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E. Willmore · SciRah

Researcher profile · Semantic Scholar

E. Willmore

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E. Willmore — researcher profile on SciRah

h-index: 25
Works: 94
Citations: 2,229

Most-cited papers

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
E. Willmore, Sarah de Caux, N. Sunter, M. Tilby +3 more
2004Blood276 citations Open access
Semantic Scholar
Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique.
E. Willmore, Adrian J. Frank, K. Padget, Michael J. Tilby +1 more
1998Molecular Pharmacology144 citations
Semantic Scholar
The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks
Lisa M. Smith, E. Willmore, C. Austin, N. Curtin
2005Clinical Cancer Research132 citations Open access
Semantic Scholar
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.
M. López-Lázaro, E. Willmore, C. Austin
2010Mutation research109 citations Open access
Semantic Scholar
Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
Alessio Iannetti, Adeline C. Ledoux, S. Tudhope, H. Sellier +9 more
2014PLoS Genetics108 citations Open access
Semantic Scholar
Expression, Domain Structure, and Enzymatic Properties of an Active Recombinant Human DNA Topoisomerase IIβ (*)
C. Austin, K. Marsh, R. Wasserman, E. Willmore +3 more
1995Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation.
F. Errington, E. Willmore, Michael J. Tilby, L. Li +4 more
1999Molecular Pharmacology97 citations
Semantic Scholar
DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
E. Willmore, Sarah L. Elliott, T. Mainou-fowler, G. Summerfield +11 more
2008Clinical Cancer Research93 citations Open access
Semantic Scholar
Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL
M. Haselager, R. Thijssen, C. West, L. Young +5 more
2021Cell Death and Differentiation79 citations Open access
Semantic Scholar
Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180).
M. Cornarotti, S. Tinelli, E. Willmore, F. Zunino +3 more
1996Molecular Pharmacology77 citations
Semantic Scholar
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
M. López-Lázaro, E. Willmore, A. Jobson, K. Gilroy +3 more
2007Journal of Natural Products74 citations Open access
Semantic Scholar
Cells lacking DNA topoisomerase IIβ are resistant to genistein
M. López-Lázaro, E. Willmore, C. Austin
200761 citations Open access
Semantic Scholar
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
Catherine E. Willoughby, Yan-Yan Jiang, H. Thomas, E. Willmore +19 more
2019Journal of Clinical Investigation56 citations Open access
Semantic Scholar
Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase
P. Znojek, E. Willmore, N. Curtin
2014British Journal of Cancer53 citations Open access
Semantic Scholar
Mitoxantrone in combination with an inhibitor of DNA‐dependent protein kinase: a potential therapy for high risk B‐cell chronic lymphocytic leukaemia
Sarah L. Elliott, Clark Crawford, E. Mulligan, G. Summerfield +7 more
2011British Journal of Haematology46 citations
Semantic Scholar
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells.
E. Willmore, F. Errington, M. Tilby, C. Austin
2002Biochemical Pharmacology40 citations Open access
Semantic Scholar
Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail.
I. Cowell, E. Willmore, David Chalton, K. Marsh +3 more
1998Experimental Cell Research39 citations Open access
Semantic Scholar
ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors
Hannah L. Smith, E. Willmore, L. Prendergast, N. Curtin
2024British Journal of Cancer38 citations Open access
Semantic Scholar
NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699
Jill E. Hunter, E. Willmore, J. Irving, Z. Hostomský +2 more
2011Oncogene37 citations Open access
Semantic Scholar
Differences in the longevity of topo IIα and topo IIβ drug-stabilized cleavable complexes and the relationship to drug sensitivity
F. Errington, E. Willmore, C. Leontiou, M. Tilby +1 more
2004Cancer Chemotherapy and Pharmacology35 citations
Semantic Scholar
Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.
M. Bigioni, Franco Zunino, S. Tinelli, C. Austin +2 more
1996Biochemistry31 citations Open access
Semantic Scholar
Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β
K. Marsh, E. Willmore, S. Tinelli, M. Cornarotti +4 more
199631 citations Open access
Semantic Scholar
Cells lacking DNA topoisomerase II beta are resistant to genistein.
M. López-Lázaro, E. Willmore, C. Austin
2007Journal of Natural Products30 citations
Semantic Scholar
PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia
A. Herriott, S. Tudhope, Gesa Junge, Natalie A. Rodrigues +12 more
2015OncoTarget29 citations Open access
Semantic Scholar
Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells
Carmela Ciardullo, E. Aptullahoğlu, L. Woodhouse, Wei-Yu Lin +6 more
2019Haematologica26 citations Open access
Semantic Scholar
SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.
