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P. Wren · SciRah

Researcher profile · Semantic Scholar

P. Wren

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P. Wren — researcher profile on SciRah

h-index: 13
Works: 25
Citations: 1,437

Most-cited papers

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
B. Lu, G. Nagappan, Xiao-Ming Guan, P. Nathan +1 more
2013Nature Reviews Neuroscience750 citations
Semantic Scholar
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
K. Ahn, Sarah E. Smith, M. Liimatta, D. Beidler +15 more
2011Journal of Pharmacology and Experimental Therapeutics221 citations Open access
Semantic Scholar
Innervation of the foregut of the cockroach Leucophaea maderae and inhibition of spontaneous contractile activity by callatostatin neuropeptides
H. Duve, P. Wren, A. Thorpe
199571 citations
Semantic Scholar
Peripheral inflammation increases the capsaicin sensitivity of dorsal root ganglion neurons in a nerve growth factor-dependent manner.
R. Nicholas, J. Winter, P. Wren, R. Bergmann +1 more
1999Neuroscience63 citations
Semantic Scholar
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load
V. Calsolaro, P. Matthews, C. Donat, Nicholas R. Livingston +17 more
2021Molecular Psychiatry56 citations Open access
Semantic Scholar
GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species
A. Rutter, A. Poffe, Palmina Cavallini, T. Davis +8 more
2014Journal of Pharmacology and Experimental Therapeutics55 citations Open access
Semantic Scholar
Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders.
M. Wood, P. Wren
2008Progress in Brain Research48 citations
Semantic Scholar
Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals
Nicholas R. Livingston, V. Calsolaro, R. Hinz, Joseph Nowell +14 more
2021Molecular Psychiatry36 citations Open access
Semantic Scholar
The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity
T. Davis, John J. Peterson, J. Kou, Elizabeth A. Capper-Spudich +11 more
2009Journal of Pharmacology and Experimental Therapeutics23 citations
Semantic Scholar
Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor
Jessica M. Bright, H. Carlisle, Alyssa M. A. Toda, M. Murphy +5 more
2021Movement Disorders18 citations Open access
Semantic Scholar
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.
Hongfu Lu, Ting Yang, Zhongmiao Xu, Xi-Chen Lin +12 more
2018Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.
C. Scott, E. Soffin, Matthew J. Hill, P. Atkinson +9 more
2006European Journal of Pharmacology14 citations
Semantic Scholar
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.
R. Palin, D. Barn, J. K. Clark, J. Cottney +16 more
2005Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.
Hongfu Lu, Ting Yang, Zhongmiao Xu, P. Wren +11 more
2014Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
p38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms.
Filippo Andreetta, N. Barnes, P. Wren, L. Carboni
2013Life Science12 citations
Semantic Scholar
Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain
K. Ahn, Sarah E. Smith, M. Liimatta, D. Beidler +16 more
201111 citations
Semantic Scholar
Longitudinal Characterization of Transcriptomic, Functional, and Morphological Features in Human iPSC-Derived Neurons and Their Application to Investigate Translational Progranulin Disease Biology
Gaëlle Robin, J. Evans, D. Hauser, P. Wren +1 more
2020Frontiers in Aging Neuroscience7 citations Open access
Semantic Scholar
Mechanisms of vascular disease in dementia: what does industry want to know?
P. Wren, D. Hill, A. Lockhart
2017Clinical science4 citations
Semantic Scholar
The production and analysis of transgenic mice expressing the human serotonin transporter.
M. Loder, S. Shen, P. Wren, T. Sharp +2 more
20004 citations
Semantic Scholar
Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?
S. Harris, S. Ritchie, Gonçalo D. S. Correia, B. Jiménez +12 more
2020bioRxiv3 citations Open access
Semantic Scholar
[P4–434]: PLASMA LIPID BIOMARKERS IN THE LOTHIAN BIRTH COHORT 1936: TOWARD ASSOCIATIONS WITH LIFE‐COURSE COGNITIVE FUNCTION
S. Ritchie, Sarah E. Harris, C. Fawns-Ritchie, J. Starr +4 more
20170 citations
Semantic Scholar
The Identification of a Novel PDE 4 Inhibitor , EPPA-1 , with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of
T. Davis, John J. Peterson, J. Kou, Elizabeth A. Capper-Spudich +11 more
20090 citations
Semantic Scholar
Utilisation d'un inhibiteur de kinase p38 pour le traitement de troubles psychiatriques
M. Corsi, Isidore Faiferman, E. Pich, Emiliangelo Ratti +1 more
20070 citations
Semantic Scholar
P.1.034 Chronic gepirone treatment alters regional 5-HT1A receptor coupling efficiency in rat brain
N. Ward, P. Wren, B. Henry, S. McElroy +4 more
20030 citations
Semantic Scholar
Modulation of the serotonin transporter and receptors by antidepressants and ecstasy
P. Wren
20000 citations
Semantic Scholar

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