Researcher profile · Semantic Scholar

A. Harding

h-index: 20
Works: 40
Citations: 3,270

Most-cited papers

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
I. Prior, A. Harding, Jun Yan, J. Sluimer +2 more
2001Nature Cell Biology554 citations
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Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
Sandrine Roy, Robert Luetterforst, A. Harding, Ann Apolloni +5 more
1999Nature Cell Biology480 citations
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Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
Tianhai Tian, A. Harding, Kerry L. Inder, Sarah J. Plowman +2 more
2007Nature Cell Biology404 citations
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EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.
B. Day, B. Stringer, F. Al-Ejeh, Michael J. Ting +20 more
2013Cancer Cell217 citations Open access
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Evidence for label-retaining tumour-initiating cells in human glioblastoma.
L. Deleyrolle, A. Harding, K. Cato, F. Siebzehnrubl +7 more
2011Brain : a journal of neurology188 citations Open access
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Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer
J. Coward, A. Harding
2014Frontiers in Oncology181 citations Open access
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Nur77 Regulates Lipolysis in Skeletal Muscle Cells
Megan A. Maxwell, M. Cleasby, A. Harding, A. Stark +2 more
2005Journal of Biological Chemistry173 citations Open access
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Subcellular localization determines MAP kinase signal output.
A. Harding, Tianhai Tian, Elizabeth Westbury, E. Frische +1 more
2005Current Biology171 citations Open access
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The origins of cancer robustness and evolvability.
Tianhai Tian, S. Olson, J. Whitacre, A. Harding
2011Integrative Biology161 citations Open access
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Using plasma membrane nanoclusters to build better signaling circuits
A. Harding, J. Hancock
2008Trends in Cell Biology127 citations Open access
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A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Y. Lim, T. Roberts, B. Day, A. Harding +5 more
2012Molecular Cancer Therapeutics94 citations
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Activation of the MAPK module from different spatial locations generates distinct system outputs.
Kerry L. Inder, A. Harding, Sarah J. Plowman, M. Philips +2 more
2008Molecular Biology of the Cell92 citations Open access
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Interactions of c-Raf-1 with phosphatidylserine and 14-3-3
R. McPherson, A. Harding, Sandrine Roy, A. Lane +1 more
1999Oncogene69 citations Open access
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Ras nanoclusters: Combining digital and analog signaling
A. Harding, J. Hancock
2008Cell Cycle67 citations Open access
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Mechanism of Mitosis-specific Activation of MEK1*
A. Harding, N. Giles, A. Burgess, J. Hancock +1 more
2003Journal of Biological Chemistry53 citations Open access
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KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs
Joseph Lin, A. Harding, Emanuele Giurisato, A. Shaw
2009Molecular and Cellular Biology48 citations Open access
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MAPK Pathway Activation Delays G2/M Progression by Destabilizing Cdc25B*
Puji Astuti, Tanya Pike, Charlotte H. Widberg, E. Payne +3 more
2009Journal of Biological Chemistry43 citations Open access
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Caffeine Promotes Apoptosis in Mitotic Spindle Checkpoint-arrested Cells*
B. Gabrielli, Qian-Chau Yu, N. Giles, A. Harding +2 more
2007Journal of Biological Chemistry39 citations Open access
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Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors.
P. Donovan, K. Cato, Roxane A. Legaie, R. Jayalath +6 more
2014Molecular Biosystems34 citations Open access
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The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse
Emanuele Giurisato, Joseph Lin, A. Harding, Elisa Cerutti +4 more
