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T. Paull · SciRah

Researcher profile · Semantic Scholar

T. Paull

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T. Paull — researcher profile on SciRah

h-index: 67
Works: 142
Citations: 19K

Most-cited papers

ATM Activation by Oxidative Stress
Zhi Guo, S. Kozlov, M. Lavin, M. Person +1 more
2010Science1,106 citations Open access
Semantic Scholar
Mechanisms of ATM Activation.
T. Paull
2015Annual Review of Biochemistry459 citations Open access
Semantic Scholar
ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS
Jiang-Wei Zhang, D. Tripathi, Ji Jing, Angela Alexander +11 more
2015Nature Cell Biology420 citations Open access
Semantic Scholar
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
Scott Ditch, T. Paull
2011TIBS -Trends in Biochemical Sciences. Regular ed334 citations Open access
Semantic Scholar
Quantitation of DNA double-strand break resection intermediates in human cells
Yi Zhou, P. Caron, G. Legube, T. Paull
2013Nucleic Acids Research267 citations Open access
Semantic Scholar
Cellular functions of the protein kinase ATM and their relevance to human disease
Ji-Hoon Lee, T. Paull
2021Nature reviews. Molecular cell biology261 citations
Semantic Scholar
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
E. Shim, W. Chung, Matthew L. Nicolette, Yu Zhang +5 more
2010EMBO Journal248 citations Open access
Semantic Scholar
Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks
Matthew L. Nicolette, Kihoon Lee, Zhi Guo, M. Rani +3 more
2010Nature Structural &Molecular Biology238 citations Open access
Semantic Scholar
ATM activation in the presence of oxidative stress
Zhi Guo, R. Deshpande, T. Paull
2010Cell Cycle197 citations Open access
Semantic Scholar
Catalytic and non-catalytic roles of the CtIP endonuclease in double-strand break end resection
N. Makharashvili, Anthony T. Tubbs, Soo-Hyun Yang, Hai-Long Wang +8 more
2014Molecules and Cells178 citations Open access
Semantic Scholar
Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
Logan R. Myler, Ignacio F. Gallardo, M. Soniat, R. Deshpande +4 more
2017Molecules and Cells176 citations Open access
Semantic Scholar
Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
Hòa Ngọc Nguyễn, Tsubasa Shimizu, Zhong-Wei Zhou, Zhao-Qi Wang +8 more
2016Molecules and Cells164 citations
Semantic Scholar
Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.
R. Deshpande, Ji-Hoon Lee, S. Arora, T. Paull
2016Molecules and Cells156 citations Open access
Semantic Scholar
Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway*
J. Della-Maria, Yi Zhou, Miaw-Sheue Tsai, Jeff Kuhnlein +3 more
2011Journal of Biological Chemistry154 citations Open access
Semantic Scholar
ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
R. Deshpande, G. J. Williams, Oliver Limbo, R. S. Williams +7 more
2014EMBO Journal144 citations Open access
Semantic Scholar
53BP1 promotes ATM activity through direct interactions with the MRN complex
Ji-Hoon Lee, A. Goodarzi, P. Jeggo, T. Paull
2010EMBO Journal135 citations Open access
Semantic Scholar
20 Years of Mre11 Biology: No End in Sight.
T. Paull
2018Molecules and Cells132 citations Open access
Semantic Scholar
Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM
Yi Zhou, Ji-Hoon Lee, Wen-Xia Jiang, J. Crowe +2 more
2016Molecules and Cells125 citations Open access
Semantic Scholar
DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
R. Deshpande, Logan R. Myler, M. Soniat, N. Makharashvili +4 more
2018Science Advances124 citations Open access
Semantic Scholar
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
Jae Jin Kim, S. Lee, Fade Gong, A. Battenhouse +9 more
2019Genes & Development120 citations Open access
Semantic Scholar
Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
Ji-Hoon Lee, Michael R. Mand, R. Deshpande, Eri Kinoshita +3 more
2013Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Loss of ATM kinase activity leads to embryonic lethality in mice
J. A. Daniel, Manuela Pellegrini, Baeck-seung Lee, Zhi Guo +7 more
2012Journal of Cell Biology110 citations Open access
Semantic Scholar
ATM directs DNA damage responses and proteostasis via genetically separable pathways
Ji-Hoon Lee, Michael R. Mand, C. Kao, Yi Zhou +4 more
2018Science Signaling104 citations Open access
Semantic Scholar
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia +7 more
2019Nature Communications101 citations Open access
Semantic Scholar
CtIP: A DNA damage response protein at the intersection of DNA metabolism.
