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Yvonne M. Harcus · SciRah

Researcher profile · Semantic Scholar

Yvonne M. Harcus

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Yvonne M. Harcus — researcher profile on SciRah

h-index: 32
Works: 56
Citations: 5,807

Most-cited papers

Intestinal epithelial tuft cells regulate type 2 mucosal responses required for expulsion of helminth parasites
F. Gerbe, E. Sidot, D. Smyth, Makoto Ohmoto +12 more
2016Nature837 citations Open access
Semantic Scholar
Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity
A. Buck, G. Coakley, Fabio Simbari, Henry J. McSorley +11 more
2014Nature Communications747 citations Open access
Semantic Scholar
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
J. Grainger, Katie A. Smith, James P. Hewitson, Henry J. McSorley +9 more
2010Journal of Experimental Medicine493 citations Open access
Semantic Scholar
Comparative genomics of the major parasitic worms
Avril Coghlan, Rahul Tyagi, J. Cotton, N. Holroyd +83 more
2017Nature Genetics465 citations Open access
Semantic Scholar
The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.
James P. Hewitson, Yvonne M. Harcus, R. S. Curwen, Adam A. Dowle +4 more
2008Molecular and biochemical parasitology (Print)250 citations
Semantic Scholar
Commensal-pathogen interactions in the intestinal tract
L. Reynolds, Katherine A. Smith, Kara J. Filbey, Yvonne M. Harcus +6 more
2014Gut microbes233 citations Open access
Semantic Scholar
Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity
G. Coakley, Jana L. McCaskill, J. Borger, Fabio Simbari +6 more
2017Cell Reports203 citations Open access
Semantic Scholar
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
C. Johnston, D. Smyth, Ravindra B. Kodali, M. White +17 more
2017Nature Communications191 citations Open access
Semantic Scholar
Selective maturation of dendritic cells by Nippostrongylus brasiliensis‐secreted proteins drives Th2 immune responses
Adam Balic, Yvonne M. Harcus, M. Holland, Rick M. Maizels
2004European Journal of Immunology178 citations Open access
Semantic Scholar
Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins
James P. Hewitson, Yvonne M. Harcus, J. Murray, M. van Agtmaal +10 more
2011Journal of Proteomics171 citations Open access
Semantic Scholar
Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses
M. Holland, Yvonne M. Harcus, P. Riches, Rick M. Maizels
2000European Journal of Immunology162 citations Open access
Semantic Scholar
Immune Modulation and Modulators in Heligmosomoides polygyrus infection
R. Maizels, James P. Hewitson, J. Murray, Yvonne M. Harcus +6 more
2011Experimental parasitology148 citations Open access
Semantic Scholar
Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection
Kara J. Filbey, J. Grainger, Katherine A. Smith, L. Boon +5 more
2014Immunology and Cell Biology146 citations Open access
Semantic Scholar
Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi1
Henry J. McSorley, Yvonne M. Harcus, J. Murray, Matthew D. Taylor +1 more
2008Journal of Immunology126 citations Open access
Semantic Scholar
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
C. Johnston, Elaine Robertson, Yvonne M. Harcus, J. Grainger +4 more
2015Journal of Visualized Experiments111 citations Open access
Semantic Scholar
Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens.
F. Mutapi, R. Burchmore, T. Mduluza, A. Foucher +5 more
2005Journal of Infectious Diseases104 citations Open access
Semantic Scholar
IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice.
L. Le Goff, Tracey J. Lamb, A. Graham, Yvonne M. Harcus +1 more
2002International Journal of Parasitology97 citations
Semantic Scholar
Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis*
J. Sotillo, A. Sánchez-Flores, C. Cantacessi, Yvonne M. Harcus +11 more
2014Molecular & Cellular Proteomics94 citations Open access
Semantic Scholar
Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites
Yvonne M. Harcus, J. Parkinson, C. Fernández, J. Daub +3 more
2004Genome Biology87 citations Open access
Semantic Scholar
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection
James P. Hewitson, Kara J. Filbey, Julia Esser-von Bieren, M. Camberis +15 more
2015PLoS Pathogens86 citations Open access
Semantic Scholar
Low level regulatory T cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths
Katherine A. Smith, Kara J. Filbey, L. Reynolds, James P. Hewitson +5 more
2015Mucosal Immunology78 citations Open access
Semantic Scholar
Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity
James P. Hewitson, A. Ivens, Yvonne M. Harcus, Kara J. Filbey +6 more
2013PLoS Pathogens77 citations Open access
Semantic Scholar
daf-7-related TGF-β homologues from Trichostrongyloid nematodes show contrasting life cycle expression patterns
Henry J. McSorley, John R. Grainger, Yvonne M. Harcus, J. Murray +3 more
2009Parasitology70 citations Open access
Semantic Scholar
Type 2 Innate Immunity in Helminth Infection Is Induced Redundantly and Acts Autonomously following CD11c+ Cell Depletion
Katherine A. Smith, Yvonne M. Harcus, N. Garbi, G. Hämmerling +2 more
2012Infection and Immunity67 citations Open access
Semantic Scholar
Heligmosomoides polygyrus elicits a dominant non-protective antibody response directed against restricted glycan and peptide epitopes
