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W. Benedict · SciRah

Researcher profile · Semantic Scholar

W. Benedict

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W. Benedict — researcher profile on SciRah

h-index: 50
Works: 144
Citations: 9,538

Most-cited papers

Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
David W. Dawson, O. Volpert, Paul R. Gillis, S. Crawford +3 more
1999Science1,437 citations
Semantic Scholar
Structural evidence for the authenticity of the human retinoblastoma gene.
Y. Fung, A. Murphree, A. T'ang, J. Qian +2 more
1987Science780 citations
Semantic Scholar
Expression and amplification of the N-myc gene in primary retinoblastoma
Wen-Hwa Lee, A. Murphree, W. Benedict
1984Nature442 citations
Semantic Scholar
Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene.
W. Benedict, A. Murphree, A. Banerjee, C. Spina +2 more
1983Science336 citations
Semantic Scholar
p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer.
S. Shariat, H. Tokunaga, J. Zhou, Ja‐Hong Kim +3 more
2004Journal of Clinical Oncology315 citations
Semantic Scholar
Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.
V. Cryns, A. Thor, Hong-Ji J. Xu, Shi-Xue Hu +4 more
1994New England Journal of Medicine287 citations Open access
Semantic Scholar
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.
J. Yokota, T. Akiyama, Y.-K. T. Fung, W. Benedict +6 more
1988Oncogene255 citations
Semantic Scholar
Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.
Pei Lin, S. Melmed, B. Scheithauer, Kaiman Kovacs +2 more
1995Cancer Research224 citations
Semantic Scholar
Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors.
C. Cordon-Cardo, Zuo-Feng Zhang, G. Dalbagni, M. Drobnjak +5 more
1997Cancer Research223 citations
Semantic Scholar
Asbestos-associated chromosomal changes in human mesothelial cells.
J. Lechner, T. Tokiwa, Moira A. Laveck, W. Benedict +4 more
1985Proceedings of the National Academy of Sciences of the United States of America217 citations Open access
Semantic Scholar
Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.
J. Ishikawa, Hong-Ji J. Xu, Shi-Xue Hu, D. Yandell +4 more
1991Cancer Research197 citations
Semantic Scholar
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.
Ryosuke Takahashi, T. Hashimoto, Hong-Ji J. Xu, S.-X. Hu +5 more
1991Proceedings of the National Academy of Sciences of the United States of America158 citations Open access
Semantic Scholar
Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells.
Carvell T. Nguyen, G. Liang, Tuny Nguyen, D. Tsao-Wei +5 more
2001Journal of the National Cancer Institute156 citations Open access
Semantic Scholar
A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses
D. Sterman, A. Recio, R. Carroll, C. Gillespie +20 more
2007Clinical Cancer Research147 citations Open access
Semantic Scholar
Mantle cell lymphoma: correlation of clinical outcome and biologic features with three histologic variants.
A. Majlis, W. Pugh, M. Rodríguez, W. Benedict +1 more
1997Journal of Clinical Oncology147 citations
Semantic Scholar
Role of the retinoblastoma gene in the initiation and progression of human cancer.
W. Benedict, Hong-Ji J. Xu, Shi-Xue Hu, R. Takahashi
1990Journal of Clinical Investigation141 citations Open access
Semantic Scholar
Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer
B. Czerniak, Vijaya Chaturvedi, Li Li, S. Hodges +8 more
1999Oncogene140 citations Open access
Semantic Scholar
Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer
W. Benedict, S. Lerner, J. Zhou, Xiaohua Shen +2 more
1999Oncogene125 citations Open access
Semantic Scholar
Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative photoradiation, ionizing radiation, or ultraviolet radiation.
C. Gomer, N. Rucker, A. Banerjee, W. Benedict
1983Cancer Research118 citations
Semantic Scholar
Implication of chromosome 11 in the suppression of neoplastic expression in human cell hybrids.
E. Srivatsan, W. Benedict, E. Stanbridge
1986Cancer Research116 citations
Semantic Scholar
The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells.
Hong-Ji J. Xu, Shi-Xue Hu, T. Hashimoto, R. Takahashi +1 more
1989Oncogene101 citations
Semantic Scholar
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
J. Izawa, P. Sweeney, P. Perrotte, D. Kedar +6 more
2002Clinical Cancer Research95 citations
Semantic Scholar
Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications.
P. Cagle, A. El-Naggar, Hong-Ji J. Xu, Shi-Xue Hu +1 more
1997American Journal of Pathology95 citations
Semantic Scholar
Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Interferon-Induced Apoptosis in Human Bladder Cancer Cells
A. Papageorgiou, L. Lashinger, R. Millikan, H. B. Grossman +3 more
2004Cancer Research84 citations
Semantic Scholar
Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy.
J. Slaton, R. Millikan, K. Inoue, T. Karashima +5 more
2004Journal of Urology83 citations
Semantic Scholar
Intravesical Ad-IFNα Causes Marked Regression of Human Bladder Cancer Growing Orthotopically in Nude Mice and Overcomes Resistance to IFN-α Protein
W. Benedict, Zi-Ming Tao, C. Kim, Xin-Qiao Zhang +11 more
200482 citations Open access
Semantic Scholar
Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
M. Yamashita, C. Rosser, J. Zhou, Xin-Qiao Zhang +8 more
2002Cancer Gene Therapy77 citations
Semantic Scholar
p53, Rb, and cyclin D1 expression in human oral verrucous carcinomas
