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T. Ochiai · SciRah

Researcher profile · Semantic Scholar

T. Ochiai

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T. Ochiai — researcher profile on SciRah

h-index: 20
Works: 55
Citations: 1,671

Most-cited papers

Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol.
T. Ochiai, Shigekazu Ohno, S. Soeda, Hiroyuki Tanaka +2 more
2004Neuroscience Letters303 citations
Semantic Scholar
Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.
T. Ochiai, H. Shimeno, K. Mishima, K. Iwasaki +6 more
2007Biochimica et Biophysica Acta292 citations
Semantic Scholar
Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis.
T. Ochiai, S. Soeda, Shigekazu Ohno, Hiroyuki Tanaka +2 more
2004Neurochemistry International133 citations
Semantic Scholar
Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice
A. Sakata, T. Ochiai, H. Shimeno, Sadao Hikishima +5 more
2007Immunology113 citations Open access
Semantic Scholar
Pharmacological activities of crocin in saffron
S. Soeda, T. Ochiai, H. Shimeno, H. Saito +3 more
2007Journal of Natural Medicines103 citations
Semantic Scholar
Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4(3H)-quinazolinone derivatives.
J. Tani, Yoshihisa Yamada, Toyonari Oine, T. Ochiai +2 more
1979Journal of Medicinal Chemistry74 citations
Semantic Scholar
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.
Kimiaki Hayashi, Kenichi Nunami, Jyoji Kato, N. Yoneda +3 more
1989Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity.
T. Ochiai, R. Ishida
1982Japanese Journal of Pharmacology58 citations Open access
Semantic Scholar
Synthesis of telechelic olefin polymers via catalyzed chain growth on multinuclear alkylene zinc compounds.
H. Makio, T. Ochiai, Jun-ichi Mohri, K. Takeda +4 more
2013Journal of the American Chemical Society48 citations
Semantic Scholar
Total Synthesis of the Furaquinocins
Takeshi Saito, Takao Suzuki, M. Morimoto, C. Akiyama +4 more
199846 citations
Semantic Scholar
Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress.
S. Soeda, Y. Tsuji, T. Ochiai, K. Mishima +6 more
2004Neurochemistry International44 citations
Semantic Scholar
Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice.
A. Sakata, K. Yasuda, T. Ochiai, H. Shimeno +4 more
2007Cellular Immunology43 citations
Semantic Scholar
Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities.
M. Kubo, Jyouji Kato, T. Ochiai, R. Ishida
1990Japanese Journal of Pharmacology43 citations Open access
Semantic Scholar
Effects of psychotropic drugs on emotional behavior: exploratory behavior of naive rats in holed open field.
Mototaka Nakama, T. Ochiai, Yoshio Kowa
1972Japanese Journal of Pharmacology38 citations Open access
Semantic Scholar
Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation.
T. Ochiai, Y. Takenaka, Yukako Kuramoto, Masakazu Kasuya +6 more
2008Biochimica et Biophysica Acta28 citations
Semantic Scholar
Screening of an α-Amylase Inhibitor Peptide by Photolinker–Peptide Array
T. Ochiai, Tomoya Sugita, Ryuji Kato, M. Okochi +1 more
2012Bioscience, biotechnology and biochemistry27 citations
Semantic Scholar
Concise Synthesis of Fully-Substituted Furan, Pyrrole, Butenolide, and 2-Butene-4-lactam Esters
N. Iwasawa, T. Ochiai, Katsuya Maeyama
199827 citations
Semantic Scholar
PHARMACOLOGICAL STUDIES ON 6-AMINO-2-FLUOROMETHYL-3-(O-TOLYL)-4(3H)-QUINAZOLINONE (AFLOQUALONE), A NEW CENTRALLY ACTING MUSCLE RELAXANT (I)
T. Ochiai, R. Ishida
198125 citations Open access
Semantic Scholar