James P. Hewitson, Kara J. Filbey, J. Grainger, Adam A. Dowle +4 more
2011Journal of Immunology64 citations Open access
Semantic Scholar
TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus
D. Smyth, Yvonne M. Harcus, M. White, W. F. Gregory +7 more
2018International Journal of Parasitology56 citations Open access
Semantic Scholar
C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis
Yvonne M. Harcus, G. Nicoll, J. Murray, Kara J. Filbey +2 more
2009Parasitology international52 citations Open access
Semantic Scholar
IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance.
Adam Balic, Yvonne M. Harcus, Matthew D. Taylor, F. Brombacher +1 more
2006International Immunology49 citations
Semantic Scholar
Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion
Katherine A. Smith, S. Löser, Fumi Varyani, Yvonne M. Harcus +3 more
2018eLife41 citations Open access
Semantic Scholar
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite
Kara J. Filbey, Fumi Varyani, Yvonne M. Harcus, James P. Hewitson +7 more
2019Frontiers in Immunology37 citations Open access
Semantic Scholar
MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus
L. Reynolds, Yvonne M. Harcus, Katherine A. Smith, L. Webb +10 more
2014Journal of Immunology35 citations Open access
Semantic Scholar
Dynamics of CD11c+ dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection
Adam Balic, Katherine A. Smith, Yvonne M. Harcus, R. Maizels
2009Immunology Letters32 citations Open access
Semantic Scholar
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)
Fumi Varyani, S. Löser, Kara J. Filbey, Yvonne M. Harcus +8 more
2022Mucosal Immunology31 citations Open access
Semantic Scholar
Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors.
M. Holland, Yvonne M. Harcus, Adam Balic, R. Maizels
2005Immunology Letters29 citations
Semantic Scholar
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway
John R. Grainger, Katie A. Smith, James P. Hewitson, Henry J. McSorley +9 more
201823 citations
Semantic Scholar
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis
Pamela A. Keir, David M. Brown, Anna Clouter-Baker, Yvonne M. Harcus +1 more
2004Parasite immunology (Print)23 citations
Semantic Scholar
The Secreted Triose Phosphate Isomerase of Brugia malayi Is Required to Sustain Microfilaria Production In Vivo
James P. Hewitson, D. Rückerl, Yvonne M. Harcus, J. Murray +5 more
2014PLoS Pathogens22 citations Open access
Semantic Scholar
Erratum: Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity
A. Buck, G. Coakley, Fabio Simbari, Henry J. McSorley +11 more
2015Nature Communications16 citations Open access
Semantic Scholar
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway
John R. Grainger, Katie A. Smith, James P. Hewitson, Henry J. McSorley +9 more
201713 citations
Semantic Scholar
Characterisation of the secreted apyrase family of Heligmosomoides polygyrus.
Rita Berkachy, D. Smyth, C. Schnoeller, Yvonne M. Harcus +3 more
2020International Journal of Parasitology11 citations Open access
Semantic Scholar
IL-4 R signaling is required to induce IL-10 for the establishment of Th 2 dominance
Adam Balic, Yvonne M. Harcus, Matthew D. Taylor, F. Brombacher +1 more
20069 citations
Semantic Scholar
An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes
Kyriaki Neophytou, Isaac Martínez-Ugalde, Thomas M Fenton, Elaine Robertson +15 more
2025EMBO Reports4 citations Open access
Semantic Scholar
Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides polygyrus Rodent Model
Elaine Robertson, Yvonne M. Harcus, C. Johnston, Antony P. Page +3 more
2018Journal of Parasitology3 citations Open access
Semantic Scholar
A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival
Kyriaki Neophytou, Isaac Martínez-Ugalde, Thomas M Fenton, Elaine Robertson +14 more
2025bioRxiv2 citations Open access
Semantic Scholar
Macrophage migration inhibitory factor (MIF) is essential for Type 2 effector cell immunit y t o an int est inal helmint h parasite
Kara J. Filbey, Fumi Varyani, Yvonne M. Harcus, James P. Hewitson +8 more
20200 citations
Semantic Scholar
Author response: Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion
K. Smith, S. Löser, Fumi Varyani, Yvonne M. Harcus +3 more
20180 citations Open access
Semantic Scholar
Edinburgh Explorer Innate type 2 immunity in helminth infection is induced redundantly and acts autonomously following CD11c+ cell depletion
Katherine A. Smith, Yvonne M. Harcus, N. Garbi, G. Hämmerling +2 more
20180 citations
Semantic Scholar
Edinburgh Research Explorer Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection Providing
James P. Hewitson, Kara J. Filbey, J. E. Bieren, M. Camberis +15 more
20180 citations
Semantic Scholar
A structurally distinct immunosuppressive TGF-mimic from an intestinal helminth that potently induces murine and human regulatory T cells
C. Johnston, D. Smyth, Ravindra B. Kodali, M. White +17 more
20170 citations
Semantic Scholar
Heligmosomoides polygyrus Parasite to the Gastrointestinal Helminth MyD88 Signaling Inhibits Protective
R. Maizels, A. MacDonald, A. Cunningham, S. Uematsu +8 more
20140 citations
Semantic Scholar

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