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Radim Osicka · SciRah

Researcher profile · Semantic Scholar

Radim Osicka

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Radim Osicka — researcher profile on SciRah

h-index: 33
Works: 94
Citations: 3,062

Most-cited papers

RTX proteins: a highly diverse family secreted by a common mechanism
I. Linhartova, L. Bumba, J. Masin, M. Basler +8 more
2010FEMS Microbiology Reviews516 citations Open access
Semantic Scholar
Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.
Xaver Sewald, Bettina Gebert-Vogl, Sandra Prassl, Iris Barwig +9 more
2008Cell Host and Microbe133 citations Open access
Semantic Scholar
Interaction of Bordetella pertussis Adenylate Cyclase with CD11b/CD18
M. El-Azami-El-Idrissi, C. Bauche, J. Loucká, Radim Osicka +3 more
2003Journal of Biological Chemistry127 citations Open access
Semantic Scholar
RTX cytotoxins recognize β2 integrin receptors through N-linked oligosaccharides
Jana Morová, Radim Osicka, J. Masin, P. Šebo
2008Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
Delivery of CD8+ T-Cell Epitopes into Major Histocompatibility Complex Class I Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase: Delineation of Cell Invasive Structures and Permissive Insertion Sites
Radim Osicka, Adriana Osičková, Tumay Basar, P. Guermonprez +3 more
2000Infection and Immunity107 citations Open access
Semantic Scholar
An amphipathic alpha-helix including glutamates 509 and 516 is crucial for membrane translocation of adenylate cyclase toxin and modulates formation and cation selectivity of its membrane channels.
Adriana Osičková, Radim Osicka, E. Maier, Roland Benz +1 more
1999Journal of Biological Chemistry90 citations
Semantic Scholar
Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes
M. Basler, J. Masin, Radim Osicka, P. Šebo
2006Infection and Immunity85 citations Open access
Semantic Scholar
Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin*
M. Basler, O. Knapp, J. Masin, R. Fišer +4 more
2007Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3
Radim Osicka, Adriana Osičková, Shakir Hasan, L. Bumba +2 more
2015eLife70 citations Open access
Semantic Scholar
A Novel “Clip-and-link” Activity of Repeat in Toxin (RTX) Proteins from Gram-negative Pathogens
Radim Osicka, K. Procházková, M. Sulc, I. Linhartova +2 more
2004Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Delivery of Multiple Epitopes by Recombinant Detoxified Adenylate Cyclase of Bordetella pertussisInduces Protective Antiviral Immunity
C. Fayolle, Adriana Osičková, Radim Osicka, T. Henry +4 more
2001Journal of Virology65 citations Open access
Semantic Scholar
Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif
Tomáš Wald, František Špoutil, Adriana Osičková, M. Procházková +8 more
2017Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
Semantic Scholar
Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin
Jana Vojtova-Vodolanova, M. Basler, Radim Osicka, O. Knapp +5 more
2009The FASEB Journal61 citations
Semantic Scholar
Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes
Jakub Novák, O. Cerny, Adriana Osičková, I. Linhartova +4 more
2017Toxins59 citations Open access
Semantic Scholar
Adenylate cyclase toxin translocates across target cell membrane without forming a pore
Adriana Osičková, J. Masin, C. Fayolle, J. Krůšek +5 more
2010Molecular Microbiology53 citations Open access
Semantic Scholar
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
Yifan Wu, S. Du, L. Bimler, K. E. Mauk +16 more
2023Cell Reports52 citations Open access
Semantic Scholar
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.
J. Masin, Radim Osicka, L. Bumba, P. Šebo
2015Pathogens and Disease52 citations Open access
Semantic Scholar
Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines
P. Šebo, Radim Osicka, J. Masin
2014Expert Review of Vaccines52 citations
Semantic Scholar
Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores
R. Fišer, J. Masin, L. Bumba, E. Pospíšilová +10 more
2012PLoS Pathogens49 citations Open access
Semantic Scholar
A guide to polarized airway epithelial models for studies of host–pathogen interactions
Shakir Hasan, P. Šebo, Radim Osicka
2018The FEBS Journal47 citations
Semantic Scholar
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers
Shakir Hasan, N. Kulkarni, Arni Asbjarnarson, I. Linhartova +3 more
2017Infection and Immunity42 citations Open access
Semantic Scholar
Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin
J. Masin, Adriana Osičková, Anna Sukova, R. Fišer +5 more
2016Scientific Reports42 citations Open access
Semantic Scholar
Differences in Purinergic Amplification of Osmotic Cell Lysis by the Pore-Forming RTX Toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the Role of Pore Size
J. Masin, R. Fišer, I. Linhartova, Radim Osicka +4 more
2013Infection and Immunity41 citations Open access
Semantic Scholar
Neisseria meningitidis RTX Protein FrpC Induces High Levels of Serum Antibodies during Invasive Disease: Polymorphism of frpC Alleles and Purification of Recombinant FrpC
Radim Osicka, J. Kalmusová, P. Krizova, P. Šebo
2001Infection and Immunity41 citations Open access
Semantic Scholar
Intrinsically Disordered Enamel Matrix Protein Ameloblastin Forms Ribbon-like Supramolecular Structures via an N-terminal Segment Encoded by Exon 5*
Tomáš Wald, Adriana Osičková, M. Sulc, O. Benada +10 more
2013Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells
M. Kuchař, L. Vaňková, H. Petroková, J. Černý +8 more
2013Proteins: Structure, Function, and Bioinformatics38 citations Open access
Semantic Scholar
Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding
Adriana Osičková, N. Balashova, J. Masin, M. Sulc +8 more
2018Emerging Microbes and Infections35 citations Open access
Semantic Scholar