Studies on biologically active halogenated compounds. II. Chemical modifications of 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone and the CNS depressant activities of related compounds.
J. Tani, Yoshihisa Yamada, T. Ochiai, R. Ishida +2 more
1979Chemical and pharmaceutical bulletin23 citations Open access
Semantic Scholar
Release of plasminogen activator inhibitor‐1 from human astrocytes is regulated by intracellular ceramide
M. Kimura, S. Soeda, Masatoshi Oda, T. Ochiai +3 more
2000Journal of Neuroscience Research20 citations
Semantic Scholar
Observation and Iodine Oxidation of the Protonated Anionic Propargyltungsten Species Formed in the Reaction of Fischer-Type Carbene Complexes with Alkynyllithiums
N. Iwasawa, T. Ochiai, Katsuya Maeyama
199718 citations
Semantic Scholar
Pharmacological studies on TA-6366, a new ACE inhibitor: II. Effect of long-term administration from the pre-hypertensive stage on blood pressure, relative heart weight and ACE activity of various tissues in spontaneously hypertensive rats (SHRs).
M. Kubo, T. Ochiai, Jyoji Kato, R. Ishida
1991Japanese Journal of Pharmacology17 citations Open access
Semantic Scholar
Olefin polymerization behavior of titanium(IV) pyridine-2-phenolate-6- (σ-aryl) catalysts: Impact of "py-adjacent" and phenolate substituents
Jerry C. Y. Lo, M. C. Chan, Po-Kam Lo, Kai-Chung Lau +2 more
201316 citations
Semantic Scholar
Plasminogen activator inhibitor-1 aids survival of neurites on neurons derived from pheochromocytoma (PC-12) cells
S. Soeda, T. Imatoh, T. Ochiai, S. Koyanagi +1 more
2004NeuroReport14 citations
Semantic Scholar
FI Catalysts: A Molecular Zeolite for Olefin Polymerization
H. Makio, T. Ochiai, Hidetsugu Tanaka, T. Fujita
201013 citations
Semantic Scholar
[General pharmacology of 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. I. Effects on the central nervous system (author's transl)].
T. Ochiai, M. Yamamura, Y. Kudo, R. Ishida
1981Nihon yakurigaku zasshi. Folia pharmacologica Japonica6 citations
Semantic Scholar
Preparation of .BETA.-diketone resins and an application in separation of 59Fe and 60Co.
A. Sugii, N. Ogawa, T. Ochiai
19775 citations Open access
Semantic Scholar
Pharmacology of a new hypnotic drug: HQ-355.
T. Ochiai, R. Ishida, Seiichi Nurimoto, I. Inoue +1 more
1972Japanese Journal of Pharmacology4 citations Open access
Semantic Scholar
Promising pharmacological actions of croon in crocus sativus on the central nervous system
S. Soeda, T. Ochiai, H. Shimeno, H. Saito +6 more
20033 citations
Semantic Scholar
[Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl)].
M. Yamamura, T. Ochiai, R. Ishida
1981Nihon yakurigaku zasshi. Folia pharmacologica Japonica3 citations
Semantic Scholar
STUDIES ON BIOLOGICALLY ACTIVE HALOGENATED COMPOUNDS. 1. SYNTHESIS AND CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF 2-(FLUOROMETHYL)-3-ARYL-4(3H)-QUINAZOLINONE DERIVATIVES
J. Tani, Yoshihisa Yamada, T. Oine, T. Ochiai +2 more
19793 citations
Semantic Scholar
CHOLESTEROL-INDEPENDENT, MAPK/ERK SIGNAL-MEDIATED SIMVASTATIN POTENTIATION OF NERVE GROWTH FACTOR-INDUCED NEURITE OUTGROWTH IN PC-12 CELLS
T. Ochiai, K. Fukuda, Masakazu Kasuya
20081 citations
Semantic Scholar
Prevention of PC-12 cell death by crocin via sphingomyelinase-ceramide signaling by increase of glutathione biosynthesis
T. Ochiai, S. Soeda, Shigekazu Ohno, H. Shimeno +5 more
20041 citations
Semantic Scholar
[A novel function of anti-fibrinolytic factor, PAI-1, in the central nervous system: a possible role as the neurotrophic factor].
T. Imatoh, S. Soeda, T. Ochiai, H. Shimeno
2002Nihon yakurigaku zasshi. Folia pharmacologica Japonica1 citations
Semantic Scholar
