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P. Edwards · SciRah

Researcher profile · Semantic Scholar

P. Edwards

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P. Edwards — researcher profile on SciRah

h-index: 14
Works: 55
Citations: 2,218

Most-cited papers

Assessing atropisomer axial chirality in drug discovery and development.
S. LaPlante, L. Fader, K. Fandrick, Daniel R Fandrick +4 more
2011Journal of Medicinal Chemistry595 citations
Semantic Scholar
The challenge of atropisomerism in drug discovery.
J. Clayden, W. Moran, P. Edwards, S. LaPlante
2009Angewandte Chemie581 citations
Semantic Scholar
Revealing Atropisomer Axial Chirality in Drug Discovery
S. LaPlante, P. Edwards, L. Fader, A. Jakalian +1 more
2011ChemMedChem396 citations
Semantic Scholar
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
L. Fader, É. Malenfant, M. Parisien, R. Carson +31 more
2014ACS Medicinal Chemistry Letters167 citations Open access
Semantic Scholar
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
C. Fenwick, M. Amad, M. Bailey, R. Bethell +23 more
2014Antimicrobial Agents and Chemotherapy92 citations Open access
Semantic Scholar
The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.
S. Nordhoff, Silvia Cerezo-Gálvez, A. Feurer, O. Hill +5 more
2006Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Development of Specific “Drug‐Like Property” Rules for Carboxylate‐Containing Oral Drug Candidates
A. Böcker, P. Bonneau, O. Hucke, A. Jakalian +1 more
2010ChemMedChem32 citations
Semantic Scholar
Managing the liabilities arising from structural alerts: a safe philosophy for medicinal chemists.
P. Edwards, C. Sturino
2011Current Medicinal Chemistry31 citations
Semantic Scholar
Dispiroketals: a new functional group for organic synthesis
S. Ley, Robert Downham, P. Edwards, J. E. Innes +1 more
199630 citations
Semantic Scholar
The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.
S. Nordhoff, S. Bulat, Silvia Cerezo-Gálvez, O. Hill +8 more
2009Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Synthesis of (+/-)-secosyrin 1 and a formal synthesis of (-)-secosyrin 1.
T. Donohoe, John Fisher, P. Edwards
2004Organic Letters20 citations
Semantic Scholar
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Robert Downham, P. Edwards, D. Entwistle, A. Hughes +2 more
199519 citations
Semantic Scholar
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
M. Andrews, J. Clase, Grégory L J Bar, Giovanni Tricarico +13 more
2012Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
HTS Promiscuity Analyses for Accelerating Decision Making
A. Böcker, P. Bonneau, P. Edwards
2011Journal of biomolecular screening15 citations Open access
Semantic Scholar
Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.
S. Nordhoff, Silvia Cerezo-Gálvez, Holger Deppe, O. Hill +6 more
2009Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Reactions of cyclic β-keto esters and other enol derivatives with 3-acetoxyamino-2-isopropylquinazolin-4(3H)-one: further oxidation of the cyclic α-(3,4-dihydro-2-isopropyl-4-oxoquinazolin-3-yl)amino ketones with lead tetraacetate leading to ring-expansion (in dichloromethane) and ring-cleavage (in
R. S. Atkinson, E. Barker, P. Edwards, G. A. Thomson
199514 citations
Semantic Scholar
Dispiroketals in synthesis. Part 23.1 A newroute to (+)-D-conduritol B frommyo-inositol
J. E. Innes, P. Edwards, S. Ley
199713 citations
Semantic Scholar
Dispiroketals in synthesis (Part 11): Concomitant enantioselective and regioselective protection of 2,5- dibenzoyl-myo-inositol
P. Edwards, D. Entwistle, C. Genicot, K. Kim +1 more
199413 citations
Semantic Scholar
The N–N bond as a chiral axis: 3-diacylaminoquinazolinones as chiral acylating agents
R. S. Atkinson, E. Barker, P. Edwards, G. A. Thomson
199611 citations
Semantic Scholar
Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates.
P. Edwards, D. Entwistle, C. Genicot, S. Ley +1 more
199411 citations
Semantic Scholar
Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors.
Martin R. Tremblay, R. Bethell, M. Cordingley, Patrick DeRoy +19 more
2013Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Nucleotide competing reverse transcriptase inhibitors: discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Clint James, Patrick DeRoy, M. du Plessis, P. Edwards +15 more
2013Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.
S. Nordhoff, Meritxell López-Canet, Barbara Hoffmann-Enger, S. Bulat +8 more
2009Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Value networks identify innovation in 21st century pharmaceutical research.
P. Edwards
2009Drug Discovery Today9 citations
Semantic Scholar
Dispiroketals in synthesis (part 9): Resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran.
P. Edwards, D. Entwistle, S. Ley, D. Owen +1 more
19948 citations
Semantic Scholar
