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N. Fitz · SciRah

Researcher profile · Semantic Scholar

N. Fitz

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N. Fitz — researcher profile on SciRah

h-index: 28
Works: 80
Citations: 2,322

Most-cited papers

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
Cody M. Wolfe, N. Fitz, K. Nam, I. Lefterov +1 more
2018International Journal of Molecular Sciences175 citations Open access
Semantic Scholar
Neurobiology of Disease Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-fat Diet in App23 Mice
N. Fitz, Andrea A Cronican, T. Phạm, A. Fogg +4 more
172 citations
Semantic Scholar
Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles
A. Sahu, Zachary J. Clemens, S. Shinde, S. Sivakumar +13 more
2021Nature Aging131 citations Open access
Semantic Scholar
Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
N. Fitz, K. Nam, Cody M. Wolfe, Florent Letronne +9 more
2021Nature Communications129 citations Open access
Semantic Scholar
Abca1 deficiency affects AD-like phenotype in human ApoE4 but not in ApoE3 targeted replacement mice
N. Fitz, Andrea A Cronican, Muzamil Saleem, A. Fauq +3 more
2012Journal of Neuroscience129 citations Open access
Semantic Scholar
ATP-Binding Cassette Transporter A1: from metabolism to neurodegeneration
Radosveta P. Koldamova, N. Fitz, I. Lefterov
2014Neurobiology of Disease127 citations Open access
Semantic Scholar
Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice*
I. Lefterov, N. Fitz, Andrea A Cronican, A. Fogg +4 more
2010Journal of Biological Chemistry127 citations Open access
Semantic Scholar
The role of ATP-binding cassette transporter A1 in Alzheimer’s disease and neurodegeneration
Radosveta P. Koldamova, N. Fitz, I. Lefterov
2010Biochimica et Biophysica Acta101 citations Open access
Semantic Scholar
Genome-Wide Alteration of Histone H3K9 Acetylation Pattern in Mouse Offspring Prenatally Exposed to Arsenic
Andrea A Cronican, N. Fitz, A. Carter, Muzamil Saleem +5 more
2013PLoS ONE98 citations Open access
Semantic Scholar
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
K. Nam, A. Mounier, Cody M. Wolfe, N. Fitz +9 more
2017Scientific Reports88 citations Open access
Semantic Scholar
Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration
Radosveta P. Koldamova, J. Schug, M. Lefterova, Andrea A Cronican +5 more
2013Neurobiology of Disease75 citations Open access
Semantic Scholar
Comment on: ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
N. Fitz, Andrea A Cronican, I. Lefterov, Radosveta P. Koldamova
2013Science70 citations Open access
Semantic Scholar
Memory deficits in APP23/Abca1+/− mice correlate with the level of Aβ oligomers
I. Lefterov, N. Fitz, Andrea A Cronican, Preslav I. Lefterov +2 more
2009ASN Neuro66 citations Open access
Semantic Scholar
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
I. Lefterov, Cody M. Wolfe, N. Fitz, K. Nam +7 more
2019Alzheimer's Research & Therapy65 citations Open access
Semantic Scholar
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity
A. Mounier, Danko D. Georgiev, K. Nam, N. Fitz +6 more
2015Journal of Neuroscience64 citations Open access
Semantic Scholar
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
N. Fitz, Cody M. Wolfe, Brittany E. Playso, Richard J. Biedrzycki +4 more
2020Molecular Neurodegeneration63 citations Open access
Semantic Scholar
Selective Lesion of Septal Cholinergic Neurons in Rats Impairs Acquisition of a Delayed Matching to Position T-maze Task by Delaying the Shift from a Response to a Place Strategy
N. Fitz, R. B. Gibbs, David A. Johnson
2008Brain Research Bulletin53 citations Open access
Semantic Scholar
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury
Emilie L. Castranio, A. Mounier, Cody M. Wolfe, K. Nam +5 more
2017Neurobiology of Disease49 citations Open access
Semantic Scholar
Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease
N. Fitz, K. Nam, Rada Koldamova, I. Lefterov
2019British Journal of Pharmacology45 citations Open access
Semantic Scholar
Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer’s disease
N. Fitz, Jiebiao Wang, M. Kamboh, Radosveta P. Koldamova +1 more
2021Neurobiology of Disease44 citations Open access
Semantic Scholar
Microtubules Modulate Melatonin Receptors Involved in Phase-shifting Circadian Activity Rhythms: in vitro and in vivo evidence
M. Jarzynka, Deepshikha K. Passey, David A. Johnson, N. Konduru +6 more
2008Journal of Pineal Research41 citations Open access
Semantic Scholar
Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.
N. Fitz, Victor Tapias, Andrea A Cronican, Emilie L. Castranio +5 more
2015Brain : a journal of neurology39 citations Open access
Semantic Scholar
RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment
I. Lefterov, J. Schug, A. Mounier, K. Nam +2 more
2015Neurobiology of Disease37 citations Open access
Semantic Scholar
Proton pump inhibitor Lansoprazole is a nuclear Liver X Receptor agonist
Andrea A Cronican, N. Fitz, T. Phạm, A. Fogg +3 more
2010Biochemical Pharmacology37 citations Open access
Semantic Scholar
Improvement of memory deficits and Aβ clearance in aged APP23 mice treated with a combination of anti-Aβ antibody and LXR agonist
N. Fitz, Emilie L. Castranio, A. Carter, Ravindra B. Kodali +2 more
