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I. Brock · SciRah

Researcher profile · Semantic Scholar

I. Brock

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I. Brock — researcher profile on SciRah

h-index: 24
Works: 56
Citations: 7,456

Most-cited papers

Genome-wide association study identifies novel breast cancer susceptibility loci
D. Easton, K. Pooley, A. Dunning, P. Pharoah +98 more
2007Nature2,356 citations Open access
Semantic Scholar
Association analysis identifies 65 new breast cancer risk loci
K. Michailidou, S. Lindström, J. Dennis, J. Beesley +355 more
2017Nature1,360 citations Open access
Semantic Scholar
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
K. Michailidou, P. Hall, A. González-Neira, M. Ghoussaini +215 more
2013Nature Genetics1,147 citations Open access
Semantic Scholar
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
N. Mavaddat, K. Michailidou, J. Dennis, M. Lush +265 more
2018American Journal of Human Genetics959 citations Open access
Semantic Scholar
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Shahana Ahmed, G. Thomas, M. Ghoussaini, C. Healey +131 more
2009Nature Genetics507 citations Open access
Semantic Scholar
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
R. Milne, J. Benítez, H. Nevanlinna, T. Heikkinen +89 more
2009Journal of the National Cancer Institute118 citations Open access
Semantic Scholar
The presequence of a chimeric construct dictates which of two mechanisms are utilized for translocation across the thylakoid membrane: evidence for the existence of two distinct translocation systems.
C. Robinson, D. Cai, A. Hulford, I. Brock +5 more
1994EMBO Journal96 citations
Semantic Scholar
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
J. Figueroa, M. García-Closas, M. Humphreys, R. Platte +141 more
2011Human Molecular Genetics88 citations Open access
Semantic Scholar
Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)
R. Hein, M. Maranian, J. Hopper, M. Kapuscinski +165 more
2012PLoS ONE58 citations Open access
Semantic Scholar
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival.
E. M. Azzato, J. Tyrer, P. Fasching, M. Beckmann +51 more
2010Journal of the National Cancer Institute57 citations Open access
Semantic Scholar
Genome-wide association study of germline variants and breast cancer-specific mortality
M. Escala-Garcia, Qi Guo, T. Dörk, S. Canisius +232 more
2019British Journal of Cancer54 citations Open access
Semantic Scholar
Proton gradient-driven import of the 16 kDa oxygen-evolving complex protein as the full precursor protein by isolated thylakoids
R. Klösgen, I. Brock, R. Herrmann, C. Robinson
1992Plant Molecular Biology49 citations
Semantic Scholar
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.
R. Milne, J. Herranz, K. Michailidou, J. Dennis +139 more
2014Human Molecular Genetics45 citations Open access
Semantic Scholar
Missense Variants in ATM in 26,101 Breast Cancer Cases and 29,842 Controls
O. Fletcher, N. Johnson, I. dos Santos Silva, N. Orr +85 more
2010Cancer Epidemiology, Biomarkers and Prevention41 citations Open access
Semantic Scholar
11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer
D. Lambrechts, T. Truong, C. Justenhoven, M. Humphreys +147 more
2012Human Mutation40 citations Open access
Semantic Scholar
Identification of Candidate Driver Genes in Common Focal Chromosomal Aberrations of Microsatellite Stable Colorectal Cancer
G. Burghel, Wei-Yu Lin, Helen Whitehouse, I. Brock +5 more
2013PLoS ONE36 citations Open access
Semantic Scholar
Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.
N. A. C. S. Wong, N. Mayer, C. E. Anderson, Honora C McKenzie +7 more
2003Human Pathology36 citations
Semantic Scholar
A breast cancer risk haplotype in the caspase-8 gene
Neil Shephard, R. Abo, Sushilaben H. Rigas, B. Frank +14 more
2009Cancer Research35 citations Open access
Semantic Scholar
Regulation of glutamine synthetase genes in leaves of Phaseolus vulgaris
J. Cock, I. Brock, A. Watson, R. Swarup +2 more
1991Plant Molecular Biology34 citations
Semantic Scholar
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer
R. Milne, E. Goode, M. García-Closas, F. Couch +139 more
2011Cancer Epidemiology, Biomarkers and Prevention33 citations Open access
Semantic Scholar
The pH-driven, ATP-independent Protein Translocation Mechanism in the Chloroplast Thylakoid Membrane
I. Brock, J. D. Mills, D. Robinson, C. Robinson
1995Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
N. Johnson, F. Dudbridge, N. Orr, L. Gibson +178 more
2014Breast Cancer Research30 citations Open access
Semantic Scholar
Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium
W. Howat, F. Blows, E. Provenzano, M. Brook +48 more
2014The Journal of Pathology: Clinical Research28 citations Open access
Semantic Scholar
Precursors of one integral and five lumenal thylakoid proteins are imported by isolated pea and barley thylakoids: optimisation of in vitro assays
I. Brock, L. Hazell, D. Michl, V. S. Nielsen +4 more
1993Plant Molecular Biology25 citations
Semantic Scholar
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
D. Agarwal, S. Pineda, K. Michailidou, J. Herranz +174 more
2014British Journal of Cancer24 citations Open access
