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J. Lysaght · SciRah

Researcher profile · Semantic Scholar

J. Lysaght

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J. Lysaght — researcher profile on SciRah

h-index: 32
Works: 164
Citations: 4,449

Most-cited papers

Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity.
N. Donlon, R. Power, C. Hayes, J. Reynolds +1 more
2021Cancer Letters181 citations Open access
Semantic Scholar
High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via IL8 and Alterations to the Gut Microbiome
N. Münch, H. Fang, Jonas Ingermann, H. C. Maurer +27 more
2019Gastroenterology131 citations Open access
Semantic Scholar
Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments
J. O'Sullivan, J. Lysaght, C. Donohoe, J. Reynolds
2018Nature reviews: Gastroenterology & hepatology127 citations
Semantic Scholar
Cooperation between chemotherapy and immunotherapy in gastroesophageal cancers.
M. Davern, J. Lysaght
2020Cancer Letters74 citations Open access
Semantic Scholar
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines
G. Hannon, J. Lysaght, N. Liptrott, A. Prina-Mello
2019Advancement of science68 citations Open access
Semantic Scholar
CX3CL1 Signaling in the Tumor Microenvironment.
M. Conroy, J. Lysaght
2020Advances in Experimental Medicine and Biology66 citations
Semantic Scholar
The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy.
B. Moran, M. Davern, J. Reynolds, N. Donlon +1 more
2023Cancer Letters53 citations Open access
Semantic Scholar
Complement in Tumourigenesis and the Response to Cancer Therapy
Rebecca M. O'Brien, Aoife Cannon, J. Reynolds, J. Lysaght +1 more
2021Cancers42 citations Open access
Semantic Scholar
The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies
J. Lysaght, M. Conroy
2024Nature Reviews Endocrinology37 citations
Semantic Scholar
Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients
M. Conroy, S. Maher, A. Melo, S. Doyle +4 more
2018Frontiers in Immunology36 citations Open access
Semantic Scholar
Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy
M. Davern, N. Donlon, F. O'Connell, Caoimhe Gaughan +15 more
2022Journal of Cancer Research and Clinical Oncology32 citations Open access
Semantic Scholar
Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
M. Davern, N. Donlon, F. O'Connell, Caoimhe Gaughan +14 more
2022Cancer Immunology and Immunotherapy26 citations Open access
Semantic Scholar
Examining the evidence for immune checkpoint therapy in high-grade serous ovarian cancer
A. Connor, P. M. Lyons, A. Kilgallon, J. C. Simpson +2 more
2024Heliyon23 citations Open access
Semantic Scholar
Differential Effects of Dietary versus Exercise Intervention on Intrahepatic MAIT Cells and Histological Features of NAFLD
S. Naimimohasses, P. O'Gorman, C. Wright, Deirdre Ni Fhloinn +12 more
2022Nutrients21 citations Open access
Semantic Scholar
The ‘obesity paradox’ in action with cancer immunotherapy
J. Lysaght
2019Nature Reviews Endocrinology21 citations
Semantic Scholar
A Study of the Immune Infiltrate and Patient Outcomes in Esophageal Cancer.
M. Conroy, S. Kennedy, S. Doyle, B. Hayes +6 more
2020Carcinogenesis20 citations Open access
Semantic Scholar
Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma
M. Kavanagh, M. Conroy, N. Clarke, N. Gilmartin +7 more
2019Cancer Microenvironment20 citations Open access
Semantic Scholar
An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline.
J. Royds, M. Conroy, M. Dunne, C. McCrory +1 more
2019European Neuropsychopharmacology18 citations
Semantic Scholar
Complement is increased in treatment resistant rectal cancer and modulates radioresistance.
Rebecca M. O'Brien, S. Meltzer, C. E. Buckley, A. Heeran +18 more
2024Cancer Letters17 citations Open access
Semantic Scholar
Natural killer cell therapy: A new frontier for obesity-associated cancer.
E. Mylod, J. Lysaght, M. Conroy
2022Cancer Letters17 citations Open access
Semantic Scholar
C-Reactive Protein and C-Reactive Protein-Based Scores to Predict Survival in Esophageal and Junctional Adenocarcinoma: Systematic Review and Meta-Analysis
C. Lorton, Larissa Higgins, N. O'Donoghue, C. Donohoe +5 more
2021Annals of Surgical Oncology17 citations
Semantic Scholar
Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study.
J. Royds, M. Conroy, M. Dunne, H. Cassidy +3 more
2020Journal of Neuroimmunology17 citations Open access
Semantic Scholar
Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells
M. Davern, N. Donlon, A. Sheppard, F. Connell +9 more
2021Translational Oncology16 citations Open access
Semantic Scholar
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma—An Emerging Role for Chemokines
N. Donlon, A. Sheppard, M. Davern, F. O'Connell +15 more
2020Cancers15 citations Open access
Semantic Scholar
Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: A randomised, triple-blinded, controlled trial.
D. Moore, D. Galvin, M. Conroy, Basabjit Das +3 more
2020Journal of Neuroimmunology15 citations
Semantic Scholar
Novel thioglycoside analogs of &agr;-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
