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P. Kussie · SciRah

Researcher profile · Semantic Scholar

P. Kussie

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P. Kussie — researcher profile on SciRah

h-index: 30
Works: 66
Citations: 6,492

Most-cited papers

Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
P. Kussie, S. Gorina, V. Maréchal, Brian Elenbaas +3 more
1996Science2,214 citations
Semantic Scholar
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.
Shiqing Li, K. R. Schmitz, P. Jeffrey, J. Wiltzius +2 more
2005Cancer Cell1,149 citations
Semantic Scholar
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.
Douglas B. Burtrum, Zhenping Zhu, D. Lu, D. Anderson +14 more
2003Cancer Research374 citations
Semantic Scholar
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.
Chong-Hui Cheng, P. Kussie, N. Pavletich, S. Shuman
1998Cell238 citations Open access
Semantic Scholar
Cloning and functional expression of a human heparanase gene.
P. Kussie, J. Hulmes, Dale L. Ludwig, Sheetal N. Patel +4 more
1999Biochemical and Biophysical Research Communications - BBRC213 citations
Semantic Scholar
High heparanase activity in multiple myeloma is associated with elevated microvessel density.
T. Kelly, Hua Miao, Yang Yang, Elizabeth C. Navarro +10 more
2003Cancer Research183 citations
Semantic Scholar
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity
Zhenping Zhu, K. Hattori, Hai-Fan Zhang, Xenia Jimenez +12 more
2003Leukemia169 citations
Semantic Scholar
Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Yang Yang, V. Macleod, Manali S. Bendre, Yan Huang +8 more
2004Blood147 citations
Semantic Scholar
A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.
K. Takahashi, X.-C. Jiang, N. Sakai, S. Yamashita +6 more
1993Journal of Clinical Investigation139 citations Open access
Semantic Scholar
PLACENTAL GROWTH FACTOR ADMINISTRATION ABOLISHES PLACENTAL ISCHEMIA-INDUCED HYPERTENSION
F. Spradley, Adelene Y. Tan, Woo S. Joo, G. Daniels +3 more
2016HYPERTENSION130 citations Open access
Semantic Scholar
Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.
Shiqing Li, P. Kussie, K. Ferguson
2008Structure125 citations Open access
Semantic Scholar
Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target
N. Loizos, Yan Xu, J. Huber, Meilin Liu +22 more
2005Molecular Cancer Therapeutics124 citations
Semantic Scholar
Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability.
Fang Liao, J. Doody, Jay Overholser, B. Finnerty +6 more
2002Cancer Research114 citations
Semantic Scholar
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
Haijun D. Sun, Maria Malabunga, J. Tonra, R. Direnzo +8 more
2007American Journal of Physiology. Endocrinology and Metabolism106 citations
Semantic Scholar
Development of heparanase inhibitors for anti-cancer therapy.
Hua Miao, Hu Liu, Elizabeth C. Navarro, P. Kussie +1 more
2006Current Medicinal Chemistry101 citations
Semantic Scholar
Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.
C. May, J. Doody, R. Abdullah, P. Balderes +8 more
2005Blood95 citations
Semantic Scholar
Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera.
N. Loizos, Leah Lariccia, J. Weiner, Heather Griffith +4 more
2009Arthritis & Rheumatism88 citations
Semantic Scholar
Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Xiaohu Ouyang, Xiaoling Chen, Evgueni L. Piatnitski, A. Kiselyov +22 more
2005Bioorganic & Medicinal Chemistry Letters71 citations
Semantic Scholar
Identification of the Residues in the Extracellular Region of KDR Important for Interaction with Vascular Endothelial Growth Factor and Neutralizing Anti-KDR Antibodies*
D. Lu, P. Kussie, B. Pytowski, Kris Persaud +3 more
2000Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Identification of a plasminogen binding region in streptokinase that is necessary for the creation of a functional streptokinase-plasminogen activator complex.
G. L. Reed, L. Lin, B. Parhami-Seren, P. Kussie
1995Biochemistry61 citations
Semantic Scholar
1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors.
Wei-Tao Pan, Hua Miao, Yong-Jiang Xu, Elizabeth C. Navarro +7 more
2006Bioorganic & Medicinal Chemistry Letters55 citations Open access
Semantic Scholar
Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibody.
Yiwen Li, Hong-Li Li, Mei-Nai Wang, D. Lu +13 more
2004Blood53 citations
Semantic Scholar
The structural basis for the function of two anti-VEGF receptor 2 antibodies.
M. Franklin, Elizabeth C. Navarro, Yujie Wang, Sheetal N. Patel +8 more
2011Structure49 citations Open access
Semantic Scholar
Activation of FGFR1β signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells
M. Karajannis, L. Vincent, R. Direnzo, SV Shmelkov +7 more
2006Leukemia49 citations Open access
Semantic Scholar
N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors.
Yong-Jiang Xu, Hua Miao, Wei-Tao Pan, Elizabeth C. Navarro +8 more
2006Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Defective Binding of Neutral Lipids by a Carboxyl-terminal Deletion Mutant of Cholesteryl Ester Transfer Protein
Su-Ke Wang, P. Kussie, Liping Deng, A. Tall
1995Journal of Biological Chemistry43 citations Open access
