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George R. Young · SciRah

Researcher profile · Semantic Scholar

George R. Young

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George R. Young — researcher profile on SciRah

h-index: 24
Works: 54
Citations: 2,865

Most-cited papers

Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer +8 more
2020Nature457 citations Open access
Semantic Scholar
The axolotl genome and the evolution of key tissue formation regulators
Sergej Nowoshilow, S. Schloissnig, Ji-Feng Fei, A. Dahl +15 more
2018Nature385 citations Open access
Semantic Scholar
Resurrection of endogenous retroviruses in antibody-deficient mice
George R. Young, U. Eksmond, R. Salcedo, L. Alexopoulou +2 more
2012Nature211 citations Open access
Semantic Scholar
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
K. Ng, J. Boumelha, K. Enfield, J. Almagro +327 more
2023Nature202 citations Open access
Semantic Scholar
ADAR1 averts fatal type I interferon induction by ZBP1
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann +13 more
2022Nature191 citations Open access
Semantic Scholar
The genome of S. mediterranea and the evolution of cellular core mechanisms
Markus A. Grohme, S. Schloissnig, A. Rozanski, M. Pippel +9 more
2018Nature166 citations Open access
Semantic Scholar
Author Correction: The axolotl genome and the evolution of key tissue formation regulators
Sergej Nowoshilow, S. Schloissnig, Ji-Feng Fei, A. Dahl +15 more
2018Nature112 citations Open access
Semantic Scholar
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Qiannan Tang, R. Rigby, George R. Young, A. Hvidt +6 more
2021Immunity104 citations Open access
Semantic Scholar
LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly
J. Attig, George R. Young, Louise Hosie, David Perkins +5 more
2019Genome Research103 citations Open access
Semantic Scholar
Tissue-specific and interferon-inducible expression of non-functional ACE2 through endogenous retroelement co-option
K. Ng, J. Attig, William Bolland, George R. Young +5 more
2020Nature Genetics98 citations Open access
Semantic Scholar
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
George R. Young, J. Stoye, G. Kassiotis
2013Bioessays78 citations Open access
Semantic Scholar
Negative Selection by an Endogenous Retrovirus Promotes a Higher-Avidity CD4+ T Cell Response to Retroviral Infection
George R. Young, M. Ploquin, U. Eksmond, Munisch Wadwa +2 more
2012PLoS Pathogens56 citations Open access
Semantic Scholar
Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth
Rinako Nakagawa, Amparo Toboso-Navasa, Marta Schips, George R. Young +7 more
2021Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
T. Donnarumma, George R. Young, Julia Merkenschlager, U. Eksmond +8 more
2016Cell Reports53 citations Open access
Semantic Scholar
Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes
George R. Young, Bettina Mavrommatis, G. Kassiotis
2014Retrovirology53 citations Open access
Semantic Scholar
HIV-1 Interacts with Human Endogenous Retrovirus K (HML-2) Envelopes Derived from Human Primary Lymphocytes
Daria Brinzevich, George R. Young, R. Sebra, Juan Ayllon +6 more
2014Journal of Virology52 citations Open access
Semantic Scholar
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
K. Ng, J. Attig, George R. Young, E. Ottina +3 more
2019eLife50 citations Open access
Semantic Scholar
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export
Ross Hall, Anabel Guedán, M. Yap, George R. Young +3 more
2022bioRxiv42 citations Open access
Semantic Scholar
Physiological and Pathological Transcriptional Activation of Endogenous Retroelements Assessed by RNA-Sequencing of B Lymphocytes
J. Attig, George R. Young, J. Stoye, G. Kassiotis
2017Frontiers in Microbiology38 citations Open access
Semantic Scholar
HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
George R. Young, S. Terry, L. Manganaro, Alvaro Cuesta-Dominguez +7 more
2017Journal of Virology32 citations Open access
Semantic Scholar
Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin
J. Attig, Judith Pape, Laura Doglio, A. Kazachenka +10 more
2023Journal of Clinical Investigation30 citations Open access
Semantic Scholar
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
A. Kazachenka, George R. Young, J. Attig, Chrysoula Kordella +8 more
2019Genome Medicine29 citations Open access
Semantic Scholar
Evolutionary journey of the retroviral restriction gene Fv1
George R. Young, M. Yap, J. Michaux, Scott J. Steppan +1 more
2018Proceedings of the National Academy of Sciences of the United States of America28 citations Open access
Semantic Scholar
SMARCA4 regulates the NK-mediated killing of senescent cells
Virinder Reen, M. d'Ambrosio, P. P. Søgaard, Katie Tyson +22 more
2025Science Advances24 citations Open access
Semantic Scholar
Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
M. Cottee, S. C. Letham, George R. Young, J. Stoye +1 more
2020Science Advances23 citations Open access
Semantic Scholar
Restoration of endogenous retrovirus infectivity impacts mouse cancer models
E. Ottina, Prisca Lévy, U. Eksmond, Julia Merkenschlager +6 more
2018Cancer immunology research22 citations Open access
Semantic Scholar
MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.
Julia Merkenschlager, U. Eksmond, Luca Danelli, J. Attig +4 more
2019Blood19 citations Open access