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP‐1 phosphatase activates the BimEL‐Bax pro‐apoptotic cascade in phagocytes
J. N. Ahmad, O. Cerny, I. Linhartova, J. Masin +2 more
2016Cellular Microbiology35 citations Open access
Semantic Scholar
Novel high‐affinity binders of human interferon gamma derived from albumin‐binding domain of protein G
J. N. Ahmad, Jingjing Li, L. Biedermannová, M. Kuchař +13 more
2012Proteins: Structure, Function, and Bioinformatics35 citations
Semantic Scholar
Single‐step affinity purification of recombinant proteins using a self‐excising module from Neisseria meningitidis FrpC
L. Sadílková, Radim Osicka, M. Sulc, I. Linhartova +2 more
2008Protein Science35 citations Open access
Semantic Scholar
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis
Karolína Škopová, B. Tomalová, I. Kánchev, P. Rossmann +10 more
2017Infection and Immunity34 citations Open access
Semantic Scholar
Antigen Targeting to CD11b+ Dendritic Cells in Association with TLR4/TRIF Signaling Promotes Strong CD8+ T Cell Responses
G. Dadaglio, C. Fayolle, Xiao-Ming Zhang, B. Ryffel +7 more
2014Journal of Immunology34 citations Open access
Semantic Scholar
Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin.
Tomáš Wald, Inga Petry-Podgórska, R. Fišer, Tomáš Matoušek +4 more
2014Analytical Biochemistry33 citations
Semantic Scholar
The iron‐regulated transcriptome and proteome of Neisseria meningitidis serogroup C
M. Basler, I. Linhartova, P. Halada, J. Novotná +5 more
2006Proteomics33 citations
Semantic Scholar
The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC*
K. Procházková, Radim Osicka, I. Linhartova, P. Halada +2 more
2005Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding
Shakir Hasan, Adriana Osičková, L. Bumba, P. Novák +2 more
2015FEBS Letters30 citations Open access
Semantic Scholar
Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
Rodrigo Villarino Romero, Radim Osicka, P. Šebo
2014Future Microbiology29 citations
Semantic Scholar
Neisseria meningitidis RTX Proteins Are Not Required for Virulence in Infant Rats
Stanislav Forman, I. Linhartova, Radim Osicka, X. Nassif +2 more
2003Infection and Immunity29 citations Open access
Semantic Scholar
Surface plasmon resonance biosensor based on engineered proteins for direct detection of interferon-gamma in diluted blood plasma
Hana Šípová, V. Ševců, M. Kuchař, J. N. Ahmad +4 more
201228 citations
Semantic Scholar
Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia
L. Sadílková, J. Nepeřený, V. Vrzal, P. Šebo +1 more
2012Veterinary Research28 citations Open access
Semantic Scholar
Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins
Adriana Osičková, Humaira Khaliq, J. Masin, David Jurnečka +6 more
2020Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1.
Charlotte Deloizy, Edwige Bouguyon, Even Fossum, P. Šebo +8 more
2016Developmental and Comparative Immunology25 citations Open access
Semantic Scholar
Biophysical characterization of recombinant human ameloblastin.
Tomáš Wald, L. Bednárová, Radim Osicka, P. Pachl +4 more
2011European Journal of Oral Sciences25 citations
Semantic Scholar
The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin
J. Masin, Jana Roderova, Adriana Osičková, P. Novák +4 more
2017Scientific Reports24 citations Open access
Semantic Scholar
p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells
L. Křížová, M. Kuchař, H. Petroková, Radim Osicka +5 more
2017Autoimmunity22 citations
Semantic Scholar
Rapid Purification of Endotoxin-Free RTX Toxins
O. Staněk, J. Masin, Radim Osicka, David Jurnečka +2 more
2019Toxins21 citations Open access
Semantic Scholar
The Bordetella pertussis Type III Secretion System Tip Complex Protein Bsp22 Is Not a Protective Antigen and Fails To Elicit Serum Antibody Responses during Infection of Humans and Mice
Rodrigo Villarino Romero, Ilona Bibova, O. Cerny, B. Večerek +5 more
2013Infection and Immunity21 citations Open access
Semantic Scholar
Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells.
I. Linhartova, M. Basler, J. Ichikawa, V. Pelicic +4 more
2006FEMS Microbiology Letters21 citations
Semantic Scholar
Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin
Jana Roderova, Adriana Osičková, Anna Sukova, Gabriela Mikušová +4 more
2019Scientific Reports19 citations Open access
Semantic Scholar
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
Yael Gruper, A. S. Wolff, Liad Glanz, František Špoutil +36 more
2023Nature17 citations
Semantic Scholar

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P. Šebo×45
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P. Šebo — researcher profile on SciRah
J. Masin×19
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J. Masin — researcher profile on SciRah
Adriana Osičková×16
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Adriana Osičková — researcher profile on SciRah
I. Linhartova×12
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I. Linhartova — researcher profile on SciRah

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L. Bumba — researcher profile on SciRah

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M. Basler — researcher profile on SciRah

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R. Fišer — researcher profile on SciRah

Tomáš Wald×7

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Tomáš Wald — researcher profile on SciRah

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C. Leclerc — researcher profile on SciRah

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M. Sulc — researcher profile on SciRah

L. Sadílková×4

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L. Sadílková — researcher profile on SciRah

Shakir Hasan×4

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Shakir Hasan — researcher profile on SciRah