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D. Edgerton · SciRah

Researcher profile · Semantic Scholar

D. Edgerton

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D. Edgerton — researcher profile on SciRah

h-index: 29
Works: 95
Citations: 2,682

Most-cited papers

Physiologic action of glucagon on liver glucose metabolism
C. Ramnanan, D. Edgerton, G. Kraft, A. Cherrington
2011Diabetes, obesity and metabolism267 citations Open access
Semantic Scholar
Insulin's direct effects on the liver dominate the control of hepatic glucose production.
D. Edgerton, Margaret Lautz, M. Scott, Carrie A Everett +4 more
2006Journal of Clinical Investigation180 citations Open access
Semantic Scholar
The direct and indirect effects of insulin on hepatic glucose production in vivo
A. Cherrington, D. Edgerton, D. Sindelar
1998Diabetologia132 citations Open access
Semantic Scholar
Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism.
D. Edgerton, S. Cardin, M. Emshwiller, D. Neal +5 more
2001Diabetes122 citations Open access
Semantic Scholar
Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion.
D. Edgerton, G. Kraft, Marta S. Smith, Ben Farmer +5 more
2017JCI Insight110 citations Open access
Semantic Scholar
Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo
C. Ramnanan, D. Edgerton, Noelia Rivera, José M. Irimia-Dominguez +7 more
2010Diabetes105 citations Open access
Semantic Scholar
Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo
D. Edgerton, C. Ramnanan, Carrie A. Grueter, Kathryn M. S. Johnson +4 more
2009Diabetes89 citations Open access
Semantic Scholar
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.
C. Ramnanan, V. Saraswathi, Marta S. Smith, E. Donahue +8 more
2011Journal of Clinical Investigation88 citations Open access
Semantic Scholar
Glucose absorption from starch hydrolysates in the human jejunum.
B. Jones, B. Brown, J. S. Loran, D. Edgerton +3 more
1983Gut83 citations Open access
Semantic Scholar
Biobehavioral profiles of arousal and social motivation in Autism Spectrum Disorders
B. Corbett, D. Swain, C. Newsom, Lily Wang +2 more
2013Journal of Child Psychology and Psychiatry and Allied Disciplines78 citations Open access
Semantic Scholar
Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes
P. Jacobson, T. V. von Geldern, L. Öhman, Marie Österland +21 more
2005Journal of Pharmacology and Experimental Therapeutics78 citations Open access
Semantic Scholar
Physiological consequences of phasic insulin release in the normal animal.
A. Cherrington, D. Sindelar, D. Edgerton, K. Steiner +1 more
2002Diabetes71 citations Open access
Semantic Scholar
Current strategies for the inhibition of hepatic glucose production in type 2 diabetes.
D. Edgerton, Kathryn M. S. Johnson, A. Cherrington
2009Frontiers in Bioscience66 citations Open access
Semantic Scholar
Splanchnic free fatty acid kinetics.
M. Jensen, S. Cardin, D. Edgerton, A. Cherrington
2003American Journal of Physiology. Endocrinology and Metabolism55 citations
Semantic Scholar
Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production
C. Ramnanan, D. Edgerton, A. Cherrington
2012Cell Metabolism51 citations Open access
Semantic Scholar
Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels.
Kathryn M. S. Johnson, D. Edgerton, Tiffany Rodewald, M. Scott +3 more
2007American Journal of Physiology. Endocrinology and Metabolism48 citations
Semantic Scholar
Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery.
D. Edgerton, M. Scott, Ben Farmer, P. Williams +6 more
2019JCI Insight47 citations Open access
Semantic Scholar
Glucagon as a Critical Factor in the Pathology of Diabetes
D. Edgerton, A. Cherrington
2011Diabetes47 citations Open access
Semantic Scholar
Insulin action on the liver in vivo.
A. Cherrington, M. Moore, D. Sindelar, D. Edgerton
2007Biochemical Society Transactions45 citations
Semantic Scholar
A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog
Noelia Rivera, Carrie A. Everett-Grueter, D. Edgerton, Tiffany Rodewald +7 more
2007Journal of Pharmacology and Experimental Therapeutics42 citations
Semantic Scholar
Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog
D. Edgerton, M. Moore, J. J. Winnick, M. Scott +8 more
2014Diabetes41 citations Open access
Semantic Scholar
Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog
C. Ramnanan, G. Kraft, Marta S. Smith, Ben Farmer +7 more
2012Diabetes41 citations Open access
Semantic Scholar
Islet Auto‐Transplantation into an Omental or Splenic Site Results in a Normal Beta Cell but Abnormal Alpha Cell Response to Mild Non‐Insulin‐Induced Hypoglycemia
S. Gustavson, R. Rajotte, D. Hunkeler, J. Lakey +5 more
2005American Journal of Transplantation40 citations Open access
Semantic Scholar
Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes
J. Gregory, G. Kraft, M. Scott, D. Neal +12 more
2015Diabetes37 citations Open access
Semantic Scholar
Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats.
S. Cardin, M. Emshwiller, P. A. Jackson, W. Snead +3 more
1999Journal of applied physiology37 citations
Semantic Scholar
Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.
J. J. Winnick, G. Kraft, J. Gregory, D. Edgerton +10 more
2016Journal of Clinical Investigation36 citations Open access
Semantic Scholar
Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog
D. Edgerton, Kathryn M. S. Johnson, D. Neal, M. Scott +4 more
2009Diabetes34 citations Open access
Semantic Scholar
Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes
J. Gregory, J. Muldowney, Brian G. Engelhardt, R. Tyree +5 more
