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E. Weir · SciRah

Researcher profile · Semantic Scholar

E. Weir

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E. Weir — researcher profile on SciRah

h-index: 55
Works: 224
Citations: 13K

Most-cited papers

Cellular and molecular pathobiology of pulmonary arterial hypertension.
M. Humbert, N. W. Morrell, Stephen L. Archer, K. Stenmark +7 more
2004Journal of the American College of Cardiology1,645 citations Open access
Semantic Scholar
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
N. Morrell, S. Adnot, Stephen L. Archer, J. Dupuis +8 more
2009Journal of the American College of Cardiology839 citations Open access
Semantic Scholar
An Abnormal Mitochondrial–Hypoxia Inducible Factor-1&agr;–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension
S. Bonnet, E. Michelakis, Christopher J. Porter, Miguel Andrade +8 more
2006Circulation580 citations Open access
Semantic Scholar
Acute oxygen-sensing mechanisms.
E. Weir, J. López-Barneo, K. Buckler, Stephen L. Archer
2005New England Journal of Medicine300 citations Open access
Semantic Scholar
O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.
S. Archer, H. Reeve, E. Michelakis, L. Puttagunta +4 more
1999Proceedings of the National Academy of Sciences of the United States of America286 citations Open access
Semantic Scholar
Impact of TASK-1 in Human Pulmonary Artery Smooth Muscle Cells
A. Olschewski, Yingji Li, B. Tang, J. Hanze +10 more
2006Circulation Research235 citations Open access
Semantic Scholar
Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.
J. Ross, Zhi-Gang Hong, B. Willenbring, Lepeng Zeng +7 more
2006Journal of Clinical Investigation183 citations Open access
Semantic Scholar
Alterations in a redox oxygen sensing mechanism in chronic hypoxia.
H. Reeve, E. Michelakis, Daniel P. Nelson, E. Weir +1 more
2001Journal of applied physiology152 citations
Semantic Scholar
Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells.
E. Michelakis, B. Thébaud, E. Weir, S. Archer
2004Journal of Molecular and Cellular Cardiology151 citations
Semantic Scholar
Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease
Ying-Jie Chen, Haipeng Guo, Dachun Xu, Xin Xu +8 more
2012HYPERTENSION143 citations Open access
Semantic Scholar
Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation.
S. Archer, E. Weir, H. Reeve, E. Michelakis
2000Advances in Experimental Medicine and Biology137 citations
Semantic Scholar
Differentiating COVID-19 Pneumonia from Acute Respiratory Distress Syndrome (ARDS) and High Altitude Pulmonary Edema (HAPE): Therapeutic implications
S. L. Archer, Willard W. Sharp, E. Weir
2020Circulation130 citations Open access
Semantic Scholar
Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia.
E. Weir, A. Olschewski
2006Cardiovascular Research102 citations
Semantic Scholar
Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries
C. Nagaraj, B. Tang, Z. Bálint, M. Wygrecka +7 more
2012European Respiratory Journal101 citations Open access
Semantic Scholar
Role of Dynamin Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen-Sensing and Constriction of the Ductus Arteriosus
Zhi-Gang Hong, S. Kutty, P. Toth, G. Marsboom +9 more
2013Circulation Research97 citations Open access
Semantic Scholar
Trends And Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of Nationwide Inpatient Sample Database From 2001-2012
Vidhu Anand, S. Roy, S. Archer, E. Weir +3 more
2016JAMA cardiology84 citations Open access
Semantic Scholar
Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites.
Daphne Moutsoglou, Jasmine Tatah, S. Prisco, K. Prins +10 more
2022American Journal of Respiratory and Critical Care Medicine77 citations
Semantic Scholar
Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes.
Zhi-Gang Hong, E. Weir, Daniel P. Nelson, A. Olschewski
2004American Journal of Respiratory Cell and Molecular Biology77 citations
Semantic Scholar
