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Somesh D. Sharma · SciRah

Researcher profile · Semantic Scholar

Somesh D. Sharma

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Somesh D. Sharma — researcher profile on SciRah

h-index: 21
Works: 73
Citations: 1,431

Most-cited papers

Managing protein flexibility in docking and its applications.
C. B‐Rao, J. Subramanian, Somesh D. Sharma
2009Drug Discovery Today230 citations
Semantic Scholar
In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00
Kalpana Joshi, M. Rathos, R. Joshi, M. Sivakumar +4 more
2007Molecular Cancer Therapeutics128 citations Open access
Semantic Scholar
Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes.
Somesh D. Sharma, B. Nag, Xiao-Min Su, D. Green +3 more
1991Proceedings of the National Academy of Sciences of the United States of America105 citations Open access
Semantic Scholar
Peroxisome proliferator-activated receptor-α selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice
R. Srivastava, R. Jahagirdar, S. Azhar, Somesh D. Sharma +1 more
2006Molecular and Cellular Biochemistry90 citations
Semantic Scholar
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models
Kalpana Joshi, M. Rathos, P. Mahajan, V. Wagh +7 more
2007Molecular Cancer Therapeutics79 citations
Semantic Scholar
Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery
G. Chimote, J. Sreenivasan, Nilambari Pawar, J. Subramanian +2 more
2014Drug Design, Development and Therapy66 citations Open access
Semantic Scholar
Treatment with anti-L3T4 (CD4) monoclonal antibody reduces the inflammatory response in toxoplasmic encephalitis.
D. Israelski, F. Araujo, F. Conley, Yasuhiro Suzuki +2 more
1989Journal of Immunology58 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents.
P. Neogi, Fredrick J Lakner, S. Medicherla, Jin-Chun Cheng +6 more
2003Bioorganic & Medicinal Chemistry50 citations
Semantic Scholar
Pulmonary, Gastrointestinal and Urogenital Pharmacology A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis
N. Dagia, Divya V. Kamath, P. Bhatt, R. D. Gupte +15 more
200938 citations
Semantic Scholar
A novel mTOR inhibitor is efficacious in a murine model of colitis.
M. Bhonde, R. D. Gupte, Shruta Dadarkar, Mahesh G. Jadhav +10 more
2008American Journal of Physiology - Gastrointestinal and Liver Physiology37 citations
Semantic Scholar
A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes
R. Srivastava, S. Mistry, Somesh D. Sharma
2015Nutrition and Metabolism36 citations Open access
Semantic Scholar
NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs.
K. Nemmani, S. Mali, Namdev Borhade, A. Pathan +10 more
2009Bioorganic & Medicinal Chemistry Letters36 citations
Semantic Scholar
Acute administration of GPR40 receptor agonist potentiates glucose-stimulated insulin secretion in vivo in the rat.
Lalit S. Doshi, Manoja K. Brahma, Sufyan G. Sayyed, Amol V Dixit +5 more
2009Metabolism: Clinical and Experimental35 citations Open access
Semantic Scholar
Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.
R. Srivastava, R. Jahagirdar, S. Azhar, Somesh D. Sharma +1 more
2006Molecular and Cellular Biochemistry35 citations
Semantic Scholar
Transferrin‐Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto‐Dendritic Nanosystem
S. Banerjee, A. Jalota-Badhwar, Sneha D. Satavalekar, S. Bhansali +5 more
2013Advanced Healthcare Materials33 citations
Semantic Scholar
NO-NSAIDs. Part 3: nitric oxide-releasing prodrugs of non-steroidal anti-inflammatory drugs.
Namdev Borhade, A. Pathan, Somnath Halder, M. Karwa +21 more
2012Chemical and pharmaceutical bulletin33 citations Open access
Semantic Scholar
7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation.
L. Fonseca, S. S. Dadarkar, Aurelio S. Lobo, A. Suthar +5 more
