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R. Cubas · SciRah

Researcher profile · Semantic Scholar

R. Cubas

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R. Cubas — researcher profile on SciRah

h-index: 30
Works: 61
Citations: 10K

Most-cited papers

TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
S. Mariathasan, S. Turley, D. Nickles, A. Castiglioni +38 more
2018Nature4,798 citations Open access
Semantic Scholar
Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
M. Locci, C. Havenar-Daughton, E. Landais, Jennifer E. Wu +9 more
2013Immunity849 citations Open access
Semantic Scholar
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
M. Perreau, A. Savoye, E. de Crignis, J. Corpataux +5 more
2013Journal of Experimental Medicine649 citations Open access
Semantic Scholar
Interpretation of T cell states from single-cell transcriptomics data using reference atlases
M. Andreatta, J. Corria-Osorio, Sören Müller, R. Cubas +2 more
2021Nature Communications475 citations Open access
Semantic Scholar
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer
Soyoung Oh, Dai-Chen Wu, J. Cheung, A. Navarro +14 more
2020Nature Cancer437 citations
Semantic Scholar
Inadequate T follicular cell help impairs B cell immunity during HIV infection
R. Cubas, Joseph C. Mudd, A. Savoye, M. Perreau +13 more
2013Nature Medicine379 citations Open access
Semantic Scholar
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Karl L. Banta, Xiaozheng Xu, Avantika Chitre, A. Au-Yeung +12 more
2022Immunity340 citations Open access
Semantic Scholar
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
R. Cubas, Sheng Zhang, Min Li, C. Chen +1 more
2010Molecular Cancer228 citations Open access
Semantic Scholar
Immune activation alters cellular and humoral responses to yellow fever 17D vaccine.
E. Muyanja, Aloysius Ssemaganda, Pearline Ngauv, R. Cubas +27 more
2014Journal of Clinical Investigation216 citations Open access
Semantic Scholar
Trop2: a possible therapeutic target for late stage epithelial carcinomas.
R. Cubas, Min Li, C. Chen, Q. Yao
2009Biochimica et Biophysica Acta192 citations
Semantic Scholar
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors
Talibah U. Metcalf, R. Cubas, Khader Ghneim, M. Cartwright +11 more
2015Aging Cell176 citations Open access
Semantic Scholar
Anti-PD-L1 Treatment Results in Functional Remodeling of the Macrophage Compartment.
Huizhong Xiong, S. Mittman, Ryan Rodriguez, M. Moskalenko +4 more
2019Cancer Research159 citations Open access
Semantic Scholar
Virus-like particle (VLP) Lymphatic Trafficking and Immune Response Generation after Immunization by Different Routes
R. Cubas, Sheng Zhang, Sunkuk Kwon, E. Sevick-Muraca +3 more
2009Journal of immunotherapy143 citations Open access
Semantic Scholar
Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.
J. van Grevenynghe, R. Cubas, A. Noto, S. DaFonseca +13 more
2011Journal of Clinical Investigation107 citations Open access
Semantic Scholar
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
A. Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni +27 more
2023Nature Communications94 citations Open access
Semantic Scholar
CD96 functions as a co‐stimulatory receptor to enhance CD8+ T cell activation and effector responses
E. Chiang, P. E. Almeida, Denise E. Almeida Nagata, Kristin Bowles +10 more
2020European Journal of Immunology90 citations Open access
Semantic Scholar
Reversible reprogramming of circulating memory Tfh cell function during chronic HIV infection
R. Cubas, J. van Grevenynghe, Saintedym Wills, L. Kardava +23 more
2015Journal of Immunology77 citations Open access
Semantic Scholar
CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1
Xiangnan Du, P. D. de Almeida, Nicholas A. Manieri, D. E. de Almeida Nagata +11 more
2018Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth.
E. Martín-Gayo, Jacqueline Cronin, Taylor L Hickman, Zhengyu Ouyang +12 more
2017JCI Insight54 citations Open access
Semantic Scholar
Chemotherapy Combines Effectively with Anti–PD-L1 Treatment and Can Augment Antitumor Responses
R. Cubas, M. Moskalenko, J. Cheung, Michelle Yang +6 more
2018Journal of Immunology53 citations
Semantic Scholar
Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function
J. Manuzak, T. Hensley-McBain, A. Zevin, C. Miller +10 more
2016Journal of Immunology52 citations Open access
Semantic Scholar
Virus-Like Particle Vaccine Activates Conventional B2 Cells and Promotes B Cell Differentiation to IgG2a Producing Plasma Cells
Sheng Zhang, R. Cubas, Min Li, C. Chen +1 more
2009Molecular Immunology51 citations Open access
Semantic Scholar
Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy
R. Cubas, Zia Khan, Qian Gong, M. Moskalenko +6 more
2020Journal for ImmunoTherapy of Cancer48 citations Open access
Semantic Scholar
Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models
Huizhong Xiong, S. Mittman, Ryan Rodriguez, P. Pacheco-Sanchez +13 more
2019Cancer immunology research48 citations Open access
Semantic Scholar
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yanli Yang, Sherry H. Yeh, Shravan Madireddi, W. Matochko +18 more
2019mAbs44 citations Open access
Semantic Scholar
Chimeric Trop2 Virus-like Particles: A Potential Immunotherapeutic Approach Against Pancreatic Cancer
R. Cubas, Sheng Zhang, Min Li, C. Chen +1 more
2011Journal of immunotherapy41 citations
