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V. Guadagnuolo · SciRah

Researcher profile · Semantic Scholar

V. Guadagnuolo

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V. Guadagnuolo — researcher profile on SciRah

h-index: 12
Works: 104
Citations: 609

Most-cited papers

Chromothripsis in acute myeloid leukemia: biological features and impact on survival
M. Fontana, G. Marconi, J. D. Milosevic Feenstra, Eugenio Fonzi +23 more
2017Leukemia103 citations Open access
Semantic Scholar
IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia
I. Iacobucci, N. Iraci, M. Messina, A. Lonetti +18 more
2012PLoS ONE92 citations Open access
Semantic Scholar
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
G. Simonetti, A. Padella, Í. Do Valle, M. Fontana +29 more
2018Cancer58 citations Open access
Semantic Scholar
Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia
Andrea Ghelli Luserna Di Rorà, I. Iacobucci, Enrica Imbrogno, C. Papayannidis +9 more
2016OncoTarget37 citations Open access
Semantic Scholar
Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations
G. Simonetti, C. Mengucci, A. Padella, Eugenio Fonzi +29 more
2021Leukemia34 citations Open access
Semantic Scholar
SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
G. Martinelli, M. Mancini, C. De Benedittis, M. Rondoni +28 more
2017Leukemia33 citations Open access
Semantic Scholar
IL-17/IL-10 double-producing T cells: new link between infections, immunosuppression and acute myeloid leukemia
G. Musuraca, S. De Matteis, R. Napolitano, C. Papayannidis +16 more
2015Journal of Translational Medicine32 citations Open access
Semantic Scholar
In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia
I. Iacobucci, Andrea Ghelli Luserna Di Rorà, M. Falzacappa, C. Agostinelli +19 more
2015Journal of Hematology & Oncology28 citations Open access
Semantic Scholar
Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia
A. Padella, G. Simonetti, Giulia Paciello, G. Giotopoulos +23 more
2019Cancers22 citations Open access
Semantic Scholar
Intrabone transplant provides full stemness of cord blood stem cells with fast hematopoietic recovery and low GVHD rate: results from a prospective study
F. Bonifazi, E. Dan, M. Labopin, M. Sessa +13 more
2018Bone Marrow Transplantation20 citations Open access
Semantic Scholar
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells
G. Giordani, Marilena Barraco, A. Giangrande, G. Martinelli +4 more
2016OncoTarget17 citations Open access
Semantic Scholar
Leukemia Associated TP53 Mutations in AML Patients ARE Strongly Associated with Complex Karyotype and Poor Outcome
A. Ferrari, C. Papayannidis, Carmen Baldazzi, I. Iacobucci +14 more
20149 citations
Semantic Scholar
PF-04449913 Reverts Multi Drug Resistance (MDR) by a Strong Down-Regulation of ABCA2 and BCL2 on Leukemia Stem Cells in Phase I Acute Myeloid Leukemia and Chronic Myeloid Leukemia Treated Patients
C. Papayannidis, V. Guadagnuolo, I. Iacobucci, S. Durante +18 more
20117 citations
Semantic Scholar
Ex-Vivo Drug Response Profiling for Precision Medicine Approaches in Acute Myeloid Leukemia with the Open Microwell Microfluidic Platform
L. Rocchi, A. Faenza, L. Rambelli, V. Guadagnuolo +10 more
20165 citations
Semantic Scholar
Gas1 and Kif27 Genes Are Strongly up-Regulated Biomarkers of Hedgehog Inhibition (PF-04449913) on Leukemia Stem Cells in Phase I Acute Myeloid Leukemia and Chronic Myeloid Leukemia Treated Patients
V. Guadagnuolo, C. Papayannidis, I. Iacobucci, S. Durante +18 more
20115 citations
Semantic Scholar
Genome-Wide Molecular Portrait of Aggressive Systemic Mastocytosis and Mast Cell Leukemia Depicted By Whole Exome Sequencing and Copy Number Variation Analysis
S. Soverini, C. De Benedittis, M. Mancini, M. Rondoni +18 more
20153 citations
Semantic Scholar
A Case Report of Acute Myeloid Leukemia and Neurofibromatosis 1
C. Sartor, C. Papayannidis, Maria Chiara Abbenante, A. Curti +5 more
2013Hematology Reports3 citations Open access
Semantic Scholar
Chromothripsis in Acute Myeloid Leukemia Is Strongly Associated with Poor Prognosis and TP53 Alterations
M. Fontana, G. Marconi, J. D. Milosevic Feenstra, C. Papayannidis +18 more
20162 citations
Semantic Scholar
Inactivation of the SETD2 Tumor Suppressor Gene in Mast Cell Leukemia
