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H. Hellinga · SciRah

Researcher profile · Semantic Scholar

H. Hellinga

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H. Hellinga — researcher profile on SciRah

h-index: 41
Works: 110
Citations: 6,172

Most-cited papers

Computational design of receptor and sensor proteins with novel functions
L. Looger, M. Dwyer, James J. Smith, H. Hellinga
2003Nature687 citations
Semantic Scholar
Periplasmic binding proteins: a versatile superfamily for protein engineering.
M. Dwyer, H. Hellinga
2004Current Opinion in Structural Biology331 citations
Semantic Scholar
Computational Design of a Biologically Active Enzyme
M. Dwyer, L. Looger, H. Hellinga
2004Science278 citations
Semantic Scholar
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis
Wei-Na Wang, H. Hellinga, L. Beese
2011Proceedings of the National Academy of Sciences of the United States of America261 citations Open access
Semantic Scholar
Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.
L. Looger, H. Hellinga
2001Journal of Molecular Biology212 citations
Semantic Scholar
Structures of human exonuclease I DNA complexes suggest a unified mechanism for nuclease family
J. Orans, E. McSweeney, R. R. Iyer, M. Hast +3 more
2011Cell171 citations Open access
Semantic Scholar
The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors.
Jonathan S. Marvin, E. Corcoran, N. Hattangadi, J.-V. Zhang +2 more
1997Proceedings of the National Academy of Sciences of the United States of America164 citations Open access
Semantic Scholar
Conversion of a maltose receptor into a zinc biosensor by computational design
J. Marvin, H. Hellinga
2001Proceedings of the National Academy of Sciences of the United States of America150 citations Open access
Semantic Scholar
Manipulation of ligand binding affinity by exploitation of conformational coupling
J. Marvin, H. Hellinga
2001Nature Structural Biology149 citations
Semantic Scholar
Engineering Biosensors by Introducing Fluorescent Allosteric Signal Transducers: Construction of a Novel Glucose Sensor
J. Marvin, H. Hellinga
1998148 citations Open access
Semantic Scholar
Structural analysis, identification, and design of calcium‐binding sites in proteins
Wei Yang, Hsiau-Wei Lee, H. Hellinga, Jenny J. Yang
2002Proteins: Structure, Function, and Bioinformatics128 citations
Semantic Scholar
Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins
D. E. Benson, D. Conrad, R. M. de, Lorimier +2 more
2001Science125 citations
Semantic Scholar
Control of a biomolecular motor-powered nanodevice with an engineered chemical switch
Haiqing Liu, J. Schmidt, G. Bachand, Shahir S. Rizk +3 more
2002Nature Materials121 citations
Semantic Scholar
Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway
Mauricio S. Antunes, K. Morey, J. Smith, Kirk D. Albrecht +7 more
2011PLoS ONE120 citations Open access
Semantic Scholar
Protein engineering and the development of generic biosensors.
H. Hellinga, Jonathan S. Marvin
1998Trends in Biotechnology120 citations
Semantic Scholar
Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes.
Curtis J. Layton, H. Hellinga
2010Biochemistry114 citations Open access
Semantic Scholar
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics
S. Long, Paula J. Hancock, A. Kral, H. Hellinga +1 more
2001Proceedings of the National Academy of Sciences of the United States of America105 citations Open access
Semantic Scholar
Structural Reorganization and Preorganization in Enzyme Active Sites: Comparisons of Experimental and Theoretically Ideal Active Site Geometries in the Multi-step Serine Esterase Reaction Cycle
Adam J. T. Smith, R. Müller, M. Toscano, P. Kast +3 more
2008Journal of the American Chemical Society104 citations Open access
Semantic Scholar
Computational design of receptors for an organophosphate surrogate of the nerve agent soman.
Malin J. Allert, Shahir S. Rizk, L. Looger, H. Hellinga
2004Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Rational design of nascent metalloenzymes.
D. E. Benson, Michael S. Wisz, H. Hellinga
2000Proceedings of the National Academy of Sciences of the United States of America102 citations Open access
Semantic Scholar
Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation
J. S. Grimley, Li Li, Wei-Na Wang, Lei Wen +3 more
2013Journal of Neuroscience100 citations Open access
Semantic Scholar
Construction of a catalytically active iron superoxide dismutase by rational protein design.
Annette L. Pinto, H. Hellinga, J. P. Caradonna
1997Proceedings of the National Academy of Sciences of the United States of America99 citations Open access
Semantic Scholar
An empirical model for electrostatic interactions in proteins incorporating multiple geometry‐dependent dielectric constants
Michael S. Wisz, H. Hellinga
2003Proteins: Structure, Function, and Bioinformatics95 citations Open access
Semantic Scholar
Rational design of a calcium-binding protein.
Wei Yang, L. Jones, Leanne Isley, Yi-Ming Ye +7 more
2003Journal of the American Chemical Society86 citations
Semantic Scholar
Rational protein design: combining theory and experiment.
H. Hellinga
1997Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
The rational design and construction of a cuboidal iron-sulfur protein.
C. Coldren, H. Hellinga, J. P. Caradonna