L. Evans, Lin-Di Chen, G. Milazzo, S. Gherardi +4 more
2015Cancer Letters23 citations Open access
Semantic Scholar
Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity.
Emily V. A. Mould, P. Berry, D. Jamieson, C. Hill +6 more
2014Biochemical Pharmacology23 citations Open access
Semantic Scholar
Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer.
K. Pors, Zennia Paniwnyk, P. Teesdale-Spittle, J. Plumb +3 more
2003Molecular Cancer Therapeutics21 citations
Semantic Scholar
Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
N. Sunter, I. Cowell, E. Willmore, G. Watters +1 more
2010Journal of Nucleic Acids20 citations Open access
Semantic Scholar
Cytotoxic mechanisms of 5-fluoropyrimidines. Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids.
E. Willmore, B. Durkacz
1993Biochemical Pharmacology19 citations Open access
Semantic Scholar
Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia
T. Barrow, S. Nakjang, F. Lafta, K. Bilotkach +9 more
2020British Journal of Cancer18 citations Open access
Semantic Scholar
Analysis of retrotransposon subfamily DNA methylation reveals novel early epigenetic changes in chronic lymphocytic leukemia
T. Barrow, N. W. Doo, R. Milne, G. Giles +3 more
2020Haematologica18 citations Open access
Semantic Scholar
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity.
F. Errington, E. Willmore, C. Leontiou, M. Tilby +1 more
2004Cancer Chemotherapy and Pharmacology17 citations
Semantic Scholar
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer
Beth Adamson, Nicholas Brittain, Laura Walker, Ruaridh Duncan +18 more
2023Journal of Clinical Investigation16 citations Open access
Semantic Scholar
Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases
A. Jobson, E. Willmore, M. Tilby, P. Mistry +2 more
2009Cancer Chemotherapy and Pharmacology15 citations Open access
Semantic Scholar
Selenite induces topoisomerase I and II‐DNA complexes in K562 leukemia cells
M. López-Lázaro, E. Willmore, Sarah L. Elliott, C. Austin
2008International Journal of Cancer15 citations Open access
Semantic Scholar
Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition
E. Aptullahoğlu, Carmela Ciardullo, J. Wallis, H. Marr +4 more
2023International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia
K. Szoltysek, Carmela Ciardullo, P. Zhou, A. Walaszczyk +7 more
2020International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Correlation of enhanced 6-mercaptopurine cytotoxicity with increased phosphoribosylpyrophosphate levels in Chinese hamster ovary cells treated with 3-aminobenzamide.
K. Moses, E. Willmore, A. Harris, B. Durkacz
1990Cancer Research14 citations
Semantic Scholar
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Wei-Yu Lin, S. Fordham, N. Sunter, C. Elstob +32 more
2021Nature Communications13 citations Open access
Semantic Scholar
Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL
Shilu Amin, M. Walsh, C. Wilson, A. Parker +4 more
2012Journal of Cellular and Molecular Medicine13 citations Open access
Semantic Scholar
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase.
Islam Al-Khawaldeh, Mohammed J. Al Yasiri, Gregory G. Aldred, C. Basmadjian +28 more
2021Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia
Carmela Ciardullo, K. Szoltysek, P. Zhou, M. Pietrowska +11 more
2021Cancers12 citations Open access
Semantic Scholar
Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability.
Katherine L. West, R. M. Turnbull, E. Willmore, J. Lakey +1 more
2002Nucleic Acids Research12 citations Open access
Semantic Scholar
Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta.
K. Marsh, E. Willmore, S. Tinelli, M. Cornarotti +4 more
1996Biochemical Pharmacology10 citations
Semantic Scholar
SF3B1 Mutations Are Associated with Resistance to Non-Genotoxic MDM2 Inhibition in Chronic Lymphocytic Leukemia
E. Aptullahoğlu, Jonathan P. Wallis, H. Marr, Scott Marshall +3 more
2023International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Differences in Durability of PARP Inhibition by Clinically Approved PARP Inhibitors: Implications for Combinations and Scheduling
Hannah L. Smith, E. Willmore, A. Mukhopadhyay, Y. Drew +1 more
2022bioRxiv9 citations Open access
Semantic Scholar
The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution.
Suzanne Jones, E. Willmore, B. Durkacz
1994Carcinogenesis7 citations Open access
Semantic Scholar
Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling
Evan A. Mulligan, S. Tudhope, Jill E. Hunter, Arabella E. G. Clift +7 more
2023Cancers6 citations Open access
Semantic Scholar
DNAPK inhibition preferentially compromises the repair of radiation-induced DNA double-strand breaks in chronically hypoxic tumor cells in xenograft models
Yan-Yan Jiang, E. Willmore, S. Wedge, A. J. Ryan
2021Molecular Cancer Therapeutics6 citations Open access
Semantic Scholar

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