Semantic Scholar
Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer
Wei-Yu Lin, I. Brock, D. Connley, H. Cramp +7 more
2013PLoS ONE23 citations Open access
Semantic Scholar
9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
H. Warren, F. Dudbridge, O. Fletcher, N. Orr +136 more
2012Cancer Epidemiology, Biomarkers and Prevention21 citations Open access
Semantic Scholar
Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and “BRCA-Like” Status, in Both Blood and Tumour DNA
Sarah L. Daniels, G. Burghel, P. Chambers, S. Al-Baba +8 more
2016PLoS ONE19 citations Open access
Semantic Scholar
Meningiomas, dicentric chromosomes, gliomas, and telomerase activity
Thomas Carroll, E. Maltby, I. Brock, J. Royds +2 more
1999Journal of Pathology19 citations
Semantic Scholar
A BCL2 promoter polymorphism rs2279115 is not associated with BCL2 protein expression or patient survival in breast cancer patients
C. Searle, I. Brock, S. Cross, S. Balasubramanian +2 more
2012SpringerPlus16 citations Open access
Semantic Scholar
An N-terminal peptide extension results in efficient expression, but not secretion, of a synthetic horseradish peroxidase gene in transgenic tobacco.
M. Kis, E. Burbridge, I. Brock, L. Heggie +2 more
2004Annals of Botany16 citations Open access
Semantic Scholar
Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
T. Kirchhoff, M. Gaudet, A. Antoniou, L. McGuffog +126 more
2012PLoS ONE14 citations Open access
Semantic Scholar
Genome-Wide Analysis of Circulating Cell-Free DNA Copy Number Detects Active Melanoma and Predicts Survival.
S. Silva, S. Danson, D. Teare, Fiona G. Taylor +11 more
2018Clinical Chemistry12 citations Open access
Semantic Scholar
Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
N. Camp, Wei-Yu Lin, Alex Bigelow, G. Burghel +22 more
2016Cancer Research11 citations Open access
Semantic Scholar
7q21-rs6964587 and breast cancer risk: an extended case–control study by the Breast Cancer Association Consortium
R. Milne, J. Lorenzo-Bermejo, B. Burwinkel, N. Malats +80 more
2011Journal of Medical Genetics6 citations Open access
Semantic Scholar
The common PARK8 mutation LRRK2G2019S is not a risk factor for breast cancer in the absence of Parkinson’s disease
H. Mortiboys, A. Cox, I. Brock, O. Bandmann
2013Journal of Neurology5 citations
Semantic Scholar
Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
K. Stevens, M. García-Closas, Z. Fredericksen, M. Kosel +97 more
2011British Journal of Cancer5 citations Open access
Semantic Scholar
Correction: Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)
R. Hein, M. Maranian, J. Hopper, M. Kapuscinski +165 more
2012PLoS ONE4 citations Open access
Semantic Scholar
Association of genetic variants with patient reported quality of life and pain experience in patients in the UK NCRI Myeloma X Relapse [Intensive]) trial; an exploratory study
J. Snowden, S. Ahmedzai, A. Cox, D. Cairns +8 more
2022Bone Marrow Transplantation1 citations Open access
Semantic Scholar
Assessing melanoma BRAF status through ddPCR of cfDNA
L. Passby, S. Silva, I. Brock, G. Wells +2 more
2019Annals of Oncology1 citations Open access
Semantic Scholar
Genome-wide association study identiﬁes novel breast cancer susceptibility
D. Easton, K. Pooley, A. Dunning, P. Pharoah +224 more
1 citations
Semantic Scholar
Clarifying risk-factor associations with quantitative breast tumor features: a pooled analysis of 24 studies.
Daniel Adams, A. Hurson, T. Ahearn, I. Andrulis +82 more
2026Journal of the National Cancer Institute0 citations Open access
Semantic Scholar
PRANA: A Deep Learning Method for Adapting Polygenic Risk Scores to Diverse Ethnic Groups
Hagai Levi, Qin Wang, M. Bolla, J. Dennis +95 more
2026medRxiv0 citations Open access
Semantic Scholar
7 Assessing melanoma BRAF status through ddPCR of cfDNA
Lauren Passy, S. Silva, I. Brock, G. Wells +2 more
2019Postgraduate medical journal0 citations
Semantic Scholar
Discordant Haplotype Sequencing Identifies Functional Variants at the 2 q 33 Breast Cancer Risk Locus Journal Item
N. Camp, Wei-Yu Lin, Alex Bigelow, G. Burghel +24 more
20190 citations
Semantic Scholar
Copy-number profiles from circulating cell-free DNA as a potential biomarker in melanoma
S. Silva, A. Cox, D. Teare, J. Bradford +6 more
20170 citations
Semantic Scholar
The isolation and characterisation of circulating tumour cells from patients with hepatocellular carcinoma
I. Brock, A. Cox, S. Richman, M. Seymour +3 more
20160 citations
Semantic Scholar
Circulating cell-free DNA copy-number profiles as a biomarker in melanoma
S. Silva, D. Teare, J. Bradford, I. Brock +6 more
20160 citations
Semantic Scholar
Genetic variation at CYP 3 A is associated with age at menarche and breast cancer risk : a case-control study
N. Johnson, F. Dudbridge, Nick Orr, L. Gibson +158 more
20140 citations
Semantic Scholar
SNP rs2180341 per-allele hazard ratios (HRs) and 95% confidence intervals (CIs) among Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) in A. BRCA1 mutation carriers B. BRCA2 mutation carriers.
T. Kirchhoff, M. Gaudet, A. Antoniou, L. McGuffog +129 more
20120 citations Open access
Semantic Scholar

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