1997Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Computational design of a Zn2+ receptor that controls bacterial gene expression
M. Dwyer, L. Looger, H. Hellinga
2003Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
Wei Yang, Anna L. Wilkins, Yi-Ming Ye, Zhi-Ren Liu +6 more
2005Journal of the American Chemical Society72 citations
Semantic Scholar
Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center.
David E. Benson, Michael S. Wisz, Wen-Tian Liu, H. Hellinga
1998Biochemistry67 citations
Semantic Scholar
Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides*
Wei-Na Wang, Eugene Y. Wu, H. Hellinga, L. Beese
2012Journal of Biological Chemistry64 citations Open access
Semantic Scholar
The construction of metal centers in proteins by rational design.
H. Hellinga
1998Folding & design60 citations Open access
Semantic Scholar
Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design.
D. E. Benson, A. Haddy, H. Hellinga
2002Biochemistry52 citations
Semantic Scholar
Structure‐based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose‐binding protein
Yaji Tian, M. Cuneo, A. Changela, B. Höcker +2 more
2007Protein Science47 citations Open access
Semantic Scholar
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I
Yuqian Shi, H. Hellinga, L. Beese
2017Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites.
M. Cuneo, A. Changela, J. J. Warren, L. Beese +1 more
2006Journal of Molecular Biology44 citations
Semantic Scholar
Computational protein engineering
H. Hellinga
1998Nature Structural Biology44 citations
Semantic Scholar
The development of new biotechnologies using metalloprotein design.
David E. Benson, Michael S. Wisz, H. Hellinga
1998Current Opinion in Biotechnology39 citations
Semantic Scholar
Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design.
Michael S. Wisz, Christopher Z. Garrett, H. Hellinga
1998Biochemistry39 citations
Semantic Scholar
A Miniaturized Technique for Assessing Protein Thermodynamics and Function Using Fast Determination of Quantitative Cysteine Reactivity
D. Isom, Philippe Marguet, Terrence G. Oas, H. Hellinga
2011Proteins: Structure, Function, and Bioinformatics37 citations Open access
Semantic Scholar
Genetic engineering of a single-chain antibody fragment for surface immobilization in an optical biosensor.
R. Piervincenzi, W. Reichert, H. Hellinga
1998Biosensors & bioelectronics37 citations
Semantic Scholar
Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues.
M. Ermácora, D. W. Ledman, H. Hellinga, Gene W. Hsu +1 more
1994Biochemistry35 citations
Semantic Scholar
Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity
D. Isom, E. Vardy, T. G. Oas, H. Hellinga
2010Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Construction of a Blue Copper Analogue through Iterative Rational Protein Design Cycles Demonstrates Principles of Molecular Recognition in Metal Center Formation
H. Hellinga
199832 citations
Semantic Scholar
Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold*
M. Cuneo, L. Beese, H. Hellinga
2009Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Ligand-induced conformational changes in a thermophilic ribose-binding protein
M. Cuneo, L. Beese, H. Hellinga
2008BMC Structural Biology31 citations Open access
Semantic Scholar
Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins.
M. Cuneo, A. Changela, L. Beese, H. Hellinga
2009Journal of Molecular Biology30 citations
Semantic Scholar
Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport*
M. Cuneo, A. Changela, Aleksandr E. Miklos, L. Beese +2 more
2008Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Binding and signaling of surface‐immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins
Robert M. de Lorimier, Yaji Tian, H. Hellinga
2006Protein Science28 citations Open access
Semantic Scholar
Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.
J. Ladbury, Nand Kishore, H. Hellinga, Richard Wynn +1 more
1994Biochemistry26 citations
Semantic Scholar
Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design
M. Mabanglo, M. Hast, Nathan B. Lubock, H. Hellinga +1 more
2014Protein Science23 citations Open access
Semantic Scholar

Frequent co-authors

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L. Beese×13
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L. Beese — researcher profile on SciRah
M. Cuneo×7
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L. Looger×6
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L. Looger — researcher profile on SciRah
Michael S. Wisz×5
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Michael S. Wisz — researcher profile on SciRah

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A. Changela — researcher profile on SciRah

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M. Dwyer — researcher profile on SciRah

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Wei-Na Wang — researcher profile on SciRah

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J. Marvin — researcher profile on SciRah

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Wei Yang — researcher profile on SciRah

Jenny J. Yang×3

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Jenny J. Yang — researcher profile on SciRah

D. E. Benson×3

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D. E. Benson — researcher profile on SciRah

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M. Hast — researcher profile on SciRah