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Ulrike Garscha · SciRah

Researcher profile · Semantic Scholar

Ulrike Garscha

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Ulrike Garscha — researcher profile on SciRah

h-index: 26
Works: 64
Citations: 1,843

Most-cited papers

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
N. Gilbert, J. Gerstmeier, E. Schexnaydre, Friedemann R. Börner +4 more
2020Nature Chemical Biology210 citations Open access
Semantic Scholar
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
H. Pein, Alexia Ville, S. Pace, V. Temml +27 more
2018Nature Communications130 citations Open access
Semantic Scholar
Targeting biosynthetic networks of the pro-inflammatory and pro-resolving lipid metabolome
Markus Werner, P. M. Jordan, Erik Romp, Anna Czapka +9 more
2019The FASEB Journal127 citations Open access
Semantic Scholar
Identification of Dioxygenases Required for Aspergillus Development
Ulrike Garscha, F. Jernerén, Dawoon Chung, N. Keller +2 more
2007Journal of Biological Chemistry98 citations Open access
Semantic Scholar
Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening
B. Waltenberger, Ulrike Garscha, V. Temml, J. Liers +3 more
2016Journal of Chemical Information and Modeling52 citations
Semantic Scholar
Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry.
E. Oliw, Ulrike Garscha, T. Nilsson, M. Cristea
2006Analytical Biochemistry52 citations
Semantic Scholar
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
Ulrike Garscha, Erik Romp, S. Pace, A. Rossi +13 more
2017Scientific Reports51 citations Open access
Semantic Scholar
Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes
J. Gerstmeier, C. Weinigel, S. Rummler, O. Rådmark +2 more
2016The FASEB Journal51 citations
Semantic Scholar
An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis.
J. Gerstmeier, C. Weinigel, D. Barz, O. Werz +1 more
2014Biochimica et Biophysica Acta45 citations
Semantic Scholar
Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells.
Helen A. Andersson, Ulrike Garscha, E. Brittebo
2011Toxicology45 citations Open access
Semantic Scholar
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).
E. Banoglu, E. Çelikoğlu, Susanna Völker, A. Olğaç +7 more
2016European journal of medicinal chemistry44 citations Open access
Semantic Scholar
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.
C. Pergola, N. Gaboriaud-Kolar, Nadine Jestädt, Stefanie König +10 more
2014Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Steric analysis of 8-hydroxy- and 10-hydroxyoctadecadienoic acids and dihydroxyoctadecadienoic acids formed from 8R-hydroperoxyoctadecadienoic acid by hydroperoxide isomerases.
Ulrike Garscha, E. Oliw
2007Analytical Biochemistry42 citations
Semantic Scholar
Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening
V. Temml, Ulrike Garscha, Erik Romp, Gregor Schubert +7 more
2017Scientific Reports41 citations Open access
Semantic Scholar
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly.
Ulrike Garscha, Susanna Voelker, S. Pace, J. Gerstmeier +12 more
2016Biochemical Pharmacology41 citations
Semantic Scholar
A lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.
Cynthia Palmieri-Thiers, S. Canaan, Virginie Brunini, V. Lorenzi +6 more
2009Biochimica et Biophysica Acta41 citations Open access
Semantic Scholar
Leucine/Valine Residues Direct Oxygenation of Linoleic Acid by (10R)- and (8R)-Dioxygenases
Ulrike Garscha, E. Oliw
2009Journal of Biological Chemistry41 citations Open access
Semantic Scholar
5‐Lipoxygenase‐activating protein rescues activity of 5‐lipoxygenase mutations that delay nuclear membrane association and disrupt product formation
J. Gerstmeier, M. Newcomer, Sophie Dennhardt, Erik Romp +3 more
2016The FASEB Journal39 citations Open access
Semantic Scholar
Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry.
Ulrike Garscha, T. Nilsson, E. Oliw
2008Journal of chromatography. B, Analytical technologies in the biomedical and life sciences39 citations
Semantic Scholar
Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms.
E. Oliw, F. Jernerén, Inga Hoffmann, M. Sahlin +1 more
2011Biochimica et Biophysica Acta38 citations
Semantic Scholar
Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.
Inga Hoffmann, F. Jernerén, Ulrike Garscha, E. Oliw
2011Archives of Biochemistry and Biophysics37 citations
Semantic Scholar
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
O. Werz, J. Gerstmeier, Ulrike Garscha
2017Expert Opinion on Therapeutic Patents35 citations
Semantic Scholar
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
F. Jernerén, Ulrike Garscha, Inga Hoffmann, M. Hamberg +1 more
2010Biochimica et Biophysica Acta32 citations
Semantic Scholar
Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction
F. Mayr, G. Möller, Ulrike Garscha, Jana Fischer +14 more
2020bioRxiv31 citations Open access
Semantic Scholar
