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M. Seinen · SciRah

Researcher profile · Semantic Scholar

M. Seinen

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M. Seinen — researcher profile on SciRah

h-index: 17
Works: 53
Citations: 937

Most-cited papers

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8‐year intercept cohorts
B. Jharap, M. Seinen, N. D. de Boer, J. V. van Ginkel +4 more
2010Inflammatory Bowel Diseases207 citations Open access
Semantic Scholar
Safety and Effectiveness of Long-term Allopurinol–Thiopurine Maintenance Treatment in Inflammatory Bowel Disease
F. Hoentjen, M. Seinen, S. Hanauer, N. D. de Boer +4 more
2013Inflammatory Bowel Diseases96 citations
Semantic Scholar
The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.
M. Seinen, D. V. van Asseldonk, N. D. de Boer, N. Losekoot +5 more
2013Journal of Crohn's & Colitis52 citations Open access
Semantic Scholar
Dosing 6-thioguanine in inflammatory bowel disease: expert-based guidelines for daily practice.
M. Seinen, D. V. van Asseldonk, C. Mulder, N. D. de Boer
2010Journal of Gastrointestinal and Liver Diseases48 citations
Semantic Scholar
The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review
A. Bayoumy, M. Simsek, M. Seinen, C. Mulder +3 more
2020Expert Opinion on Drug Metabolism & Toxicology47 citations Open access
Semantic Scholar
Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
D. V. van Asseldonk, M. Seinen, N. D. de Boer, A. V. van Bodegraven +1 more
2012Journal of Crohn's & Colitis40 citations Open access
Semantic Scholar
Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, A. V. van Bodegraven
2016Molecular Diagnosis & Therapy38 citations Open access
Semantic Scholar
Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn's disease.
M. Seinen, C. Ponsioen, N. D. de Boer, B. Oldenburg +3 more
2013Clinical Gastroenterology and Hepatology38 citations
Semantic Scholar
Electronic Nose Sensor Drift Affects Diagnostic Reliability and Accuracy of Disease-Specific Algorithms
S. Bosch, R. D. de Menezes, Suzanne Pees, D. Wintjens +6 more
2022Italian National Conference on Sensors33 citations Open access
Semantic Scholar
Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies
M. Simsek, D. Deben, C. Horjus, M. Bénard +8 more
2019Alimentary Pharmacology and Therapeutics33 citations Open access
Semantic Scholar
Thiopurine Therapy in Inflammatory Bowel Diseases: Making New Friends Should Not Mean Losing Old Ones.
N. D. de Boer, V. Ahuja, S. Almér, A. Ansari +16 more
2019Gastroenterology33 citations Open access
Semantic Scholar
Routinely Established Skewed Thiopurine Metabolism Leads to a Strikingly High Rate of Early Therapeutic Failure in Patients With Inflammatory Bowel Disease
J. Kreijne, M. Seinen, A. J. Wilhelm, G. Bouma +3 more
2015Therapeutic Drug Monitoring30 citations Open access
Semantic Scholar
Rac1 as a Potential Pharmacodynamic Biomarker for Thiopurine Therapy in Inflammatory Bowel Disease
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, C. J. Mulder +2 more
2016Therapeutic Drug Monitoring28 citations Open access
Semantic Scholar
Allopurinol Enhances the Activity of Hypoxanthine-Guanine Phosphoribosyltransferase in Inflammatory Bowel Disease Patients During Low-Dose Thiopurine Therapy: Preliminary Data of an Ongoing Series
M. Seinen, N. D. de Boer, K. Smid, D. V. van Asseldonk +3 more
2011Nucleosides, Nucleotides & Nucleic Acids28 citations
Semantic Scholar
Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
Berrie Meijer, M. Seinen, Remco van Egmond, G. Bouma +3 more
2017Inflammatory Bowel Diseases27 citations Open access
Semantic Scholar
Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol–Thiopurine Combination Therapy
