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C. Gregorio · SciRah

Researcher profile · Semantic Scholar

C. Gregorio

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C. Gregorio — researcher profile on SciRah

h-index: 49
Works: 136
Citations: 10K

Most-cited papers

The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.
Melanie K. Miller, M. Bang, C. Witt, D. Labeit +6 more
2003Journal of Molecular Biology360 citations
Semantic Scholar
Overview of the Muscle Cytoskeleton
C. Henderson, Christopher G. Gomez, S. Novak, Mi-Mi Lei +1 more
2017Comprehensive Physiology242 citations Open access
Semantic Scholar
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Michaela Yuen, S. Sandaradura, J. Dowling, A. Kostyukova +53 more
2014Journal of Clinical Investigation175 citations Open access
Semantic Scholar
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
Laura T Donlin, Christian Andresen, S. Just, Eugene Rudensky +12 more
2012Genes & Development162 citations Open access
Semantic Scholar
The sensitive giant: the role of titin-based stretch sensing complexes in the heart.
Melanie K. Miller, H. Granzier, E. Ehler, C. Gregorio
2004Trends in Cell Biology119 citations
Semantic Scholar
Nebulin: the nebulous, multifunctional giant of striated muscle.
A. McElhinny, S. Kazmierski, S. Labeit, C. Gregorio
2003Trends in cardiovascular medicine119 citations
Semantic Scholar
The Nebulin Family: an Actin Support Group
C. T. Pappas, Katherine T. Bliss, A. Zieseniss, C. Gregorio
2010Trends in Cell Biology113 citations Open access
Semantic Scholar
Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle
T. Tsukada, C. T. Pappas, N. Moroz, P. Antin +2 more
2010Journal of Cell Science111 citations Open access
Semantic Scholar
Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development
A. McElhinny, Cynthia N. Perry, C. Witt, S. Labeit +1 more
2004Journal of Cell Science110 citations Open access
Semantic Scholar
Nebulin regulates actin filament lengths by a stabilization mechanism
C. T. Pappas, P. Krieg, C. Gregorio
2010Journal of Cell Biology108 citations Open access
Semantic Scholar
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
Kimberly L. Fritz-Six, Patrick R. Cox, Robert S. Fischer, Bisong Xu +3 more
2003Journal of Cell Biology108 citations Open access
Semantic Scholar
A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics*
A. Raskin, S. Lange, Katherine Banares, R. Lyon +8 more
2012Journal of Biological Chemistry106 citations Open access
Semantic Scholar
Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc.
C. T. Pappas, Nandini Bhattacharya, J. Cooper, C. Gregorio
2008Molecular Biology of the Cell105 citations Open access
Semantic Scholar
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality
C. T. Pappas, Rachel M. Mayfield, C. Henderson, Nima Jamilpour +9 more
2015Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Nebulin regulates the assembly and lengths of the thin filaments in striated muscle
A. McElhinny, Catherine M. Schwach, Melinda Valichnac, Sarah Mount-Patrick +1 more
2005Journal of Cell Biology92 citations Open access
Semantic Scholar
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
C. Witt, Y. Ono, E. Puschmann, M. Mcnabb +9 more
2004Journal of Molecular Biology91 citations
Semantic Scholar
Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
H. Granzier, K. Hutchinson, P. Tonino, Mei Methawasin +7 more
2014Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
The complete mouse nebulin gene sequence and the identification of cardiac nebulin.
S. Kazmierski, P. Antin, C. Witt, N. Huebner +3 more
2003Journal of Molecular Biology89 citations
Semantic Scholar
The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes
Ryan E. Mudry, Cynthia N. Perry, M. Richards, V. Fowler +1 more
2003Journal of Cell Biology70 citations Open access
Semantic Scholar
HSPB7 is indispensable for heart development by modulating actin filament assembly
Tong-Bin Wu, Yong-Xin Mu, J. Bogomolovas, Xi Fang +7 more
2017Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle
P. Tonino, C. T. Pappas, Bryan D. Hudson, S. Labeit +2 more
2010Journal of Cell Science67 citations Open access
Semantic Scholar
Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy
J. D. de Winter, B. Joureau, Eun-Jeong Lee, Balázs Kiss +19 more
2016Annals of Neurology65 citations Open access
Semantic Scholar
A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture.
Gloria M. Conover, Syerra N Henderson, C. Gregorio
2008Molecular Biology of the Cell65 citations Open access
Semantic Scholar
Cellular self-organization by autocatalytic alignment feedback
M. Junkin, S. Leung, S. Whitman, C. Gregorio +1 more
2011Journal of Cell Science62 citations Open access
Semantic Scholar
Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle
C. Gregorio, Cynthia N. Perry, A. McElhinny
2006Journal of Muscle Research and Cell Motility61 citations
