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M. Ruponen · SciRah

Researcher profile · Semantic Scholar

M. Ruponen

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M. Ruponen — researcher profile on SciRah

h-index: 35
Works: 116
Citations: 4,712

Most-cited papers

Pharmacokinetic aspects of retinal drug delivery.
Eva M. del Amo Paez, A. Rimpelä, Emma M. Heikkinen, Otto K. Kari +17 more
2017Progress in retinal and eye research633 citations Open access
Semantic Scholar
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties.
A. Subrizi, Eva M. del Amo Paez, V. Korzhikov-Vlakh, T. Tennikova +2 more
2019Drug Discovery Today218 citations Open access
Semantic Scholar
Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye
Eva Ramsay, Eva M. del Amo Paez, Elisa Toropainen, Unni Tengvall‐Unadike +3 more
2018European Journal of Pharmaceutical Sciences135 citations Open access
Semantic Scholar
Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface.
Shirin Tavakoli, K. Peynshaert, T. Lajunen, J. Devoldere +5 more
2020Journal of Controlled Release110 citations Open access
Semantic Scholar
Creation of a library of induced pluripotent stem cells from Parkinsonian patients
S. Holmqvist, Š. Lehtonen, Margarita Chumarina, K. Puttonen +12 more
2016npj Parkinson's Disease97 citations Open access
Semantic Scholar
Undefined role of mucus as a barrier in ocular drug delivery.
M. Ruponen, A. Urtti
2015European journal of pharmaceutics and biopharmaceutics92 citations
Semantic Scholar
l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
Johanna Huttunen, Soile Peltokangas, Mikko Gynther, T. Natunen +5 more
2019Scientific Reports79 citations Open access
Semantic Scholar
Polyplex‐mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans
Marjo Männistö, M. Reinisalo, M. Ruponen, P. Honkakoski +2 more
2007Journal of Gene Medicine66 citations
Semantic Scholar
Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture.
C. Qu, K. Puttonen, H. Lindeberg, M. Ruponen +3 more
2013International Journal of Biochemistry and Cell Biology65 citations
Semantic Scholar
The effect of light sensitizer localization on the stability of indocyanine green liposomes
T. Lajunen, R. Nurmi, Danny Wilbie, Teemu Ruoslahti +6 more
2018Journal of Controlled Release60 citations Open access
Semantic Scholar
Expression, activity and pharmacokinetic impact of ocular transporters☆
Kati-Sisko Vellonen, Laura Hellinen, E. Mannermaa, M. Ruponen +2 more
2017Advanced Drug Delivery Reviews58 citations Open access
Semantic Scholar
Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model.
Eva Ramsay, M. Ruponen, Théo Picardat, U. Tengvall +5 more
2017Journal of Pharmacy and Science56 citations Open access
Semantic Scholar
Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
Elisa Toropainen, S. Fraser-Miller, D. Novakovic, Eva M. del Amo Paez +12 more
2021Pharmaceutics55 citations Open access
Semantic Scholar
Mechanisms of polyethylenimine‐mediated DNA delivery: free carrier helps to overcome the barrier of cell‐surface glycosaminoglycans
M. Hanzlíková, M. Ruponen, E. Galli, A. Raasmaja +4 more
2011Journal of Gene Medicine52 citations
Semantic Scholar
Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation.
Eva Ramsay, Marja Hagström, Kati-Sisko Vellonen, Susanna Boman +5 more
2019European journal of pharmaceutics and biopharmaceutics44 citations Open access
Semantic Scholar
Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal Cord Injury
Yuriy Pomeshchik, K. Puttonen, Iurii Kidin, M. Ruponen +5 more
2015Cell Transplantation43 citations Open access
Semantic Scholar
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.
Suvi K Soininen, J. Repo, V. Karttunen, S. Auriola +2 more
2015Toxicology Letters43 citations
Semantic Scholar
Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region
V Junnuthula, Amir Sadeghi Boroujeni, Shou-Peng Cao, Shirin Tavakoli +5 more
2021Pharmaceutics42 citations Open access
Semantic Scholar
Chemokine‐derived peptides as carriers for gene delivery to CXCR4 expressing cells
A. Egorova, A. Kiselev, M. Hakli, M. Ruponen +2 more
2009Journal of Gene Medicine42 citations
Semantic Scholar
Liposomal sunitinib for ocular drug delivery: a potential treatment for choroidal neovascularization.
Shirin Tavakoli, Jooseppi Puranen, S. Bahrpeyma, Veera E. Lautala +5 more
2022International journal of pharmaceutics41 citations Open access
Semantic Scholar
Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection.
M. Ruponen, S. Arkko, A. Urtti, M. Reinisalo +1 more
2009Journal of Controlled Release41 citations
Semantic Scholar
Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model
Laura Hellinen, Marja Hagström, Heidi Knuutila, M. Ruponen +2 more
2019Scientific Reports40 citations Open access
Semantic Scholar
Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Mikko Gynther, Elena Puris, Soile Peltokangas, S. Auriola +5 more
2018Pharmaceutical Research40 citations Open access
Semantic Scholar
Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines
K. Puttonen, M. Ruponen, N. Naumenko, O. Hovatta +2 more
2015Frontiers in Cellular Neuroscience39 citations Open access
Semantic Scholar
Inhibition Activity of Wild Berry Juice Fractions against Streptococcus pneumoniae Binding to Human Bronchial Cells
S. Huttunen, M. Toivanen, S. Arkko, M. Ruponen +1 more
2011Phytotherapy Research39 citations
Semantic Scholar
Improved Ocular Delivery of Quercetin and Resveratrol: A Comparative Study Between Binary and Ternary Cyclodextrin Complexes.
