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R. Langley · SciRah

Researcher profile · Semantic Scholar

R. Langley

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R. Langley — researcher profile on SciRah

h-index: 35
Works: 165
Citations: 13K

Most-cited papers

Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial
E. Smyth, A. Wotherspoon, C. Peckitt, D. Gonzalez +12 more
2017JAMA Oncology496 citations Open access
Semantic Scholar
Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis
C. Coyle, F. Cafferty, C. Vale, R. Langley
2016Annals of Oncology420 citations Open access
Semantic Scholar
Individual Patient Data Meta-Analysis of the Value of Microsatellite Instability As a Biomarker in Gastric Cancer.
F. Pietrantonio, R. Miceli, A. Raimondi, Y. Kim +20 more
2019Journal of Clinical Oncology413 citations Open access
Semantic Scholar
Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial
N. Clarke, Adnan Ali, F. Ingleby, A. Hoyle +46 more
2019Annals of Oncology368 citations Open access
Semantic Scholar
Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol
G. Attard, L. Murphy, N. Clarke, W. Cross +150 more
2021The Lancet321 citations Open access
Semantic Scholar
Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial
E. Smyth, M. Fassan, D. Cunningham, W. Allum +12 more
2016Journal of Clinical Oncology269 citations Open access
Semantic Scholar
Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial
D. Alderson, D. Cunningham, M. Nankivell, J. Blazeby +13 more
2017The Lancet Oncology210 citations Open access
Semantic Scholar
ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours
C. Coyle, F. Cafferty, S. Rowley, M. Mackenzie +9 more
2016Contemporary Clinical Trials150 citations Open access
Semantic Scholar
Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study
H. Muti, Lara R. Heij, G. Keller, Meike Kohlruss +31 more
2021The Lancet Digital Health104 citations Open access
Semantic Scholar
Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial
C. Parker, Nicholas D. James, C. Brawley, N. Clarke +42 more
2022PLoS Medicine103 citations Open access
Semantic Scholar
Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol
G. Attard, L. Murphy, N. Clarke, A. Sachdeva +51 more
2023The Lancet Oncology97 citations Open access
Semantic Scholar
Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis
D. Gilbert, K. Wakeham, R. Langley, C. Vale
2018British Journal of Cancer75 citations Open access
Semantic Scholar
Testing many treatments within a single protocol over 10 years at MRC CTU at UCL: Multi-arm, multi stage platform, umbrella and basket protocols
M. Parmar, M. Sydes, F. Cafferty, B. Choodari-Oskooei +10 more
2017Clinical Trials70 citations Open access
Semantic Scholar
Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial.
N. Joharatnam-Hogan, F. Cafferty, R. Hubner, D. Swinson +40 more
2019The Lancet Gastroenterology and Hepatology60 citations Open access
Semantic Scholar
Epstein-Barr virus and mismatch repair deficiency status differ between oesophageal and gastric cancer: A large multi-centre study
L. Hewitt, I. Inam, Y. Saito, T. Yoshikawa +11 more
2018European Journal of Cancer56 citations Open access
Semantic Scholar
Quality of Life in Men With Prostate Cancer Randomly Allocated to Receive Docetaxel or Abiraterone in the STAMPEDE Trial
H. Rush, L. Murphy, A. Morgans, N. Clarke +33 more
2021Journal of Clinical Oncology54 citations Open access
Semantic Scholar
This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols
F. Schiavone, R. Bathia, K. Letchemanan, Lindsey Masters +17 more
2019Trials50 citations Open access
Semantic Scholar
Quality‐of‐life outcomes from the Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) trial evaluating luteinising hormone‐releasing hormone agonists versus transdermal oestradiol for androgen suppression in advanced prostate cancer
D. Gilbert, T. Duong, H. Kynaston, A. Alhasso +14 more
2017BJU International49 citations Open access
Semantic Scholar
Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone?
C. Coyle, F. Cafferty, R. Langley
2016Current Colorectal Cancer Reports48 citations Open access
Semantic Scholar