Semantic Scholar
Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control
M. Cottee, Sean L. Beckwith, S. C. Letham, Sarah J Kim +4 more
2021Nature Communications17 citations Open access
Semantic Scholar
Emergence of new subgenomic mRNAs in SARS-CoV-2
Harriet V. Mears, George R. Young, Theo Sanderson, R. Harvey +14 more
2022bioRxiv16 citations Open access
Semantic Scholar
Counterpoise between the microbiome, host immune activation and pathology.
Bettina Mavrommatis, George R. Young, G. Kassiotis
2013Current Opinion in Immunology16 citations Open access
Semantic Scholar
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
Harriet V. Mears, George R. Young, Theo Sanderson, Ruth Harvey +23 more
2025PLoS Biology15 citations Open access
Semantic Scholar
Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event
V. Panova, J. Attig, George R. Young, J. Stoye +1 more
2020PLoS Pathogens14 citations Open access
Semantic Scholar
Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses
M. Yap, George R. Young, R. Varnaitė, S. Morand +1 more
2020PLoS Genetics13 citations Open access
Semantic Scholar
Effective T helper cell responses against retroviruses: are all clonotypes equal?
G. Thorborn, George R. Young, G. Kassiotis
2014Journal of Leukocyte Biology10 citations Open access
Semantic Scholar
Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer +8 more
2020Nature9 citations Open access
Semantic Scholar
E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion
E. Ottina, V. Panova, Laura Doglio, A. Kazachenka +11 more
2021Oncogene8 citations Open access
Semantic Scholar
Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice
George R. Young, G. Kassiotis, J. Stoye
2012Retrovirology8 citations Open access
Semantic Scholar
Tissue-specific and interferon-inducible expression of non-functional ACE2 through endogenous retrovirus co-option
K. Ng, J. Attig, William Bolland, George R. Young +3 more
2020bioRxiv7 citations Open access
Semantic Scholar
Competition shapes the landscape of X-chromosome-linked genetic diversity
Teresa Buenaventura, Hakan Bagci, Ilinca Patrascan, Joshua J. Graham +11 more
2024Nature Genetics6 citations Open access
Semantic Scholar
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
A. Kazachenka, Jane Loong, J. Attig, George R. Young +6 more
2023NAR Cancer6 citations Open access
Semantic Scholar
Gv1, a Zinc Finger Gene Controlling Endogenous MLV Expression
George R. Young, A. Ferron, V. Panova, U. Eksmond +3 more
2021Molecular biology and evolution5 citations Open access
Semantic Scholar
Recognition of Z-RNA by ADAR1 limits interferon responses
Qiannan Tang, R. Rigby, George R. Young, Astrid Korning-Hvidt +5 more
2020bioRxiv5 citations Open access
Semantic Scholar
Structure of D. melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag
M. Cottee, S. C. Letham, George R. Young, J. Stoye +1 more
2019bioRxiv3 citations Open access
Semantic Scholar
Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein
Bryony Jenkins, U. Eksmond, George R. Young, G. Kassiotis
2016Wellcome Open Research2 citations Open access
Semantic Scholar
Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
Bettina Mavrommatis, L. Baudino, Prisca Lévy, Julia Merkenschlager +5 more
2016Journal of Immunology2 citations Open access
Semantic Scholar
Author response: Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
K. Ng, J. Attig, George R. Young, E. Ottina +3 more
20191 citations Open access
Semantic Scholar
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
K. Ng, J. Boumelha, K. Enfield, J. Almagro +327 more
2026Nature0 citations Open access
Semantic Scholar
Wee1 opposes APC/CCdh1 activity to promote S-phase entry
Luc-Alban Vuillemenot, Lucas G. Morales, Calin-Mihai Dragoi, Betheney R. Pennycook +13 more
2025bioRxiv0 citations Open access
Semantic Scholar
Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors
Carmen R. Moncayo, Restuadi Restuadi, Guanying Zhang, Daniel J B Marks +21 more
2025bioRxiv0 citations Open access
Semantic Scholar
Murine Leukemia and Sarcoma Viruses (Retroviridae)
George R. Young, K. Bishop
20200 citations
Semantic Scholar

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G. Kassiotis×32
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G. Kassiotis — researcher profile on SciRah
J. Stoye×16
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J. Stoye — researcher profile on SciRah
J. Attig×14
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J. Attig — researcher profile on SciRah
U. Eksmond×8
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K. Ng — researcher profile on SciRah

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C. Swanton — researcher profile on SciRah

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E. Ottina — researcher profile on SciRah

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Julia Merkenschlager×4

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Julia Merkenschlager — researcher profile on SciRah

A. Kazachenka×4

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A. Kazachenka — researcher profile on SciRah

Huipeng Jiao×3

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Huipeng Jiao — researcher profile on SciRah

Laurens Wachsmuth×3

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Laurens Wachsmuth — researcher profile on SciRah