Luna Krstić, P. Jarho, M. Ruponen, A. Urtti +2 more
2022International journal of pharmaceutics38 citations Open access
Semantic Scholar
Esterase activity in porcine and albino rabbit ocular tissues
Emma M. Heikkinen, Eva M. del Amo Paez, V. Ranta, A. Urtti +2 more
2018European Journal of Pharmaceutical Sciences35 citations Open access
Semantic Scholar
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Laura Pelkonen, Unni Tengvall‐Unadike, M. Ruponen, H. Kidron +3 more
2017European Journal of Pharmaceutical Sciences35 citations Open access
Semantic Scholar
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling.
Suvi K Soininen, Kati-Sisko Vellonen, Aki T. Heikkinen, S. Auriola +3 more
2016Molecular Pharmaceutics33 citations
Semantic Scholar
Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives
Karlis Pajuste, Zanna Hyvönen, O. Petrichenko, D. Kaldre +11 more
201333 citations
Semantic Scholar
Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits.
A. Fayyaz, V. Ranta, Elisa Toropainen, Kati-Sisko Vellonen +7 more
2020European Journal of Pharmaceutical Sciences32 citations Open access
Semantic Scholar
Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide.
M. Ruponen, Henna Rusanen, R. Laitinen
2020Journal of Pharmacy and Science29 citations Open access
Semantic Scholar
Permeability of glibenclamide through a PAMPA membrane: The effect of co‐amorphization
M. Ruponen, Maiju Visti, Rami Ojarinta, R. Laitinen
2018European journal of pharmaceutics and biopharmaceutics29 citations Open access
Semantic Scholar
Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers.
Iuliia Pilipenko, V. Korzhikov-Vlakh, Annika Valtari, Yuri A Anufrikov +5 more
2021International Journal of Biological Macromolecules28 citations
Semantic Scholar
Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits.
Amir Sadeghi, Jooseppi Puranen, M. Ruponen, Annika Valtari +4 more
2021European Journal of Pharmaceutical Sciences28 citations Open access
Semantic Scholar
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye.
A. Fayyaz, Kati-Sisko Vellonen, V. Ranta, Elisa Toropainen +10 more
2021European journal of pharmaceutics and biopharmaceutics28 citations Open access
Semantic Scholar
Ocular metabolism and distribution of drugs in the rabbit eye: quantitative assessment after intracameral and intravitreal administrations.
Eva M. del Amo Paez, Anam Hammid, Melanie Tausch, Elisa Toropainen +8 more
2021International journal of pharmaceutics28 citations Open access
Semantic Scholar
Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems.
P. Ilina, Z. Hyvonen, M. Saura, K. Sandvig +2 more
2012Journal of Controlled Release27 citations
Semantic Scholar
Understanding dexamethasone kinetics in the rabbit tear fluid: drug release and clearance from solution, suspension and hydrogel formulations.
Anusha Balla, M. Ruponen, Annika Valtari, Elisa Toropainen +5 more
2022European journal of pharmaceutics and biopharmaceutics26 citations Open access
Semantic Scholar
The effect of co-amorphization of glibenclamide on its dissolution properties and permeability through an MDCKII-MDR1 cell layer.
Henri Sormunen, M. Ruponen, R. Laitinen
2019International journal of pharmaceutics26 citations Open access
Semantic Scholar
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Emma M. Heikkinen, S. Auriola, V. Ranta, N. Demarais +6 more
2019Molecular Pharmaceutics25 citations Open access
Semantic Scholar
Imaging, quantitation and kinetic modelling of intravitreal nanomaterials.
Amir Sadeghi, M. Ruponen, Jooseppi Puranen, Shou-Peng Cao +7 more
2022International journal of pharmaceutics23 citations Open access
Semantic Scholar
Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs
M. Ruponen, Konsta Kettunen, Monica Santiago Pires, R. Laitinen
2021Pharmaceutics22 citations Open access
Semantic Scholar
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues
Anusha Balla, S. Auriola, A. Grey, N. Demarais +6 more
2021Pharmaceutics22 citations Open access
Semantic Scholar
Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery
Eva Kicková, Amir Sadeghi, Jooseppi Puranen, Shirin Tavakoli +10 more
2021Pharmaceutics21 citations Open access
Semantic Scholar
Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models.
P. Ilina, Susanna Partti, Johanna Niklander, M. Ruponen +2 more
2015Experimental Cell Research20 citations
Semantic Scholar
Cell-surface glycosaminoglycans inhibit intranuclear uptake but promote post-nuclear processes of polyamidoamine dendrimer-pDNA transfection.
Zarrintaj Ziraksaz, A. Nomani, M. Ruponen, M. Soleimani +2 more
2013European Journal of Pharmaceutical Sciences19 citations
Semantic Scholar
Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers.
Zanna Hyvönen, V. Hämäläinen, M. Ruponen, B. Lucas +5 more
2012Journal of Controlled Release19 citations
Semantic Scholar
Targeted delivery via avidin fusion protein: intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes.
Suvi K Soininen, Pauliina Lehtolainen-Dalkilic, Tanja Karppinen, Tiina Puustinen +11 more
2012European Journal of Pharmaceutical Sciences18 citations
Semantic Scholar
A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound
Anusha Balla, Bao Tran, Annika Valtari, P. Steven +5 more
2022Pharmaceutics17 citations Open access
Semantic Scholar

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Eva M. del Amo Paez×15
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