S. Soverini, C. De Benedittis, M. Rondoni, M. Mancini +24 more
20142 citations
Semantic Scholar
Very Poor Outcome and Chemoresistance of Acute Myeloid Leukemia Patients with TP53 Mutations: Correlation with Complex Karyotype and Clinical Outcome
C. Papayannidis, A. Ferrari, S. Paolini, Carmen Baldazzi +21 more
20142 citations
Semantic Scholar
Adult B-Cell Precursor Acute Lymphoblastic Leukemia (BC-ALL) Negative For Recurrent Fusion Genes Are Characterized By a High Complex Genetic Heterogeneity Influencing Prognosis
A. Ferrari, M. Perricone, V. Robustelli, C. Papayannidis +22 more
20132 citations
Semantic Scholar
Abstract 906:Gas1andKif27genes are strongly up-regulated biomarkers of Hedgehog inhibition (PF-04449913) on leukemia stem cells in Phase I Acute Myeloid Leukemia and Chronic Myeloid Leukemia treated patients
V. Guadagnuolo, C. Papayannidis, I. Iacobucci, S. Durante +18 more
20122 citations
Semantic Scholar
The Novel Small Molecule Chk1/Chk2 Inhibitor PF-0477736 (Pfizer) Is Highly Active As Single Agent in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
I. Iacobucci, F. Cattina, Silvia Pomella, A. Lonetti +16 more
20112 citations
Semantic Scholar
Inter-Cell Networking Profiling Enables Comprehensive Characterization of Immune-Mediated Activity of Anti-CD38 Therapy through Ex-Vivo Analysis of Multiple Myeloma Patients
Alice Bettelli, Rita Ruggiano, S. Bocchi, L. Rocchi +15 more
2019Blood1 citations Open access
Semantic Scholar
Abstract 3613: Lab-on-a-chip-based in-vitro functional profiling proves to be effective in predicting therapy outcome in AML patients
L. Rocchi, A. Faenza, V. Guadagnuolo, L. Rambelli +14 more
2018Clinical research1 citations
Semantic Scholar
Aggressive Aneuploid Acute Myeloid Leukemia Is Dependent on Alterations of P53, Gain of APC and PLK1 and Loss of RAD50
G. Simonetti, A. Padella, M. Manfrini, Ì. Valle +22 more
20161 citations
Semantic Scholar
Alterations in Pathways Regulating Phosphatidil Inositol 3 Phosphate (PI3P) Produce Both Cell Proliferation and Therapy Resistance, and Define a Group of Patients with Poor Prognosis in Acute Myeloid Leukemia (AML)
G. Marconi, C. Papayannidis, M. Fontana, A. Padella +21 more
20161 citations
Semantic Scholar
The Genomic and Transcriptomic Landscape of Systemic Mastocytosis
S. Soverini, C. De Benedittis, M. Rondoni, C. Papayannidis +22 more
20161 citations Open access
Semantic Scholar
Abstract A27: European Network NGS-PTL preliminary data: Whole exome sequencing identifies mutations of ALDH2, RETSAT, HSPG2, CHPF and other metabolic genes as a novel functional category in acute myeloid leukemia
G. Simonetti, A. Padella, I. Iacobucci, Ì. Valle +28 more
20161 citations
Semantic Scholar
Impact on survival of catastrophic karyotype events in 101 consecutive acute myeloid leukemia (AML) patients: High risk karyotype and chromothripsis.
M. Fontana, G. Marconi, C. Papayannidis, V. Guadagnuolo +15 more
20161 citations
Semantic Scholar
Abstract 90: A cell cycle-related genomic and transcriptomic signature distinguish aneuploid and euploid acute myeloid leukemia
G. Simonetti, A. Padella, M. Manfrini, ĺtalo Faria do Valle +22 more
20161 citations
Semantic Scholar
Abstract 2723: The synergistic efficacy of Chk1/Chk2 inhibitors and doxorubicin in the treatment of acute lymphoblastic leukemia
Andrea Ghelli Luserna di Rorà, I. Iacobucci, Enrica Imbrogno, E. Derenzini +7 more
20161 citations
Semantic Scholar
RNA Sequencing Reveals Novel and Rare Fusion Transcripts in Acute Myeloid Leukemia
A. Padella, G. Simonetti, Giulia Paciello, A. Ferrari +14 more
20151 citations
Semantic Scholar
PKC412 (midostaurin) is safe and highly effective in systemic mastocytosis: Follow up of a single-center Italian compassionate use.
C. Papayannidis, S. Soverini, C. Benedittis, M. Rondoni +15 more
20141 citations
Semantic Scholar
Ultra-Deep Sequencing Strategy Is a Precious Tool to Find Small Clones Harbouring FLT3 Mutations in AML Patients
E. Zuffa, E. Franchini, C. Papayannidis, Carmen Baldazzi +10 more
20141 citations
Semantic Scholar
Abstract 746: PKC412 (Midostaurin) is safe and highly effective in systemic mastocytosis patients: Follow up of a single-center Italian compassionate use