2019Nutrition & Diabetes30 citations Open access
Semantic Scholar
Effects of Habitat Complexity on Pair-Housed Zebrafish.
V. Keck, D. Edgerton, S. Hajizadeh, L. Swift +3 more
2015Journal of the American Association for Laboratory Animal Science29 citations
Semantic Scholar
Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog.
D. Edgerton, S. Cardin, Catherine Pan, D. Neal +3 more
2002Diabetes29 citations
Semantic Scholar
Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog
G. Kraft, Anthony C. Vrba, M. Scott, Eric J. Allen +5 more
2019Diabetes28 citations Open access
Semantic Scholar
Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice
V. Saraswathi, C. Ramnanan, A. Wilks, C. Desouza +6 more
2013Metabolism: Clinical and Experimental27 citations Open access
Semantic Scholar
Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog.
D. Edgerton, R. Basu, C. Ramnanan, Tiffany D. Farmer +5 more
2010American Journal of Physiology. Endocrinology and Metabolism27 citations Open access
Semantic Scholar
Splanchnic Cortisol Production in Dogs Occurs Primarily in the Liver
R. Basu, D. Edgerton, Ravinder J. Singh, A. Cherrington +1 more
2006Diabetes27 citations Open access
Semantic Scholar
Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog.
S. Cardin, P. A. Jackson, D. Edgerton, D. Neal +2 more
2001Diabetes26 citations Open access
Semantic Scholar
Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs.
D. Edgerton, D. Neal, M. Scott, L. Bowen +6 more
2005Diabetes25 citations
Semantic Scholar
Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion.
M. Moore, S. Cardin, D. Edgerton, Ben Farmer +3 more
2004American Journal of Physiology. Endocrinology and Metabolism25 citations
Semantic Scholar
Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo.
L. A. Hornbuckle, D. Edgerton, Julio E. Ayala, C. A. Svitek +5 more
2001American Journal of Physiology. Endocrinology and Metabolism23 citations
Semantic Scholar
Importance of the route of insulin delivery to its control of glucose metabolism.
D. Edgerton, M. Moore, J. Gregory, G. Kraft +1 more
2021American Journal of Physiology. Endocrinology and Metabolism21 citations Open access
Semantic Scholar
Triglyceride Uptake and Lipoprotein Lipase–Generated Fatty Acid Spillover in the Splanchnic Bed of Dogs
R. Nelson, D. Edgerton, R. Basu, J. C. Roesner +2 more
2007Diabetes20 citations Open access
Semantic Scholar
Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization.
Kathryn M. S. Johnson, D. Edgerton, Tiffany Rodewald, M. Scott +3 more
2008American Journal of Physiology. Endocrinology and Metabolism19 citations
Semantic Scholar
Biologic Comparison of Inhaled Insulin Formulations: ExuberaTM and Novel Spray-Dried Engineered Particles of Dextran-10
P. Kuehl, A. Cherrington, Dan E. Dobry, D. Edgerton +8 more
2014AAPS PharmSciTech17 citations Open access
Semantic Scholar
Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog.
Zhibo An, C. Dicostanzo, M. Moore, D. Edgerton +3 more
2008American Journal of Physiology. Endocrinology and Metabolism17 citations
Semantic Scholar
The Role of Insulin in the Regulation of PEPCK and Gluconeogenesis In Vivo
C. Ramnanan, D. Edgerton, A. Cherrington
200916 citations Open access
Semantic Scholar
Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis.
J. J. Winnick, C. Ramnanan, V. Saraswathi, J. Roop +6 more
2013American Journal of Physiology. Endocrinology and Metabolism15 citations Open access
Semantic Scholar
The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output.
Carrie A. Everett-Grueter, D. Edgerton, E. Donahue, Suzan Vaughan +3 more
2006American Journal of Physiology. Endocrinology and Metabolism15 citations
Semantic Scholar
Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection.
A. Cherrington, D. Neal, D. Edgerton, D. Glass +5 more
2004Diabetes15 citations
Semantic Scholar
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.
D. Edgerton, P. Jacobson, T. Opgenorth, B. Zinker +6 more
2006Metabolism: Clinical and Experimental14 citations
Semantic Scholar
Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog.
D. Edgerton, S. Cardin, D. Neal, Ben Farmer +3 more
2004American Journal of Physiology. Endocrinology and Metabolism14 citations
Semantic Scholar
Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?
D. Edgerton, A. Cherrington
2015Diabetes13 citations Open access
Semantic Scholar

Frequent co-authors

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A. Cherrington — researcher profile on SciRah
D. Neal×24
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M. Scott×13
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Ben Farmer×13
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Ben Farmer — researcher profile on SciRah

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C. Ramnanan — researcher profile on SciRah

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S. Cardin — researcher profile on SciRah

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G. Kraft — researcher profile on SciRah

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Margaret Lautz — researcher profile on SciRah

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E. Donahue — researcher profile on SciRah

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Marta S. Smith — researcher profile on SciRah

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Kathryn M. S. Johnson — researcher profile on SciRah

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M. Moore — researcher profile on SciRah