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Saara Ollila · SciRah

Researcher profile · Semantic Scholar

Saara Ollila

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Saara Ollila — researcher profile on SciRah

h-index: 14
Works: 31
Citations: 853

Most-cited papers

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR)
Philip A. Chan, Sekhar Duraisamy, Peter J. Miller, Joan A. Newell +9 more
2007Human Mutation148 citations Open access
Semantic Scholar
Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon.
Denis Dermadi, Satu Valo, Saara Ollila, R. Soliymani +6 more
2017Cancer Research74 citations Open access
Semantic Scholar
The tumor suppressor kinase LKB1: lessons from mouse models.
Saara Ollila, T. Mäkelä
2011Journal of Molecular Cell Biology70 citations Open access
Semantic Scholar
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
Saara Ollila, Laura Sarantaus, R. Kariola, Philip A. Chan +10 more
2006Gastroenterology69 citations Open access
Semantic Scholar
Tellu – an object-detector algorithm for automatic classification of intestinal organoids
Eva Domènech-Moreno, Anders Brandt, Toni T. Lemmetyinen, Linnea Wartiovaara +2 more
2023Disease Models & Mechanisms68 citations Open access
Semantic Scholar
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway
Saara Ollila, Eva Domènech-Moreno, Kaisa Laajanen, I. P. Wong +11 more
2017Journal of Clinical Investigation65 citations Open access
Semantic Scholar
Mechanisms of pathogenicity in human MSH2 missense mutants
Saara Ollila, Denis Dermadi Bebek, J. Jiricny, Minna Nyström
2008Human Mutation65 citations Open access
Semantic Scholar
Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.
Jian Zhang, Annette Lindroos, Saara Ollila, A. Russell +5 more
2006Cancer Research63 citations Open access
Semantic Scholar
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling
Yan Yan, Saara Ollila, I. P. Wong, Tea Vallenius +3 more
2015Nature Communications46 citations Open access
Semantic Scholar
Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome
S. Gargiulo, M. Torrini, Saara Ollila, S. Nasti +13 more
2009Familial Cancer45 citations
Semantic Scholar
Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth
Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, T. Kaprio +6 more
2023Disease Models & Mechanisms23 citations Open access
Semantic Scholar
The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC.
Saara Ollila, Roslyn Fitzpatrick, Laura Sarantaus, R. Kariola +10 more
2006International Journal of Oncology23 citations
Semantic Scholar
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin.
Sharif Iqbal, S. Andersson, Ernesta Nesta, Nalle Pentinmikko +21 more
2025Cell Stem Cell19 citations Open access
Semantic Scholar
Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification
Saara Ollila, Denis Dermadi Bebek, M. Greenblatt, Minna Nyström
2008International Journal of Cancer16 citations Open access
Semantic Scholar
Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh1 +/- Mice
Marjaana Pussila, Laura Sarantaus, Denis Dermadi Bebek, Satu Valo +6 more
2013PLoS ONE13 citations Open access
Semantic Scholar
MutSβ exceeds MutSα in dinucleotide loop repair
Jukka Kantelinen, Minttu Kansikas, M. Korhonen, Saara Ollila +3 more
2010British Journal of Cancer13 citations Open access
Semantic Scholar
Genome wide association study identifies 4 novel risk loci for small intestinal neuroendocrine tumors including a missense mutation in LGR5.
A. Giri, M. Aavikko, Linnea Wartiovaara, Toni T. Lemmetyinen +21 more
2023Gastroenterology7 citations Open access
Semantic Scholar
A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one
Jukka Kantelinen, Thomas V. O. Hansen, Minttu Kansikas, L. Krogh +5 more
2011Familial Cancer7 citations
Semantic Scholar
PDPR Gene Variants Predisposing to Papillary Thyroid Cancer
P. Brock, Myriam Sévigny, S. Liyanarachchi, Daniel F. Comiskey +8 more
2023Thyroid5 citations Open access
Semantic Scholar
In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing
K. Mätlik, Soophie Olfat, M. Cowlishaw, E. Moreno +2 more
2023Heliyon5 citations Open access
Semantic Scholar
Stromal Lkb 1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11 – JAK / STAT 3 pathway
Saara Ollila, Eva Domènech-Moreno, Kaisa Laajanen, I. P. Wong +11 more
20185 citations
Semantic Scholar
Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation
Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, Pekka Paivinen +7 more
2024iScience3 citations Open access
Semantic Scholar
Interleukin‐11 expressed in the polyp‐enriched fibroblast subset is a potential therapeutic target in Peutz‐Jeghers syndrome
Eva Domènech-Moreno, Wei-Wen Lim, Melissa G Montrose, Myriam Sévigny +6 more
2025Journal of Pathology2 citations Open access
Semantic Scholar
High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblasts
Emma W. Viitala, Ella Salminen, Mitro Miihkinen, N. Chalkidi +11 more
2025bioRxiv1 citations Open access
Semantic Scholar
An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts.
Emma W. Viitala, Ella Salminen, Mitro Miihkinen, Toni T. Lemmetyinen +14 more
2026Molecular Systems Biology0 citations Open access
Semantic Scholar
Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis
Eva Domènech-Moreno, Wei-Wen Lim, Anders Brandt, Toni T. Lemmetyinen +4 more
2024bioRxiv0 citations Open access
Semantic Scholar
Abstract 712: Mechanisms of stromal Lkb1 loss induced tumorigenesis in mouse models of Peutz-Jeghers syndrome
Saara Ollila, Kari Vaahtomeri, I. P. Wong, Kaisa Laajanen +1 more
20160 citations
Semantic Scholar
Abstract 4857: Clonal expansion of Lkb1-deficient stromal cells underlies polyp development in mouse models of Peutz-Jeghers syndrome
Saara Ollila, Kaisa Laajanen, I. P. Wong, Kari Vaahtomeri +1 more
20140 citations
Semantic Scholar
Abstract C55: Investigating mechanisms of gastrointestinal polyposis and osteoblastic tumor formation induced by mesenchymal Lkb1 deficiency
Kaisa Laajanen, Saara Ollila, I. P. Wong, Kari Vaahtomeri +3 more
20130 citations
Semantic Scholar
Pathogenicity, functional significance and clinical phenotype of mismatch repair gene MSH2 variants found in cancer patients
Saara Ollila
20080 citations
Semantic Scholar
Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh 1 ( + /-) Mice Pussila , Marjaana 2013-1008
Marjaana Pussila, Laura Sarantaus, Denis Dermadi Bebek, Satu Valo +6 more
0 citations
Semantic Scholar

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