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase
Dachun Xu, Haipeng Guo, Xin Xu, Zhong-Bing Lu +11 more
2011HYPERTENSION73 citations Open access
Semantic Scholar
Redox control of oxygen sensing in the rabbit ductus arteriosus
H. Reeve, S. Tolarova, Daniel P. Nelson, S. Archer +1 more
2001Journal of Physiology70 citations Open access
Semantic Scholar
A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent.
H. Reeve, E. Weir, Stephen L. Archer, D. Cornfield
1998American Journal of Physiology - Lung cellular and Molecular Physiology70 citations
Semantic Scholar
Graded response of K+ current, membrane potential, and [Ca2+]i to hypoxia in pulmonary arterial smooth muscle.
A. Olschewski, Zhi-Gang Hong, Daniel P. Nelson, E. Weir
2002American Journal of Physiology - Lung cellular and Molecular Physiology61 citations
Semantic Scholar
Anorectic drugs and pulmonary hypertension from the bedside to the bench.
E. Michelakis, E. Weir
2001American Journal of the Medical Sciences56 citations
Semantic Scholar
Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus.
A. Olschewski, Zhi-Gang Hong, D. Peterson, Daniel P. Nelson +2 more
2004American Journal of Physiology - Lung cellular and Molecular Physiology55 citations
Semantic Scholar
Role of Store-Operated Calcium Channels and Calcium Sensitization in Normoxic Contraction of the Ductus Arteriosus
Zhi-Gang Hong, Fangxiao Hong, A. Olschewski, J. A. Cabrera +3 more
2006Circulation54 citations Open access
Semantic Scholar
Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species.
E. Weir, S. Archer
2006Journal of applied physiology53 citations
Semantic Scholar
The serotonin transporter: a vehicle to elucidate pulmonary hypertension?
E. Weir, Zhi-Gang Hong, A. Varghese
2004Circulation Research52 citations
Semantic Scholar
A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension.
E. Weir, H. Reeve, Gerhard J. Johnson, E. Michelakis +2 more
1998Chest45 citations
Semantic Scholar
Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture.
E. Weir, H. Reeve, D. Peterson, E. Michelakis +2 more
1998Chest43 citations
Semantic Scholar
Redox Regulation of Ion Channels in the Pulmonary Circulation
A. Olschewski, E. Weir
2015Antioxidants and Redox Signaling40 citations Open access
Semantic Scholar
Pergolide Is an Inhibitor of Voltage-Gated Potassium Channels, Including Kv1.5, and Causes Pulmonary Vasoconstriction
Zhi-Gang Hong, Andrew J. Smith, S. Archer, Xi-Chen Wu +4 more
2005Circulation38 citations Open access
Semantic Scholar
Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension
S. Prisco, M. Eklund, Daphne M Moutsoglou, Anthony R. Prisco +4 more
2021Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease37 citations Open access
Semantic Scholar
Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.
K. Prins, Lauren Rose, S. Archer, M. Pritzker +4 more
2018American Journal of Respiratory and Critical Care Medicine35 citations Open access
Semantic Scholar
Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension
C. Nagaraj, B. Tang, B. Nagy, R. Papp +9 more
2016European Respiratory Journal34 citations Open access
Semantic Scholar
Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential.
H. Reeve, Stephen L. Archer, M. Soper, E. Weir
1999American Journal of Physiology - Lung cellular and Molecular Physiology33 citations
Semantic Scholar
Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells.
E. Michelakis, E. Weir, Daniel P. Nelson, H. Reeve +2 more
1999Journal of Pharmacology and Experimental Therapeutics32 citations
Semantic Scholar
Generation of oxidants by hypoxic human pulmonary and coronary smooth-muscle cells.
J. Mehta, J. Campian, J. Guardiola, J. A. Cabrera +2 more
2008Chest31 citations
Semantic Scholar
Contribution of the K(Ca) channel to membrane potential and O2 sensitivity is decreased in an ovine PPHN model.
A. Olschewski, Zhi-Gang Hong, B. Linden, V. Porter +2 more
2002American Journal of Physiology - Lung cellular and Molecular Physiology30 citations