The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
A. M. Schaible, R. Filosa, Verena Krauth, V. Temml +17 more
2016Biochemical Pharmacology30 citations
Semantic Scholar
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.
D. de Lucia, Oscar Méndez Lucio, B. Musio, A. Bender +8 more
2015European journal of medicinal chemistry27 citations Open access
Semantic Scholar
Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.
Ann-Kathrin Häfner, J. Gerstmeier, Michael Hörnig, S. George +5 more
2015Biochimica et Biophysica Acta26 citations
Semantic Scholar
Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases
E. Oliw, A. Wennman, Inga Hoffmann, Ulrike Garscha +2 more
2011Journal of Lipid Research26 citations Open access
Semantic Scholar
Critical amino acids for the 8(R)‐dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases
Ulrike Garscha, E. Oliw
2008FEBS Letters24 citations Open access
Semantic Scholar
Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis
Erik Romp, Vandana Arakandy, Jana Fischer, C. Wolz +5 more
2019Cellular and Molecular Life Sciences22 citations Open access
Semantic Scholar
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
S. M. Noha, K. Fischer, A. Koeberle, Ulrike Garscha +2 more
2015Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
A Multi‐step Virtual Screening Protocol for the Identification of Novel Non‐acidic Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors
S. Shekfeh, B. Çalışkan, K. Fischer, Tansu Yalçın +3 more
2018ChemMedChem18 citations
Semantic Scholar
Impact of food polyphenols on oxylipin biosynthesis in human neutrophils.
N. Hartung, Jana Fischer, A. I. Ostermann, Ina Willenberg +3 more
2019Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids16 citations
Semantic Scholar
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation
K. Neukirch, Khaled Alsabil, C. Dinh, Rossella Bilancia +28 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.
Stefanie König, Erik Romp, Verena Krauth, Michael Rühl +9 more
2019Cell Chemical Biology15 citations Open access
Semantic Scholar
Modulation of microRNA processing by 5‐lipoxygenase
Stella Uebbing, Marius Kreiß, Friederike Scholl, Ann-Kathrin Häfner +8 more
2020The FASEB Journal14 citations Open access
Semantic Scholar
Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases
C. Tolksdorf, E. Moritz, R. Wolf, Ulrike Meyer +5 more
2022International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
Candida albicans‐induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology
Jana Fischer, M. Gresnigt, O. Werz, B. Hube +1 more
2021The FASEB Journal13 citations Open access
Semantic Scholar
Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids.
S. Liening, Erik Romp, O. Werz, G. Scriba +1 more
2019Prostaglandins & other lipid mediators13 citations
Semantic Scholar
Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors
Lisa Vieider, Erik Romp, V. Temml, J. Fischer +9 more
2018ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
A. Svouraki, Ulrike Garscha, Eirini Kouloura, S. Pace +8 more
2017Journal of Natural Products13 citations Open access
Semantic Scholar
Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
Serkan Levent, J. Gerstmeier, A. Olğaç, Felix Nikels +6 more
2016European journal of medicinal chemistry13 citations Open access
Semantic Scholar
A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection.
O. Scherer, Marten B. Maess, Saskia Lindner, Ulrike Garscha +4 more
2015JIM - Journal of Immunological Methods13 citations
Semantic Scholar
Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase
T. Teder, Stefanie König, Rajkumar Singh, B. Samuelsson +3 more
2023International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase.
Ulrike Garscha, E. Oliw
2008Biochemical and Biophysical Research Communications - BBRC12 citations
Semantic Scholar
Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Tuğba Gürses, A. Olğaç, Ulrike Garscha, Tuğçe Gür Maz +6 more
2021Bioorganic chemistry (Print)10 citations
Semantic Scholar
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol
A. Olğaç, A. Carotti, C. Kretzer, Stephanie Zergiebel +5 more
2020Journal of Chemical Information and Modeling10 citations
Semantic Scholar
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.
S. Liening, G. Scriba, S. Rummler, C. Weinigel +4 more
2016Biochimica et Biophysica Acta10 citations
Semantic Scholar
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility.
Martin Schoenthaler, Lorenz Waltl, T. Hasenoehrl, David Seher +12 more
2023Bioorganic chemistry (Print)9 citations Open access
Semantic Scholar
Development of SFC-MS Method for Quantification of Eicosanoids Biosynthesized in Primary Human Blood Cells
L. Schmidt, Laura Burmeister, A. Greinacher, Stefanie König +1 more
2022Metabolites8 citations Open access
Semantic Scholar

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