L. Wong

Most-cited papers

1. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models.

   K. Hoeflich, Daniel C. Gray, M. Eby, Janet Y. Tien +9 more

   2006Cancer Research232 citations Open access

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2. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

   C. Lee, L. Wong, E. Tse, He Liu +5 more

   2012Cancer Research225 citations Open access

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3. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

   K. Hoeflich, S. Herter, Janet Y. Tien, L. Wong +11 more

   2009Cancer Research178 citations

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4. IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-κB Activation

   L. Wong, I. P. Lam, T. Wong, Wai-Lung Lai +3 more

   2013PLoS ONE48 citations Open access

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5. Pharmacodynamics of 2-{4-[(1E)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a Potent and Selective B-Raf Kinase Inhibitor: Understanding Relationships between Systemic Concentrations, Phosphorylated Mitogen-Activated Protein Kinase Kinase 1 Inh

   H. Wong, M. Belvin, S. Herter, K. Hoeflich +3 more

   2009Journal of Pharmacology and Experimental Therapeutics47 citations

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6. PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis.

   Hai-Tao Xu, Wai-Lung Lai, He Liu, L. Wong +2 more

   2016Cancer Research41 citations

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7. The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities

   Mei Y. Choi, Ying Wang, L. Wong, B. Lu +4 more

   2012PLoS ONE41 citations Open access

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8. The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation.

   C. K. Lee, Wai-Hung Sit, S. Fan, K. Man +5 more

   2010International Journal of Oncology34 citations Open access

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9. Research Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells

   J. Wan, Wai-Hung Sit, Xiao-Tong Yang, P. Jiang +1 more

   201021 citations

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10. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity

    L. Wong, S. Fan, K. Man, Wai-Hung Sit +6 more

    2011Human and Experimental Toxicology18 citations

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11. The centrosomal protein tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin‐dependent kinase 2

    Wai-Lung Lai, W. Hung, L. Wong, Yuan Zhou +5 more

    2012Hepatology14 citations Open access

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12. Pharmacodynamics of 2-{ 4-[ ( 1 E )-1-( Hydroxyimino )-2 , 3-dihydro-1 H-inden-5-yl ]-3-( pyridine-4-yl )-1 H-pyrazol-1-yl } ethan-1-ol ( GDC-0879 ) , a Potent and Selective B-Raf Kinase Inhibitor : Understanding Relationships between Systemic Concentrations , Phosphorylated Mitogen-Activated Protei

    H. Wong, M. Belvin, S. Herter, K. Hoeflich +3 more

    200911 citations

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13. Pharmacodynamics of GDC-0879, a Potent and Selective B-Raf Kinase Inhibitor: Understanding Relationships between Systemic Concentrations, pMEK1 Inhibition, and Efficacy

    H. Wong, M. Belvin, S. Herter, K. Hoeflich +3 more

    20092 citations

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14. Title Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin ( CPT ) on human leukemia HL-60 cells

    J. Wan, Wai-Hung Sit, Xiao-Tong Yang, P. Jiang +1 more

    20100 citations

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15. Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAF V600E Mutational Status and Sustained Extracellular

    K. Hoeflich, S. Herter, Janet Y. Tien, L. Wong +10 more

    20090 citations

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