2010European Journal of Pharmacology33 citations
Semantic Scholar
A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential.
Debendranath Dey, S. Medicherla, P. Neogi, M. Gowri +5 more
2003Metabolism: Clinical and Experimental26 citations
Semantic Scholar
A novel computational analysis of ligand-induced conformational changes in the ATP binding sites of cyclin dependent kinases.
J. Subramanian, Somesh D. Sharma, C. B‐Rao
2006Journal of Medicinal Chemistry25 citations
Semantic Scholar
CDK-4 inhibitor P276 sensitizes Pancreatic Cancer cells to Gemcitabine induced Apoptosis
D. Subramaniam, G. Periyasamy, Sivapriya Ponnurangam, Debarshi Chakrabarti +6 more
2012Molecular Cancer Therapeutics23 citations Open access
Semantic Scholar
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
S. Balachandran, Atish H. Rodge, Pradip K Gadekar, V. N. Yadav +7 more
2009Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen.
Machhindra Gund, P. Gaikwad, Namdev Borhade, A. Burhan +10 more
2014Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
Modeling and Selection of Flexible Proteins for Structure‐Based Drug Design: Backbone and Side Chain Movements in p38 MAPK
J. Subramanian, Somesh D. Sharma, C. B‐Rao
2008ChemMedChem18 citations
Semantic Scholar
P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity
A. Jalota-Badhwar, Dimple Bhatia, S. Boreddy, Asavari Joshi +13 more
2015Molecular Cancer Therapeutics17 citations
Semantic Scholar
Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes.
Asha A. Kulkarni-Almeida, A. Suthar, H. Goswami, R. Vishwakarma +3 more
2008Phytomedicine17 citations
Semantic Scholar
Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery.
Nilambari Yewalkar, Vijaykumar Deore, Amol A. Padgaonkar, S. Manohar +6 more
2010Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Efficacy and safety of Glycebal (PDM011011) capsules as adjuvant therapy in subjects with type 2 diabetes mellitus: an open label, randomized, active controlled, phase II trial
A. Suthar, Anand Deshmukh, Vijaya Babu, V. Mohan +5 more
201614 citations Open access
Semantic Scholar
Intramolecular charge heterogeneity in purified major histocompatibility class II alpha and beta polypeptide chains.
Bishwajit Nag, Subhashini Arimilli, B. Koukis, E. Rhodes +2 more
1994Journal of Biological Chemistry14 citations Open access
Semantic Scholar
Synthesis and biological activity of novel MIF antagonists.
S. Balachandran, Pradip K Gadekar, Santosh Parkale, V. N. Yadav +5 more
2011Bioorganic & Medicinal Chemistry Letters13 citations
Semantic Scholar
Efficacy and Safety of PDM011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus: An Open-Label, Randomized, Active-Controlled, Multicentric, Phase III Study
A. Suthar, Vikas G. Pai, Y. Kadam, Aniruddha Tongaonkar +8 more
201611 citations Open access
Semantic Scholar
NPS31807, a Standardized Extract from Sphaeranthus indicus, Inhibits Inflammatory, Migratory and Proliferative Activity in Keratinocytes and Immune Cells
Debarshi Chakrabarti, A. Suthar, G. Jayaraman, B. Muthuvelan +2 more
201210 citations Open access
Semantic Scholar
P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer
V. A. Venkatesha, Asavari Joshi, Magesh Venkataraman, V. Sonawane +15 more
2014Molecular Cancer9 citations Open access
Semantic Scholar
Antitumor activity of NPB001-05, an orally active inhibitor of Bcr-Abl tyrosine kinase.
V. Wagh, Prabha B. Mishra, Arvind D. Thakkar, V. Shinde +3 more
2011Frontiers in Bioscience9 citations
Semantic Scholar
Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat
A. Pathan, M. Karwa, V. Pamidiboina, J. J. Deshattiwar +9 more
2010InflammoPharmacology9 citations
Semantic Scholar
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
Vijaykumar Deore, Nilambari Yewalkar, Dimple Bhatia, Nikesh Desai +12 more