M. Seinen, D. V. van Asseldonk, N. D. de Boer, G. Bouma +4 more
2017Inflammatory Bowel Diseases21 citations
Semantic Scholar
The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients.
D. Wong, M. Pierik, M. Seinen, A. V. van Bodegraven +7 more
2014Journal of Crohn's & Colitis20 citations Open access
Semantic Scholar
Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease
F. Crouwel, M. Simsek, M. D. de Boer, C. Mulder +28 more
2022Journal of Crohn's & Colitis14 citations Open access
Semantic Scholar
Key insights from therapeutic drug monitoring in Crohn’s disease patients
M. Seinen, N. D. de Boer, A. V. van Bodegraven
2019Expert Opinion on Drug Metabolism & Toxicology13 citations Open access
Semantic Scholar
Safe use of allopurinol and low-dose mercaptopurine therapy during pregnancy in an ulcerative colitis patient.
M. Seinen, N. D. de Boer, M. V. van Hoorn, A. V. van Bodegraven +1 more
2013Inflammatory Bowel Diseases12 citations
Semantic Scholar
Subcutaneous administration, higher age and lower renal function are associated with erythrocyte methotrexate accumulation in Crohn’s disease: a cross-sectional study
M. M. van de Meeberg, M. Seinen, H. Fidder, M. Lin +5 more
2022BMC Gastroenterology10 citations Open access
Semantic Scholar
Clinical Value of Mercaptopurine After Failing Azathioprine Therapy in Patients With Inflammatory Bowel Disease
Berrie Meijer, M. Seinen, Niek N. W. Leijte, C. J. Mulder +2 more
2016Therapeutic Drug Monitoring10 citations Open access
Semantic Scholar
PACSIN2 Does Not Influence Thiopurine-Related Toxicity In Patients With Inflammatory Bowel Disease
R. Roberts, M. Wallace, M. Seinen, K. Krishnaprasad +9 more
2014American Journal of Gastroenterology10 citations
Semantic Scholar
High inter-individual variability of serum xanthine oxidoreductase activity in IBD patients
Berrie Meijer, M. Seinen, Tessa Hosman, R. Linskens +5 more
2018Nucleosides, Nucleotides & Nucleic Acids9 citations Open access
Semantic Scholar
High TPMT activity as a risk factor for severe myelosuppression during thiopurine therapy.
M. Seinen, A. V. van Bodegraven, A. V. van Kuilenburg, N. D. de Boer
2013Netherlands Journal of Medicine9 citations
Semantic Scholar
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
R. Roberts, M. Wallace, M. Seinen, A. V. van Bodegraven +18 more
2018Inflammatory Bowel Diseases8 citations Open access
Semantic Scholar
Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol–thiopurine cotherapy
M. Simsek, M. Seinen, N. D. de Boer
2018European Journal of Gastroenterology and Hepathology5 citations Open access
Semantic Scholar
Safety and Effectiveness of Long-term Allopurinol – Thiopurine Maintenance Treatment in In ﬂ ammatory Bowel Disease
F. Hoentjen, M. Seinen, S. Hanauer, N. D. de Boer +4 more
5 citations
Semantic Scholar
Corrigendum: PACSIN2 Does Not Influence Thiopurine-Related Toxicity in Patients With Inflammatory Bowel Disease
R. Roberts, M. Wallace, M. Seinen, K. Krishnaprasad +9 more
2015American Journal of Gastroenterology3 citations
Semantic Scholar
Exploring the role of oxidative stress and the effect of N‐acetylcysteine in thiopurine‐induced liver injury in inflammatory bowel disease: A randomized crossover pilot study
D. V. van Asseldonk, F. Crouwel, M. Seinen, Peter Scheffer +5 more
2024Basic & Clinical Pharmacology & Toxicology2 citations Open access
Semantic Scholar
Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, A. V. van Bodegraven
2016Molecular Diagnosis & Therapy2 citations Open access
Semantic Scholar
Letter: thiopurines during pregnancy and intrauterine exposure to metabolites
N. K. D. Boer, B. Jharap, M. Seinen, A. Bodegraven
