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H. Heyn · SciRah

Researcher profile · Semantic Scholar

H. Heyn

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H. Heyn — researcher profile on SciRah

h-index: 63
Works: 225
Citations: 20K

Most-cited papers

The emerging landscape of spatial profiling technologies
Jeffrey R. Moffitt, E. Lundberg, H. Heyn
2022Nature reviews genetics378 citations
Semantic Scholar
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
A. Garrido-Trigo, A. Corraliza, M. Veny, I. Dotti +23 more
2023Nature Communications290 citations Open access
Semantic Scholar
Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Adrià Cañellas-Socias, C. Cortina, Xavier Hernando-Momblona, S. Palomo-Ponce +26 more
2022Nature232 citations Open access
Semantic Scholar
Spatiotemporal omics for biology and medicine.
Long-Qi Liu, Ao Chen, Yu-Xiang Li, Jan Mulder +2 more
2024Cell203 citations Open access
Semantic Scholar
An atlas of cells in the human tonsil
Ramon Massoni-Badosa, Sergio Aguilar-Fernández, Juan C. Nieto, Paula Soler-Vila +45 more
2022bioRxiv143 citations Open access
Semantic Scholar
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
A. Álvarez-Varela, L. Novellasdemunt, F. Barriga, Xavier Hernando-Momblona +19 more
2022Nature Cancer133 citations
Semantic Scholar
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
F. Nadeu, R. Royo, Ramon Massoni-Badosa, Heribert Playa-Albinyana +48 more
2022Nature Medicine125 citations Open access
Semantic Scholar
Targeting lymphoid-derived IL-17 signaling to delay skin aging
P. Solá, E. Mereu, J. Bonjoch, M. Casado-Peláez +9 more
2023Nature Aging80 citations Open access
Semantic Scholar
Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin.
C. Garcia-Diaz, Anni Pöysti, E. Mereu, Melanie P. Clements +13 more
2023Cell Reports62 citations Open access
Semantic Scholar
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
Ana Henriques, Maria Salvany-Celades, P. Nieto, S. Palomo-Ponce +22 more
2025Nature Genetics54 citations Open access
Semantic Scholar
Architecture of the neutrophil compartment
Daniela Cerezo-Wallis, Andrea Rubio-Ponce, M. Richter, Emanuele Pitino +59 more
2025Nature52 citations Open access
Semantic Scholar
Systematic benchmarking of single-cell ATAC-sequencing protocols
Florian V. De Rop, G. Hulselmans, Christopher C. Flerin, Paula Soler-Vila +41 more
2023Nature Biotechnology51 citations Open access
Semantic Scholar
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy
Marta Redondo-Muñoz, F. J. Rodríguez-Baena, P. Aldaz, Adriá Caballé-Mestres +26 more
2023Nature Metabolism47 citations Open access
Semantic Scholar
Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
Irene Robles-Rebollo, S. Cuartero, Adrià Cañellas-Socias, Sarah Wells +12 more
2022Nature Communications40 citations Open access
Semantic Scholar
Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution
R. Martínez-Hernández, Nuria Sánchez de la Blanca, Pablo Sacristán-Gómez, A. Serrano-Somavilla +5 more
2024Nature Communications39 citations Open access
Semantic Scholar
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
Anthony Beucher, I. Miguel-Escalada, D. Balboa, M. D. De Vas +9 more
2022Nature Cell Biology39 citations Open access
Semantic Scholar
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
J. Rodríguez-Ubreva, A. Arutyunyan, M. Bonder, L. Del Pino-Molina +23 more
2022Nature Communications39 citations Open access
Semantic Scholar
Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas
Enrique Blanco-Carmona, Ashwin Narayanan, Inmaculada Hernández, J. Nieto +16 more
2023Cell Reports Medicine37 citations Open access
Semantic Scholar
Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas.
Helena Mazuelas, Míriam Magallón-Lorenz, J. Fernández-Rodríguez, Itziar Uriarte-Arrazola +13 more
2022Cell Reports30 citations Open access
Semantic Scholar
Controlled X‐chromosome dynamics defines meiotic potential of female mouse in vitro germ cells
Jacqueline Severino, M. Bauer, Tom Mattimoe, N. Arecco +11 more
2022EMBO Journal25 citations Open access
Semantic Scholar
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging
Emanuele Pitino, A. Pascual-Reguant, Felipe Segato-Dezem, Kellie Wise +23 more
2024bioRxiv24 citations Open access
Semantic Scholar
Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer.
F. Pedretti, Mohmed Abdalfttah, Benedetta Pellegrino, Francesca Mateo +29 more
2025Cancer Research21 citations
Semantic Scholar
Converging and evolving immuno-genomic routes toward immune escape in breast cancer
J. Blanco-Heredia, Carla Anjos Souza, J. Trincado, M. González-Cao +19 more
2024Nature Communications21 citations Open access
Semantic Scholar
Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony.
Matthias Eder, Olivier Martin, Natasha Oswal, Lucia Sedlackova +6 more
2024Cell20 citations Open access
Semantic Scholar
Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer
E. Güç, A. Treveil, E. Leach, Anna Broomfield +14 more
