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D. Leclerc · SciRah

Researcher profile · Semantic Scholar

D. Leclerc

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D. Leclerc — researcher profile on SciRah

h-index: 30
Works: 65
Citations: 4,073

Most-cited papers

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.
Aaron J. Wilson, R. Platt, Qing Wu, D. Leclerc +4 more
1999Molecular Genetics and Metabolism464 citations
Semantic Scholar
Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.
D. Leclerc, E. Campeau, P. Goyette, C. Adjalla +6 more
1996Human Molecular Genetics418 citations Open access
Semantic Scholar
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.
D. Leclerc, Aaron D. Wilson, R. Dumas, C. Gafuik +7 more
1998Proceedings of the National Academy of Sciences of the United States of America390 citations Open access
Semantic Scholar
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
B. Christensen, L. Arbour, P. Tran, D. Leclerc +7 more
1999American journal of medical genetics314 citations
Semantic Scholar
Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.
D. Phaneuf, N. Wakamatsu, Jing-Qi Huang, A. Borowski +12 more
1996Human Molecular Genetics241 citations
Semantic Scholar
Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis
A. Pshezhetsky, C. Richard, L. Michaud, Suleiman A. Igdoura +7 more
1997Nature Genetics211 citations
Semantic Scholar
Identification of the gene responsible for the cblB complementation group of vitamin B12-dependent methylmalonic aciduria.
C. Dobson, T. Wai, D. Leclerc, H. Kadir +5 more
2002Human Molecular Genetics159 citations
Semantic Scholar
Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
C. Dobson, T. Wai, D. Leclerc, Aaron J. Wilson +5 more
2002Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
C. L. Elmore, Xu-Chu Wu, D. Leclerc, Erica D. Watson +7 more
2007Molecular Genetics and Metabolism110 citations Open access
Semantic Scholar
Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli.
A. León-Del-Río, D. Leclerc, B. Akerman, N. Wakamatsu +1 more
1995Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
Semantic Scholar
Oncogenic role of PDK4 in human colon cancer cells
D. Leclerc, D. Pham, N. Lévesque, M. Truongcao +3 more
2017British Journal of Cancer97 citations Open access
Semantic Scholar
Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.
I. Morin, A. Devlin, D. Leclerc, N. Sabbaghian +3 more
2003Molecular Genetics and Metabolism81 citations
Semantic Scholar
Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms
D. Leclerc, Sahar Sibani, R. Rozen
201377 citations
Semantic Scholar
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms
P. Tran, D. Leclerc, M. Chan, A. Pai +6 more
2002Mammalian Genome70 citations
Semantic Scholar
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
N. Jadavji, Li-Yuan Deng, D. Leclerc, O. Malysheva +3 more
2012Molecular Genetics and Metabolism63 citations
Semantic Scholar
Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD‐responsive mutation
Sahar Sibani, D. Leclerc, I. Weisberg, E. O'Ferrall +4 more
2003Human Mutation61 citations Open access
Semantic Scholar
Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene.
D. Leclerc, M. Odièvre, Qing Wu, Aaron J. Wilson +4 more
1999Gene61 citations
Semantic Scholar
Clustering of mutations in the biotin-binding region of holocarboxylase synthetase in biotin-responsive multiple carboxylase deficiency.
L. Dupuis, A. León-Del-Río, D. Leclerc, E. Campeau +5 more
1996Human Molecular Genetics60 citations Open access
Semantic Scholar
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.
C. Ananth, D. A. Elsasser, Wendy L. Kinzler, M. Peltier +3 more
2007Molecular Genetics and Metabolism58 citations Open access
Semantic Scholar
Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism
Jordan P. Lerner-Ellis, C. Dobson, T. Wai, D. Watkins +6 more
2004Human Mutation58 citations Open access
Semantic Scholar
SLC7A9 mutations in all three cystinuria subtypes.
D. Leclerc, M. Boutros, D. Suh, Qing Wu +4 more
2002Kidney International55 citations Open access
Semantic Scholar
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Erin Knock, Li-Yuan Deng, Qing Wu, D. Leclerc +2 more
2006Cancer Research49 citations Open access
Semantic Scholar
ApcMin/+ mouse model of colon cancer: Gene expression profiling in tumors
D. Leclerc, Li-Yuan Deng, J. Trasler, R. Rozen
2004Journal of Cellular Biochemistry47 citations
Semantic Scholar
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency
M. Roy, D. Leclerc, Qing Wu, Sapna Gupta +2 more
2008Journal of Cellular Biochemistry43 citations Open access
Semantic Scholar
Identification of Candidate Active Site Residues in Lysosomal β-Hexosaminidase A*