Semantic Scholar
Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology.
H. Reeve, Daniel P. Nelson, S. Archer, E. Weir
1999American Journal of Physiology - Lung cellular and Molecular Physiology29 citations
Semantic Scholar
Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox
C. Nagaraj, C. Tabeling, B. Nagy, P. Jain +11 more
2017European Respiratory Journal27 citations Open access
Semantic Scholar
Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine.
Zhi-Gang Hong, A. Olschewski, H. Reeve, Daniel P. Nelson +2 more
2004American Journal of Physiology - Lung cellular and Molecular Physiology27 citations
Semantic Scholar
A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system.
S. Archer, E. Michelakis, B. Thébaud, S. Bonnet +3 more
2006Novartis Foundation symposium26 citations
Semantic Scholar
Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling.
L. Shang, X. Weng, Dong-Zhi Wang, W. Yue +7 more
2019Free Radical Biology & Medicine25 citations
Semantic Scholar
Activation of the EGFR/p38/JNK Pathway by Mitochondrial-Derived Hydrogen Peroxide Contributes To Oxygen-induced Contraction Of Ductus Arteriosus
Zhi-Gang Hong, J. A. Cabrera, S. Mahapatra, S. Kutty +2 more
2014Journal of molecular medicine25 citations Open access
Semantic Scholar
Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus
E. Weir, M. Obreztchikova, A. Vargese, J. A. Cabrera +2 more
2008British Journal of Pharmacology23 citations Open access
Semantic Scholar
The role of ion channels in hypoxic pulmonary vasoconstriction.
E. Weir, J. A. Cabrera, S. Mahapatra, D. Peterson +1 more
2010Advances in Experimental Medicine and Biology21 citations
Semantic Scholar
Low potassium dextran lung preservation solution reduces reactive oxygen species production.
Rosemary F. Kelly, J. Murar, Zhi-Gang Hong, Daniel P. Nelson +3 more
2003Annals of Thoracic Surgery21 citations
Semantic Scholar
The Fetal and Neonatal Pulmonary Circulations
E. Weir, S. Archer, J. T. Reeves
200014 citations
Semantic Scholar
Effect of normoxia and hypoxia on K(+) current and resting membrane potential of fetal rabbit pulmonary artery smooth muscle.
Zhi-Gang Hong, E. Weir, A. Varghese, A. Olschewski
2005Physiological Research12 citations Open access
Semantic Scholar
Acute Normoxia Increases Fetal Pulmonary Artery Endothelial Cell Cytosolic Ca2+ Via Ca2+-Induced Ca2+ Release
R. Tirosh, E. Resnik, Jean M. Herron, David J. Sukovich +3 more
2006Pediatric Research10 citations
Semantic Scholar

Frequent co-authors

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S. Archer×17
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S. Archer — researcher profile on SciRah
Zhi-Gang Hong×15
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Zhi-Gang Hong — researcher profile on SciRah
Daniel P. Nelson×14
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Daniel P. Nelson — researcher profile on SciRah
A. Olschewski×13
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A. Olschewski — researcher profile on SciRah

×11

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H. Reeve — researcher profile on SciRah

E. Michelakis×10

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E. Michelakis — researcher profile on SciRah

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D. Peterson — researcher profile on SciRah

J. A. Cabrera×5

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J. A. Cabrera — researcher profile on SciRah

Stephen L. Archer×4

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Stephen L. Archer — researcher profile on SciRah

G. Kwapiszewska×4

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G. Kwapiszewska — researcher profile on SciRah

H. Olschewski×4

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H. Olschewski — researcher profile on SciRah

T. Thenappan×4

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T. Thenappan — researcher profile on SciRah