Semantic Scholar
A functional analysis of the antigenicity of streptokinase using monoclonal antibody mapping and recombinant streptokinase fragments.
G. L. Reed, P. Kussie, B. Parhami-Seren
1993Journal of Immunology42 citations Open access
Semantic Scholar
Cloning, expression, and purification of mouse heparanase.
Hua Miao, Elizabeth C. Navarro, Sheetal N. Patel, David Sargent +7 more
2002Protein Expression and Purification40 citations
Semantic Scholar
Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.
M. Tuma, A. Malikzay, Xiaohu Ouyang, D. Surguladze +8 more
2010Translational Oncology35 citations Open access
Semantic Scholar
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.
M. Duncton, Eugene L. Piatnitski Chekler, R. Katoch-Rouse, D. Sherman +16 more
2009Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Interfacial properties of recombinant human cholesterol ester transfer protein.
Richard B. Weinberg, V. R. Cook, J. B. Jones, P. Kussie +1 more
1994Journal of Biological Chemistry35 citations Open access
Semantic Scholar
A single engineered amino acid substitution changes antibody fine specificity.
P. Kussie, B. Parhami-Seren, L. Wysocki, M. N. Margolies
1994Journal of Immunology33 citations Open access
Semantic Scholar
Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells.
M. Karajannis, L. Vincent, R. Direnzo, S. Shmelkov +7 more
2006Leukemia30 citations
Semantic Scholar
Modulation of antibody affinity by an engineered amino acid substitution.
Yee-Wah Wong, P. Kussie, B. Parhami-Seren, M. N. Margolies
1995Journal of Immunology25 citations Open access
Semantic Scholar
Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases.
Wei-Tao Pan, Hu Liu, Yong-Jiang Xu, Xin Chen +7 more
2005Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Conservation of binding site geometry among p-azophenylarsonate-specific antibodies.
B. Parhami-Seren, P. Kussie, R. Strong, M. N. Margolies
1993Journal of Immunology22 citations Open access
Semantic Scholar
Conservation of receptor antagonist anti-tumor activity by epidermal growth factor receptor antibody expressed in transgenic corn seed
D. Ludwig, L. Witte, D. Hicklin, M. Prewett +26 more
2004Human Antibodies19 citations Open access
Semantic Scholar
Production and characterization of monoclonal idiotypes and anti-idiotypes for small ligands.
P. Kussie, G. Albright, D. Linthicum
1989Methods in Enzymology18 citations
Semantic Scholar
1‐[4‐(1H‐Benzoimidazol‐2‐yl)‐phenyl]‐3‐ [4‐(1H‐benzoimidazol‐2‐yl)‐phenyl]‐urea Derivatives as Small Molecule Heparanase Inhibitors.
Wei-Tao Pan, Hua Miao, Yong-Jiang Xu, Elizabeth C. Navarro +7 more
200613 citations
Semantic Scholar
Analysis of the binding site architecture of monoclonal antibodies to morphine by using competitive ligand binding and molecular modeling.
P. Kussie, Jerry M. Anchin, Shankar Subramaniam, J. Glasel +1 more
1991Journal of Immunology13 citations Open access
Semantic Scholar
Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand.
D. Linthicum, M. Bolger, P. Kussie, G. Albright +3 more
1988Clinical Chemistry13 citations
Semantic Scholar
Prenatal exposure to drugs of abuse in humans: effects on placental neurotransmitter receptors.
B. Perry, D. J. Pesavento, P. Kussie, D. U'prichard +1 more
1984Neurobehavioral toxicology and teratology9 citations
Semantic Scholar
Molecular analysis of monoclonal idiotypes and anti-idiotypes.
P. Kussie, M. Sherman, Dario Marchetti, D. Linthicum
1989Methods in Enzymology4 citations
Semantic Scholar
Administration of recombinant human placental growth factor (rhPlGF) decreases blood pressure in obese hypertensive pregnant rats
A. Palei, Adelene Y. Tan, Woo S. Joo, P. Kussie +3 more
2020Journal of Hypertension3 citations Open access
Semantic Scholar
Abstract 14994: Inactivation of α2-Antiplasmin Promotes Thrombus Dissolution in Humans: Preliminary Results of the Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
G. Reed, P. Kussie, Karen Lee, Tie-Qiang Zhao +2 more
20163 citations
Semantic Scholar
A fully human monoclonal antibody against VEGFR-1 inhibits growth of human breast cancers
Yan Wu, Z. Zhong, Hui-Ling Li, J. Huber +11 more
20043 citations
Semantic Scholar
Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs
Adelene Y. Tan, Ken Kearney, Courtney J. Jenkins, S. Karumanchi +2 more
2022Hypertension in Pregnancy2 citations
Semantic Scholar
Defining the structural correlates responsible for loss of arsonate affinity in an IDCR antibody isolated from an autoimmune mouse.
David J. Panka, D. Very, B. A. Jacobson, P. Kussie +3 more
1993Molecular Immunology1 citations
Semantic Scholar
O-001. Acute cardiovascular and hemodynamic consequences of placental growth factor administration in guinea pigs
Adelene Y. Tan, K. Kearney, Courtney J. Jenkins, A. Karumanchi +2 more
2021Pregnancy Hypertension0 citations
Semantic Scholar
Abstract 150: Obese Hypertensive Pregnant Rats Have Reduced Placental Growth Factor Whereas Increasing It's Levels Decreases Their Blood Pressure
F. Spradley, A. Palei, Woo S. Joo, P. Kussie +1 more
2019HYPERTENSION0 citations
Semantic Scholar

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