A. Melo, Lei Zhang, É. Dockry, A. Petrasca +9 more
2018Glycobiology15 citations Open access
Semantic Scholar
The Immune Response to Major Gastrointestinal Cancer Surgery and Potential Implications for Adjuvant Immunotherapy.
N. Donlon, M. Davern, C. Hayes, R. Power +4 more
2022Critical reviews in oncology/hematology14 citations
Semantic Scholar
The Impact of Esophageal Oncological Surgery on Perioperative Immune Function; Implications for Adjuvant Immune Checkpoint Inhibition
N. Donlon, M. Davern, A. Sheppard, F. O'Connell +15 more
2022Frontiers in Immunology14 citations Open access
Semantic Scholar
The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation
M. Morrissey, R. Byrne, C. Nulty, N. Mccabe +13 more
2020BMC Cancer14 citations Open access
Semantic Scholar
Radiation and Immunotherapy in Upper Gastrointestinal Cancers: The Current State of Play
N. Donlon, R. Power, C. Hayes, M. Davern +2 more
2021International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma
A. Mongan, N. Lynam-Lennon, S. Doyle, R. Casey +8 more
2019International Journal of Medical Sciences13 citations Open access
Semantic Scholar
Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma.
A. Melo, E. Mylod, Vivienne Fitzgerald, N. Donlon +8 more
2021Clinical Immunology12 citations Open access
Semantic Scholar
PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma
M. Davern, Rebecca M. O' Brien, Jason McGrath, N. Donlon +7 more
2022Scientific Reports11 citations Open access
Semantic Scholar
Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1+CD27− NK Cells in Obesity-Associated Cancer
E. Mylod, A. Melo, N. Donlon, M. Davern +4 more
2021Journal of Immunology11 citations Open access
Semantic Scholar
pSTAT3 Levels Have Divergent Expression Patterns and Associations with Survival in Squamous Cell Carcinoma and Adenocarcinoma of the Oesophagus
K. O. O' Sullivan, A. J. Michielsen, E. O'Regan, M. Cathcart +6 more
2018International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
A. Buckley, M. Dunne, M. Morrissey, S. Kennedy +11 more
2020Scientific Reports10 citations Open access
Semantic Scholar
Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells
M. Davern, Dara Bracken-Clarke, N. Donlon, A. Sheppard +15 more
2023Journal of Cancer Research and Clinical Oncology9 citations Open access
Semantic Scholar
CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies
A. Melo, M. Conroy, E. Foley, É. Dockry +4 more
2020Cancer Immunology and Immunotherapy9 citations Open access
Semantic Scholar
PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma
M. Davern, Caoimhe Gaughan, F. O'Connell, B. Moran +20 more
2023Frontiers in Immunology7 citations Open access
Semantic Scholar
PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours
M. Davern, M. Fitzgerald, C. E. Buckley, A. Heeran +12 more
2022Translational Oncology7 citations Open access
Semantic Scholar
The Omentum in Obesity-Associated Cancer: A Hindrance to Effective Natural Killer Cell Migration towards Tumour Which Can Be Overcome by CX3CR1 Antagonism
E. Mylod, F. O'Connell, N. Donlon, Christine Butler +3 more
2021Cancers7 citations Open access
Semantic Scholar
Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma
M. Davern, Cillian O' Donovan, N. Donlon, E. Mylod +10 more
2024Biomedicines6 citations Open access
Semantic Scholar
Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid
J. Royds, H. Cassidy, M. Conroy, M. Dunne +2 more
2020Brain, Behavior, & Immunity - Health6 citations Open access
Semantic Scholar
Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma
M. Davern, N. Donlon, F. O'Connell, A. Sheppard +13 more
2022Translational Oncology5 citations Open access
Semantic Scholar
Chemokine-targeted therapies: An opportunity to remodel immune profiles in gastro-oesophageal tumours.
Cillian O' Donovan, M. Davern, N. Donlon, J. Lysaght +1 more
2021Cancer Letters5 citations Open access
Semantic Scholar
The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling
N. Donlon, M. Davern, A. Sheppard, R. Power +12 more
2021Cancers5 citations Open access
Semantic Scholar
High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via IL8 and Alterations to the Gut Microbiome
N. Münch, H. Fang, Jonas Ingermann, H. C. Maurer +30 more
20195 citations
Semantic Scholar
Real-time ex vivo monitoring of NK cell migration toward obesity-associated oesophageal adenocarcinoma following modulation of CX3CR1
E. Mylod, F. O'Connell, N. Donlon, M. Davern +5 more
2024Scientific Reports4 citations Open access
Semantic Scholar
Involving patients in healthcare research is well documented but can it work in lab-based research?
A. Connor, Claire Hughes, Lea Schäfer, L. McNally +8 more
2023Research Involvement and Engagement4 citations Open access
Semantic Scholar
An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study
J. Royds, H. Cassidy, M. Conroy, M. Dunne +3 more
2020Journal of Neuroimmune Pharmacology4 citations
Semantic Scholar

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