C. Papayannidis, S. Soverini, C. Benedittis, M. Abbenante +14 more
20141 citations
Semantic Scholar
Ponatinib Is Well Tolerated and Active In Patients With Relapsed/Refractory Philadelphia Positive Acute Lymphoblastic Leukemia (PH+ ALL) and Advanced Phase Of Chronic Myelogenous Leukemia (CML) Harbouring T315I Mutation: The Bologna Experience
C. Papayannidis, C. Benedittis, S. Soverini, I. Iacobucci +24 more
20131 citations
Semantic Scholar
In Vitro and in Vivo Single-Agent Efficacy of Checkpoint Kinase 1 (Chk1) and 2 (Chk2) Inhibitor PF-0477736 (Pfizer) in B- and T-Acute Lymphoblastic Leukemia (ALL)
I. Iacobucci, Andrea Ghelli Luserna di Rorà, M. Falzacappa, E. Derenzini +12 more
20121 citations
Semantic Scholar
Down-Regulation of BMI-1 Is a New Marker of Sensitivity to Mdm2 Inhibition in B-Acute Lymphoblastic Leukemia.
I. Iacobucci, D. Erriquez, A. Ferrari, C. Papayannidis +14 more
20121 citations
Semantic Scholar
Abstract 3811: A germline polymorphism in the ANRIL (CDKN2BAS) locus is associated with susceptibility to Philadelphia-positive acute lymphoblastic leukemia (ALL)
A. Ferrari, I. Iacobucci, M. Sazzini, A. Lonetti +13 more
20111 citations
Semantic Scholar
Abstract 311: Loss of the tumor suppressor genesCDKN2A/ARFimpairs prognosis in adultBCR-ABL1positive acute lymphoblastic leukemia (ALL)
I. Iacobucci, A. Ferrari, C. Papayannidis, F. Paoloni +11 more
20111 citations
Semantic Scholar
Efficacy and Feasibility of Nelarabine Savage Therapy In Adult Relapsed or Refractory T Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoblastic Lymphoma (T-LBL) Strongly Indicates the Introduction of a Nelarabine-Based First Line Regimen
C. Papayannidis, I. Iacobucci, M. Abbenante, S. Paolini +10 more
20101 citations
Semantic Scholar
Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)
I. Iacobucci, E. Ottaviani, V. Guadagnuolo, A. Lonetti +14 more
20101 citations
Semantic Scholar
Use of a High Sensitive Nanofluidic Array for the Detection of Rare Copies of BCR-ABL1 Transcript In Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia (ALL).
I. Iacobucci, A. Lonetti, A. Ferrari, C. Papayannidis +12 more
20101 citations
Semantic Scholar
Whole Transcriptome Resequencing of Paired Diagnosis-Relapse BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Samples Reveals the Loss of Cell Cycle Regulation as the Main Mechanism Responsible for Leukemia Progression.
I. Iacobucci, A. Lonetti, A. Ferrarini, M. Sazzini +11 more
20101 citations
Semantic Scholar
PS997 A NEW BIOMARKER OF RESPONSE TO 5-AZACITIDINE THERAPY IN MDS AND AML PATIENTS: SIRPB1
C. Cerchione, V. Guadagnuolo, C. Papayannidis, I. Iacobucci +17 more
2019HemaSphere0 citations Open access
Semantic Scholar
PS1020 SNP ARRAY REVEALS A NEW DELETION OF JAK2 IN AML PATIENTS
C. Cerchione, V. Guadagnuolo, C. Papayannidis, M. Fontana +12 more
2019HemaSphere0 citations Open access
Semantic Scholar
Abstract 1766: Distinct pattern of alterations in tp53 mutated and wild type acute myeloid leukemia (AML) patients
A. Ferrari, Eugenio Fonzi, M. Fontana, A. G. L. D. Rorà +18 more
20170 citations
Semantic Scholar
Abstract 515: Alterations in phosphatidylinositol 3-phosphate (PI3P) pathway and cAMP pathway confirm poor prognosis and reduced overall survival (OS) in a series of 209 acute myeloid leukemia patients
M. Abbenante, M. Fontana, G. Marconi, G. Simonetti +12 more
20170 citations
Semantic Scholar
Abstract 4671: Co-occurrence of alterations in the DNA damage repair genes synergize with uncontrolled proliferation and associate with very-poor prognosis in acute myeloid leukemia patients
A. Padella, G. Simonetti, M. Fontana, M. Manfrini +14 more
20170 citations
Semantic Scholar

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C. Papayannidis×47
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G. Martinelli×47
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E. Ottaviani×34
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I. Iacobucci×32
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A. Ferrari — researcher profile on SciRah

M. Abbenante×27

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S. Soverini×24

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Carmen Baldazzi×22

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