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T. Kume · SciRah

Researcher profile · Semantic Scholar

T. Kume

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T. Kume — researcher profile on SciRah

h-index: 41
Works: 118
Citations: 6,694

Most-cited papers

Retinoic acid from the meninges regulates cortical neuron generation
Julie A. Siegenthaler, A. Ashique, Konstantinos S. Zarbalis, Katelin P. Patterson +9 more
2009Cell396 citations Open access
Semantic Scholar
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.
T. Kume, Haiyan Jiang, Jolanta M. Topczewska, B. Hogan
2001Genes & Development372 citations Open access
Semantic Scholar
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.
Seungwoon Seo, Hideo Fujita, A. Nakano, Myengmo Kang +2 more
2006Developmental Biology291 citations Open access
Semantic Scholar
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer.
H. Yamagishi, Jun Maeda, Tonghuan Hu, John R. McAnally +5 more
2003Genes & Development273 citations Open access
Semantic Scholar
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation
Y. Omatsu, Masanari Seike, Tatsuki Sugiyama, T. Kume +1 more
2014Nature235 citations
Semantic Scholar
Foxc Transcription Factors Directly Regulate Dll4 and Hey2 Expression by Interacting with the VEGF-Notch Signaling Pathways in Endothelial Cells
Hisaki Hayashi, T. Kume
2008PLoS ONE180 citations Open access
Semantic Scholar
Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract.
Seungwoon Seo, T. Kume
2006Developmental Biology178 citations Open access
Semantic Scholar
A lymphatic defect causes ocular hypertension and glaucoma in mice.
Benjamin R. Thomson, S. Heinen, M. Jeansson, A. Ghosh +13 more
2014Journal of Clinical Investigation161 citations Open access
Semantic Scholar
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential
Kenneth Lay, T. Kume, E. Fuchs
2016Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Absence of Erythrogenesis and Vasculogenesis in Plcg1-deficient Mice*
Hong-Jun Liao, T. Kume, Catriona Mckay, Ming-Jiang Xu +2 more
2002Journal of Biological Chemistry141 citations Open access
Semantic Scholar
Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease.
Curtis R. French, S. Seshadri, A. Destefano, M. Fornage +13 more
2014Journal of Clinical Investigation130 citations Open access
Semantic Scholar
Specification of arterial, venous, and lymphatic endothelial cells during embryonic development
T. Kume
2010Histology and Histopathology119 citations
Semantic Scholar
Novel insights into the differential functions of Notch ligands in vascular formation
T. Kume
2009Journal of Angiogenesis Research118 citations Open access
Semantic Scholar
Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin*
Jianghui Zhang, S. Fukuhara, Keisuke Sako, T. Takenouchi +4 more
2011Journal of Biological Chemistry114 citations Open access
Semantic Scholar
Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth
Seungwoon Seo, H. Singh, P. Lacal, Amy Sasman +6 more
2011Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors.
M. Lagha, S. Brunelli, G. Messina, A. Cumano +3 more
2009Developmental Cell101 citations Open access
Semantic Scholar
The Foxc2 Transcription Factor Regulates Angiogenesis via Induction of Integrin β3 Expression*
Hisaki Hayashi, H. Sano, Seungwoon Seo, T. Kume
2008Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.
Hisaki Hayashi, T. Kume
2008Biochemical and Biophysical Research Communications - BBRC92 citations Open access
Semantic Scholar
Foxc1 is required by pericytes during fetal brain angiogenesis
Julie A. Siegenthaler, Youngshik Choe, Katelin P. Patterson, Ivy Hsieh +6 more
2013Biology Open80 citations Open access
Semantic Scholar
Escape of hair follicle stem cells causes stem cell exhaustion during ageing
Chi Zhang, Dongmei Wang, Jingjing Wang, Li Wang +4 more
2021Nature Aging77 citations Open access
Semantic Scholar
Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.
A. Fatima, Ying Wang, Yutaka Uchida, Pieter R. Norden +7 more
2016Journal of Clinical Investigation77 citations Open access
Semantic Scholar
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Biniam Adane, Haobin Ye, Nabilah Khan, Shanshan Pei +17 more
2019Cell Reports73 citations Open access
Semantic Scholar
Foxc2 transcription factor: a newly described regulator of angiogenesis
T. Kume
2008Trends in cardiovascular medicine72 citations Open access
Semantic Scholar
Ligand-dependent Notch signaling in vascular formation.
T. Kume
2012Advances in Experimental Medicine and Biology71 citations
Semantic Scholar
The Foxc2 transcription factor regulates tumor angiogenesis
H. Sano, Jared P. LeBoeuf, S. Novitskiy, Seungwoon Seo +3 more
2010Biochemical and Biophysical Research Communications - BBRC67 citations Open access
Semantic Scholar
The cooperative roles of Foxc1 and Foxc2 in cardiovascular development.
T. Kume
2009Advances in Experimental Medicine and Biology62 citations
Semantic Scholar
Role of Cross Talk between PI3-Kinase and ERK/MAP Kinase Pathways in Artery-Vein Specification
C. Hong, T. Kume, R. Peterson
2008Circulation Research61 citations Open access
Semantic Scholar
Interaction between Foxc1 and Fgf8 during Mammalian Jaw Patterning and in the Pathogenesis of Syngnathia
K. Inman, Patricia Purcell, T. Kume, P. Trainor
2013PLoS Genetics60 citations Open access
Semantic Scholar
Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation
Pieter R. Norden, A. Sabine, Ying Wang, Cansaran Saygili Demir +3 more
