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H. Fearnhead · SciRah

Researcher profile · Semantic Scholar

H. Fearnhead

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H. Fearnhead — researcher profile on SciRah

h-index: 28
Works: 66
Citations: 4,804

Most-cited papers

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin +496 more
20161,544 citations Open access
Semantic Scholar
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
L. Faleiro, R. Kobayashi, H. Fearnhead, Y. Lazebnik
1997EMBO Journal372 citations Open access
Semantic Scholar
Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.
Gerald M. Cohen, Xiao-Ming Sun, H. Fearnhead, M. MacFarlane +3 more
1994Journal of Immunology215 citations
Semantic Scholar
Increased membrane permeability of apoptotic thymocytes: a flow cytometric study.
M. G. Ormerod, Xiao-Ming Sun, R. Snowden, R. Davies +2 more
1993Cytometry204 citations Open access
Semantic Scholar
Oncogene-dependent apoptosis is mediated by caspase-9.
H. Fearnhead, Joe Rodriguez, E. Govek, Wenjun Guo +3 more
1998Proceedings of the National Academy of Sciences of the United States of America187 citations Open access
Semantic Scholar
A non-apoptotic role for caspase-9 in muscle differentiation
Thomas V. A. Murray, J. McMahon, B. Howley, Alanna Stanley +4 more
2008Journal of Cell Science181 citations Open access
Semantic Scholar
An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells
Hui-Jun Zhu, H. Fearnhead, G. Cohen
1995FEBS Letters171 citations Open access
Semantic Scholar
How do we fit ferroptosis in the family of regulated cell death?
H. Fearnhead, P. Vandenabeele, T. V. Berghe
2017Cell Death and Differentiation146 citations Open access
Semantic Scholar
The Apaf‐1•procaspase‐9 apoptosome complex functions as a proteolytic‐based molecular timer
S. Malladi, Madhavi Challa-Malladi, H. Fearnhead, S. B. Bratton
2009EMBO Journal134 citations Open access
Semantic Scholar
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome.
D. Chandra, S. B. Bratton, M. Person, Ya-Nan Tian +5 more
2006Cell132 citations Open access
Semantic Scholar
An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes
H. Fearnhead, D. Dinsdale, Gerald M. Cohen
1995FEBS Letters121 citations
Semantic Scholar
Molecular Cloning of ILP-2, a Novel Member of the Inhibitor of Apoptosis Protein Family
B. Richter, S. Mir, L. Eiben, Jennifer M. Lewis +10 more
2001Molecular and Cellular Biology108 citations Open access
Semantic Scholar
New roles for old enzymes: killer caspases as the engine of cell behavior changes
P. Connolly, Richard Jäger, H. Fearnhead
2014Frontiers in Physiology94 citations Open access
Semantic Scholar
Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis
G. Malet, Angel Martin, M. Orzáez, M. Vicent +7 more
2006Cell Death and Differentiation75 citations
Semantic Scholar
Caspases as therapeutic targets
B. Howley, H. Fearnhead
2008Journal of Cellular and Molecular Medicine68 citations Open access
Semantic Scholar
Oncogene-dependent apoptosis in extracts from drug-resistant cells.
H. Fearnhead, M. McCurrach, Jason W. O'Neill, Kam Y. J. Zhang +2 more
1997Genes & Development66 citations Open access
Semantic Scholar
Cdc2 activation is not required for thymocyte apoptosis.
C. Norbury, M. MacFarlane, H. Fearnhead, G. Cohen
1994Biochemical and Biophysical Research Communications - BBRC63 citations
Semantic Scholar
Apocytochrome c Blocks Caspase-9 Activation and Bax-induced Apoptosis*
Angel G. Martín, H. Fearnhead
2002Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers
S. Elliman, BV Howley, D. Mehta, H. Fearnhead +2 more
2014Oncogenesis58 citations Open access
Semantic Scholar
Assay for Ubiquitin Ligase Activity: High-Throughput Screen for Inhibitors of HDM2
I. Davydov, D. Woods, Yassamin J. Safiran, Pankaj Oberoi +6 more
2004Journal of biomolecular screening56 citations Open access
Semantic Scholar
Autophagosomal IκBα Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-α-induced Nuclear Factor-κB (NF-κB) Activity*
Amy Colleran, A. Ryan, A. O’Gorman, C. Mureau +4 more
2011Journal of Biological Chemistry54 citations Open access
Semantic Scholar
A pre‐existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli
H. Fearnhead, A. Rivett, D. Dinsdale, Gerald M. Cohen
1995FEBS Letters54 citations Open access
Semantic Scholar
Non-Canonical Roles of Apoptotic Caspases in the Nervous System
M. H. Dehkordi, R. Munn, H. Fearnhead
2022Frontiers in Cell and Developmental Biology50 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts
M. H. Dehkordi, Amin Tashakor, E. O'Connell, H. Fearnhead
