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Nicole M. Ashpole · SciRah

Researcher profile · Semantic Scholar

Nicole M. Ashpole

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Nicole M. Ashpole — researcher profile on SciRah

h-index: 30
Works: 76
Citations: 3,174

Most-cited papers

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
Joel M. Brittain, D. Duarte, S. M. Wilson, Wei-Guo Zhu +28 more
2011Nature Medicine232 citations Open access
Semantic Scholar
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives
R. Tandon, J. Sharp, Fu-Ming Zhang, V. Pomin +7 more
2020Journal of Virology212 citations Open access
Semantic Scholar
GROWTH HORMONE, INSULIN-LIKE GROWTH FACTOR-1 AND THE AGING BRAIN
Nicole M. Ashpole, J. Sanders, Erik L. Hodges, Han Yan +1 more
2014Experimental Gerontology208 citations Open access
Semantic Scholar
Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites*
Nicole M. Ashpole, Anthony W. Herren, K. Ginsburg, J. D. Brogan +4 more
2012Journal of Biological Chemistry173 citations Open access
Semantic Scholar
IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging
Peter Toth, S. Tarantini, Nicole M. Ashpole, Zsuzsanna Tucsek +7 more
2015Aging Cell152 citations Open access
Semantic Scholar
Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights: Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase
Peter Toth, S. Tarantini, Zsuzsanna Tucsek, Nicole M. Ashpole +7 more
2014151 citations Open access
Semantic Scholar
The Effects of Exercise on Memory Function Among Young to Middle-Aged Adults: Systematic Review and Recommendations for Future Research
P. Loprinzi, E. Frith, Meghan K. Edwards, E. Sng +1 more
2018American Journal of Health Promotion139 citations
Semantic Scholar
Insulin-like growth factor-1 in CNS and cerebrovascular aging
W. Sonntag, F. Deák, Nicole M. Ashpole, Peter Toth +3 more
2013Frontiers in Aging Neuroscience136 citations Open access
Semantic Scholar
IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
Nicole M. Ashpole, Sreemathi Logan, A. Yabluchanskiy, Matthew C. Mitschelen +10 more
2017GeroScience130 citations Open access
Semantic Scholar
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability*
Nicole M. Ashpole, Wei-Hua Song, T. Brustovetsky, E. Engleman +3 more
2012Journal of Biological Chemistry110 citations Open access
Semantic Scholar
Insulin‐like growth factor 1 deficiency exacerbates hypertension‐induced cerebral microhemorrhages in mice, mimicking the aging phenotype
S. Tarantini, N. Valcarcel‐Ares, A. Yabluchanskiy, Zsolt Springó +8 more
2017Aging Cell105 citations Open access
Semantic Scholar
Excitotoxic neuroprotection and vulnerability with CaMKII inhibition.
Nicole M. Ashpole, A. Hudmon
2011Molecular and cellular neurosciences105 citations
Semantic Scholar
Whole Brain Radiation-Induced Vascular Cognitive Impairment: Mechanisms and Implications
J. Warrington, Nicole M. Ashpole, A. Csiszar, Yong-Woo Lee +2 more
2013Journal of Vascular Research102 citations Open access
Semantic Scholar
Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging
S. Tarantini, Zsuzsanna Tucsek, M. N. Valcarcel-Ares, Peter Toth +9 more
2016AGE100 citations Open access
Semantic Scholar
Neuroprotection against Traumatic Brain Injury by a Peptide Derived from the Collapsin Response Mediator Protein 2 (CRMP2)*
Joel M. Brittain, Liang Chen, S. M. Wilson, T. Brustovetsky +11 more
2011Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Aging Impairs Myogenic Adaptation to Pulsatile Pressure in Mouse Cerebral Arteries
Zsolt Springó, Peter Toth, S. Tarantini, Nicole M. Ashpole +5 more
2014Journal of Cerebral Blood Flow and Metabolism69 citations Open access
Semantic Scholar
Resveratrol Treatment Rescues Neurovascular Coupling in Aged Mice: Role of Improved Cerebromicrovascular Endothelial Function and Down‐Regulation of NADPH Oxidase
Peter Toth, S. Tarantini, Zsuzsanna Tucsek, Nicole M. Ashpole +7 more
201568 citations
Semantic Scholar
Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics
Wan-Hung Lee, Zhili Xu, Nicole M. Ashpole, A. Hudmon +4 more
2015Neuropharmacology60 citations Open access
Semantic Scholar
Target-Specific Support Vector Machine Scoring in Structure-Based Virtual Screening: Computational Validation, In Vitro Testing in Kinases, and Effects on Lung Cancer Cell Proliferation
Liwei Li, M. Khanna, Inha Jo, Fang Wang +3 more
2011Journal of Chemical Information and Modeling55 citations Open access
Semantic Scholar
IGF-1 REGULATES VERTEBRAL BONE AGING THROUGH SEX-SPECIFIC AND TIME-DEPENDENT MECHANISMS
Nicole M. Ashpole, J. C. Herron, Matthew C. Mitschelen, Julie A. Farley +8 more
2015Journal of Bone and Mineral Research51 citations Open access
Semantic Scholar
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging
S. Tarantini, Priya Balasubramanian, A. Yabluchanskiy, Nicole M. Ashpole +9 more
2021GeroScience50 citations Open access
Semantic Scholar
Loss of Calcium/Calmodulin-dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP*
Nicole M. Ashpole, Aarti R. Chawla, Mat Martin, T. Brustovetsky +2 more
2013Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Astrocyte senescence contributes to cognitive decline
Tamás Csípő, Á. Lipécz, Nicole M. Ashpole, Priya Balasubramanian +1 more
2019GeroScience45 citations Open access
Semantic Scholar
Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke
C. Hayes, M. N. Valcarcel-Ares, Nicole M. Ashpole
