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R. Chai · SciRah

Researcher profile · Semantic Scholar

R. Chai

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R. Chai — researcher profile on SciRah

h-index: 63
Works: 398
Citations: 14K

Most-cited papers

AAV gene therapy for autosomal recessive deafness 9: a single-arm trial
Jie-Yu Qi, Liyan Zhang, Ling Lu, Fangzhi Tan +17 more
2025Nature Medicine53 citations
Semantic Scholar
Advances in Biocompatible Metal‐Organic Frameworks for Biomedical Applications
Zhe Li, M. He, Yuan-Bo Wang, Jing Yang +6 more
2025Advances in Materials48 citations
Semantic Scholar
Artificial Intelligence‐Based Approaches for AAV Vector Engineering
Fangzhi Tan, Yue Dong, Jie-Yu Qi, Wen-Wu Yu +1 more
2025Advancement of science34 citations Open access
Semantic Scholar
Combined AAV-mediated specific Gjb2 expression restores hearing in DFNB1 mouse models.
Qiuhan Sun, Fangzhi Tan, Liyan Zhang, Yicheng Lu +10 more
2025Molecular Therapy33 citations Open access
Semantic Scholar
Biomaterial-based drug delivery systems in the treatment of inner ear disorders
Hong Cheng, Bin Zhang, Pei Jiang, Menghui Liao +7 more
2025Journal of Nanobiotechnology27 citations Open access
Semantic Scholar
Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging
Guoqiang Sun, Xiao-Long Fu, Yandong Zheng, Guo-Dong Hong +15 more
2025Nature Aging26 citations
Semantic Scholar
A Silk Fibroin Nanoparticle Hydrogel Loaded With NK1R Antagonist Has Synergistic Anti‐Inflammatory and Reparative Effects on Dry Eye Disease
Bo Gong, Yi Liu, Huan Li, Xue-Ming Ju +9 more
2025Advancement of science23 citations Open access
Semantic Scholar
RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation
Yong-Jie Wei, Yu-Hua Zhang, Wei Cao, Nan Cheng +15 more
2025Advancement of science21 citations Open access
Semantic Scholar
Targeting ferroptosis to enhance the efficacy of mesenchymal stem cell-based treatments for intervertebral disc degeneration
Yu-Zhu Xu, Xuanfei Xu, R. Chai, Xiaotao Wu
2025International Journal on Biological Sciences21 citations Open access
Semantic Scholar
GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL
Yu Xiao, Xiaohan Zhang, Si-Wei Guo, Zi-Yi Liu +16 more
2025Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
A force-sensitive adhesion GPCR is required for equilibrioception
Zhao Yang, Shu-Hua Zhou, Qi-Yue Zhang, Zhi-Chen Song +23 more
2025Cell Research20 citations Open access
Semantic Scholar
Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation
Su-han Guo, Cheng Cheng, Yun-Hao Wu, Kaidi Shen +8 more
2025Advancement of science20 citations Open access
Semantic Scholar
OTOF-related gene therapy: a new way but a long road ahead.
Jie-Yu Qi, Lei Xu, Fan-Gang Zeng, R. Chai
2025The Lancet19 citations
Semantic Scholar
Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis
Yun-Hao Wu, Li Zhang, Shengda Cao, Jing-Wen Zhang +9 more
2025Advancement of science16 citations Open access
Semantic Scholar
Treating Hearing Loss: From Cochlear Implantation to Gene Therapy
Fan-Gang Zeng, Jie-Yu Qi, Chen-Chi Wu, Yi-Lai Shu +1 more
2025Advancement of science15 citations Open access
Semantic Scholar
AAV‐mediated Gpm6b expression supports hair cell reprogramming
Qiuhan Sun, Liyan Zhang, Tian Chen, Nian-Ci Li +11 more
2024Cell Proliferation15 citations Open access
Semantic Scholar
Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation
Lei Ren, Yang-Nan Hu, Xiaoqiong Ding, Menghui Liao +12 more
2025Advancement of science14 citations Open access
Semantic Scholar
The X-Age Project to construct a Chinese aging clock
Jia-Ming Li, Mengmeng Jiang, Qiaoran Wang, Zi-Kai Zheng +266 more
2025Nature Aging13 citations
Semantic Scholar
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Xiao-Long Fu, Sijia Wang, Yun-Hao Wu, Yu Sun +37 more
2025Life Medicine13 citations
Semantic Scholar
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice
Si-Wei Guo, Jieying Cao, Guo-Dong Hong, Yu-Ning Song +16 more
2025Nature Aging13 citations
Semantic Scholar
Proton perception and activation of a proton-sensing GPCR.
Li-Nan Chen, Hui Zhou, Kun Xi, Shizhuo Cheng +16 more
2025Molecules and Cells12 citations
Semantic Scholar
Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery
Jing-Ru Ai, Sha-Sha Zhang, Mingchen Dai, Pei Jiang +11 more
2025Advancement of science11 citations Open access
Semantic Scholar
Targeting prominin-2/BACH1/GLS pathway to inhibit oxidative stress-induced ferroptosis of bone mesenchymal stem cells
Yu-Zhu Xu, Lele Zhang, Xuanfei Xu, Yuao Tao +4 more
2025Stem cell research & therapeutics11 citations Open access
Semantic Scholar
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials.
Xin-Tai Fan, Zi-Wen Gao, Jia-Ke Zhong, Yu-Xin Chen +62 more
2025i Medicina11 citations Open access
Semantic Scholar
Engineering neural recovery: Micro/nano-structured materials for nerve regeneration
Hui Zhang, Junhui Sha, Sixing Cao, Jin Feng +8 more
2025Materials Today Bio11 citations Open access
Semantic Scholar
Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis
Sha-Sha Zhang, Hairong Xiao, Yanqin Lin, Xujun Tang +6 more
2025Neuroscience Bulletin11 citations Open access
Semantic Scholar
Magnetic Mesoporous Nanoparticles Loaded with Lycium barbarum Glycopeptide for Targeted Therapy of Noise‐Triggered Auditory Dysfunction
Menghui Liao, Qian Zhu, Hong Cheng, Yuyang Qiu +10 more
2026Advances in Materials9 citations
Semantic Scholar
Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target.
Xiaoyan Ge, Jie Cheng, Li-Jun Zhang, Lu-lu Guo +21 more
2026Cell8 citations
Semantic Scholar
Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles
Huiwen Ren, Yayan Hou, Chengsen Mu, Yinghong Zheng +11 more
2025Advancement of science8 citations Open access
Semantic Scholar
Establishment of a Cochlear Organoid Platform for Remodeling the Extracellular Matrix.
Nian-Ci Li, Ziyu Zhang, Liyan Zhang, Danqi Wu +10 more
2025ACS Nano8 citations
Semantic Scholar
Bioactive hydrogels for the reconstruction of sensorineural hearing loss
Xinyi Pang, Xu Zhang, Dong-Yu Xu, Chuan Bu +8 more
2025Bioactive Materials7 citations Open access
Semantic Scholar
Optimized in vivo base editing restores auditory function in a DFNA15 mouse model
Man Wang, Ziyu Zhang, Xiao-Han Wang, Liyan Zhang +9 more
2025Nature Communications7 citations Open access
Semantic Scholar
Engineering vascularized inner ear organoids: Challenges and advances in recapitulating the cochlear microenvironment.
Hao Rong, Qian Zhu, Zhong-Hong Zhang, Xinyi Pang +9 more
2025Biomaterials6 citations
Semantic Scholar
Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea
Hairong Xiao, Jiheng Wu, Li-Xuan Huang, Ying Ma +11 more
2025Advancement of science6 citations Open access
Semantic Scholar
