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A. Yart · SciRah

Researcher profile · Semantic Scholar

A. Yart

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A. Yart — researcher profile on SciRah

h-index: 25
Works: 39
Citations: 2,534

Most-cited papers

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway.
M. Dance, A. Montagner, J. Salles, A. Yart +1 more
2008Cellular Signalling353 citations
Semantic Scholar
A Novel Role for Gab1 and SHP2 in Epidermal Growth Factor-induced Ras Activation*
A. Montagner, A. Yart, M. Dance, B. Perret +2 more
2005Journal of Biological Chemistry221 citations Open access
Semantic Scholar
SHP2 sails from physiology to pathology.
Mylène Tajan, Audrey de Rocca Serra, P. Valet, T. Edouard +1 more
2015European Journal of Medical Genetics217 citations
Semantic Scholar
The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway.
Mylène Tajan, Romain Paccoud, S. Branka, T. Edouard +1 more
2018Endocrine reviews210 citations Open access
Semantic Scholar
The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II
A. Yart, M. Gstaiger, C. Wirbelauer, M. Pečnik +3 more
2005Molecular and Cellular Biology190 citations Open access
Semantic Scholar
A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor*
A. Yart, M. Laffargue, P. Mayeux, S. Chrétien +6 more
2001Journal of Biological Chemistry146 citations Open access
Semantic Scholar
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature
Audrey De Rocca Serra-Nédélec, T. Edouard, K. Tréguer, Mylène Tajan +10 more
2012Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling
T. Edouard, J. Combier, A. Nédélec, Sophie Bel-Vialar +9 more
2010Molecular and Cellular Biology101 citations Open access
Semantic Scholar
An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid*
M. Laffargue, P. Raynal, A. Yart, Christine Pérès +4 more
1999Journal of Biological Chemistry88 citations Open access
Semantic Scholar
A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid*
A. Yart, S. Roche, R. Wetzker, M. Laffargue +4 more
2002Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.
A. Yart, H. Chap, P. Raynal
2002Biochimica et Biophysica Acta77 citations
Semantic Scholar
The Adaptor Protein Gab1 Couples the Stimulation of Vascular Endothelial Growth Factor Receptor-2 to the Activation of Phosphoinositide 3-Kinase*
M. Dance, A. Montagner, A. Yart, B. Masri +4 more
2006Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Modulation of phosphoinositide 3‐kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling
Christine Pérès, A. Yart, B. Perret, J. Salles +1 more
2003FEBS Letters65 citations Open access
Semantic Scholar
Signal Strength Dictates Phosphoinositide 3-Kinase Contribution to Ras/Extracellular Signal-Regulated Kinase 1 and 2 Activation via Differential Gab1/Shp2 Recruitment: Consequences for Resistance to Epidermal Growth Factor Receptor Inhibition
Carla Sampaio, M. Dance, A. Montagner, T. Edouard +5 more
2007Molecular and Cellular Biology59 citations Open access
Semantic Scholar
LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity
Mylène Tajan, Aurélie Batut, T. Cadoudal, S. Deleruyelle +17 more
2014Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Growth patterns of patients with Noonan syndrome: correlation with age and genotype.
C. Cessans, V. Ehlinger, C. Arnaud, A. Yart +15 more
2016European Journal of Endocrinology53 citations Open access
Semantic Scholar
Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene
Jianming Zhao, A. Yart, S. Frigerio, A. Perren +5 more
2007Oncogene53 citations Open access
Semantic Scholar
How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?
Thomas Edouard, A. Montagner, M. Dance, F. Conte +5 more
2007Cellular and Molecular Life Sciences52 citations Open access
Semantic Scholar
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations
Romain Paccoud, Céline Saint-Laurent, E. Piccolo, Mylène Tajan +29 more