2020eLife59 citations Open access
Semantic Scholar
Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development
Seungwoon Seo, Lisheng Chen, Wenzhong Liu, De‐ying Zhao +6 more
2017Investigative Ophthalmology and Visual Science54 citations Open access
Semantic Scholar
Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development
Kazuki Kodo, S. Shibata, S. Miyagawa-Tomita, S. Ong +5 more
2017Scientific Reports50 citations Open access
Semantic Scholar
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.
I. Jang, Yi-Fen Lu, Long Zhao, Pamela L. Wenzel +13 more
2015Blood48 citations Open access
Semantic Scholar
In vivo corneal neovascularization imaging by optical-resolution photoacoustic microscopy
Wenzhong Liu, Kathryn M. Schultz, Kevin Zhang, Amy Sasman +3 more
2014Photoacoustics48 citations Open access
Semantic Scholar
The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.
Deidre M. Mattiske, T. Kume, B. Hogan
2006Developmental Biology48 citations Open access
Semantic Scholar
Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis.
John D. Welsh, M. Hoofnagle, S. Bamezai, Michael Oxendine +9 more
2019Journal of Clinical Investigation43 citations Open access
Semantic Scholar
Murine Notch1 is required for lymphatic vascular morphogenesis during development
A. Fatima, Austin Culver, Ford Culver, Ting Liu +5 more
2014Developmental Dynamics41 citations Open access
Semantic Scholar
Foxc2 Is a Common Mediator of Insulin and Transforming Growth Factor &bgr; Signaling to Regulate Plasminogen Activator Inhibitor Type I Gene Expression
Hideo Fujita, Myengmo Kang, M. Eren, L. Gleaves +2 more
2006Circulation Research41 citations Open access
Semantic Scholar
Generation of conditional alleles for Foxc1 and Foxc2 in mice
Amy Sasman, Carey Nassano-Miller, K. S. Shim, H. Koo +7 more
2012Genesis40 citations Open access
Semantic Scholar
Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes
E. Lambers, B. Arnone, A. Fatima, Gangjian Qin +2 more
2016Stem Cells38 citations Open access
Semantic Scholar
The Role of FoxC2 Transcription Factor in Tumor Angiogenesis
T. Kume
2011Journal of Oncology38 citations Open access
Semantic Scholar
Organ/Tissue-Specific Vascular Endothelial Cell Heterogeneity in Health and Disease.
T. Minami, M. Muramatsu, T. Kume
2019Biological and Pharmaceutical Bulletin37 citations Open access
Semantic Scholar
In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT
Xian Zhang, Lisa Beckmann, David A Miller, Guang-Bin Shao +8 more
2020Investigative Ophthalmology and Visual Science36 citations Open access
Semantic Scholar
Human venous valve disease caused by mutations in FOXC2 and GJC2
O. Lyons, P. Saha, C. Seet, A. Kuchta +20 more
2017Journal of Experimental Medicine34 citations Open access
Semantic Scholar
Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis
Alicia Mayeuf-Louchart, D. Montarras, Catherine Bodin, T. Kume +2 more
2016Development34 citations Open access
Semantic Scholar
Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity
Pieter R. Norden, T. Kume
2021Frontiers in Cell and Developmental Biology33 citations Open access
Semantic Scholar
The Role of Lymphatic Vascular Function in Metabolic Disorders
Pieter R. Norden, T. Kume
2020Frontiers in Physiology32 citations Open access
Semantic Scholar
Endothelial immune activation programmes cell‐fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4‐ERK‐FOXC2 signalling
S. Xia, Heather L. Menden, Thomas R. Korfhagen, T. Kume +1 more
2018Journal of Physiology30 citations Open access
Semantic Scholar
Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
M. Corriere, C. M. Rogers, J. Eliason, Jimbob Faulk +3 more
2008Journal of Surgical Research30 citations Open access
Semantic Scholar
Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia–reperfusion injury
Can Tan, Pieter R. Norden, Wei Yu, Ting Liu +9 more
2023EMBO Reports29 citations Open access
Semantic Scholar
Foxc1 and Foxc2 are necessary to maintain glomerular podocytes
M. Motojima, T. Kume, T. Matsusaka
2017Experimental Cell Research26 citations
Semantic Scholar

Frequent co-authors

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Ting Liu×8
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Ting Liu — researcher profile on SciRah
Seungwoon Seo×6
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Seungwoon Seo — researcher profile on SciRah
A. Fatima×5
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A. Fatima — researcher profile on SciRah
Pieter R. Norden×5
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Pieter R. Norden — researcher profile on SciRah

×4

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Amy Sasman — researcher profile on SciRah

Julie A. Siegenthaler×3

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Julie A. Siegenthaler — researcher profile on SciRah

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B. Hogan — researcher profile on SciRah

Myengmo Kang×3

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Myengmo Kang — researcher profile on SciRah

Hisaki Hayashi×3

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Hisaki Hayashi — researcher profile on SciRah

William H. Dietz×3

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William H. Dietz — researcher profile on SciRah

Kathryn M. Schultz×3

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Kathryn M. Schultz — researcher profile on SciRah

Hao F. Zhang×3

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Hao F. Zhang — researcher profile on SciRah