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D. Kotton · SciRah

Researcher profile · Semantic Scholar

D. Kotton

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D. Kotton — researcher profile on SciRah

h-index: 53
Works: 211
Citations: 9,505

Most-cited papers

Human distal airways contain a multipotent secretory cell that can regenerate alveoli
M. Basil, F. Cardenas-Diaz, J. Kathiriya, M. Morley +24 more
2022Nature245 citations Open access
Semantic Scholar
Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
J. Kathiriya, Chao-Qun Wang, Minqi Zhou, A. Brumwell +10 more
2021Nature Cell Biology220 citations Open access
Semantic Scholar
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
B. Yan, Tilo Freiwald, Daniel Chauss, Luo-Pin Wang +26 more
2021Science immunology178 citations Open access
Semantic Scholar
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
Yi-Ze Li, D. Renner, Courtney E. Comar, Jillian N. Whelan +16 more
2021Proceedings of the National Academy of Sciences of the United States of America147 citations Open access
Semantic Scholar
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry
J. Kee, Samuel Thudium, D. Renner, Karl M. Glastad +21 more
2022Nature118 citations Open access
Semantic Scholar
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
Da-Yuan Chen, C. Chin, D. Kenney, A. H. Tavares +20 more
2023Nature115 citations Open access
Semantic Scholar
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19
C. Mirabelli, J. W. Wotring, Charles J. Zhang, S. McCarty +19 more
2021Proceedings of the National Academy of Sciences of the United States of America106 citations Open access
Semantic Scholar
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
R. Hekman, A. Hume, R. Goel, K. Abo +46 more
2021Molecules and Cells105 citations Open access
Semantic Scholar
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information
Shou-Wen Wang, M. Herriges, Kilian Hurley, D. Kotton +1 more
2022Nature Biotechnology103 citations Open access
Semantic Scholar
Co-development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids
Yifei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang +26 more
2025Cell90 citations Open access
Semantic Scholar
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway
Da-Yuan Chen, Nazimuddin Khan, Brianna J. Close, R. Goel +15 more
2021Journal of Virology71 citations Open access
Semantic Scholar
Collective curvature sensing and fluidity in three-dimensional multicellular systems
Wen-Lang Tang, Amit Das, A. Pegoraro, Yulong Han +7 more
2022Nature Physics60 citations
Semantic Scholar
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier +11 more
2021Nature Communications59 citations Open access
Semantic Scholar
Lung repair and regeneration: advanced models and insights into human disease
M. Basil, Konstantinos-Dionysios Alysandratos, D. Kotton, E. Morrisey
2024Cell Stem Cell53 citations
Semantic Scholar
Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium
K. Abo, Julio Sainz de Aja, J. Lindstrom-Vautrin, Konstantinos-Dionysios Alysandratos +13 more
2022JCI Insight53 citations Open access
Semantic Scholar
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells
Liang Ma, B. Thapa, J. L. Le Suer, Andrew M. Tilston-Lunel +13 more
2023Cell Stem Cell49 citations Open access
Semantic Scholar
Generation of human alveolar epithelial type I cells from pluripotent stem cells
C. Burgess, Jessie Huang, P. Bawa, Konstantinos-Dionysios Alysandratos +14 more
2024Cell Stem Cell43 citations Open access
Semantic Scholar
Generation of human alveolar epithelial type I cells from pluripotent stem cells
C. L. Burgess, Jessie Huang, P. Bawa, Konstantinos-Dionysios Alysandratos +11 more
2023bioRxiv41 citations Open access
Semantic Scholar
Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Konstantinos-Dionysios Alysandratos, Carolina Garcia-de-Alba, C. Yao, P. Pessina +12 more
2022JCI Insight39 citations Open access
Semantic Scholar
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
R. Werder, T. Liu, K. Abo, J. Lindstrom-Vautrin +11 more
2022Science Advances36 citations Open access
Semantic Scholar
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
M. Herriges, Maria Yampolskaya, B. Thapa, J. Lindstrom-Vautrin +9 more
2023Cell Stem Cell32 citations Open access
Semantic Scholar
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection
Kristina Dobrindt, Daisy A. Hoagland, Carina Seah, Bibi S. Kassim +20 more
2021Stem Cell Reports32 citations Open access
Semantic Scholar
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
E. Hoffman, Anit Shah, W. R. Barboza, Luis R. Rodríguez +20 more
2025Nature Communications26 citations Open access
Semantic Scholar
Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells
W. H. Ng, Elizabeth K. Johnston, J. Tan, Jacqueline M. Bliley +7 more
2022eLife25 citations Open access
Semantic Scholar
Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo
J. Torchia, A. H. Tavares, Laura S Carstensen, Da-Yuan Chen +12 more
2022Science Advances25 citations Open access
