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S. Shaw · SciRah

Researcher profile · Semantic Scholar

S. Shaw

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S. Shaw — researcher profile on SciRah

h-index: 13
Works: 36
Citations: 501

Most-cited papers

AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes
Y. Jenkins, Tianduo Sun, V. Markovtsov, M. Foretz +35 more
2013PLoS ONE58 citations Open access
Semantic Scholar
Toward understanding how the lactone moiety of discodermolide affects activity.
S. Shaw, Kurt F. Sundermann, Mark A. Burlingame, D. Myles +4 more
2005Journal of the American Chemical Society52 citations
Semantic Scholar
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Kristen A. Baltgalvis, Kathy White, Wei Li, Mark D. Claypool +25 more
2014American Journal of Physiology. Heart and Circulatory Physiology41 citations Open access
Semantic Scholar
The structure activity relationship of discodermolide analogues.
S. Shaw
2008Mini-Reviews in Medical Chemistry40 citations
Semantic Scholar
AMPK mediates energetic stress‐induced liver GDF15
Logan K. Townsend, A. Weber, Emily A. Day, Hesham Shamshoum +5 more
2020The FASEB Journal37 citations
Semantic Scholar
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
Amos B. Smith, B. Scott Freeze, M. LaMarche, T. Hirose +8 more
2005Organic Letters36 citations
Semantic Scholar
Traceless Linkers for Solid-phase Synthesis. Homo- and Hetero-Diels-Alder Reactions of o-Quinodimethanes
D. Craig, M. Robson, S. Shaw
199830 citations
Semantic Scholar
Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction.
Rajinder Singh, A. Sran, D. C. Carroll, Jia-Ning Huang +7 more
2015Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.
Amos B. Smith, B. Scott Freeze, M. LaMarche, T. Hirose +7 more
2005Organic Letters25 citations
Semantic Scholar
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
Mark A. Burlingame, S. Shaw, K. Sundermann, Dan Zhang +8 more
2004Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways
Y. Jenkins, Tianduo Sun, Yingwu Li, V. Markovtsov +8 more
2014BMC Research Notes16 citations Open access
Semantic Scholar
Microtubule Targeting Agents
B. R. Hearn, S. Shaw, D. Myles
200715 citations
Semantic Scholar
Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.
S. Shaw, Yue Chen, Hao Zheng, Hong Fu +9 more
2009Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Structural requirements for VanA activity of vancomycin analogues
Zhong Chen, Ulrike S. Eggert, Steven D. Dong, S. Shaw +3 more
200213 citations
Semantic Scholar
Enantioselective synthesis of cis-3-fluoropiperidin-4-ol, a building block for medicinal chemistry.
S. Shaw, D. Goff, Luke A. Boralsky, M. Irving +1 more
2013Journal of Organic Chemistry12 citations
Semantic Scholar
Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product--a further simplification of the lactone region.
S. Shaw, Hugo G Menzella, D. Myles, Ming Xian +1 more
2007Organic and biomolecular chemistry12 citations
Semantic Scholar
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
S. Shaw, D. Goff, Nan Lin, Rajinder Singh +5 more
2017Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions.
S. Shaw, K. Sundermann, Mark A. Burlingame, Dan Zhang +2 more
2006Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.
Yao-Quan Liu, Yong Li, D. Myles, Mark D. Claypool +2 more
2010Bioorganic & Medicinal Chemistry6 citations Open access
Semantic Scholar
Fragment Assembly: An Alternative Approach to Generating Complex Polyketides
S. Shaw, Dan Zhang, K. Sundermann, D. Myles
20065 citations
Semantic Scholar
Investigating Carboxylic Acid Analogues of Ambruticin through Semi‐Synthesis
Yuan Xu, Zhan Wang, Zong-Qiang Tian, Yong Li +1 more
2006ChemMedChem5 citations
Semantic Scholar
Ring‐Opening of Benzocyclobutenol with Mild Bases and Trapping with Dieneophiles
S. Shaw
20074 citations
Semantic Scholar
The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series.
Yao-Quan Liu, C. Carreras, Mark D. Claypool, D. Myles +1 more
2011Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Investigating Amine Derivatives of Ambruticin VS‐5 and VS‐4
Zong-Qiang Tian, Zhan Wang, Yuan Xu, C. Trần +7 more
2008ChemMedChem3 citations
Semantic Scholar
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.
S. Shaw, D. Goff, D. C. Carroll, Rajinder Singh +8 more
2022Bioorganic & Medicinal Chemistry2 citations Open access
Semantic Scholar
Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats
Ana M. Cruz, Katie M. Partridge, Yasaman Malekizadeh, Julia M. Vlachaki Walker +5 more
2021Frontiers in Endocrinology2 citations Open access
Semantic Scholar
Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution
Jacques LePaih, D. Goff, Rajinder Singh, S. Shaw
20211 citations
Semantic Scholar
AMP-activated protein kinase bound to pharmacological activator R739
Yan Yan, X.-E. Zhou, S. Novick, S. Shaw +6 more
20181 citations
Semantic Scholar
AMPK activation by a novel small molecule of mitochondrial regulation enhances fatty acid oxidation, ketogenesis and branched chain amino acid catabolism in vivo
Y. Hitoshi, Y. Jenkins, V. Markovtsov, Tianduo Sun +21 more
20131 citations
Semantic Scholar
Brain permeable AMPK activator R481 raises glycemia by autonomic nervous system activation and amplifies the counterregulatory response to hypoglycemia in rats
Ana M. Cruz, Yasaman Malekizadeh, Julia M. Vlachaki Walker, Paul G. Weightman Potter +4 more
2019bioRxiv0 citations Open access
Semantic Scholar
119-OR: Amplified Glucagon Response to Hypoglycemia following AMP-Activated Protein Kinase (AMPK) Activator R481 Treatment in Healthy Rats
Ana M. Cruz, Yasaman Malekizadeh, Julia M. Vlachaki Walker, S. Shaw +2 more
2019Diabetes0 citations
Semantic Scholar
AMP-activated protein kinase bound to pharmacological activator R734
Yan Yan, X.-E. Zhou, S. Novick, S. Shaw +6 more
20180 citations
Semantic Scholar
Pyrazole amide compounds as irak inhibitors
K. Tso, Hui Li, Yan Chen, R. Yen +4 more
20170 citations
Semantic Scholar
Abstract 3021: Development of small molecule direct AMPK activators for the treatment of cancer
Y. Hitoshi, Y. Jenkins, Yingwu Li, Elmer Sampang +10 more
20160 citations
Semantic Scholar
Ring-Opening of Benzocyclobutenol with Mild Bases and Trapping with Dieneophiles.
S. Shaw
20080 citations
Semantic Scholar
Phosphine, Diphenyl‐2‐propylene
D. Myles, S. Shaw
20040 citations
Semantic Scholar

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