[Synthesis of sphingomyelin analogues as a sphingomyelinase inhibitor and the application as a blocking agent of extracellular stress signaling].
Y. Tsuji, S. Soeda, T. Ochiai, K. Mishima +7 more
2002Nihon yakurigaku zasshi. Folia pharmacologica Japonica1 citations
Semantic Scholar
A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative.
M. Yamamura, H. Nakagawa, K. Kinoshita, T. Ochiai +1 more
1988Japanese Journal of Pharmacology1 citations Open access
Semantic Scholar
新規中枢性筋弛緩薬 Afloqualone の行動薬理学的研究ラットにおける低率分化餌強化(DRL)反応および条件情動反応(CER)に対する影響
M. Yamamura, T. Ochiai, R. Ishida
19811 citations Open access
Semantic Scholar
[General pharmacology of 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. II. Effects on the peripheral system (author's transl)].
T. Ochiai, I. Fukuchi, H. Ego, M. Yamamura +2 more
1981Nihon yakurigaku zasshi. Folia pharmacologica Japonica1 citations
Semantic Scholar
STUDIES ON BIOLOGICALLY ACTIVE HALOGENATED COMPOUNDS. II. CHEMICAL MODIFICATIONS OF 6-AMINO-2-FLUOROMETHYL-3-(O-TOLYL)-4(3H)-QUINAZOLINONE AND THE CNS DEPRESSANT ACTIVITIES OF RELATED COMPOUNDS
J. Tani, Yoshihisa Yamada, T. Ochiai, R. Ishida +2 more
19801 citations
Semantic Scholar
Effects of 1-morpholinoacetyl-2-methyl-3-phenyl-4-oxo-1,2,3,4-tetrahydro quinazoline hydrochloride (HQ-275) on alpha-naphtyl isothio-cyanate- and/or thioacetamide-induced liver damage in rats.
T. Ochiai
1974Japanese Journal of Pharmacology1 citations Open access
Semantic Scholar
Relationship of HQ-275 to biliary excretion and portal blood flow in dogs.
T. Ochiai, T. Nagao, S. Murata, Kenichi Yoshimoto +1 more
1973Japanese Journal of Pharmacology1 citations Open access
Semantic Scholar
Effects of 1-morpholinoacetyl-2-methyl-3-phenyl-4-oxo-1, 2, 3, 4-tetrahydroquinazoline hydrochloride (HQ-275) on acute experimental hepatic injury induced by carbon tetrachloride in rats.
T. Ochiai, Masaki Hori, Yoshio Kowa
1973Japanese Journal of Pharmacology1 citations Open access
Semantic Scholar
Choleretic activities of 1-morpholinoacetyl-2-methyl-3-phenyl-4-oxo-1, 2, 3, 4-tetrahydro quinazoline hydrochloride (HQ-275).
T. Ochiai, Yoshio Kowa, K. Okumura
1972Japanese Journal of Pharmacology1 citations Open access
Semantic Scholar
Sphingomyelinase Inhibition Suggests a Possible New Strategy for the Treatment of Inflammatory Bowel Disease
S. Soeda, A. Sakata, T. Ochiai, K. Yasuda +7 more
20080 citations
Semantic Scholar
Forthcoming papers
Bo Jin, Richard Wang, Qu Qi, F. Sugauchi +52 more
20070 citations Open access
Semantic Scholar
Fluorinated cycloolefin and process for their preparation, and their use
Hirofumi Io, K. Kawamura, H. Kouno, T. Morita +5 more
20020 citations
Semantic Scholar
Total Synthesis of the Furaquinocins.
Takeshi Saito, Takao Suzuki, M. Morimoto, C. Akiyama +4 more
19990 citations
Semantic Scholar
Concise Synthesis of Fully-Substituted Furan, Pyrrole, Butenolide, and 2-Butene-4-lactam Esters.
N. Iwasawa, T. Ochiai, Katsuya Maeyama
19980 citations
Semantic Scholar
Studies on Angiotensin‐Converting Enzyme Inhibitors. Part 4. Synthesis and Angiotensin‐Converting Enzyme Inhibitory Activities of 3‐Acyl‐1‐alkyl‐2‐oxoimidazolidine‐4‐carboxylic Acid Derivatives.
Kimiaki Hayashi, K. Nunami, Jyoji Kato, N. Yoneda +3 more
19890 citations
Semantic Scholar
Imidazolidinone compounds, processes for their preparation, compositions containing these compounds and their application value for the fabrication of medicines with a therapeutic.
M. Takeda, M. Inage, H. Wada, H. Tamaki +1 more
19870 citations
Semantic Scholar

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