I. Gimenez-Conti, A. Collet, H. Lanfranchi, Maria E. Itoiz +5 more
1996Cancer73 citations Open access
Semantic Scholar
Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder.
S. Shariat, Kazumasa Matsumoto, Ja‐Hong Kim, G. Ayala +4 more
2003Journal of Urology71 citations
Semantic Scholar
Genetic modeling of human urinary bladder carcinogenesis
B. Czerniak, Li Li, Vijaya Chaturvedi, J. Ro +3 more
2000Genes, Chromosomes and Cancer69 citations
Semantic Scholar
An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies
Takafumi Watanabe, N. Shinohara, A. Sazawa, T. Harabayashi +9 more
2000Cancer Gene Therapy68 citations
Semantic Scholar
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers
O. Alhalabi, Jianfeng Chen, Yu-Xue Zhang, Yang Lu +41 more
2022Nature Communications64 citations Open access
Semantic Scholar
Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.
L. Zukerberg, W. Benedict, A. Arnold, N. Dyson +2 more
1996Blood57 citations Open access
Semantic Scholar
Purification, biochemical characterization, and biological function of human esterase D.
Wen-Hwa Lee, W. Wheatley, W. Benedict, Chun‐Ming Huang +1 more
1986Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
A Phase l Study of a Tumor-targeted Systemic Nanodelivery System, SGT-94, in Genitourinary Cancers.
A. Siefker-Radtke, Xin-Qiao Zhang, Charles C. Guo, Yu Shen +8 more
2016Molecular Therapy52 citations Open access
Semantic Scholar
Immunohistochemical detection of p53, bcl-2, and retinoblastoma proteins in follicular lymphoma.
Phuong L. Nguyen, L. Zukerberg, W. Benedict, N. Harris
1996American Journal of Clinical Pathology51 citations
Semantic Scholar
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
Sangkyou Lee, Joon Jeong, Tadeusz Majewski, S. Scherer +18 more
2007Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo
K. Pirollo, A. Rait, Qi Zhou, Xin-Qiao Zhang +4 more
2008Clinical Cancer Research49 citations Open access
Semantic Scholar
Imaging of human tumor xenografts in nude mice with radiolabeled monoclonal antibodies. Limitations of specificity due to nonspecific uptake of antibody
B. D. Mann, M. B. Cohen, R. Saxton, D. Morton +6 more
1984Cancer49 citations Open access
Semantic Scholar
Differential retinoblastoma and p16INK4A protein expression in neuroendocrine tumors of the lung
H. Dosaka-Akita, Philip T. Cagle, H. Hiroumi, M. Fujita +4 more
2000Cancer48 citations Open access
Semantic Scholar
Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.
W. Benedict, Zi-Ming Tao, Chang-Soo Kim, Xin-Qiao Zhang +11 more
2004Molecular Therapy46 citations
Semantic Scholar
Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells.
Xin-Qiao Zhang, A. Multani, J. Zhou, J. Shay +6 more
2003Cancer Research42 citations
Semantic Scholar
Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia
S. Kornblau, Hong-Ji J. Xu, Wei Zhang, Shi-Xue Hu +6 more
199440 citations
Semantic Scholar
Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis.
A. Nakamizo, Toshiyuko Amano, Wei Zhang, Xin-Qiao Zhang +8 more
2008Neuro-Oncology37 citations Open access
Semantic Scholar
TabBO: a model reflecting common molecular features of androgen-independent prostate cancer.
N. Navone, Maria Del C. Rodriguez-Vargas, W. Benedict, P. Troncoso +4 more
2000Clinical Cancer Research35 citations
Semantic Scholar
Combination therapy with IFN-α plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
A. Papageorgiou, A. Kamat, W. Benedict, C. Dinney +1 more
2006Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
Increased sister-chromatid exchange in bone-marrow cells of mice exposed to whole cigarette smoke.
W. Benedict, A. Banerjee, Ken K. Kangalingam, David R. Dansie +2 more
1984Mutation research33 citations
Semantic Scholar
Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression
J. Zhou, C. Rosser, Motoyoshi Tanaka, Meng Yang +3 more
2002Cancer Gene Therapy31 citations Open access
Semantic Scholar
Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression.
T. Hashimoto, R. Takahashi, D. Yandell, Hong-Ji J. Xu +3 more
1991Oncogene29 citations
Semantic Scholar
Noninvasive detection of bladder cancer in an orthotopic murine model with green fluorescence protein cytology.
Motoysohi Tanaka, J. Gee, J. D. De La Cerda, C. Rosser +3 more
2003Journal of Urology25 citations
Semantic Scholar

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J. Zhou — researcher profile on SciRah
Hong-Ji J. Xu×11
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Hong-Ji J. Xu — researcher profile on SciRah
Xin-Qiao Zhang×9
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Xin-Qiao Zhang — researcher profile on SciRah
B. Czerniak×7
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B. Czerniak — researcher profile on SciRah

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Shi-Xue Hu — researcher profile on SciRah

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C. Dinney — researcher profile on SciRah

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R. Takahashi — researcher profile on SciRah

A. Papageorgiou×4

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A. Papageorgiou — researcher profile on SciRah

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C. Rosser — researcher profile on SciRah

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A. Murphree — researcher profile on SciRah

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A. Banerjee — researcher profile on SciRah