2020Cell Death and Disease44 citations Open access
Semantic Scholar
Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B
Angel G. Martín, J. Trama, D. Crighton, K. Ryan +1 more
2009Aging40 citations Open access
Semantic Scholar
Viral hijacking of host caspases: an emerging category of pathogen–host interactions
P. Connolly, H. Fearnhead
2017Cell Death and Differentiation39 citations Open access
Semantic Scholar
Apo cytochrome c inhibits caspases by preventing apoptosome formation.
Angel G. Martín, J. Nguyen, J. Wells, H. Fearnhead
2004Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9.
A. Noori, Amin Tashakor, M. Nikkhah, L. Eriksson +2 more
2020Biochimie28 citations
Semantic Scholar
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle.
H. Fearnhead, Maciej Chwalinski, R. Snowden, M. G. Ormerod +1 more
1994Biochemical Pharmacology25 citations
Semantic Scholar
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.
J. Oprey, D. Crighton, Angel G. Martín, K. Vousden +2 more
2010Cell Cycle24 citations
Semantic Scholar
p53-mediated induction of Noxa and p53AIP1 requires NFκB
J. Oprey, D. Crighton, Angel G. Martín, K. Vousden +2 more
201023 citations Open access
Semantic Scholar
Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues.
D. Monaghan, E. O'Connell, Faye L Cruickshank, Barry O’Sullivan +3 more
2014Biochemical and Biophysical Research Communications - BBRC22 citations Open access
Semantic Scholar
“Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet
Richard Jäger, H. Fearnhead
2012Biochemistry Research International22 citations Open access
Semantic Scholar
DNA degradation and proteolysis in thymocyte apoptosis.
H. Fearnhead, Marion MacFarlane, D. Dinsdale, Gerald M. Cohen
1995Toxicology Letters22 citations
Semantic Scholar
A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation
P. Marchese, N. Mahajan, E. O'Connell, H. Fearnhead +5 more
2020Marine Drugs18 citations Open access
Semantic Scholar
Oxygenated Acyclic Diterpenes with Anticancer Activity from the Irish Brown Seaweed Bifurcaria bifurcata
Vangelis Smyrniotopoulos, Christian Merten, D. Firsova, H. Fearnhead +1 more
2020Marine Drugs17 citations Open access
Semantic Scholar
Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney.
M. M. Duffy, B. McNicholas, D. Monaghan, S. Hanley +5 more
2014AJP - Renal Physiology17 citations
Semantic Scholar
Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation
Afshin Samali, Martin E O'Mahoney, J. Reeve, S. Logue +3 more
2007Apoptosis17 citations
Semantic Scholar
Density Functional Theory (DFT)-Aided Structure Elucidation of Linear Diterpenes from the Irish Brown Seaweed Bifurcaria bifurcata
Vangelis Smyrniotopoulos, D. Firsova, H. Fearnhead, L. Grauso +2 more
2021Marine Drugs14 citations Open access
Semantic Scholar
Chapter 7 Cell-free systems to study apoptosis
H. Fearnhead
200114 citations
Semantic Scholar
Apoptosome Formation through Disruption of the K192-D616 Salt Bridge in the Apaf-1 Closed Form
Fatemeh Sahebazzamani, S. Hosseinkhani, L. Eriksson, H. Fearnhead
2021ACS Omega13 citations Open access
Semantic Scholar
The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway
Elaheh Sadat Hosseini, M. Nikkhah, A. Hamidieh, H. Fearnhead +2 more
2020Journal of Cell Science13 citations
Semantic Scholar
A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
Amin Tashakor, Mahshid H‐Dehkordi, E. O'Connell, Sergi Gomez Ganau +4 more
2019FEBS Open Bio13 citations Open access
Semantic Scholar
TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells
Zsolt Fábián, Phillipe D. O'Brien, Kamilla Pajęcka, H. Fearnhead
2009Apoptosis12 citations
Semantic Scholar
A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury
Vaibhav Patil, E. O'Connell, L. Quinlan, H. Fearnhead +2 more
2020iScience11 citations Open access
Semantic Scholar
DNA‐PK activity is associated with caspase‐dependent myogenic differentiation
P. Connolly, H. Fearnhead
2016The FEBS Journal10 citations Open access
Semantic Scholar
Getting Back on Track, or what to do when apoptosis is de-railed: Recoupling Oncogenes to the Apoptotic Machinery
H. Fearnhead
2004Cancer Biology & Therapy10 citations Open access
Semantic Scholar
Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins
E. Arama, L. A. Baena‐Lopez, H. Fearnhead
2020The FEBS Journal8 citations Open access
Semantic Scholar
In vitro co-culture of Fasciola hepatica newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions
A. Vitkauskaite, Emma McDermott, R. Lalor, Carolina De Marco Verissimo +6 more
2025Virulence7 citations Open access
Semantic Scholar

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