Semantic Scholar
Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-β1a subunit (CACNB1).
C. Pérez, J. Eltit, Jose R. Lopez, D. Bodnár +3 more
2018American Journal of Physiology - Cell Physiology10 citations Open access
Semantic Scholar
Feedback contributions to excitation–contraction coupling in native functioning striated muscle
S. Salvage, A. Dulhunty, K. Jeevaratnam, A. Jackson +1 more
2023Philosophical Transactions of the Royal Society of London. Biological Sciences9 citations Open access
Semantic Scholar
The Anthracycline Metabolite Doxorubicinol Abolishes RyR2 Sensitivity to Physiological Changes in Luminal Ca2+ through an Interaction with Calsequestrin
Amy D. Hanna, Alex Lam, C. Thekkedam, H. Willemse +2 more
2017Molecular Pharmacology9 citations Open access
Semantic Scholar
The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes
R. Hewawasam, Dan Liu, M. Casarotto, P. Board +1 more
2016PLoS ONE9 citations Open access
Semantic Scholar
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Michael Maxwell, C. Thekkedam, C. Lamboley, Yan-Ni K. Y. Chin +10 more
2023Nature Communications8 citations Open access
Semantic Scholar
Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels.
A. Dulhunty, P. Board, N. Beard, M. Casarotto
2017Advances in Pharmacology8 citations
Semantic Scholar
Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors
E. Wium, A. Dulhunty, N. Beard
2016Pflügers Archiv: European Journal of Physiology8 citations
Semantic Scholar
Structural and biophysical analyses of the skeletal dihydropyridine receptor β subunit β1a reveal critical roles of domain interactions for stability
N. Norris, Soumya Joseph, Shouvik Aditya, Yamuna Karunasekara +4 more
2017Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit
Robyn T. Rebbeck, H. Willemse, L. Groom, M. Casarotto +4 more
2015Skeletal Muscle7 citations Open access
Semantic Scholar
Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels
K. Robinson, C. Easton, A. Dulhunty, M. Casarotto
2018ChemMedChem6 citations
Semantic Scholar
Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes.
K. Samarasinghe, Dan Liu, P. Tummala, J. Cappello +5 more
2015Biochemical Pharmacology6 citations
Semantic Scholar

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