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J. Beyrath · SciRah

Researcher profile · Semantic Scholar

J. Beyrath

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J. Beyrath — researcher profile on SciRah

h-index: 23
Works: 39
Citations: 1,245

Most-cited papers

A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins.
Damien Destouches, N. Page, Y. Hamma-Kourbali, Valérie Machi +14 more
2011Cancer Research102 citations Open access
Semantic Scholar
Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy
Eligio F. Iannetti, J. Smeitink, J. Beyrath, P. Willems +1 more
2016Nature Protocols92 citations Open access
Semantic Scholar
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.
V. Pavet, J. Beyrath, C. Pardin, Alexandre Morizot +8 more
2010Cancer Research89 citations Open access
Semantic Scholar
Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting.
J. Thomann, B. Heurtault, Steffen Weidner, Mélanie Brayé +4 more
2011Biomaterials82 citations
Semantic Scholar
KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery
J. Beyrath, Mina Pellegrini, H. Renkema, L. Houben +6 more
2018Scientific Reports69 citations Open access
Semantic Scholar
in children : toward development of small-molecule treatment strategies
W. Koopman, J. Beyrath, C. Fung, S. Koene +3 more
201860 citations
Semantic Scholar
The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders
M. Janssen, S. Koene, P. D. de Laat, Pleun Hemelaar +7 more
2018Clinical pharmacology and therapy55 citations Open access
Semantic Scholar
Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease
R. de Haas, D. Das, A. Garanto, H. Renkema +9 more
2017Scientific Reports49 citations Open access
Semantic Scholar
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans
Inge E. Krabbendam, B. Honrath, Benjamin Dilberger, Eligio F. Iannetti +13 more
2020Cell Death and Disease43 citations Open access
Semantic Scholar
Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.
K. Górska, J. Beyrath, S. Fournel, G. Guichard +1 more
2010Chemical Communications43 citations Open access
Semantic Scholar
Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning
L. Blanchet, J. Smeitink, S. E. van Emst-de Vries, C. Vogels +7 more
2015Scientific Reports42 citations Open access
Semantic Scholar
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+
Eligio F. Iannetti, J. Smeitink, P. Willems, J. Beyrath +1 more
2018Cell Death and Disease41 citations Open access
Semantic Scholar
KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers
S. Koene, E. Spaans, L. van Bortel, G. Van Lancker +4 more
2017Orphanet Journal of Rare Diseases36 citations Open access
Semantic Scholar
Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia
S. Copsel, A. Bruzzone, M. May, J. Beyrath +5 more
2014OncoTarget36 citations Open access
Semantic Scholar
Toward high-content screening of mitochondrial morphology and membrane potential in living cells.
Eligio F. Iannetti, P. Willems, Mina Pellegrini, J. Beyrath +3 more
2015International Journal of Biochemistry and Cell Biology35 citations
Semantic Scholar
Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons
Aurélie Schwartzentruber, Camilla Boschian, F. Lopes, Monika A. Myszczynska +5 more
2020Scientific Reports34 citations Open access
Semantic Scholar
Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly*
C. Smulski, J. Beyrath, M. Decossas, Neila Chekkat +6 more
2013Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling
C. Smulski, M. Decossas, Neila Chekkat, J. Beyrath +7 more
2017Cell Death and Disease33 citations Open access
Semantic Scholar
Mitochondrial disorders in children: toward development of small‐molecule treatment strategies
W. Koopman, J. Beyrath, C. Fung, S. Koene +3 more
2016EMBO Molecular Medicine32 citations Open access
Semantic Scholar
Hypothesis: mPGES-1-Derived Prostaglandin E2, a So Far Missing Link in COVID-19 Pathophysiology?
J. Smeitink, Xiao-Lan Jiang, S. Pecheritsyna, H. Renkema +2 more
202030 citations Open access
Semantic Scholar
Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics.
Sarah Foriel, P. Willems, J. Smeitink, A. Schenck +1 more