Impact of sex and age on chemotherapy efficacy, toxicity and survival in localised oesophagogastric cancer: A pooled analysis of 3265 individual patient data from four large randomised trials (OE02, OE05, MAGIC and ST03).
A. Athauda, M. Nankivell, R. Langley, D. Alderson +5 more
2020European Journal of Cancer39 citations Open access
Semantic Scholar
Prognostic value of pathological lymph node status and primary tumour regression grading following neoadjuvant chemotherapy – results from the MRC OE02 oesophageal cancer trial
Nasser Davarzani, G. Hutchins, N. West, L. Hewitt +7 more
2018Histopathology38 citations Open access
Semantic Scholar
The International Collaboration for Research methods Development in Oncology (CReDO) workshops –Shaping the future of global oncology research
P. Ranganathan, G. Chinnaswamy, M. Sengar, D. Gadgil +23 more
2021The Lancet Oncology35 citations Open access
Semantic Scholar
Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study
M. A. Frouws, E. Bastiaannet, R. Langley, W. Chia +8 more
2017British Journal of Cancer35 citations Open access
Semantic Scholar
A Randomised Comparison Evaluating Changes in Bone Mineral Density in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol
R. Langley, H. Kynaston, A. Alhasso, T. Duong +12 more
2016European Urology34 citations Open access
Semantic Scholar
Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme
R. Langley, D. Gilbert, T. Duong, N. Clarke +27 more
2021The Lancet32 citations Open access
Semantic Scholar
Genomic Profiles of De Novo High- and Low-Volume Metastatic Prostate Cancer: Results From a 2-Stage Feasibility and Prevalence Study in the STAMPEDE Trial.
C. Gilson, F. Ingleby, D. Gilbert, M. Parry +21 more
2020JCO Precision Oncology30 citations
Semantic Scholar
Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial
N. Joharatnam-Hogan, Duaa Hatem, F. Cafferty, G. Petrucci +42 more
2023British Journal of Cancer29 citations Open access
Semantic Scholar
Whole brain radiotherapy for brain metastases from non-small lung cancer: Quality of life (QoL) and overall survival (OS) results from the UK Medical Research Council QUARTZ randomised clinical trial (ISRCTN 3826061).
P. Mulvenna, M. Nankivell, R. Barton, C. Faivre-Finn +15 more
201528 citations Open access
Semantic Scholar
2201 Peri-operative chemotherapy ± bevacizumab for resectable gastro-oesophageal adenocarcinoma: Results from the UK Medical Research Council randomised ST03 trial (ISRCTN 46020948)
D. Cunningham, E. Smyth, S. Stenning, L. Stevenson +16 more
201528 citations Open access
Semantic Scholar
Statins as Potential Chemoprevention or Therapeutic Agents in Cancer: a Model for Evaluating Repurposed Drugs
N. Joharatnam-Hogan, L. Alexandre, J. Yarmolinsky, B. Lake +5 more
2020Current Oncology Reports27 citations Open access
Semantic Scholar
Accessing routinely collected health data to improve clinical trials: recent experience of access
A. Macnair, Sharon B. Love, M. Murray, D. Gilbert +6 more
2021Trials26 citations Open access
Semantic Scholar
Docetaxel for Nonmetastatic Prostate Cancer: Long-Term Survival Outcomes in the STAMPEDE Randomized Controlled Trial
N. James, F. Ingleby, N. Clarke, C. Amos +43 more
2022JNCI Cancer Spectrum21 citations Open access
Semantic Scholar
Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units
Sharon B. Love, F. Cafferty, C. Snowdon, K. Carty +32 more
2022Trials20 citations Open access
Semantic Scholar
MSI-GC-01: Individual patient data (IPD) meta-analysis of microsatellite instability (MSI) and gastric cancer (GC) from four randomized clinical trials (RCTs).
F. Pietrantonio, A. Raimondi, Yoon Young Choi, W. Kang +16 more
2019Journal of Clinical Oncology20 citations
Semantic Scholar
Pathological regression of primary tumour and metastatic lymph nodes following chemotherapy in resectable OG cancer: pooled analysis of two trials
A. Athauda, M. Nankivell, R. Langer, S. Pritchard +6 more
2023British Journal of Cancer19 citations Open access
Semantic Scholar
REFINE (REduced Frequency ImmuNE checkpoint inhibition in cancers): A multi-arm phase II basket trial testing reduced intensity immunotherapy across different cancers
S. Merrick, M. Nankivell, Matteo Quartagno, C. Clarke +16 more
2022Contemporary Clinical Trials18 citations Open access
Semantic Scholar
Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma
E. Smyth, S. Rowley, F. Cafferty, W. Allum +16 more
2019JAMA Oncology18 citations Open access
Semantic Scholar
Comparative quality of life in patients randomized contemporaneously to docetaxel or abiraterone in the STAMPEDE trial.
H. Rush, A. Cook, C. Brawley, L. Murphy +12 more
202017 citations
Semantic Scholar
Transdermal oestradiol as a method of androgen suppression for prostate cancer within the STAMPEDE trial platform
D. Gilbert, T. Duong, M. Sydes, A. Bara +5 more
2018BJU International16 citations Open access
Semantic Scholar
Biopsy proportion of tumour predicts pathological tumour response and benefit from chemotherapy in resectable oesophageal carcinoma: results from the UK MRC OE02 trial
Matthew D. Hale, M. Nankivell, G. Hutchins, S. Stenning +10 more
2016OncoTarget16 citations Open access
Semantic Scholar
Individual patient data meta-analysis of neoadjuvant chemotherapy followed by surgery versus upfront surgery for carcinoma of the oesophagus or the gastro-oesophageal junction.
M. Faron, Armel Maurice Cheugoua-Zanetsie, P. Thirion, M. Nankivell +19 more
2021European Journal of Cancer13 citations Open access
Semantic Scholar
Prognostic Significance of Negative Lymph Node Long Axis in Esophageal Cancer
M. Kloft, J. Ruisch, G. Raghuram, J. Emmerson +5 more
2021Annals of Surgery13 citations Open access
Semantic Scholar
The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
N. Joharatnam-Hogan, F. Cafferty, A. Macnair, A. Ring +1 more
2020Women's Health13 citations Open access
Semantic Scholar
Docetaxel for hormone-naïve prostate cancer (PCa): Results from long-term follow-up of non-metastatic (M0) patients in the STAMPEDE randomised trial
N. James, F. Ingleby, N. Clarke, C. Amos +15 more
2019Annals of Oncology13 citations Open access
Semantic Scholar
Pharmacogenetic analysis of the UKMRC (Medical Research Council) MAGIC trial: association of polymorphisms with toxicity and survival in patients treated with perioperative epirubicin, cisplatin and 5-fluorouracil (ECF) chemotherapy
E. Smyth, Shenli Zhang, D. Cunningham, A. Wotherspoon +11 more
2017Clinical Cancer Research12 citations Open access
Semantic Scholar
Reduced genomic tumor heterogeneity after neoadjuvant chemotherapy is related to favorable outcome in patients with esophageal adenocarcinoma
Askar Obulkasim, B. Ylstra, H. V. van Essen, C. Benner +10 more
2016OncoTarget11 citations Open access
Semantic Scholar
LBA-03Neoadjuvant chemotherapy for resectable oesophageal and junctional adenocarcinoma: results from the UK Medical Research Council randomised OEO5 trial (ISRCTN 01852072)
D. Cunningham, R. Langley, M. Nankivell, J. Blazeby +13 more
201511 citations Open access
Semantic Scholar
A comparison of different population-level summary measures for randomised trials with time-to-event outcomes, with a focus on non-inferiority trials
Matteo Quartagno, T. Morris, D. Gilbert, R. Langley +3 more
2023Clinical Trials9 citations Open access
Semantic Scholar
Highlights from the 2019 International Aspirin Foundation Scientific Conference, Rome, 28 June 2019: benefits and risks of antithrombotic therapy for cardiovascular disease prevention
Jaqui Walker, M. Cattaneo, L. Badimón, G. Agnelli +8 more
2020ecancermedicalscience9 citations Open access
Semantic Scholar
Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin
Jaqui Walker, Pippa J. Hutchison, J. Ge, Dong-Hui Zhao +10 more
2018ecancermedicalscience8 citations Open access
Semantic Scholar

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M. Nankivell×20
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M. Nankivell — researcher profile on SciRah
D. Gilbert×17
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D. Cunningham×15
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D. Cunningham — researcher profile on SciRah
H. Grabsch×15
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M. Parmar — researcher profile on SciRah

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M. Sydes — researcher profile on SciRah

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W. Allum — researcher profile on SciRah

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E. Smyth — researcher profile on SciRah