N. Makharashvili, T. Paull
2015DNA Repair100 citations
Semantic Scholar
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1
Olivia Barton, S. Naumann, Ronja Diemer-Biehs, Julia Künzel +10 more
2014Journal of Cell Biology100 citations Open access
Semantic Scholar
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Yichong Zhang, Ji-Hoon Lee, T. Paull, S. Gehrke +7 more
2018Science Signaling97 citations Open access
Semantic Scholar
MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining
Putzer J. Hung, Britney Johnson, Bo-Ruei Chen, Andrea K. Byrum +17 more
2018Molecules and Cells96 citations Open access
Semantic Scholar
Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
Logan R. Myler, Ignacio F. Gallardo, Yi Zhou, Fade Gong +5 more
2016Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.
Begoña Cánovas, Ana Igea, A. Sartori, R. Gomis +7 more
2018Cancer Cell91 citations Open access
Semantic Scholar
The SOSS1 single‐stranded DNA binding complex promotes DNA end resection in concert with Exo1
Soo-Hyun Yang, Ruo-Bo Zhou, Judy L. Campbell, Jun-Jie Chen +2 more
2012EMBO Journal87 citations Open access
Semantic Scholar
Making the Best of the Loose Ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection
T. Paull
2010DNA Repair82 citations Open access
Semantic Scholar
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair
Justin W. C. Leung, N. Makharashvili, Poonam Agarwal, Li-Ya Chiu +8 more
2017Genes & Development81 citations Open access
Semantic Scholar
ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control*
M. Gatei, B. Jakob, Philip C. Chen, A. Kijas +13 more
2011Journal of Biological Chemistry78 citations Open access
Semantic Scholar
RPA phosphorylation inhibits DNA resection
M. Soniat, Logan R. Myler, Hung-Che Kuo, T. Paull +1 more
2019Molecules and Cells77 citations Open access
Semantic Scholar
EXD2 promotes homologous recombination by facilitating DNA-end resection
R. Broderick, J. Nieminuszczy, H. T. Baddock, R. Deshpande +4 more
2016Nature Cell Biology74 citations Open access
Semantic Scholar
Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
S. Ryu, R. Stewart, D. Chase Pectol, N. Ender +7 more
2020PLoS Biology71 citations Open access
Semantic Scholar
Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species
Ji-Hoon Lee, T. Paull
2020Redox Biology68 citations Open access
Semantic Scholar
Sae2/CtIP prevents R-loop accumulation in eukaryotic cells
N. Makharashvili, S. Arora, Yizhi Yin, Qiong Fu +6 more
2018bioRxiv68 citations Open access
Semantic Scholar
DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM)*
Yi Zhou, T. Paull
2013Journal of Biological Chemistry65 citations Open access
Semantic Scholar
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma
Xiangyu Zeng, Fei Zhao, G. Cui, Yong Zhang +28 more
2022Nature Cancer62 citations Open access
Semantic Scholar
Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET
B. Cannon, Jeff Kuhnlein, Soo-Hyun Yang, Anita Cheng +4 more
2013Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1.
Wen-Ling Lin, Jung-Kuei Chen, Xuemei Wen, Wei He +5 more
2022Cell Reports53 citations Open access
Semantic Scholar
Homology-directed repair protects the replicating genome from metabolic assaults.
Kumar Somyajit, Julian Spies, F. Coscia, Ufuk Kirik +8 more
2021Developmental Cell52 citations Open access
Semantic Scholar
Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress
C. Cirotti, S. Rizza, Paola Giglio, N. Poerio +12 more
2020EMBO Reports51 citations Open access
Semantic Scholar
Functional Activation of ATM by the Prostate Cancer Suppressor NKX3.1
Bo-Wen Cai, J. Ju, Ji-Hoon Lee, T. Paull +1 more
2013Cell Reports45 citations Open access
Semantic Scholar
Phosphorylation-Regulated Transitions in an Oligomeric State Control the Activity of the Sae2 DNA Repair Enzyme
Qiong Fu, Julia Chow, Kara A. Bernstein, N. Makharashvili +5 more
2013Molecular and Cellular Biology45 citations Open access
Semantic Scholar
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency
Ji-Hoon Lee, S. Ryu, N. Ender, T. Paull
2020bioRxiv44 citations Open access
Semantic Scholar
The Mre11/Rad50/Nbs1 Complex: recent insights into catalytic activities and ATP-driven conformational changes
T. Paull, R. Deshpande
2014Experimental Cell Research43 citations Open access
Semantic Scholar
BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination
Hòa Ngọc Nguyễn, Junya Kobayashi, Masato Omura, Mayumi Hirakawa +5 more
2015PLoS ONE41 citations Open access
Semantic Scholar

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