2021Journal of Cerebral Blood Flow and Metabolism43 citations Open access
Semantic Scholar
IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis
S. Tarantini, C. Giles, J. Wren, Nicole M. Ashpole +5 more
2016AGE42 citations Open access
Semantic Scholar
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Gavin A. Pharaoh, Daniel B. Owen, Alexander Yeganeh, Pavithra Premkumar +6 more
2019Molecular Neurobiology41 citations Open access
Semantic Scholar
Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio)
Z. Pandelides, C. Thornton, Anika S. Faruque, Alyssa P. Whitehead +2 more
2020GeroScience40 citations Open access
Semantic Scholar
Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish
C. Thornton, Kennedy Dickson, Dennis R. Carty, Nicole M. Ashpole +1 more
2020Epilepsy & Behavior37 citations Open access
Semantic Scholar
Aging Circadian Rhythms and Cannabinoids
Erik L. Hodges, Nicole M. Ashpole
2019Neurobiology of Aging37 citations Open access
Semantic Scholar
Loss of insulin-like growth factor-1 signaling in astrocytes disrupts glutamate handling
Disha S. Prabhu, S. M. Khan, Katherine Blackburn, J. P. Marshall +1 more
2019Journal of Neurochemistry33 citations Open access
Semantic Scholar
The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A*
Dong-Mei Zhang, M. C. Marlin, Zhimin Liang, Mohiuddin Ahmad +4 more
2016Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
Nicole M. Ashpole, J. Warrington, Matthew C. Mitschelen, Han Yan +6 more
2014American Journal of Physiology. Heart and Circulatory Physiology27 citations Open access
Semantic Scholar
Developmental exposure to Δ9-tetrahydrocannabinol (THC) causes biphasic effects on longevity, inflammation, and reproduction in aged zebrafish (Danio rerio)
Z. Pandelides, C. Thornton, K. Lovitt, Anika S. Faruque +3 more
2020GeroScience22 citations Open access
Semantic Scholar
Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice
Nicole M. Ashpole, J. C. Herron, Patrick N. Estep, Sreemathi Logan +4 more
2016AGE22 citations Open access
Semantic Scholar
Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
Han Yan, Matthew C. Mitschelen, Peter Toth, Nicole M. Ashpole +8 more
2014The journals of gerontology. Series A, Biological sciences and medical sciences21 citations Open access
Semantic Scholar
Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency
Alaina M. Reagan, Xiao-Wu Gu, Sijalu Paudel, Nicole M. Ashpole +8 more
2018Neurobiology of Aging20 citations Open access
Semantic Scholar
IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
Nicole M. Ashpole, Sreemathi Logan, A. Yabluchanskiy, Matthew C. Mitschelen +10 more
2017GeroScience20 citations Open access
Semantic Scholar
HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status
Alaa N. Qrareya, F. Mahdi, M. J. Kaufman, Nicole M. Ashpole +1 more
2020GeroScience15 citations Open access
Semantic Scholar
Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions.
C. Hayes, D. Wilson, M. A. D. de León, M. Mustapha +3 more
2024Frontiers in neuroendocrinology (Print)14 citations
Semantic Scholar
Insulin-Like Growth Factor-1 Differentially Modulates Glutamate-Induced Toxicity and Stress in Cells of the Neurogliovascular Unit
C. Hayes, Brandon G. Ashmore, A. Vijayasankar, J. P. Marshall +1 more
2021Frontiers in Aging Neuroscience14 citations Open access
Semantic Scholar
Safety and Pharmacokinetics of Intranasally Administered Heparin
Hannah M. Harris, K. L. Boyet, Hao Liu, R. Dwivedi +14 more
2021Pharmaceutical Research12 citations Open access
Semantic Scholar
Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
Erik L. Hodges, J. P. Marshall, Nicole M. Ashpole
2020npj Aging and Mechanisms of Disease11 citations Open access
Semantic Scholar
Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice
Alaa N. Qrareya, F. Mahdi, M. J. Kaufman, Nicole M. Ashpole +1 more
2022Aging10 citations Open access
Semantic Scholar
6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects
Nicholas S. Akins, Nisha Mishra, Hannah M. Harris, N. Dudhipala +7 more
2021ChemMedChem9 citations Open access
Semantic Scholar
First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-PBD Analogs As Selective CB2 Modulators Targeting Neurodegenerative Disorders
D. Mingle, M. Ospanov, Mohamed O. Radwan, Nicole M. Ashpole +5 more
2020Medicinal Chemistry Research9 citations Open access
Semantic Scholar
Acute Exercise, Psychological Stress Induction, and Episodic Memory.
P. Loprinzi, L. Koehler, E. Frith, Pamela Ponce +5 more
2019American Journal of Health Behavior7 citations
Semantic Scholar
Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage
C. Hayes, Nyah I. Morgan, Kamryn C. Thomas, M. J. Pushie +5 more
2023bioRxiv6 citations Open access
Semantic Scholar
Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3’,4’,5’-trihydroxyflavone and 3’,4’,5’-trimethoxyflavone
Maali D. Alshammari, P. Kucheryavy, Nicole M. Ashpole, David A. Colby
2020Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor
M. Ospanov, S. Sulochana, Jason J. Paris, J. Rimoldi +5 more
2022Molecules5 citations Open access
Semantic Scholar
Rotenoids and Other Specialized Metabolites from the Roots of Mirabilis multiflora: Opioid and Cannabinoid Receptor Radioligand Binding Affinities.
V. Sharma, Radhakrishnan Srivedavyasasri, Z. Ali, J. Zjawiony +4 more
2021Journal of Natural Products5 citations
Semantic Scholar

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