2015International Journal of Biochemistry and Cell Biology24 citations
Semantic Scholar
Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m
X. Jiang, H. Renkema, B. Pennings, S. Pecheritsyna +4 more
2021Scientific Reports23 citations Open access
Semantic Scholar
Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function
Eligio F. Iannetti, A. Prigione, J. Smeitink, W. Koopman +2 more
2019Frontiers in Genetics23 citations Open access
Semantic Scholar
Mitochondrial Migraine: Disentangling the angiopathy paradigm in m.3243A>G patients
J. Smeitink, S. Koene, J. Beyrath, C. Saris +2 more
2019JIMD Reports21 citations Open access
Semantic Scholar
Design and synthesis of intrinsically cell-penetrating nucleopeptides.
Piero Geotti-Bianchini, J. Beyrath, O. Chaloin, F. Formaggio +1 more
2008Organic and biomolecular chemistry21 citations
Semantic Scholar
Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons
T. K. Klein Gunnewiek, A. Verboven, Iris Pelgrim, Mark Hogeweg +8 more
2020bioRxiv19 citations Open access
Semantic Scholar
Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model
Sarah Foriel, J. Beyrath, I. Eidhof, R. Rodenburg +2 more
2018Disease Models & Mechanisms17 citations Open access
Semantic Scholar
Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice.
Tom J. J. Schirris, S. Rossell, R. de Haas, Sanne J. C. M. Frambach +8 more
2020Biochimica et Biophysica Acta - Molecular Basis of Disease15 citations Open access
Semantic Scholar
A Drosophila Mitochondrial Complex I Deficiency Phenotype Array
Sarah Foriel, G. Renkema, Yvonne Lasarzewski, J. Berkhout +4 more
2019Frontiers in Genetics15 citations Open access
Semantic Scholar
Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels
J. Beyrath, Neila Chekkat, C. Smulski, C. Lombardo +7 more
2016OncoTarget12 citations Open access
Semantic Scholar
Replacement of Ala by Aib improves structuration and biological stability in thymine-based alpha-nucleopeptides.
Piero Geotti-Bianchini, A. Moretto, C. Peggion, J. Beyrath +2 more
2010Organic and biomolecular chemistry8 citations
Semantic Scholar
Sonlicromanol’s active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth
Xiao-Lan Jiang, H. Renkema, J. Smeitink, J. Beyrath
2021PLoS ONE6 citations Open access
Semantic Scholar
Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
M. Spanedda, B. Heurtault, Steffen Weidner, Corinne Baehr +6 more
2010Bioorganic & Medicinal Chemistry Letters6 citations
Semantic Scholar
DROSOPHILA AS A MODEL TO STUDY THERAPEUTIC APPROACHES FOR MITOCHONDRIAL DISEASES
Sarah Foriel, J. Smeitink, P. Willems, A. Schenck +1 more
20163 citations
Semantic Scholar
A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111
E. Spaans, Denisa Wilkes, M. Schreurs, J. Beyrath +6 more
2026Blood vessels, thrombosis & hemostasis0 citations Open access
Semantic Scholar
First in-Human Study with Okl-1111, a Novel Small Molecule Universal Anticoagulant and Platelet Inhibitor Reversal Agent
E. Spaans, Denisa Wilkes, M. Schreurs, Alex Zwiers +5 more
2024Blood0 citations
Semantic Scholar
Exogenous NAD+ prevents galactose-induced death of Leigh Syndrome patient fibroblasts with isolated complex I deficiency
W. Koopman, Eligio F. Iannetti, J. Smeitink, P. Willems +1 more
2018Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
KH176: A NEW SMALL MOLECULE TO POTENTIALLY COMBAT MITOCHONDRIAL DISEASES
J. Beyrath, Mina Pellegrini, P. van Zandvoort, L. Houben +7 more
20150 citations
Semantic Scholar
Development and biological characterization of synthetic molecules targeting Death Receptor 5 : potential applications in cancer therapy
J. Beyrath
20100 citations
Semantic Scholar

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P. Willems×11
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W. Koopman×10
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S. Fournel×7
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Eligio F. Iannetti×6

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Mina Pellegrini×4

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S. Pecheritsyna×4

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