Current parallel chemistry principles and practice: application to the discovery of biologically active molecules.
P. Edwards
2009Current opinion in drug discovery & development7 citations
Semantic Scholar
Asymmetric induction mediated by an N–N chiral axis
R. S. Atkinson, P. Edwards, G. A. Thomson
19927 citations
Semantic Scholar
Expediting drug discovery: recent advances in fast medicinal chemistry--optimization of hits and leads.
P. Edwards, B. Allart, M. Andrews, J. Clase +1 more
2006Current opinion in drug discovery & development6 citations
Semantic Scholar
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
C. Sturino, Y. Bousquet, Clint James, Patrick DeRoy +18 more
2013Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Cover Picture: Revealing Atropisomer Axial Chirality in Drug Discovery (ChemMedChem 3/2011)
S. LaPlante, P. Edwards, L. Fader, A. Jakalian +1 more
20114 citations
Semantic Scholar
Peptides as Leads for Drug Discovery
P. Edwards, S. LaPlante
20114 citations
Semantic Scholar
Dispiroketals in Synthesis. Part 19. Dispiroketals as Enantioselective and Regioselective Protective Agents for Symmetric Cyclic and Acyclic Polyols.
Robert Downham, P. Edwards, D. Entwistle, A. Hughes +2 more
19964 citations
Semantic Scholar
Reaction of 3-(acetoxyamino)quinazolin-4(3H)-ones with enolic β-diketones: the N–N bond as a chiral axis in N-(3,4-dihydro-4-oxoquinazolin-3-yl)-N-acyl-α-aminoketones; reductive and base-catalysed cleavage of the N–N bond in N-acetyl-N-(3,4-dihydro-4-oxoquinazolin-3-yl)-α-amino acid esters
R. S. Atkinson, P. Edwards, G. A. Thomson
19944 citations
Semantic Scholar
Dispiroketals in Synthesis (Part 18)1: Regioselective and Enantioselective Protection of Symmetric Polyol Substrates Using an Enantiopure (2S,2’S)-Dimethyl-bis-dihydropyran
P. Edwards, S. Ley
19953 citations
Semantic Scholar
The impact of parallel chemistry in drug discovery.
P. Edwards
2006IDrugs : the investigational drugs journal2 citations
Semantic Scholar
N-(3,4-dihydro-4-oxoquinazolin-3-yl)pyridmium imides: aziridinating agents for alkenes: measurement of rotational barriers around each N–N bond in an N–N–N system
R. S. Atkinson, E. Barker, P. Edwards, G. A. Thomson
19952 citations
Semantic Scholar
Preparation of cyclic α-(3,4-dihydro-2-isopropyl-4-oxoquinazolin-3-yl)amino-β-ketoesters: Further oxidation with lead tetra-acetate in dichloromethane and in methanol leading to ring-expansion and ring-cleavage products, respectively
R. S. Atkinson, E. Barker, P. Edwards, G. A. Thomson
19942 citations
Semantic Scholar
CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms The vascular Ca -sensing receptor regulates blood vessel tone and blood pressure
M. Schepelmann, P. Yarova, I. Lopez-Fernandez, T. Davies +16 more
20150 citations
Semantic Scholar
1 Peptides as Leads for Drug Discovery
P. Edwards, S. LaPlante
20110 citations
Semantic Scholar
Part I The Academia – Market Bouncing of Peptide Drugs – Challenges and Strategies in Translational Research with Peptide Drugs
P. Edwards, S. LaPlante
20110 citations
Semantic Scholar
Dispiroketals in Synthesis. Part 23. A New Route to (+)-D-Conduritol B from myo-Inositol.
J. E. Innes, P. Edwards, S. Ley
20100 citations
Semantic Scholar
The Challenge of Atropisomerism in Drug Discovery
J. Clayden, W. Moran, P. Edwards, S. LaPlante
20090 citations
Semantic Scholar
Replication inhibitors of human immunodeficiency virus
Y. Tsantrizos, M. Bailey, P. Bhardwaj, Christian Brochu +7 more
20080 citations
Semantic Scholar
Triazolopyrazinforbindelser which can be used for the treatment of degenerative and inflammatory diseases
M. Andrews, P. Edwards, M. Chambers, W. Schmidt +4 more
20070 citations
Semantic Scholar
Triazolopyrazinverbindungen for treatment of degenerative and inflammatory diseases
A. Burritt, P. Edwards, W. Schmidt, V. Birault +4 more
20070 citations
Semantic Scholar
Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor
S. Nordhoff, S. Cerezo-Galvez, Holger Deppe, O. Hill +6 more
20060 citations
Semantic Scholar
Crystal Structure Of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Tetrahydroisoquinoline Inhibitor
S. Nordhoff, Silvia Cerezo-Gálvez, A. Feurer, O. Hill +5 more
20060 citations
Semantic Scholar
Crystal Structure Of Porcine Dipeptidyl Peptidase IV (Cd26) in Complex With a Low Molecular Weight Inhibitor.
S. Nordhoff, S. Cerezo-Galvez, A. Feurer, O. Hill +5 more
20060 citations
Semantic Scholar
Synthesis of (.+-.)-Secosyrin 1 and a Formal Synthesis of (-)-Secosyrin 1
T. Donohoe, John Fisher, P. Edwards
20040 citations
Semantic Scholar
Dispiroketals in Synthesis. Part 11. Concomitant Enantioselective and Regioselective Protection of 2,5-Dibenzoyl-myo-inositol.
P. Edwards, D. Entwistle, C. Genicot, K. Kim +1 more
19950 citations
Semantic Scholar

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