Semantic Scholar
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
Joseph C. Mudd, P. Murphy, M. Manion, R. Debernardo +16 more
2013Blood37 citations Open access
Semantic Scholar
Mesothelin Virus-Like Particle Immunization Controls Pancreatic Cancer Growth through CD8+ T Cell Induction and Reduction in the Frequency of CD4+foxp3+ICOS− Regulatory T Cells
Sheng Zhang, L. Yong, Dali Li, R. Cubas +2 more
2013PLoS ONE34 citations Open access
Semantic Scholar
Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV
V. Tardif, Roshell Muir, R. Cubas, Marita Chakhtoura +4 more
2019Nature Communications32 citations Open access
Semantic Scholar
Foxo3a: an integrator of immune dysfunction during HIV infection
J. van Grevenynghe, R. Cubas, S. DaFonseca, Talibah U. Metcalf +5 more
2012Cytokine & growth factor reviews30 citations Open access
Semantic Scholar
The dysfunction of T follicular helper cells
R. Cubas, M. Perreau
2014Current Opinion in HIV and AIDS20 citations Open access
Semantic Scholar
Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling
Marita Chakhtoura, Mike Fang, R. Cubas, M. O'Connor +7 more
2021PLoS Pathogens16 citations Open access
Semantic Scholar
Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge
B. Alicke, K. Totpal, J. Schartner, Amy M. Berkley +4 more
2020Journal for ImmunoTherapy of Cancer15 citations Open access
Semantic Scholar
Colorectal cancer: New advances in immunotherapy
R. Cubas, Min Li, C. Chen, Q. Yao
2007Cancer Biology & Therapy14 citations Open access
Semantic Scholar
8O_PRTGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
S. Mariathasan, S. Turley, D. Nickles, A. Castiglioni +15 more
20179 citations Open access
Semantic Scholar
Abstract 2746: Preclinical activity and manufacturing feasibility of genetically modified PDCD-1 knockout (KO) tumor-infiltrating lymphocyte (TIL) cell therapy
A. Natarajan, Anand Veerapathran, A. Wells, Kenneth Onimus +5 more
2022Cancer Research6 citations
Semantic Scholar
Effect of a novel expansion process on tumor-infiltrating lymphocyte (TIL) polyfunctionality, cytotoxicity, and expansion, while preserving cells in a less differentiated and more stem-like phenotype.
A. Yuhas, Joe Dean, Tim Erickson, M. Machin +3 more
2023Journal of Clinical Oncology5 citations Open access
Semantic Scholar
Projecting single-cell transcriptomics data onto a reference T cell atlas to interpret immune responses
M. Andreatta, Jesus Corria-Osorio, Sören Müller, R. Cubas +2 more
2020bioRxiv4 citations Open access
Semantic Scholar
CARBON CONTENTS AND MODELLING OF TOTAL ORGANIC CARBON FOR Pinus taeda L. FROM NATURAL REGENERATION
R. Cubas, Emanuel Arnoni Costa, Viviane Zaniz
20163 citations Open access
Semantic Scholar
ANATOMY AND IDENTIFICATION OF CHARCOAL MARKETED IN THE REGION OF PAPANDUVA, SANTA CATARINA, SOUTHERN BRAZIL.
Franciele Gmach, R. Cubas, Simone Ribeiro Morrone, S. Nisgoski
2023FLORESTA2 citations Open access
Semantic Scholar
Decitabine Treatment of Tumor-Infiltrating Lymphocytes (TIL) during Ex Vivo Expansion Induces a More Memory-like Phenotype, Reduces Inhibitory Receptor Expression, and Increases Functionality
Yongliang Zhang, A. Yuhas, M. Machin, R. Cubas
2022Transplantation and Cellular Therapy2 citations Open access
Semantic Scholar
Adenosine DeAminase (ADA) as an adjuvant molecule for human HIV-1 vaccine
V. Tardif, E. Gary, Roshell Muir, Marita Chakhtoura +4 more
2017Journal of Immunology2 citations
Semantic Scholar
Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis (Journal of Clinical Investigation (2011) 121, 10 (3877-3888) DOI: 10.1172/JCI59211)
J. van Grevenynghe, R. Cubas, A. Noto, S. DaFonseca +13 more
20122 citations Open access
Semantic Scholar
54P AKT inhibition during ex vivo tumor-infiltrating lymphocyte (TIL) expansion enhances cytokine production and function while increasing the population of less differentiated (CD39-CD69-) CD8+ T-cells
R. Cubas, A. Yuhas, M. Machin, Y. Zhang
2021Annals of Oncology1 citations Open access
Semantic Scholar
Abstract 2979: A balance of genomic instability, tumor-immune contexture and TGF-β signaling contributing to exclusion of T cells governs response to PD-L1 checkpoint blockade
S. Mariathasan, S. Turley, D. Nickles, A. Castiglioni +14 more
2018Immunology1 citations
Semantic Scholar
Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[superscript lo] Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth
E. Martín-Gayo, Jacqueline Cronin, Taylor L Hickman, Zhengyu Ouyang +12 more
20171 citations
Semantic Scholar
OpinionResponse to: Letter to the Editor: R. Cubas, M. Li, C. Chen and Q. Yao, Biochim Biophys Acta 1796 (2009) 309–1
R. Cubas, C. Chen, Q. Yao
20101 citations
Semantic Scholar
Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms
Katherine Williams, S. Mittman, Natalie S. Firmino, J. Larrick +22 more
2026bioRxiv0 citations Open access
Semantic Scholar
Abstract A120: Intratumoral dendritic cell dynamics in responsive and nonresponsive syngeneic murine tumor models
Huizhong Xiong, S. Mittman, Ryan Rodriguez, M. Moskalenko +3 more
2019Tackling the Tumor Microenvironment: Beyond T-cells0 citations
Semantic Scholar
Abstract A29: Multimeric anti-human OX40 induces robust immune responses
Shravan Madireddi, Yanli Yang, Sherry H. Yeh, Chen Gu +7 more
2018Checkpoints and Immunomodulation0 citations
Semantic Scholar

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