MgFe-LDH-doped GelMA hydrogel scaffold repaired spinal cord injury via immunoregulation and enhancement of neuronal differentiation
Shasha Zheng, Rui Huang, Xu-Gang Zhuang, Qian Zhu +14 more
2026Nano Today5 citations
Semantic Scholar
Aligned nanofiber-based responsive sponge scaffolds for peripheral nerve regeneration
Si-Zhe Song, Ying Zhang, Dong-Yu Xu, Hui Zhang +4 more
2025Journal of Nanobiotechnology5 citations Open access
Semantic Scholar
Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage
Sha-Sha Zhang, Rui-Ying Qiang, Yuan Zhang, Jinxia Wan +11 more
2025Advancement of science5 citations Open access
Semantic Scholar
Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation
Man Wang, Yue-Chen Han, Weibin An, Xue Wang +11 more
2025Cell Communication and Signaling5 citations Open access
Semantic Scholar
AAV-Sparcl1 Promotes Hair Cell Regeneration by Increasing Supporting Cell Plasticity.
Nian-Ci Li, Fangzhi Tan, Liyan Zhang, Xiaoqiong Ding +9 more
2025Molecular Therapy5 citations Open access
Semantic Scholar
Multifunctional Self‐Assembling Peptide System for Preventing Noise‐Induced Hearing Loss
Jia-Wen Li, Zhuo-Wen Hao, Fang-Zi Ke, Chuan Bu +15 more
2026Advances in Materials4 citations
Semantic Scholar
Molecular heterogeneity of the non-human primate cochlea
Xin Chen, Yuwei Che, Jie-Yu Qi, M. Cen +15 more
2026Nature Communications4 citations Open access
Semantic Scholar
Advances and challenges of metal-organic frameworks in controlled drug delivery
Xingqi Zhu, Menghui Liao, Hao Wei, Yue Jiang +6 more
2026Materials Today Bio4 citations Open access
Semantic Scholar
Neural stem cell-loaded biohybrid hydrogel improves cochlear implants by electrode-neural coupling and neural regeneration
Menghui Liao, Xin Zhou, Hao Wei, Yanru Qi +9 more
2026Theranostics4 citations Open access
Semantic Scholar
Advances in the production, purification, and concentration of bacteriophage bionanoparticles for biomedical applications.
Xin Gao, Shasha Zheng, Xu-Gang Zhuang, Ji-Yang Zuo +5 more
2025Advances in Colloid and Interface Science4 citations
Semantic Scholar
Inner Ear Organoids: A Hydrogel-Based Platform for Drug Screening and Deafness Modeling
Yuyu Cao, Xiao-Tao Liu, R. Chai, Zu-Hong He
2025Neuroscience Bulletin4 citations Open access
Semantic Scholar
Conductive Nerve Guidance Conduits Loaded With Adipose Mesenchymal Stem Cells for Peripheral Nerve Regeneration
Hong Cheng, Yang-Nan Hu, Menghui Liao, Xinyi Pang +7 more
2025Smart Medicine4 citations
Semantic Scholar
Blood–labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus
Zi-He Zhao, Ao Li, Yan Zhu, Shao-Qin Cen +11 more
2025Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
Semantic Scholar
Viscoelastic and conductive nerve guidance conduits for peripheral nerve repair.
Hai-Yan Yin, Yang-Nan Hu, Hong Cheng, Bin Zhang +7 more
2025Nanoscale4 citations
Semantic Scholar
Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model.
Ziyu Zhang, Man Wang, Fangzhi Tan, Liyan Zhang +10 more
2026i Medicina3 citations
Semantic Scholar
Contrastive analysis of degradation behavior for WE43 magnesium alloy stents in cerebrovascular versus coronary hemodynamic environments
Chunhao Yu, Hong-Kang Zhang, Yunong Shen, Yi-Ming Huang +6 more
2026Journal of Magnesium and Alloys3 citations Open access
Semantic Scholar

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