Semantic Scholar
Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function
Xin-Yao Sun, Swetansu K. Hota, Yu-Qing Zhou, S. Novak +8 more
2017Biology Open52 citations Open access
Semantic Scholar
Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart
A. S. Warkman, S. Whitman, Melanie K. Miller, R. Garriock +3 more
2012Cytoskeleton52 citations Open access
Semantic Scholar
Nebulin, a multi-functional giant
Miensheng Chu, C. Gregorio, C. T. Pappas
2016Journal of Experimental Biology47 citations Open access
Semantic Scholar
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy
R. Ahrens-Nicklas, C. T. Pappas, Gerrie P. Farman, Rachel M. Mayfield +10 more
2019Science Advances46 citations Open access
Semantic Scholar
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Michaela Yuen, S. Sandaradura, J. Dowling, A. Kostyukova +53 more
2015Journal of Clinical Investigation44 citations Open access
Semantic Scholar
Desmoplakin and talin2 are novel mRNA targets of Fragile X Related Protein-1 in cardiac muscle
S. Whitman, C. Cover, Lily Yu, D. Nelson +2 more
2011Circulation Research44 citations Open access
Semantic Scholar
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis
Chinedu U Nworu, R. Kraft, Daniel C. Schnurr, C. Gregorio +1 more
2015Journal of Cell Science41 citations Open access
Semantic Scholar
Cardiac-Specific Knockout of Lmod2 Results in a Severe Reduction in Myofilament Force Production and Rapid Cardiac Failure
C. T. Pappas, Gerrie P. Farman, Rachel M. Mayfield, J. Konhilas +1 more
2018Journal of Molecular and Cellular Cardiology39 citations Open access
Semantic Scholar
Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes*
T. Tsukada, L. Kotlyanskaya, R. Huynh, B. Desai +4 more
2010Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes
Franziska Rudolph, Judith Hüttemeister, Katharina da Silva Lopes, R. Jüttner +8 more
2019Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy
M. Trembley, Pearl J. Quijada, E. Agulló-Pascual, Kevin M. Tylock +12 more
2018Circulation35 citations Open access
Semantic Scholar
Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation.
Y. Ono, Catherine M. Schwach, P. Antin, C. Gregorio
2005Developmental Biology35 citations Open access
Semantic Scholar
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle
Balázs Kiss, Jochen Gohlke, P. Tonino, Z. Hourani +7 more
2020Science Advances34 citations Open access
Semantic Scholar
Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein.
A. Zieseniss, A. Terasaki, C. Gregorio
2008Cell Motility and the Cytoskeleton32 citations
Semantic Scholar
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments
D. Tolkatchev, Garry E. Smith, Lauren E Schultz, Mert Colpan +4 more
2020PLoS Biology31 citations Open access
Semantic Scholar
The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation
Y. Ono, M. Shindo, N. Doi, F. Kitamura +2 more
2014Proceedings of the National Academy of Sciences of the United States of America29 citations Open access
Semantic Scholar
Translational Research in Acute Lung Injury and Pulmonary Fibrosis c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury
P. Fu, P. Usatyuk, A. Lele, A. Harijith +4 more
201527 citations
Semantic Scholar
The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments
Gloria M. Conover, C. Gregorio
2011Journal of Cell Science27 citations Open access
Semantic Scholar
The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2’s function
Thu Ly, N. Moroz, C. T. Pappas, S. Novak +6 more
2016Molecular Biology of the Cell26 citations Open access
Semantic Scholar
Increased cardiac arrhythmogenesis associated with gap junction remodeling with upregulation of RNA binding protein FXR1
Miensheng Chu, S. Novak, C. Cover, A. A. Wang +5 more
2017Circulation25 citations Open access
Semantic Scholar
Investigating lasp-2 in cell adhesion: new binding partners and roles in motility
Katherine T. Bliss, Miensheng Chu, Colin M. Jones-Weinert, C. Gregorio
2013Molecular Biology of the Cell24 citations Open access
Semantic Scholar
Fragile hearts: New insights into translational control in cardiac muscle
D. Zarnescu, C. Gregorio
2013Trends in cardiovascular medicine24 citations Open access
Semantic Scholar
Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle
Carlos M. Moran, R. Garriock, Melanie K. Miller, R. Heimark +3 more
2008Cell Motility and the Cytoskeleton24 citations Open access
Semantic Scholar
In vivo elongation of thin filaments results in heart failure
Mi-Mi Lei, Gerrie P. Farman, Rachel M. Mayfield, J. Strom +3 more
2020PLoS ONE22 citations Open access
Semantic Scholar
PLEIAD/SIMC1/C5orf25, a Novel Autolysis Regulator for a Skeletal-Muscle-Specific Calpain, CAPN3, Scaffolds a CAPN3 Substrate, CTBP1
Y. Ono, S. Iemura, S. Novak, N. Doi +4 more
2013Journal of Molecular Biology22 citations Open access
Semantic Scholar

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