2025Nature Communications19 citations Open access
Semantic Scholar
FixNCut: single-cell genomics through reversible tissue fixation and dissociation
Laura Jiménez-Gracia, Domenica Marchese, Juan C. Nieto, G. Caratù +24 more
2023bioRxiv19 citations Open access
Semantic Scholar
Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias
M. Guerrero-Murillo, A. Rill-Hinarejos, J. Trincado, À. Bataller +17 more
2024bioRxiv17 citations Open access
Semantic Scholar
scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
Samuel Schäfer, Martin Smelik, O. Sysoev, Ye-Lin Zhao +13 more
2024Genome Medicine15 citations Open access
Semantic Scholar
Interpretable inflammation landscape of circulating immune cells
Laura Jiménez-Gracia, D. Maspero, Sergio Aguilar-Fernández, Francesco Craighero +44 more
2025bioRxiv14 citations Open access
Semantic Scholar
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
Edgar Bernardo, M. D. De Vas, D. Balboa, Mirabai Cuenca-Ardura +18 more
2025Cell Metabolism11 citations Open access
Semantic Scholar
Differential performance of strategies for single-cell whole-genome amplification
N. Estévez-Gómez, Tamara Prieto, Laura Tomás, Pilar Alvariño +4 more
2025Cell Reports Methods10 citations Open access
Semantic Scholar
Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis
J. Clària, F. Aguilar, J. Lozano, Laura Jiménez-Gracia +24 more
2024JHEP Reports10 citations Open access
Semantic Scholar
Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells
T. Velasco-Hernández, J. Trincado, M. Vinyoles, A. Closa +25 more
2024HemaSphere10 citations Open access
Semantic Scholar
Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors
Ángel Bayón-Gil, Inmaculada Hernández, J. Dalmau, J. Nieto +20 more
2024i Medicina10 citations Open access
Semantic Scholar
Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues
Mario Acera-Mateos, X. Adiconis, Jessica Li, Domenica Marchese +23 more
2026Genome Biology8 citations Open access
Semantic Scholar
Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer
L. Angelats, L. Paré, C. Rubio-Perez, E. Sanfeliu +33 more
2025ESMO Open8 citations Open access
Semantic Scholar
Tracing colorectal malignancy transformation from cell to tissue scale
Helena L. Crowell, Irene Ruano, Ze-Dong Hu, Yourae Hong +14 more
2025bioRxiv8 citations Open access
Semantic Scholar
Decoding the muscle transcriptome of patients with late-onset Pompe disease reveals markers of disease progression
Alexandra Monceau, Rasya Gokul Nath, X. Suárez-Calvet, O. Musumeci +31 more
2024Brain : a journal of neurology8 citations Open access
Semantic Scholar
scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
Samuel Schäfer, Martin Smelik, O. Sysoev, Ye-Lin Zhao +13 more
2023bioRxiv8 citations Open access
Semantic Scholar
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia
Violeta García‐Hernández, David Arambilet, Yolanda Guillén, Teresa Lobo-Jarne +12 more
2023EMBO Molecular Medicine8 citations Open access
Semantic Scholar
Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection
Anis Barmada, Louis-François Handfield, Gerard Godoy-Tena, Carlos de la Calle-Fabregat +34 more
2023European Journal of Immunology7 citations Open access
Semantic Scholar
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
K. McGrail, Paula Granado-Martínez, Roberto Orsenigo, G. Caratù +7 more
2025Oncogene6 citations Open access
Semantic Scholar
Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.
F. Aguilar, J. Lozano, J. Clària, S. R. Reinartz Groba +23 more
2025Journal of Hepatology5 citations
Semantic Scholar
Author Correction: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
A. Garrido-Trigo, A. Corraliza, M. Veny, I. Dotti +23 more
2024Nature Communications5 citations Open access
Semantic Scholar
Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease
P. Nieto, S. Klinsing, G. Caratù, M. Dettki +18 more
2026Cell Reports Medicine4 citations Open access
Semantic Scholar
In Situ Inference of Copy Number Variations in Image-Based Spatial Transcriptomics
August F. Jensen, Helena L. Crowell, Anna Pascual Reguant, Irene Ruano +4 more
2025bioRxiv3 citations Open access
Semantic Scholar
Latent plasticity of the human pancreas across development, health, and disease
E. Mereu, D. Balboa, J. Liebig, Aitor Gonzalez-Herrero +40 more
2025bioRxiv3 citations Open access
Semantic Scholar
A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts
Helena L. Crowell, L. Llaó-Cid, G. Frigola, Samuel Gunz +8 more
2025bioRxiv3 citations Open access
Semantic Scholar
Dual Biological Role and Clinical Impact of De Novo Chromatin Activation in Chronic Lymphocytic Leukemia.
V. Chapaprieta, A. Maiqués-Díaz, F. Nadeu, G. Clot +22 more
2025Blood3 citations
Semantic Scholar
Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer
D. Maspero, Giovanni Marteletto, Francesco Lapi, B. Galuzzi +8 more
2026npj Systems Biology and Applications2 citations Open access
Semantic Scholar

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