2021Science Translational Medicine42 citations
Semantic Scholar
Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth
Mylène Tajan, J. Pernin-Grandjean, Nicolas Beton, I. Gennero +8 more
2018Human Molecular Genetics41 citations Open access
Semantic Scholar
Novel therapeutic perspectives in Noonan syndrome and RASopathies
Céline Saint-Laurent, Laurène Mazeyrie, A. Yart, Thomas Edouard
2023European Journal of Pediatrics37 citations Open access
Semantic Scholar
A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.
A. Yart, S. Roche, R. Wetzker, M. Laffargue +4 more
2002Journal of Biological Chemistry36 citations
Semantic Scholar
Noonan syndrome: an update on growth and development
A. Yart, T. Edouard
2017Current Opinion in Endocrinology, Diabetes & Obesity33 citations
Semantic Scholar
Catalytic dysregulation of SHP2 leading to Noonan syndromes impacts on platelet signaling and functions.
Marie Bellio, C. Garcia, T. Edouard, S. Voisin +9 more
2019Blood27 citations Open access
Semantic Scholar
Gab1, SHP-2 and other novel regulators of Ras: targets for anticancer drug discovery?
A. Yart, P. Mayeux, P. Raynal
2003Current Cancer Drug Targets27 citations
Semantic Scholar
Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency.
S. Moniez, C. Pienkowski, B. Lepage, S. Hamdi +11 more
2018European Journal of Endocrinology24 citations
Semantic Scholar
Low bone mass in Noonan syndrome children correlates with decreased muscle mass and low IGF-1 levels.
Marine Delagrange, V. Rousseau, C. Cessans, C. Pienkowski +8 more
2021Bone20 citations Open access
Semantic Scholar
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Jean Personnaz, E. Piccolo, A. Dortignac, J. Iacovoni +29 more
2022Science Advances18 citations Open access
Semantic Scholar
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
Céline Saint-Laurent, Laurène Mazeyrie, Mylène Tajan, Romain Paccoud +6 more
2022Biomedicines9 citations Open access
Semantic Scholar
Noonan syndrome causing-SHP2 mutants inhibit IGF-I release via GH-induced ERK1/2 hyper-activation, which contributes to short stature
A. De Rocca Serra-Nédélec, T. Edouard, K. Tréguer, Mylène Tajan +10 more
20123 citations
Semantic Scholar
Gab1/Shp2 Recruitment: Consequences for Resistance to EGFR Inhibition
Carla Sampaio, M. Dance, A. Montagner, T. Edouard +4 more
20073 citations
Semantic Scholar
[Lysophospholipids and cancer: current status and perspectives].
P. Raynal, A. Montagner, M. Dance, A. Yart
2005Pathologie et biologie3 citations
Semantic Scholar
[New molecular mechanisms of growth hormone insensitivity].
T. Edouard, P. Raynal, A. Yart, F. Conte-Auriol +2 more
2008Archives de pédiatrie1 citations
Semantic Scholar
EndoCompass Project: Research Roadmap for Growth Disorders
E. Gevers, Anita C Hokken-Koelega, M. Tauber, Gerhard Binder +17 more
2025Hormone Research in Paediatrics0 citations Open access
Semantic Scholar
Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor
Jean Personnaz, E. Piccolo, A. Dortignac, J. Iacovoni +22 more
2021bioRxiv0 citations Open access
Semantic Scholar
Gonadal Function of Female Patients with Noonan Syndrome
S. Moniez, Y. Capri, C. Pienkowski, B. Lepage +11 more
20190 citations
Semantic Scholar
Noonan Syndrome-Causing SHP2 Mutants Inhibit Murine Growth Plate Chondrogenesis and Bone Development: Role of Ras/MAPK Hyperactivation
A. Yart, Mylène Tajan, F. Capilla, Nicolas Beton +4 more
20150 citations
Semantic Scholar
R39: Impact des mutations de PTPN11 (SHP2) responsables du syndrome LEOPARD sur la signalisation PI3K/Akt/GSK-3beta induite par l’epidermal growth factor (EGF) : implication dans la tumorogenèse ?
A. Nédélec, T. Édouard, J. Combier, Sophie Bel-Vialar +9 more
20100 citations
Semantic Scholar
[Translational studies in children].
Jean-Pierre Salles, Thomas Edouard, J. Gouze, F. Conte-Auriol +5 more
2009Archives de pédiatrie0 citations
Semantic Scholar

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