2012Alimentary Pharmacology and Therapeutics2 citations
Semantic Scholar
Effectiveness and Tolerability of Maintenance Methotrexate Therapy in Crohn's Disease Patients; Analysis of a Referral Hospital-Based 10-Years Intercept Cohort
M. Seinen, N. D. de Boer, C. Mulder, G. Bouma +1 more
20112 citations
Semantic Scholar
Optimalisation of conventional therapies in inflammatory bowel disease: Old wine in new bottles
M. Seinen
20161 citations
Semantic Scholar
Allopurinol–thiopurine combination therapy in inflammatory bowel disease
M. Seinen, K. D. de Boer, A. V. van Bodegraven, S. Hanauer +1 more
20141 citations
Semantic Scholar
Oxidation-mediated DNA crosslinking contributes to toxicity of 6-thioguanine in human cells -- letter.
N. D. de Boer, D. V. van Asseldonk, M. Seinen, A. V. van Bodegraven
2013Cancer Research1 citations Open access
Semantic Scholar
P107 Predictors for Failing Thiopurine Therapy in Inflammatory Bowel Disease Patients; Treated at an Academic Or General District Hospital
B. Jharap, M. Seinen, R. Linskens, J. Kneppelhout +3 more
20081 citations Open access
Semantic Scholar
P312 Erythrocyte methotrexate polyglutamate concentrations in patients with Crohn’s Disease: towards a new therapeutic drug monitoring tool
M. M. van de Meeberg, M. Lin, M. Seinen, H. Fidder +4 more
20210 citations
Semantic Scholar
A plea for TDM-based optimisation for treatment of Crohn's disease.
M. Seinen, N. D. de Boer
2017The Lancet Gastroenterology and Hepatology0 citations
Semantic Scholar
Inter-Individual Variability of Serum Xanthine Oxidase Activity in Patients with Inflammatory Bowel Disease
Berrie Meijer, M. Seinen, Tessa Hosman, R. Linskens +5 more
20170 citations
Semantic Scholar
EXPLORING HEPATOTO XICIT Y OF THIOPURINES
I. Parti, D. V. van Asseldonk, M. Seinen, A. Veldkamp +5 more
20150 citations
Semantic Scholar
HEPATOTOXICIT Y ASSOCIATED WITH 6-METHYL MERC APTOPURINE FORMATION DURING A Z ATHIOPRINE AND MERC APTOPURINE THER APY DOES NOT OCCUR ON THE SHORT-TERM DURING T IOGUANINE THER APY IN IBD TREATMENT
D. V. van Asseldonk, M. Seinen, N. D. de Boer, A. V. van Bodegraven +1 more
20150 citations
Semantic Scholar
DOSING T IOGUANINE IN INFL AMMATORY BOWEL DISEASE: EXPERT BASED GUIDELINES FOR DAILY PR AC TICE
M. Seinen, D. V. van Asseldonk, C. Mulder, N. D. de Boer +1 more
20150 citations
Semantic Scholar
P343 Skewed thiopurine metabolism leads to early therapeutic failure in the majority of patients with inflammatory bowel disease
J. Kreijne, M. Seinen, A. Sinjewel, G. Bouma +3 more
20140 citations Open access
Semantic Scholar
P433 Mercaptopurine therapy in IBD patients modulates GTPase Rac1
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, J. V. van Bezu +2 more
20130 citations Open access
Semantic Scholar
Mo1066 Mercaptopurine Therapy in IBD Patients Modulates GTPase RAC1
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, J. V. van Bezu +2 more
20130 citations
Semantic Scholar
Reply: To PMID 23333660.
M. Seinen, N. D. de Boer, A. V. van Bodegraven
2013Clinical Gastroenterology and Hepatology0 citations
Semantic Scholar
Intrauterine exposure to thiopurines.
B. Jharap, M. Seinen, A. V. van Bodegraven, N. D. de Boer
2012Reproductive Toxicology0 citations
Semantic Scholar
Tu1230 RAC1 Modulation by Thiopurine Therapy in IBD Patients
M. Seinen, G. P. van Nieuw Amerongen, N. D. de Boer, J. V. van Bezu +2 more
20120 citations Open access
Semantic Scholar
Tolerability and Safety of Conventional Thiopurines Concomitantly With Allopurinol in IBD-Patients With a Skewed Thiopurine Metabolism
M. Seinen, D. V. van Asseldonk, N. D. de Boer, K. Smid +4 more
20110 citations Open access
Semantic Scholar

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