2014Journal of Alzheimer's Disease35 citations Open access
Semantic Scholar
Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice
K. Nam, Cody M. Wolfe, N. Fitz, Florent Letronne +5 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease33 citations Open access
Semantic Scholar
RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers
K. Nam, A. Mounier, N. Fitz, Cody M. Wolfe +3 more
2016Scientific Reports32 citations Open access
Semantic Scholar
Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease*
R. Sweet, M. MacDonald, C. M. Kirkwood, Ying Ding +9 more
2016Molecular & Cellular Proteomics31 citations Open access
Semantic Scholar
Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice
Yi Lu, Carolina Saibro-Girardi, N. Fitz, Mikayla Ranae McGuire +4 more
2023Cell Reports25 citations Open access
Semantic Scholar
ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice
N. Fitz, A. Carter, Victor Tapias, Emilie L. Castranio +3 more
2017Journal of Alzheimer's Disease22 citations Open access
Semantic Scholar
Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice
A. Carter, Florent Letronne, N. Fitz, A. Mounier +6 more
2017PLoS ONE22 citations Open access
Semantic Scholar
APOEε4 and risk of Alzheimer’s disease – time to move forward
I. Lefterov, N. Fitz, Yi Lu, Radosveta P. Koldamova
2023Frontiers in Neuroscience16 citations Open access
Semantic Scholar
ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms
Emilie L. Castranio, Cody M. Wolfe, K. Nam, Florent Letronne +3 more
2018Acta Neuropathologica Communications16 citations Open access
Semantic Scholar
Genome-wide alteration of histone methylation profiles associated with cognitive changes in response to developmental arsenic exposure in mice
N. Fitz, A. Barchowsky, Radosveta P. Koldamova, I. Lefterov
2022Toxicology Reports15 citations Open access
Semantic Scholar
Extracellular Vesicles in Young Serum Contribute to the Restoration of Age-Related Brain Transcriptomes and Cognition in Old Mice
N. Fitz, A. Sahu, Yi Lu, F. Ambrosio +2 more
2023International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections.
N. Fitz, R. B. Gibbs, David A. Johnson
2006Brain Research Bulletin13 citations Open access
Semantic Scholar
The Effect of The Steroid Sulfatase Inhibitor (p-O-sulfamoyl)–Tetradecanoyl Tyramine (DU-14) on Learning and Memory in Rats with Selective Lesion of Septal-Hippocampal Cholinergic Tract
P. A. Babalola, N. Fitz, Robert B. Gibbs, P. Flaherty +2 more
2012Neurobiology of Learning and Memory9 citations Open access
Semantic Scholar
Serum‐Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults
N. Fitz, Ashish Kumar, Yi-Xin Su, Mitu Sharma +7 more
2026Aging Cell3 citations Open access
Semantic Scholar
RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling
Yi Lu, Xuebao Wang, Carolina Saibro-Girardi, N. Fitz +2 more
2025Cells3 citations Open access
Semantic Scholar
A novel technique for monitoring Alzheimer’s disease associated changes in brain-derived extracellular vesicle cargos in mouse models
N. Fitz, MD Shahnu Alam, Mary Ann Ostach, Sia Garg +2 more
2026bioRxiv2 citations Open access
Semantic Scholar
Brain Single-Cell Transcriptional Responses to Bexarotene-Activated RXR in an Alzheimer’s Disease Model
Carolina Saibro-Girardi, Yi Lu, N. Fitz, D. Gelain +2 more
2026International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Transcriptomic Response to Neuromuscular Electrical Stimulation in Muscle, Brain, and Plasma EVs in WT and Klotho-Deficient Mice
C. Cavanaugh, Amanda E Moore, N. Fitz, I. Lefterov +1 more
2025International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Macrophage dynamics and the role of TREM2 at the oral mucosal barrier
Taiana C. Leite, Jiamiao Chen, A. Diacou, Sangmin Park +6 more
2025Journal of Translational Medicine2 citations Open access
Semantic Scholar
Small nucleolar RNAs in plasma and their discriminatory power as diagnostic biomarkers of Alzheimer's disease
N. Fitz, K. Nam, Jiebiao Wang, M. Kamboh +2 more
2021medRxiv1 citations Open access
Semantic Scholar
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
N. Fitz, Cody M. Wolfe, Brittany E. Playso, Richard J. Biedrzycki +4 more
2020Molecular Neurodegeneration1 citations Open access
Semantic Scholar
[P1–156]: FAMILIAL AGGREGATION OF ATYPICAL DEMENTIA IN A LARGE CANADIAN FAMILY: THE MISSING GENE
K. Nam, N. Fitz, Cody M. Wolfe, J. Schug +2 more
20171 citations Open access
Semantic Scholar
P2‐113: High‐Fat Diet Affects Inflammation and Increases TREM2 Level in App Mice
N. Fitz, K. Nam, Cody M. Wolfe, A. Mounier +3 more
20161 citations
Semantic Scholar
P1‐074: EFFECTS OF APOLIPOPROTEIN E ON COGNITIVE PERFORMANCE AND AMYLOID OLIGOMERIZATION IN A MOUSE MODEL
N. Fitz, Emilie L. Castranio, A. Carter, I. Lefterov +1 more
20141 citations
Semantic Scholar
Selective Lesion of Cholinergic Neurons of the Septal-Hippocampal Tract: Memory and Learning
N. Fitz
20091 citations
Semantic Scholar
Linking cross-species trajectories of cerebrovascular remodeling in aging and Alzheimer’s disease to brain vessel transcriptome
N. Schweitzer, Yucheng Shen, Yifan Zhao, Christopher Cover +10 more
2026bioRxiv0 citations Open access
Semantic Scholar

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