2009Molecular and Cellular Biology26 citations Open access
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Identification of Residues and Domains of Raf Important for Function in Vivo and in Vitro*
A. Harding, Virginia Hsu, Kerry Kornfeld, J. Hancock
2003Journal of Biological Chemistry19 citations Open access
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How MAP kinase modules function as robust, yet adaptable, circuits
Tianhai Tian, A. Harding
2014Cell Cycle11 citations Open access
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T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation
J. Whitacre, Joseph Lin, A. Harding
2011Front. Gene.9 citations Open access
Semantic Scholar
MAP kinase modules: Two kinases, not three
A. Harding
20138 citations
Semantic Scholar
Glioblastoma tumours can harbour a subset of polyploid cells that are resistant to conventional therapy and may increase the adaptive capacity of patient tumours
R. Jayalath, P. Donovan, K. Cato, G. Olsson +4 more
20121 citations
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Direction, Not Distance: A Mortality-Associated Physiological Axis Maps the Sex–Mortality Gap and Informs Sex-Balanced Trial Recruitment
A. Harding, Jim Coward, Jinping Feng, Tianhai Tian
2026bioRxiv0 citations Open access
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Elisa the Immunological Synapse of Extracellular Signal-Regulated Kinase to Scaffold KSR 1 Is Required for Recruitment The Mitogen-Activated Protein Kinase
A. Shaw, Cerutti, M. Cella, Robert E. Lewis +4 more
20160 citations
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Ploidy as a biomarker for targeting metabolism in ovarian cancer.
Matthew Whybird, A. Purdon, A. Harding, J. Coward
20150 citations
Semantic Scholar
PO01DISPARATE RADIATION RESPONSE OF SLOW PROLIFERATING CANCER STEM CELLS
F. Siebzehnrubl, N. Nabilsi, N. Pasternack, M. Rohaus +8 more
20150 citations Open access
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CB-07DISTINCT RADIATION RESPONSE OF SLOW-DIVIDING CANCER STEM CELLS.
L. Deleyrolle, N. Nabilsi, B. Griffith, N. Pasternack +8 more
20140 citations Open access
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the Immunological Synapse of Extracellular Signal-Regulated Kinase to Scaffold KSR1 Is Required for Recruitment The Mitogen-Activated Protein Kinase
A. Shaw, M. Cella, Robert E. Lewis, M. Colonna +3 more
20140 citations
Semantic Scholar
Fundamental System Outputs Activation in T Cells without Altering Mitogen-Activated Protein Kinase Pathway KSR1 Modulates the Sensitivity of
A. Shaw, Joseph Lin, A. Harding, Emanuele Giurisato
20140 citations
Semantic Scholar
in radioresistance of glioma initiating cells 2
Y. Lim, T. Roberts, B. Day, A. Harding +6 more
20120 citations
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Response of glioma initiating cells to ionising radiation
Y. Lim, T. Roberts, B. Day, A. Harding +5 more
20120 citations
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Abstract 1197: EphA3 kinase ablation induces glioblastoma differentiation and prevents tumor progression
B. Day, Michael J. Ting, B. Stringer, Kathleen S. Ensbey +13 more
20110 citations
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Abstract 3324: Evidence for label-retaining tumor initiating cells in human glioblastoma
L. Deleyrolle, A. Harding, K. Cato, F. Siebzehnrubl +8 more
20110 citations
Semantic Scholar
Low Dose Ionizing Radiation Responses and Knockdown of ATM Kinase Activity in Glioma Stem Cells
Y. Lim, T. Roberts, A. Harding, Bryan Day +3 more
20090 citations
Semantic Scholar
Toward using an oxidatively damaged plasmid as an intra- and inter-laboratory standard for ancient DNA studies
Loraine Watson, J. Connell, A. Harding, C. Whitchurch
20090 citations Open access
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S1e1-2 Plasma membrane signaling platforms(S1-e1: "Unraveling the membrane microdomains using new biophysical tools",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)
J. Hancock, R. Parton, D. Nicolau, Sarah J. Plowman +2 more
20060 citations Open access
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A biochemical analysis of the MAP kinase pathway in mammalian cells
A. Harding
20040 citations
Semantic Scholar

R. Parton

×5

B. Day×5

Kathleen S. Ensbey×5

Y. Lim×5

S. Olson×5

B. Gabrielli×5

Joseph Lin×5

A. Shaw×5