2009Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Abstract 3054: P1446A-05: a new oral cyclin-dependent kinase inhibitor with potent preclinical antitumor activity
Kalpana Joshi, Amol A. Padgaonkar, M. Rathos, V. Wagh +5 more
20125 citations
Semantic Scholar
comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery
G. Chimote, J. Sreenivasan, Nilambari Pawar, J. Subramanian +3 more
20143 citations
Semantic Scholar
Discovery of P1736, a Novel Antidiabetic Compound That Improves Peripheral Insulin Sensitivity in Mice Models
Jessy Anthony, A. Kelkar, Chandan Wilankar, V. Ranjith +6 more
2013PLoS ONE3 citations Open access
Semantic Scholar
Abstract 3759: P7170, a novel inhibitor of phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) as a new therapeutic option for Kras mutated non small cell lung cancer (NSCLC)
V. Agarwal, Asavari Joshi, Magesh Venkataraman, Dimple Bhatia +4 more
20123 citations
Semantic Scholar
18F9 (4-(3,6-bis (ethoxycarbonyl)-4,5,6,7-tetrahydrothieno (2,3-c) pyridin-2-ylamino)-4-oxobutanoic acid) enhances insulin-mediated glucose uptake in vitro and exhibits antidiabetic activity in vivo in db/db mice.
R. Anandharajan, Sufyan G. Sayyed, Lalit S. Doshi, P. Dixit +10 more
2009Metabolism: Clinical and Experimental3 citations Open access
Semantic Scholar
Efficacy and safety of Glycebal ( PDM 011011 ) capsules as adjuvant therapy in subjects with type 2 diabetes mellitus : an open label , randomized , active controlled , phase II trial
A. Suthar, Anand Deshmukh, Vijaya Babu, V. Mohan +5 more
20162 citations
Semantic Scholar
Abstract 3742: P7170: A potent and oral phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) inhibitor with anti-tumor and anti-angiogenic activity
V. Agarwal, Asavari Joshi, Magesh Venkataraman, Nikesh Desai +12 more
20122 citations
Semantic Scholar
NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells.
V. Wagh, Shailaja A. Chile, Sonal Monahar, B. Pal +3 more
2011Frontiers in Bioscience2 citations Open access
Semantic Scholar
Efficacy and Safety of PDM 011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus : An Open-Label , Randomized , Active-Controlled , Multicentric , Phase III Study
A. Suthar, Vikas G. Pai, Y. Kadam, Aniruddha Tongaonkar +8 more
20161 citations
Semantic Scholar
Efficacy and Safety of Two Doses of Sphaeranthus indicus Extract in the Management of Plaque Psoriasis : A Randomized , Double Blind , Placebo Controlled Phase II Trial
S. Velaskar, C. Nayak, R. Torsekar, Vishalakshi Viswanath +12 more
20161 citations
Semantic Scholar
Cell Targeting: Transferrin‐Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto‐Dendritic Nanosystem (Adv. Healthcare Mater. 6/2013)
S. Banerjee, A. Jalota-Badhwar, Sneha D. Satavalekar, S. Bhansali +5 more
20131 citations
Semantic Scholar
Development of Novel Inhibitors Targeting HIF‐1α Towards Anticancer Drug Discovery.
Nilambari Yewalkar, Vijaykumar Deore, Amol A. Padgaonkar, S. Manohar +6 more
20111 citations
Semantic Scholar
P1738, a novel insulin sensitizer improves metabolic control with a favourable weight profile in mice
R. Marita, G. Raza, R. Rathish, Sujit Kaur Bhumra +5 more
20101 citations
Semantic Scholar
Efficacy and Safety of Tinefcon® Tablets in Subjects with Plaque Psoriasis: An Open Label, Non-Comparative, Multicenter, Phase IV Trial
Somesh D. Sharma, K. Bhatia, M. Agarwal, Sandesh Gupta +25 more
20160 citations Open access
Semantic Scholar
Skuteczność i bezpieczeństwo stosowania kapsułek Glycebal (PDM011011) jako leczenia wspomagającego u chorych na cukrzycę typu 2 — otwarte badanie drugiej fazy z randomizacją i grupą kontrolną
A. Suthar, Anand Deshmukh, V. Babu, V. Mohan +5 more
20160 citations
Semantic Scholar

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