Semantic Scholar
Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia.
A. Pradhan, Lixiao Che, V. Ustiyan, Abid A. Reza +11 more
2022American Journal of Respiratory and Critical Care Medicine24 citations
Semantic Scholar
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
A. B. Alber, H. Marquez, Liang Ma, George Kwong +9 more
2022bioRxiv21 citations Open access
Semantic Scholar
Recombinant Lloviu virus as a tool to study viral replication and host responses
A. Hume, Baylee Heiden, J. Olejnik, Ellen L. Suder +21 more
2022PLoS Pathogens21 citations Open access
Semantic Scholar
Heterogeneity in Human Induced Pluripotent Stem Cell – derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters
Yuliang L. Sun, K. Hurley, C. Villacorta-Martin, Jessie Huang +8 more
202121 citations
Semantic Scholar
Human alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells
E. Hoffman, J. Uriarte, F. Uhl, Korin M. Eckstrom +7 more
2023Scientific Reports19 citations Open access
Semantic Scholar
Heterogeneity in Human iPSC-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters.
Yuliang L. Sun, K. Hurley, C. Villacorta-Martin, Jessie Huang +8 more
2021American Journal of Respiratory Cell and Molecular Biology19 citations Open access
Semantic Scholar
Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine
A. Posabella, A. B. Alber, Hendrik J Undeutsch, R. Droeser +3 more
2021Frontiers in Endocrinology19 citations Open access
Semantic Scholar
Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection
Ruo-Bing Wang, A. Hume, M. Beermann, C. Simone-Roach +15 more
2021bioRxiv18 citations
Semantic Scholar
Differentiation of human pluripotent stem cells into functional airway basal stem cells
Shingo Suzuki, F. Hawkins, Cristina Barillà, M. Beermann +2 more
2021STAR Protocols17 citations Open access
Semantic Scholar
Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels
Madeline K. Eiken, Charlie J. Childs, Lindy K. Brastrom, T. Frum +10 more
2024Stem Cell Reports16 citations Open access
Semantic Scholar
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
M. Herriges, Maria Yampolskaya, B. Thapa, J. Lindstrom-Vautrin +8 more
2022bioRxiv16 citations
Semantic Scholar
Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations
Yuliang L. Sun, Erin Hennessey, Hillary Heins, Ping Yang +8 more
2024Journal of Clinical Investigation15 citations Open access
Semantic Scholar
De Novo Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells
Ruo-Bing Wang, C. Simone-Roach, J. Lindstrom-Vautrin, Fei-Ya Wang +10 more
2023American Journal of Respiratory and Critical Care Medicine15 citations Open access
Semantic Scholar
Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice
C. Gil, D. Chakraborty, Cristiano P. Vieira, Nutan Prasain +20 more
2022Science Advances14 citations Open access
Semantic Scholar
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron
Da-Yuan Chen, D. Kenney, C. Chin, A. H. Tavares +19 more
2022bioRxiv14 citations Open access
Semantic Scholar
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
J. Kaserman, R. Werder, Fei-Ya Wang, T. Matte +15 more
2022Cell Reports13 citations Open access
Semantic Scholar
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
Lisa Miorin, C. Mire, S. Ranjbar, A. Hume +31 more
2022bioRxiv13 citations Open access
Semantic Scholar
Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis
Luis R. Rodríguez, Konstantinos-Dionysios Alysandratos, Jeremy B. Katzen, A. Murthy +17 more
2025JCI Insight12 citations Open access
Semantic Scholar
Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells.
R. Werder, Jessie Huang, K. Abo, O. Hix +8 more
2022Journal of Visualized Experiments12 citations Open access
Semantic Scholar
Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways
Monika Evdokimova, Shuchen Feng, Allen Caobi, F. R. Moreira +9 more
2025Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar
Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis
Luis R. Rodríguez, Konstantinos-Dionysios Alysandratos, Jeremy B. Katzen, A. Murthy +16 more
2024bioRxiv11 citations Open access
Semantic Scholar
Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells
Liang Ma, B. Thapa, J. L. Le Suer, Andrew M. Tilston-Lunel +6 more
2024Nature Protocols11 citations
Semantic Scholar
Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report
S. Montesi, Christian R. Gomez, M. Beers, Robert Brown +30 more
2023American Journal of Respiratory and Critical Care Medicine11 citations Open access
Semantic Scholar
Topology and Nuclear Size Determine Cell Packing on Growing Lung Spheroids
Wen-Lang Tang, Jessie Huang, A. Pegoraro, James H. Zhang +4 more
2025Physical Review X10 citations Open access
Semantic Scholar
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses
Allen Caobi, Chia-Ming Su, Christian M. Beusch, D. Kenney +20 more
2025Proceedings of the National Academy of Sciences of the United States of America10 citations Open access
Semantic Scholar

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