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M. Freeman · SciRah

Researcher profile · Semantic Scholar

M. Freeman

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M. Freeman — researcher profile on SciRah

h-index: 17
Works: 42
Citations: 1,250

Most-cited papers

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
M. Freeman, C. Gurgui, M. Helf, B. I. Morinaka +5 more
2012Science310 citations
Semantic Scholar
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.
M. Freeman, M. Helf, Agneya Bhushan, B. I. Morinaka +1 more
2017Nature Chemistry111 citations
Semantic Scholar
Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products.
B. I. Morinaka, A. Vagstad, M. Helf, M. Gugger +4 more
2014Angewandte Chemie110 citations
Semantic Scholar
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products.
Niels S. J. Van der Velden, N. Kalin, M. Helf, J. Piel +2 more
2017Nature Chemical Biology109 citations Open access
Semantic Scholar
A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli
M. Rust, Eric J. N. Helfrich, M. Freeman, Pakjira Nanudorn +8 more
2020Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Genome mining- and synthetic biology-enabled production of hypermodified peptides
Agneya Bhushan, P. Egli, Eike E Peters, M. Freeman +1 more
2019Nature Chemistry64 citations Open access
Semantic Scholar
Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria.
M. Freeman, A. Vagstad, J. Piel
2016Current Opinion in Chemical Biology59 citations
Semantic Scholar
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds
Haigang Song, Niels S. J. Van der Velden, Sally L Shiran, Patrick Bleiziffer +9 more
2018Science Advances52 citations Open access
Semantic Scholar
Distinct Autocatalytic α- N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products.
M. Quijano, C. Zach, F. S. Miller, Aileen R. Lee +3 more
2019Journal of the American Chemical Society46 citations Open access
Semantic Scholar
Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics
Micah J. Bodner, Ryan M. Phelan, M. Freeman, Rong-Feng Li +1 more
2010Journal of the American Chemical Society38 citations Open access
Semantic Scholar
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis
M. Freeman, Kristos A. Moshos, Micah J. Bodner, Rong-Feng Li +1 more
2008Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis
F. S. Miller, K. Crone, M. Jensen, S. Shaw +3 more
2021Nature Communications34 citations Open access
Semantic Scholar
An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.
B. I. Morinaka, Marjan Verest, M. Freeman, M. Gugger +1 more
2017Angewandte Chemie33 citations
Semantic Scholar
Dissection of the Stepwise Mechanism to β-Lactam Formation and Elucidation of a Rate-determining Conformational Change in β-Lactam Synthetase*
Mary L. Raber, M. Freeman, C. Townsend
2009Journal of Biological Chemistry31 citations Open access
Semantic Scholar
The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules.
Tobias A. M. Gulder, M. Freeman, J. Piel
2011Topics in current chemistry28 citations
Semantic Scholar
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement
A. R. Buller, M. Freeman, N. Wright, J. Schildbach +1 more
2012Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.
Xiao-Feng Cai, R. Teta, Christoph Kohlhaas, M. Crüsemann +4 more
2013Chemistry and Biology23 citations Open access
Semantic Scholar
Diverse Protein Architectures and α-N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters
Aman S. Imani, Aileen R. Lee, N. Vishwanathan, Floris de Waal +1 more
2021bioRxiv16 citations Open access
Semantic Scholar
Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis
A. R. Buller, Jason W. Labonte, M. Freeman, N. Wright +2 more
2012Journal of Molecular Biology13 citations Open access
Semantic Scholar
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis
M. Helf, M. Freeman, J. Piel
2019Journal of Industrial Microbiology & Biotechnology11 citations Open access
Semantic Scholar
TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes
Vinod K. Gupta, Utpal Bakshi, Daniel Chang, Aileen R. Lee +5 more