M. Fernandes, S. Yew, D. Leclerc, B. Henrissat +4 more
1997Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation
M. Aarabi, Karen E. Christensen, D. Chan, D. Leclerc +4 more
2018Human Molecular Genetics42 citations Open access
Semantic Scholar
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.
A. Lossos, Omri Teltsh, T. Milman, V. Meiner +14 more
2014JAMA Neurology41 citations Open access
Semantic Scholar
Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: a novel cause of mild methylmalonic aciduria.
C. Dobson, Abigail B. Gradinger, N. Longo, Xu-Chu Wu +7 more
2006Molecular Genetics and Metabolism37 citations
Semantic Scholar
Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
D. Leclerc, N. Lévesque, Yuanhang Cao, Li-Yuan Deng +4 more
2013Cancer Prevention Research31 citations Open access
Semantic Scholar
Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism
M. Cosín-Tomás, Y. Luan, D. Leclerc, O. Malysheva +5 more
2020Nutrients30 citations Open access
Semantic Scholar
Infant methionine synthase variants and risk for spina bifida
G. Shaw, K. Todoroff, R. Finnell, E. Lammer +3 more
1999Journal of Medical Genetics30 citations
Semantic Scholar
β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells.
D. Pham, D. Leclerc, N. Lévesque, Li-Yuan Deng +1 more
2013American Journal of Clinical Nutrition28 citations Open access
Semantic Scholar
Effects of betaine in a murine model of mild cystathionine-β-synthase deficiency
B. Schwahn, U. Wendel, S. Lussier‐Cacan, M. Mar +5 more
200427 citations
Semantic Scholar
Reduced folate carrier 80A→G polymorphism, plasma folate, and risk of placental abruption
C. Ananth, M. Peltier, D. F. Moore, Wendy L. Kinzler +2 more
2008Human Genetics24 citations Open access
Semantic Scholar
Endoplasmic Reticulum Stress Increases the Expression of Methylenetetrahydrofolate Reductase through the IRE1 Transducer*
D. Leclerc, R. Rozen
2008Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver
D. Leclerc, Karen E. Christensen, Olivia Cauvi, Ethan Yang +10 more
2018Molecular Nutrition & Food Research22 citations
Semantic Scholar
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency
Renata Bahous, M. Cosín-Tomás, Li-Yuan Deng, D. Leclerc +7 more
2018Molecular Neurobiology21 citations
Semantic Scholar
Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
D. Leclerc, Yuanhang Cao, Li-Yuan Deng, L. Mikael +2 more
2013Molecular Nutrition & Food Research21 citations
Semantic Scholar
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
Erin Knock, Li-Yuan Deng, Natalia I. Krupenko, Ryan D. Mohan +7 more
2011Journal of Nutritional Biochemistry21 citations
Semantic Scholar
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice
Başak Çeltikçi, D. Leclerc, A. K. Lawrance, Li-Yuan Deng +7 more
2008Pharmacogenetics & Genomics21 citations
Semantic Scholar
Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?
D. Leclerc, Qing Wu, J. R. Ellis, P. Goodyer +1 more
2001Molecular Genetics and Metabolism21 citations
Semantic Scholar
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-specific Placental Transcription Changes.
Y. Luan, D. Leclerc, M. Cosín-Tomás, O. Malysheva +4 more
2021Molecular Nutrition & Food Research18 citations
Semantic Scholar
[Molecular genetics of MTHFR: polymorphisms are not all benign].
D. Leclerc, R. Rozen
2007Medecine sciences : M/S17 citations
Semantic Scholar
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos
Yansong Luan, M. Cosín-Tomás, D. Leclerc, O. Malysheva +2 more
2022Nutrients16 citations Open access
Semantic Scholar
High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.
D. Leclerc, J. Jelinek, Karen E. Christensen, J. Issa +1 more
2020Journal of Nutritional Biochemistry16 citations
Semantic Scholar
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity.
L. Pickell, P. Tran, D. Leclerc, J. Hiscott +1 more
2005Biochimica et Biophysica Acta16 citations
Semantic Scholar
Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation
L. Pickell, Qing Wu, Xiao-ling Wang, D. Leclerc +3 more
2011Mammalian Genome15 citations
Semantic Scholar
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
B. Schwahn, U. Wendel, S. Lussier‐Cacan, M. Mar +5 more
2004Metabolism: Clinical and Experimental14 citations
Semantic Scholar
Identification of candidate active site residues in lysosomal beta-hexosaminidase A.
M. Fernandes, S. Yew, D. Leclerc, B. Henrissat +4 more
1997Journal of Biological Chemistry9 citations
Semantic Scholar
Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency
D. Leclerc, Kurt Dejgaard, Alexander Mazur, Li-Yuan Deng +3 more
2014Proteomics8 citations
Semantic Scholar

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