2021bioRxiv9 citations Open access
Semantic Scholar
Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression.
M. Freeman
2018Methods in Enzymology5 citations
Semantic Scholar
Clinical characteristics of patients with an abnormal clomiphene citrate challenge test.
Ana B. Tobar Hicks, M. Fox, L. Sanchez-Ramos, A. Kaunitz +1 more
2003American Journal of Obstetrics and Gynecology4 citations
Semantic Scholar
Enzyme-mediated backbone N-methylation in ribosomally encoded peptides.
Emmanuel Matabaro, Haigang Song, Clara Chepkirui, Hannelore Kaspar +4 more
2021Methods in Enzymology2 citations Open access
Semantic Scholar
Structure and Biosynthesis of Proteusin RiPP Natural Products
M. Jensen, M. Freeman
20202 citations
Semantic Scholar
Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT
A. R. Buller, M. Freeman, J. Schildbach, C. Townsend
2014Biochemistry2 citations Open access
Semantic Scholar
Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics
Jason W. Labonte, F. Kudo, M. Freeman, Mary L. Raber +1 more
2012MedChemComm2 citations Open access
Semantic Scholar
RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product
K. Crone, Takahiro Jomori, F. S. Miller, J. Gralnick +2 more
2023RSC Chemical Biology1 citations Open access
Semantic Scholar
Structure of the alpha-N-methyltransferase (SonM mutant R67A) and RiPP precursor (SonA) heteromeric complex (with SAH)
F. S. Miller, K. Crone, M. R. Jensen, S. Shaw +3 more
20210 citations
Semantic Scholar
Structure of the alpha-N-methyltransferase (SonM mutant Y93F) and RiPP precursor (SonA) heteromeric complex (no cofactor)
F. S. Miller, K. Crone, M. R. Jensen, S. Shaw +3 more
20210 citations
Semantic Scholar
Structure of the alpha-N-methyltransferase (SonM mutant Y58F) and RiPP precursor (SonA) heteromeric complex (no cofactor)
F. S. Miller, K. Crone, M. R. Jensen, S. Shaw +3 more
20210 citations
Semantic Scholar
Structure of the alpha-N-methyltransferase (SonM) and RiPP precursor (SonA) heteromeric complex (no cofactor)
F. S. Miller, K. Crone, M. Jensen, S. Shaw +3 more
20210 citations
Semantic Scholar
Structure of the heteromeric complex between the alpha-N-methyltransferase (SonM) and a truncated construct of the RiPP precursor (SonA) (with SAM)
F. S. Miller, K. Crone, M. R. Jensen, S. Shaw +3 more
20210 citations
Semantic Scholar
Abstract 436: Prediction of aggressive disease in metastatic castration-resistant prostate cancer: The role of very small nuclear circulating tumor cells
Pin-Jung Chen, Jen-Jan Yu, Pai-Chi Teng, Jie-Fu Chen +8 more
2019Clinical research0 citations
Semantic Scholar
Chapter 11:Impact of Synthetic Biology on Secondary Metabolite Biosynthesis
F. S. Miller, M. Freeman
20180 citations
Semantic Scholar
RiPPing apart the rules for peptide natural products
Aman S. Imani, M. Freeman
2018Synthetic and Systems Biotechnology0 citations Open access
Semantic Scholar
32 A SIGNALING NETWORKING EVOKED BY THE INTERSTITIAL CYSTITIS-ASSOCIATED FRIZZLED 8-RELATED ANTIPROLIFERATIVE FACTOR
S. You, J. Anger, Tack Lee, S. Keay +2 more
20130 citations
Semantic Scholar
511 NFAT5 AS A TRANSCRIPTIONAL MEDIATOR OF MESENCHYMAL-AMOEBOID TRANSITION INDUCED BY DIAPH3 LOSS IN PROSTATE CANCER
S. You, Julie Yang, Mirja Rotinen, S. Morley +2 more
20130 citations
Semantic Scholar
512 MICROVESICLES SHED FROM DIAPH3-SILENCED, AMOEBOID PROSTATE CANCER CELLS ENHANCE GROWTH OF OTHER TUMOR CELLS AND SUPPRESS PROLIFERATION OF IMMUNE CELLS
S. You, S. Morley, D. Di Vizio, Kim Jayoung +1 more
20130 citations
Semantic Scholar
1871 AN EGFR SUBCELLULAR TRAFFICKING NETWORK IN CHEMORESISTANT BLADDER CANCER
S. You, S. Yun, H. Kim, E. Posadas +5 more
20130 citations
Semantic Scholar
Chemical surprises from an uncultivated sponge symbiont
J. Piel, M. Freeman, C. Gurgui, M. Helf +14 more
20120 citations
Semantic Scholar
1295 SCAFFOLD ATTACHMENT FACTOR B1 IS AN ANDROGEN RECEPTOR CO-REPRESSOR AND MEDIATES ASSOCIATION OF THE AKT1 AND MST1 KINASES WITH CHROMATIN
N. Mukhopadhyay, M. Hager, Jayoung Kim, D. Di Vizio +6 more
20100 citations
Semantic Scholar

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